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Impact of metabolic dysfunction-associated steatotic liver disease on COVId-19 hospitalizations:A propensity-matched analysis of the United States

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World Journal of Virology 2024年第1期13卷 51-60页

作者： Abdullah Sohail Hassam Ali Pratik Patel Subanandhini Subramanium dushyant singh dahiya Amir H Sohail Manesh Kumar Gangwani Sanjaya K Satapathy department of Internal Medicine University of Iowa Roy J and Lucille A Carver College of MedicineIowaIA 52242United States division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States department of Gastroenterology Mather Hospital/Hofstra University Zucker School of MedicineNY11777United States department of Internal Medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States department of Surgery University of New MexicoAlbuquerqueNM 87106United States department of Internal Medicine The University of ToledoToledoOH 43606United States Section on Gastroenterology and Hepatology North Shore University Hospital and Long Island Jewish Medical CenterManhassetNY 11030United States

BACKGrOUNd Metabolic dysfunction-associated steatotic liver disease(MASLd),formally known as nonalcoholic fatty liver disease,is the most common chronic liver disease in the United *** with MASLd have been reported to be at a higher risk of developing severe coronavirus disease 2019(COVId-19)and ***,most studies are single-center studies,and nationwide data in the AIM To study the influence of MASLd on COVId-19 hospitalizations during the initial phase of the *** We retrospectively analyzed the 2020 National Inpatient Sample(NIS)database to identify primary COVId-19 hospitalizations based on an underlying diagnosis of MASLd.A matched comparison cohort of COVId-19 hospit-alizations without MASLd was identified from NIS after 1:N propensity score matching based on gender,race,and comorbidities,including hypertension,heart failure,diabetes,and *** primary outcomes included inpatient mortality,length of stay,and hospitalization *** outcomes included the prevalence of systemic *** A total of 2210 hospitalizations with MASLd were matched to 2210 hospitalizations without MASLd,with a good comorbidity ***,there was a higher prevalence of severe disease with more intensive care unit admissions(9.5%vs 7.2%,P=0.007),mechanical ventilation(7.2%vs 5.7%,P=0.03),and septic shock(5.2%vs 2.7%,Pd cohort than in the non-MASLd ***,there was no difference in mortality(8.6%vs 10%,P=0.49),length of stay(5 d vs 5 d,P=0.25),and hospitalization costs(42081.5$vs 38614$,P=0.15)between the MASLd and non-MASLd *** The presence of MAFLd with or without liver cirrhosis was not associated with increased mortality in COVId-19 hospitalizations;however,there was an increased incidence of severe COVId-19 *** data(2020)predates the availability of COVId-19 vaccines,and many MASLd patients have since been *** will be interesting to see if these trends are

关键词： COVId-19 Metabolic dysfunction-associated steatotic liver disease Prevalence Hospital charges Inpatient resource utilization

Time dependent differences in gray matter volume post mild traumatic brain injury

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Neural regeneration research 2016年第6期11卷 920-921页

作者： Prabhjyot singh William d.S.Killgore department of Psychiatry University of Arizona

When the brain is subjected to excessive physical forces,including blunt impact,high-speed rotation,or blast overpressure waves,its tissue structure and function can be compromised,leading to traumatic brain injury（... 详细信息

关键词： traumatic rotation cortical fusiform blast cortex distraction blunt gyrus medial

Effect of UrM infills on seismic vulnerability of Indian code designed rC frame buildings

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 233-241页

作者： Putul Haldar Yogendra singh d.K.Paul department of Earthquake Engineering IIT RoorkeeRoorkee-247667India

Unreinforced Masonry (UrM) is the most common partitioning material in framed buildings in India and many other countries. Although it is well-known that under lateral loading the behavior and modes of failure of the frame buildings change significantly due to infill-frame interaction, the general design practice is to treat infills as nonstructural elements and their stiffness, strength and interaction with the frame is often ignored, primarily because of difficulties in simulation and lack of modeling guidelines in design codes. The Indian Standard, like many other national codes, does not provide explicit insight into the anticipated performance and associated vulnerability of infilled frames. This paper presents an analytical study on the seismic performance and fragility analysis of Indian code-designed rC frame buildings with and without UrM infills. Infills are modeled as diagonal struts as per ASCE 41 guidelines and various modes of failure are considered. HAZUS methodology along with nonlinear static analysis is used to compare the seismic vulnerability of bare and infilled frames. The comparative study suggests that UrM infills result in a significant increase in the seismic vulnerability of rC frames and their effect needs to be properly incorporated in design codes.

关键词： UrM infill rC frame building Indian seismic design code seismic performance seismic vulnerability

Texture Evolution and Ultrafine Grain Formation in Cross-Cryo-rolled Zircaloy-2

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Acta Metallurgica Sinica(English Letters) 2015年第7期28卷 837-846页

作者： Sunkulp Goel r.Jayaganthan I.V.singh d.Srivastava G.K.dey N.Saibaba department of Metallurgical and Materials Engineering Centre of Nanotechnology department of Mechanical and Industrial Engineering Materials Science division Bhabha Atomic Research Center Nuclear Fuel Complex Limited

The texture and mechanical properties of cross-rolled zircaloy-2 at 77 and 300 K were *** at 77 K was performed to impart different thickness reductions of 25% and 50%,while at 300 K with 25%,50%,75% and 85% reductions to the *** analysis of deformed sample showed that near-basal orientation is not deformed completely after 50% rolling *** activation of prismatic silp,{1122} contraction twin and {1012} extension twin were evident from the deformed microstructure at 77 *** propensity for activation of basal slip〈a〉 at77 K was also *** deformation of the sample at 300 K occurs by prismatic,basal 〈a〉 and pyramidal 〈c＋a〉slips,which were predicted by pole *** annealing,the tensile strengths（735 and 710 MPa） are almost the same for 50% cryo-cross-rolled and room-temperature cross-rolled zircaloy-2 with almost 2.7% difference in their *** analysis of the deformed samples was made to estimate the stored strain energy and dislocation *** of deformed sample at 673 K for 30 min results in recrystallization,which leads to the formation of ultrafine grains.

关键词： Cross-rolling EBSd TEM Ultrafine grains Texture

Structural and optical properties of green emitting Y_(2)SiO_(5):Tb^(3+) and Gd_(2)SiO_(5):Tb^(3+) nanoparticles for modern lighting applications

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rare Metals 2021年第11期40卷 3289-3298页

作者： Sitender singh devender singh department of Chemistry Maharshi Dayanand UniversityRohtak 124001India

The optical and structural properties of Tb^(3+)-doped yttrium and gadolinium oxyorthosilicate(Y_(2)SiO_(5) and Gd_(2)SiO_(5)) phosphors were *** samples were synthesized via sol-gel combustion method using organic *** phase purity and structural properties of the samples were determined via combined approach of powder X-ray diffraction,Fourier transformation infrared(FTIr) and transmission electron microscopy(TEM).X-ray measurements revel monoclinic crystal lattice with P_(21/c) symmetry for both M_(2)SiO_(5)(pure host) and M_(2)SiO_(5):Tb^(3+)(doped) silicates,irrespective of the nature of metal(Y or Gd),presence or absence of Tb^(3+)in lattice and change in calcination temperature up to 1050℃.FTIr analysis was applied to confirm the bonding of prepared *** appearance of bands corresponding to SiO_(4) tetrahedra(880-1020 cm^(-1)) suggest the layered structure and support the diffraction *** micrographs confirm the synthesis of spherical nanoparticles with filled morphology,narrow size distribution and slightly agglomerated crystallites of the *** elemental composition of prepared materials was determined using energy dispersive X-ray *** spectra show peaks only for elements assimilated within the host *** photoluminescence(PL) emission spectra of Tb^(3+)-doped samples show ^(5)d_(4)→^(7)F_(J)(J=3-6) transitions under 254 *** dominant peak at 544 nm for ^(5)d_(4)→^(7)F_(5) transition is responsible for the emission of green light on ultraviolet-visible excitation in both the Tb^(3+)-doped host *** to advantageous properties like intense PL and high crystallinity,these nanophosphors could possess potential applications in the mercury free lighting sources and optoelectronic devices.

关键词： Structural Optical Silicates Luminescence Optoelectronic

Effect of Co substitution on the structural,dielectric and optical properties of KBiFe_(2)O_(5)

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International Journal of Minerals,Metallurgy and Materials 2021年第11期28卷 1861-1867页

作者： K.Chandrakanta r.Jena P.Pal Md.F.Abdullah S.d.Kaushik A.K.singh department of Physics and Astronomy National Institute of TechnologyRourkela-769008OdishaIndia UGC-dAE Consortium for Scientific research Mumbai Centre R-5 ShedBARCMumbai-400085India

Cobalt(Co)-modified brownmillerite KBiFe_(2)O_(5)(KBFO;[KBiFe_(2(1−x))Co_(2x)O_(5)(x=0,0.05)])polycrystalline is synthesized following the solid-state reaction *** refinement of X-ray diffraction data confirmed the phase purity of KBFO and KBiFe_(1.9)Co_(0.1)O_(5)(KBFCO).The optical bandgap energy(Eg)of KBFO decreased from 1.59 to 1.51 eV because of Co *** decrease in bandgap can be attributed to the tilting of the Fe–O tetrahedral structure of *** observed room-temperature raman peaks of KBFCO shifted by 3 cm^(−1) toward a lower wavenumber than that of *** shift in raman active modes can be attributed to the change in the bond angles and bond lengths of the Fe–O tetrahedral structure and modification in response to oxygen deficiency in KBFO because of Co *** with that of KBFO,the frequency-dependent dielectric constant and dielectric loss of KBFCO decrease at room temperature,which is a consequence of the reduction in oxygen migration and modification in response to vibrational modes present in the sample.

关键词： brownmillerite rietveld refinement raman spectroscopy bandgap

Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz Ayrton Bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni Sethi Gurpreet singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand rahat B reshi Tej I Mehta Sameh Elias Joseph d Feuerstein department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States department of Medicine University of WashingtonSeattleWA 98195United States department of radiology Johns Hopkins University HospitalBaltimoreMD 21218United States division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGrOUNd data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(Cd)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,Cd surgery rates over time,as well as the geoepidemiologic variation in Cd surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with Cd who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(r^(2)=0.035)and Europe(r^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(r^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with Cd is ***,as a paucity of data on surgery rates in Cd exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

High-throughput reaction engineering to assess the oxidation stability of MAX phases

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npj Computational Materials 2021年第1期7卷 20-32页

作者： d.Sauceda P.singh A.r.Falkowski Y.Chen T.doung G.Vazquez M.radovic r.Arroyave department of Materials Science & Engineering Texas A&M UniversityCollege StationTX 77843USA department of Mechanical Engineering Texas A&M UniversityCollege StationTX 77843USA Ames Laboratory US Department of EnergyIowa State UniversityAmesIA50011USA

The resistance to oxidizing environments exhibited by some Mn+1AXn(MAX)phases stems from the formation of stable and protective oxide layers at high operating *** MAX phases are hexagonally arranged layered nitrides or carbides with general formula M_(n+1)AX_(n),n=1,2,3,where M is early transition elements,A is A block elements,and X is C/*** attempts to model and assess oxide phase stability in these systems has been limited in scope due to higher computational *** address the issue,we developed a machine-learning driven high-throughput framework for the fast assessment of phase stability and oxygen reactivity of 211 chemistry MAX phase M_(2)*** proposed scheme combines a sure independence screening sparsifying operator-based machine-learning model in combination with grand-canonical linear programming to assess temperaturedependent Gibbs free energies,reaction products,and elemental chemical activity during the oxidation of MAX *** thermodynamic stability,and chemical activity of constituent elements of Ti_(2)AlC with respect to oxygen were fully assessed to understand the high-temperature oxidation *** predictions are in good agreement with oxidation experiments performed on Ti_(2)*** were also able to explain the metastability of Ti_(2)SiC,which could not be synthesized experimentally due to higher stability of competing *** generality of the proposed approach,we discuss the oxidation mechanism of Cr_(2)*** insights of oxidation behavior will enable more efficient design and accelerated discovery of MAX phases with maintained performance in oxidizing environments at high temperatures。

关键词： stability MAX maintained

Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias dreimann dennis Eckermann Felix rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis Katerina Falk Libor Juha department of radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum dresden-rossendorf Bautzner Landstraße 40001328 DresdenGermany dESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi