检索结果-南通市图书馆

IdH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbingα-ketoglutarate-related metabolism and epigenetic modification

引用

Life Metabolism 2024年第2期3卷 24-37页

作者： Yuanlin zhao Ying yang Risheng yang Chao Sun Xing Gao Xiwen Gu Yuan Yuan Yating Nie Shenhui Xu Ruili Han Lijun zhang Jing Li Peizhen Hu Yingmei Wang Huangtao Chen Xiangmei Cao Jing Wu zhe Wang Yu Gu Jing Ye State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of PathologyXijing Hospital and School of Basic MedicineFourth Military Medical UniversityXi’anShaanxi 710032China department of Pathology Air Force Hospital of Southern Theater CommandGuangzhouGuangdong 510000China department of Neurology Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi 710038China department of Clinical diagnosis Tangdu HospitalFourth Military Medical UniversityXi’anShaanxi 710038China department of Neurosurgery the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China department of Pathology School of Basic Medical SciencesNingxia Medical UniversityYinchuanNingxia 750004China Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049China

Isocitrate dehydrogenase(IdH)mutations frequently occur in lower-grade gliomas and secondary *** IdHs exhibit a gain-of-function activity,leading to the production of d-2-hydroxyglutarate(d-2HG)by reducing α-ketoglutarate(α-KG),a central player in metabolism and epigenetic ***,the role ofα-KG homeostasis in IdH-mutated gliomagenesis remains *** this study,we found that low expression of oxoglutarate dehydrogenase(OGdH)was a common feature in IdH-mutated gliomas,as well as *** low expression of OGdH resultedin the accumulation of α-KG and promoted astrocyte ***,IdH1 mutation significantly reducedα-KG levels and increased glutaminolysis and dNA/histone methylation in *** metabolic and epigenetic alterations inhibited astrocyte maturation and led to cortical dysplasia in ***,our results also indicated that reduced OGdH expression can promote the differentiation of glioma cells,while IdH1 mutations impeded the differentiation of glioma cells with low OGdH by reducing the accumulation ofα-KG and increasing ***,we found that l-glutamine increasedα-KG levels and augmented the differentiation-promoting effects of AGI5198,an IdH1-mutant inhibitor,in IdH1-mutant glioma ***,this study reveals that low OGdH expression is a crucial metabolic characteristic of IdH-mutant gliomas,providing a potential strategy for the treatment of IdH-mutant gliomas by targetingα-KG homeostasis.

关键词： α-ketoglutarate IdH1 mutation OGdH l-glutamine gliomas

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ground-based and additional science support for SMILE

引用

Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.Carter M.dunlop C.Forsyth K.Oksavik E.donovon A.Kavanagh S.E.Milan T.Sergienko R.C.Fear d.G.Sibeck M.Connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams J.Gjerloev R.Barnes d.d.Billet G.Chisham A.dimmock M.P.Freeman d.-S.Han M.d.Hartinger S.-Y.W.Hsieh z.-J.Hu M.K.James L.Juusola K.Kauristie E.A.Kronberg M.Lester J.Manuel J.Matzka I.McCrea Y.Miyoshi J.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh C.Wang J.Weygand J.Wild J.Yan J.zhang Q.-H.zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China department of Space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The Johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish Meteorological Institute(FMI) Finland department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFz German Research Centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE ***,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMILE data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILE conjunctions missions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of performance of the KM2A full array using the Crab Nebula

引用

Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 d.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 d.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.Heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 d.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 d.Ruffolo A.Sáiz d.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 LHAASO Collaboration Key Laboratory of Particle Astrophyics&Experimental Physics division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Hebei Normal University Shijiazhuang 050024China Key Laboratory of dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of Physics and Astronomy Yunnan UniversityKunming 650091China département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since July *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LHAASO and other experiments.

关键词： γ-ray Crab Nebula significance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A new scale for optimized cryogenic magnetocaloric effect in ErAl_2@Al_2O_3 nanocapsules

引用

Journal of Materials Science & Technology 2018年第5期34卷 848-854页

作者： F.Wei S.Ma L.yang Y.Feng J.z.Wang A.Hua X.G.zhao d.Y.Geng z.d.zhang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences

The Er Al2@Al2O3 nanocapsules with Er Al2core and Al2O3 shell were synthesized by modified arc-charge *** typical core-shell structure of the nanocapsules was confirmed by high resolution transmission electron microscopy and X-ray photoelectron *** electron microscopy analysis shows the irregular sphere of the nanocapules with an average diameter of 26 *** investigation revealed the Curie temperature of Er Al2@Al2O3 nanocapsules at 20 K and the typical superparamagnetic behavior between blocking temperature and Curie *** on the blocking temperature and average diameter,the magnetocrystalline anisotropy constant of Er Al2@Al2O3nanocapsules was estimated to illustrate the magnetic contribution to *** large-SMof 14.25 J/（kg K）was obtained under 50 k Oe at 5 K.A vital parameter β was introduced in the present work to scale the optimized magnetic characteristics and the optimized mechanism was discussed in detail according to classical superparamagnetic *** results demonstrate that the optimal-SMwill be obtained when the magnetic parameter β is close to the theoretical coefficient.

关键词： Nanocapsules Magnetocaloric effect Superparamagnetic property Cryogenic refrigeration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Further investigation on the fusion of ^(6)Li with ^(209)Bi target at near-barrier energies

引用

Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 d.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 J.J.Valiente-dobón d.Testov M.Mazzocco A.Gozzelino C.Parascandolo d.Pierroutsakou M.La Commara A.Goasduff d.Bazzacco d.R.Napoli F.Galtarossa F.Recchia A.Illana S.Bakes I.zanon S.Aydin G.de Angelis M.Siciliano R.Menegazzo S.M.Lenzi J.L.Ferreira J.Rangel Serkan Akkoyun L.F.Canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced Study in Nuclear Energy&Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly dipartimento di fisica Astronomia dell'Universita di padova PadovaItaly State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly dipartimento di Farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics division Argonne National LaboratoryLemont-ILUSA departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete and incomplete fusion cross sections for ^(6)Li+^(209)Bi were measured using the in-beamγ-ray method around the Coulomb *** cross sections of(deuteron captured)incomplete fusion(ICF)products were re-quantified experimentally for this reaction *** results reveal that the ICF cross section is equivalent to that of complete fusion(CF)above the Coulomb barrier and dominant near or below the Coulomb barrier.A theoretical calculation based on the continuum discretized coupled channel(CdCC)method was performed for the aforementioned CF and ICF cross sections;the result is consistent with the *** universal fusion function(UFF)was also compared with the measured CF cross section for different barrier parameters,demonstrating that the CF suppression factor is significantly influenced by the choice of potential,which can reflect both dynamic and static effects of breakup on the fusion process.

关键词： cross section incomplete fusion suppression factor weakly bound nuclei

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

diagnose and treatment for Type d congenital esophageal atresia with tracheoesophageal fistula

引用

Pediatric Investigation 2024年第1期8卷 37-43页

作者： dingding Wang Yong zhao Yanan zhang Kaiyun Hua Yichao Gu Shuangshuang Li Junmin Liao Shen yang Ting yang Jiawei zhao Jinshi Huang department of Neonatal Surgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Type d esophageal atresia(EA)with tracheoesophageal fistula(TEF)is characterized by EA with both proximal and distal *** is a rare congenital anomaly with a very low ***:To investigate diagnostic and treatment strategies for this rare ***:We retrospectively reviewed the clinicopathological features of patients with EA/TEF treated at our institution between January 2007 and September ***:Among 386 patients with EA/TEF,14(3.6%)had type d EA/*** two patients were diagnosed with proximal TEF *** patients were diagnosed *** patients were missed for diagnosis during the initial surgery but was later confirmed by *** the neonatal period,seven patients underwent a one-stage repair of proximal and distal TEF via thoracoscopy or *** to missed diagnosis and other reasons,the other 7 patients underwent two-stage surgery for repair of the proximal TEF,including cervical incision and *** of the 14 patients experienced postoperative complications including anastomotic leakage,pneumothorax,esophageal stricture,and *** who underwent one-stage repair of distal and proximal TEF during the neonatal period showed a higher incidence of anastomotic leak(4/7).In contrast,only one of seven patients with two-stage repair of the proximal TEF developed an anastomotic ***:Type d EA/TEF is a rare condition,and proximal TEFs are easily *** may aim to diagnose and determine the correct surgical approach.A cervical approach may be more suitable for repairing the proximal TEF.

关键词： diagnosis Therapy Tracheoesophageal fistula Type d congenital esophageal atresia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CHEMICALLY dEPOSITEd SILVER FILM USEd AS A SERS-ACTIVE OVER-COATING LAYER FOR POLYMER FILM

引用

Chinese Journal of Polymer Science 2001年第3期19卷 265-268页

作者： Stephen z.d. Cheng department of Polymer Science The University of Akron Akron OH 44325 USA

When colloidal silver particles were chemically deposited onto polymer film as an over-coating layer, surface-enhanced Raman scattering (SERS) spectra could be collected for the surface analysis. SERS measurements of ... 详细信息

关键词： surface enhanced Raman scattering chemically deposited silver polymer film

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

FACTORS ON VISCOSITY STABILITY OF MOLd FLUXES

引用

Acta Metallurgica Sinica(English Letters) 2004年第2期17卷 175-180页

作者： C.Y.zhu C.J.Liu M.F.Jiang z.d.yang NortheasternUniversity Shenyang110004China Ji＇nanIronandSteelGroupCo. Ji＇nan250101China

Viscosity stability indexes of mold flux at high temperature and low temperature havebeen introduced and the effects of flux compositions on viscosity stability indexeshave been studied. Two mold fluxes have been developed by analyzing the effects offlux viscosity stability on the process and the condition of continuous casting slab ofmedium carbon steel. The results show that the fluxes are suitable for the process.

关键词： mold flux viscosity stability index high temperature low temperature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats

引用

Virologica Sinica 2024年第4期39卷 565-573页

作者： Hao-Rui Si Ke Wu Jia Su Tian-Yi dong Yan zhu Bei Li Ying Chen yang Li zheng-Li Shi Peng zhou Wuhan Institute of Virology Chinese Academy of SciencesWuhan 43000China Guangzhou National Laboratory Guangzhou International Bio IslandGuangzhou 510005China University of Chinese Academy of Sciences Beijing 100000China State Key Laboratory of Respiratory disease The First Affiliated Hospital of Guangzhou Medical SchoolGuangzhou 510005China

Bats are the natural reservoir hosts for SARS-related coronavirus(SARSr-CoV)and other highly pathogenic ***,it is conceivable that an individual bat may harbor multiple ***,there is limited knowledge on the overall co-circulation of microorganisms in ***,we conducted a 16-year monitoring of bat viruses in south and central China and identified 238 SARSr-CoV positive samples across nine bat species from ten provinces or administrative *** these,76 individual samples were selected for further metagenomics *** found a complex microenvironment characterized by the general cocirculation of microbes from two different sources:mammal-associated viruses or environment-associated *** later includes commensal bacteria,enterobacteria-related phages,and insect or fungal viruses of food *** showed that 25%(19/76)of the samples contained at least one another mammal-associated virus,notably alphacoronaviruses(13/76)such as AlphaCoV/YN2012,HKU2-related CoV and AlphaCoV/Rf-HuB2013,along with viruses from other ***,we observed three viruses co-circulating within a single bat,comprising two coronavirus species and one *** analysis also revealed the potential presence of pathogenic bacteria or fungi in ***,we obtained 25 viral genomes from the 76 bat SARSr-CoV positive samples,some of which formed new evolutionary ***,our study reveals the complex microenvironment of bat microbiome,facilitating deeper investigations into their pathogenic potential and the likelihood of cross-species transmission.

关键词： Bat Microbiome SARS-related coronavirus Co-infection Alphacoronavirus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cyclic dinucleotide Self-Assembled Nanoparticles as a Carrier-Free delivery Platform for STING-Mediated Cancer Immunotherapy

引用

CCS Chemistry 2024年第1期6卷 177-195页

作者： Lang zhao Shao-Hua zhuo Tian-yang Wang Jun-Jun Wu Jing-Yun Su Wen-Hao Li Bo-dou zhang Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Beijing Institute for Brain disorders Beijing 100069 Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084

Cyclic dinucleotides(CdNs)are natural agonists of the stimulator of interferon genes(STING),which is an attractive immunotherapy ***,CdNs and their derivatives are being investigated ***,the poor bioavailability of exogenous CdNs has limited their application in *** nanocarriers are widely used for cytosolic delivery of CdNs,their loading capacity is insufficient,and their complicated composition and purification process raises bio-compatibility ***,we report a super-simplified CdN self-assembly strategy for carrier-free delivery of *** the presence of excess K^(+),CdNs form oligomers which further self-assemble with divalent metal ions(such as Mn^(2+))to form nanoparticles(NPs)in aqueous *** demonstrate that the self-assembled CdN NPs promote cellular uptake of CdNs and enhance tumor immunogenicity by remodeling the tumor microenvironment,inducing immunogenic tumor cell death and increasing tumorinfiltrating lymphocytes,which is conducive to the generation of tumor neoantigen-specific T-cell *** also demonstrate that the use of CdN NPs alone or in combination with immune checkpoint blockades inhibits tumor growth,highlighting the fact that CdN NPs are a potent platform for cancer immunotherapy.

关键词： cyclic dinucleotide STING carrierfree delivery tumor immunogenicity cancer immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：