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Interactions between CagA and smoking in gastric cancer

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World Journal of Gastroenterology 2011年第28期17卷 3330-3334页

作者： xiao-Qin wang Hong Yan Paul d Terry Jian-Sheng Wang Li Cheng Wen-An Wu Sen-Ke Hu department of Statistics and Epi-demiology School of Medicine Xi＇an Jiaotong University Xi＇an710061 Shaanxi Province China department of Public Health University of Ten-nessee HPER 390 Knoxville TN 37996 United States department of Thoracic Oncosurgery FirstAffiliated Hospital of Medical School Xi＇an Jiaotong UniversityXi＇an 710061 Shaanxi Province China department of Nursing School of Medicine Xi＇anJiaotong University Xi＇an 710061 Shaanxi Province China department of Radiation Oncology Cancer Hospi-tal of Shaanxi Province Xi an 710061 Shaanxi Province China Lab Center of Public Health department Schoolof Medicine Xi＇an Jiaotong University Xi＇an 710061 ShaanxiProvince China

AIM: To examine the interactions between cytotoxinassociated gene (CagA) positive Helicobacter pylori infection and smoking in non-cardiac gastric ***: A case-control study (257 cases and 514 frequency-matched controls) was conducted from September 2008 to July 2010 in Xi’an,*** were newly diagnosed,histologically confirmed non-cardiac *** were randomly selected from similar communities to the cases and were further matched by sex and age (± 5 years).A face-to-face interview was performed by the investigators for each *** were obtained using a standardized questionnaire that included questions regarding known or suspected lifestyle and environmental risk factors of gastric cancer.A 5 mL sample of fasting venous blood was *** infection was serologically detected by enzymelinked immunosorbent ***: Smoking and CagA infection were statistically significant risk factors of non-cardiac *** was categorized in tertiles,and the odds ratio (OR) was 12.4 (95% CI: 6.1-20.3,P = 0.003) for CagA after being adjusted for confounding factors when the highexposure category was compared with the low-exposure *** had an OR of 5.4 compared with subjects who never smoked (95% CI: 2.3-9.0,P = 0.002).The OR of non-cardiac cancer was 3.5 (95% CI: 1.8-5.3) for non-smokers with CagA infection,3.5 (95% CI: 1.9-5.1) for smokers without CagA infection,and 8.7 (95% CI: 5.1-11.9) for smokers with CagA infection compared with subjects without these risk *** adjusting for confounding factors,the corresponding ORs of non-cardiac cancer were 3.2 (95% CI: 1.5-6.8),2.7 (95% CI: 1.3-4.9) and 19.5 (95% CI: 10.3-42.2),*** was a multiplicative interaction between smoking and CagA,with a synergistic factor of 2.257 (z = 2.315,P = 0.021).CONCLUSION: These findings support a meaningful interaction between CagA and smoking for the risk of gastric cancer which may have implications for its early detection.

关键词： Non-cardia cancer Cytotoxin-associated gene Helicobacter pylori Interaction Smoking

Construction of hybrid z-scheme graphitic C_(3)N_(4)/reduced TiO_(2) microsphere with visible-light-driven photocatalytic activity

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Journal of Materiomics 2018年第3期4卷 238-246页

作者： C.zhou N.F.Ye X.H.Yan J.J.Wang J.M.Pan d.F.Wang Q.Wang J.X.zu X.N.Cheng School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013JiangsuChina Institute for Advanced Materials Jiangsu UniversityZhenjiang212013JiangsuChina Institute of Green Materials and Metallurgy Jiangsu UniversityZhenjiang 212013JiangsuChina

A novel z-scheme graphitic C_(3)N_(4)/reduced TiO_(2)microsphere(g-C_(3)N_(4)/r-TiO_(2))has been successfully synthesized by a solvothermal *** as-prepared samples with different contents of g-C_(3)N_(4)were characterized by X-ray diffraction,electron paramagnetic resonance,scanning electron microscope,UV *** reflectance and photoluminescence *** r-TiO_(2)microspheres are aggregated on the surface of g-C_(3)N_(4)sheets in the as-prepared g-C_(3)N_(4)/r-TiO_(2)*** g-C_(3)N_(4)/r-TiO_(2)catalysts show enhanced photocatalytic activity for the degradation of rhodamine B under visible light *** could be attributed to these influences of oxygen vacancy(changing the band gap of TiO_(2)),the large specific surface area(providing much more active sites for photocatalytic reaction),and the synergetic effect between g-C_(3)N_(4)and r-TiO_(2)(promoting the separation for photoinduced electron-hole pairs).Moreover,the z-scheme carriers transfer mechanism in the photocatalytic process has been discussed through trapping experiments of active *** work demonstrates the strategies of the construction of z-scheme carriers transfer system,the introduction of oxygen vacancy and structure designing are beneficial to design materials toward solar energy conversion like contaminant degradation.

关键词： TiO_(2) C_(3)N_(4) Oxygen vacancy z-scheme heterojunction Photocatalytic performance

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基于投影网格的全球多分辨率地形绘制

计算机工程 2009年第8期35卷 230-232页

作者：康来吴玲达宋汉辰杨冰国防科技大学信息系统与管理学院长沙410073

提出一种基于投影网格的全球多分辨率地形绘制算法。利用投影网格剖分球面,快速完成视域内球面的非均匀网格化。对地形数据分层组织、分块存储,通过可视区域计算,实现高效率的地形数据装载和更新。由于每帧网格数量保持基本不变,确保了... 详细信息

提出一种基于投影网格的全球多分辨率地形绘制算法。利用投影网格剖分球面,快速完成视域内球面的非均匀网格化。对地形数据分层组织、分块存储,通过可视区域计算,实现高效率的地形数据装载和更新。由于每帧网格数量保持基本不变,确保了稳定的帧率。实验结果表明该算法在全球三维地形实时绘制上能取得较好的视觉效果,计算量小、具有较高的效率。

关键词：投影网格全球地形实时绘制多分辨率

HR-HPV载量和HR-HPV E6/E7 mRNA在宫颈癌和癌前病变的表达和意义

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中国热带医学 2019年第7期19卷 620-626页

作者：付艳丽余杨何利珍孙翔河南理工大学第一附属医院河南省焦作市第二人民医院检验科

目的比较和分析高危型人乳头瘤病毒(HR-HPV)载量和HR-HPV E6/E7 mRNA在宫颈癌和宫颈上皮内瘤变(CIN)的表达和差异,探讨二者的关联及其在宫颈癌变进程中的临床意义。方法以339例HR-HPV持续感染者为研究对象,依病理组织学诊断分为宫颈癌和... 详细信息

目的比较和分析高危型人乳头瘤病毒(HR-HPV)载量和HR-HPV E6/E7 mRNA在宫颈癌和宫颈上皮内瘤变(CIN)的表达和差异,探讨二者的关联及其在宫颈癌变进程中的临床意义。方法以339例HR-HPV持续感染者为研究对象,依病理组织学诊断分为宫颈癌和CINⅠ、CINⅡ、CINⅢ共4组,分别采用PCR荧光法、支链dNA技术定量检测宫颈刷检物中的HPV-dNA和HPV E6/E7 mRNA,对数据资料进行统计学分析。结果(1)随宫颈病变严重程度的增加,HR-HPV dNA和HR-HPV E6/E7 mRNA的表达水平和阳性表达率均明显上升;(2)不同等级的宫颈病变中,HR-HPV dNA和HR-HPV E6/E7 mRNA的阳性表达率总体分布差异无统计学意义(P>0.05),两两比较显示,除CINⅡ组两指标检测阳性率差异无统计学意义(P>0.05),其余各组间差异有统计学意义(PdNA的总体表达水平差异均有统计学意义(Pz=-1.013,P=0.311),其余组别间差异有统计学意义(PdNA在CINⅠ和CINⅡ之间差异无统计学意义(z=-1.376,P=0.169),CINⅢ和宫颈癌之间差异无统计学意义(z=-0.991,P=0.322),其余组别间差异有统计学意义(PdNA间存在相关性(r=0.533,P0.05);(5)随着病毒载量的提高,高级别CIN和宫颈癌在宫颈病变整体构成的占比上升。结论 HR-HPV E6/E7 mRNA在CINⅠ阶段即开始表达,随着表达量激增,加速宫颈癌的发生,HR-HPV载量和HR-HPV E6/E7 mRNA存在显著相关性,病毒与宿主基因整合,干扰了HPV载量与病变严重程度的一致性。

关键词：高危型人乳头瘤病毒载量高危型人乳头瘤病毒E6/E7 mRNA 宫颈癌宫颈上皮内瘤变

Semantic and Phonemic Verbal Fluency Performance in Patients with General Anxiety disorders and Allostatic Load under Alprazolam Treatment

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Open Journal of Psychiatry 2019年第2期9卷 138-152页

作者： Carlos A. Soria Carolina Remedi Luciana d’Alessio Emilio J. A. Roldán Institute of Biosciences Henri Laborit Córdoba Argentina Buenos Aires University CONICET Buenos Aires Argentina Scientific direction Gador SA Buenos Aires Argentina

Purpose: Anxiety disorders are frequently associated with chronic stress with possible cognitive consequences. The aim of this study was to determine the verbal fluency performance in a cohort of patients with anxiety disorders and allostatic load, treated with alprazolam during 12 weeks. Methods: Patients with GAd (general anxiety disorders, dSM IV), with >6 in Hamilton Anxiety Rating Scale (HAM-A), neuroticism > 18 (NEO-FFI inventory), and normal Mini-Mental State Examination were included. Clinical and Psychiatric examination, Allostatic Load Index and cognitive assessment were analyzed before and after 12 weeks of treatment. The phonemic and semantic verbal fluency tests were determined in all patients. The scoring for each fluency task was determined by counting the number of correct words. The total score from each semantic and phonemic verbal task was analyzed comparing the individual score with normal data controlled by age and sex. Patients with scores > ?2 standard deviation (Sd) from normative data were considered impaired. Results: Fifty-four patients completed the semantic verbal fluency test before treatment and fifty patients completed after treatment. According to the z-scores before treatment 7 patients of 54 (12.9%) had verbal fluency impairments. After treatment none patients showed semantic verbal fluency deficits but 3 patients of 50 (6%) showed phonemic impairments. Impaired group was significantly associated with an older age before treatment (p = 0.033) and with a similar tendency but not significant (p = 0.09) after treatment (Student t test). Conclusion: In this study older age factor was associated with verbal fluency impairment in GAd patients. Stratified treatments analyzing age and sex factors, including allostatic load measurements and cognitive assessments may be useful tools to determine the effectiveness and the safety of psychopharmacological treatments.

关键词： Verbal Fluency Test Chronic Stress Allostatic Load Sex Age

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动态博弈频谱共享模型研究

小型微型计算机系统 2014年第2期35卷 286-289页

作者：李婷婷陈志奎刘旸大连理工大学软件学院辽宁大连116620

层出不穷的无线多媒体应用以及用户对服务质量的要求的不断提升,产生了大量的带宽需求,但频谱资源却相对有限,如何实现两者之间的平衡成为一个亟待解决的问题,因此认知无线电中的动态频谱共享问题越来越受到广泛关注,许多研究从不同角... 详细信息

层出不穷的无线多媒体应用以及用户对服务质量的要求的不断提升,产生了大量的带宽需求,但频谱资源却相对有限,如何实现两者之间的平衡成为一个亟待解决的问题,因此认知无线电中的动态频谱共享问题越来越受到广泛关注,许多研究从不同角度建立了基于博弈论的竞争/合作模型.本文建立的是一个动态博弈模型.当次用户认知到主用户的空闲频谱资源时,根据本地的信息,给出有利于次用户的支付方案:建立价格与购买量之间的关系.然后,主用户根据次用户的方案,利用定价最大化自身的收益.仿真分析了主用户定价对其收益的影响以及在整体网络质量改变时,对定价及收益的影响.

关键词：认知无线电动态频谱共享收益函数动态博弈模型

液相色谱质谱联用法同时测定人血浆中伊立替康及其代谢产物的浓度

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中国临床药理学杂志 2023年第2期39卷 276-280页

作者：薄云海周军许凌霄杨芬北京大学肿瘤医院暨北京市肿瘤防治研究所国家药物临床试验机构恶性肿瘤发病机制及转化研究教育部重点实验室北京100142 北京大学肿瘤医院暨北京市肿瘤防治研究所消化内科恶性肿瘤发病机制及转化研究教育部重点实验室北京100142

目的建立液相色谱质谱联用(LC-MS/MS)法同时测定人血浆中伊立替康(CPT-11)及其4个代谢产物SN38、SN38G、APC和NPC的浓度,并将方法应用于肠癌患者的治疗药物监测。方法选用SN38-d3作为内标,人血浆样本经甲醇沉淀蛋白法前处理,通过高效... 详细信息

目的建立液相色谱质谱联用(LC-MS/MS)法同时测定人血浆中伊立替康(CPT-11)及其4个代谢产物SN38、SN38G、APC和NPC的浓度,并将方法应用于肠癌患者的治疗药物监测。方法选用SN38-d3作为内标,人血浆样本经甲醇沉淀蛋白法前处理,通过高效液相色谱-质谱检测,色谱柱Agilent zORBAX Eclipse Plus RRHd-C18(2.1 mm×50.0 mm, 1.8μm),柱温:40℃,流动相:乙腈-水(含0.1%甲酸)梯度洗脱,流速:0.4 mL·min^(-1)。质谱分析用电喷雾离子源(ESI),以多反应监测(MRM)及正离子采集模式进行定量分析,定量分析离子对分别为m/z 587.1→m/z 166.9(CPT-11),m/z 393.1→m/z 349.1(SN38),m/z 569.0→m/z 393.0(SN38G),m/z 619.1→m/z 348.8(APC),m/z 519.0→m/z 349.0(NPC),m/z 396.1→m/z 352.1(SN38-d3)。结果 CPT-11、SN38、SN38G、APC和NPC分别在40.00~2 000.00,2.00~100.00,4.00~200.00,2.00~100.00和0.10~5.00 ng·mL^(-1)内线性关系良好(r≥0.99),批内、批间准确度以相对误差(RE%)表示,RE%在-11.17%~2.45%,精密度以变异系数(CV%)表示,CV%≤12.78%。结论本法能够快速、灵敏、准确的测定人血浆中CPT-11及其4个代谢产物,适用于肠癌患者给予CPT-11后的治疗药物监测。

关键词：伊立替康代谢产物人血药浓度液质联用法肠癌患者

不同黑麦品种(品系)对持续干旱胁迫的形态适应性研究

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草地学报 2020年第1期28卷 122-129页

作者：杨丹张舒芸田新会杜文华甘肃农业大学草业学院草业生态系统教育部重点实验室中-美草地畜牧业可持续研究中心

为筛选适应我国西北干旱半干旱区的抗旱黑麦(Secale cereale L.)种质,本研究采用两因素随机区组试验设计,以黑麦品系C15,C33,C39,z7和z27为试验材料,‘甘引1号’黑麦品种(CK1)和黑饲麦品种(CK2)为对照,通过防雨棚遮雨法控制降雨,于三叶... 详细信息

为筛选适应我国西北干旱半干旱区的抗旱黑麦(Secale cereale L.)种质,本研究采用两因素随机区组试验设计,以黑麦品系C15,C33,C39,z7和z27为试验材料,‘甘引1号’黑麦品种(CK1)和黑饲麦品种(CK2)为对照,通过防雨棚遮雨法控制降雨,于三叶期测定上述材料在正常灌水和干旱胁迫第7 d,14 d,21 d,35 d,49 d,63 d的株高、分蘖数、叶片数、地上生物量和地下生物量。结果表明:随着胁迫天数增加,供试黑麦材料的平均相对分蘖数、地上生物量和地下生物量总体呈下降趋势,而相对株高和叶片数呈上升趋势。7份黑麦材料中,C15的平均相对分蘖数,地下生物量和地上生物量最大;C33的平均相对叶片数最多;CK2的平均相对株高最高。从黑麦材料与干旱胁迫天数间的交互作用来看,重度干旱胁迫(第63 d)下各黑麦材料形态指标的相对值与轻度干旱(第7 d)的相对值差异最明显。基于隶属函数的综合评价表明:供试黑麦材料抗旱性强弱依次为:C15>C33>CK1>CK2>C39>z27>z7,可见,C15属于强抗旱型,C33属于中抗旱型,CK1和CK2属于中间型,C39和z27属于干旱较敏感型,z7属于干旱敏感型。说明在干旱胁迫下,参试材料C15的抗旱性最强,可作为我国西北干旱半干旱区抗旱黑麦新品种选育和抗旱种质资源开发利用的基础材料。

关键词：黑麦形态指标抗旱性综合评价

淋巴结超声造影可提高早期乳腺癌前哨淋巴结的术前诊断效能

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国际医学放射学杂志 2023年第3期 363-363页

作者： z.H.Niu Y.J.Gao M.S.Xiao F.Mao Y.d.zhou Q.L.zhu 吕律

摘要目的评估淋巴结超声造影（CEUS）对早期乳腺癌前哨淋巴结（SLN）的术前诊断价值。方法前瞻性连续收集2021年7—10月共102例临床诊断为淋巴结阴性的早期乳

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