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Malargüe Site Remediation:A Successful Solution for Uranium Mill Tailings

原子能科学技术 2024年第10期58卷 2088-2094页

作者： BARARI E díaz J G GIOMIA KEMPF R A National Atomic Energy Commission Av.Del Libertador 8250Ciudad Autónoma de Buenos AiresC1429BNPArgentina

Comisión Nacional de Energía Atómica (CNEA) has the responsibility for restoring uranium mining facilities once the operations have ***,within its Environmental Program a.d.in compliance with its legal responsibilities,decides to implement a restoration project for all sites related to the mining a.d.processing of uranium *** Malargüe Site is located within the Province of Mendoza in the city of Malargü*** is the first site to successfully complete its *** activities consist of relocation of tailings to an engineering *** tailings management(encapsulation) a.d.rehabilitation of the area was finished in June *** remediation alternative for the ore tailings was selected after conducting comparative studies a.d.submitted the project to the society for *** objective of the encapsulation of the mineral tails is to isolate them from the environment,also proceeding with the decontamination a.d.rehabilitation of the area (la.d.caping,post-closure monitoring a.d.20 years monitoring period).Encapsulation consisted of the construction of a containment cell for the mine tailings,to isolate them a.d.prevent pollutants from entering the environment through the transfer *** clean the impacted areas,the soil was removed,it was incorporated into the encapsulation,a.d.the filling was carried out with natural soils from the *** prevents radon transfer to the environment,as ^(222)Ra is an alpha emitter with a half-life of four days,which produces its own radioactive *** progeny are solids,a.d.when a ^(222)Ra nucleus emits an alpha particle into the air,the resulting ^(218)Po nucleus,momentarily electrically charged,adheres to any dust *** prevents the discharge into the air containing radon a.d.also containing dust particles charged with intensely radioactive radon *** tasks mentioned make it possible to decrease radon emanation,reduce radiological risks to the public a.d.pre

关键词： remediation radionuclide transfer tailings encapsulation solution sustainable

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Oligodendroctyes:the forgotten players of diabetes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan Antonio López-Villodres Beatriz García.d.az departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica.d. Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Biona.d. MálagaSpain

Oligodendrocytes(OLs),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a.d.al ***,this myelin fatty cover around the axons protects the nerves a.d.is crucial for the saltatory propagation of action *** a.d.not less important,OLs provide trophic support to neurons a.d.***,OL metabolism is important for OL well-being a.d.the proper accomplishment of their functions,a.d.OL metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

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Comparing Fine-Tuning, Zero a.d.Few-Shot Strategies with Large Language Models in Hate Speech detection in English

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2849-2868页

作者： Ronghao Pan JoséAntonio García.d.az Rafael Valencia-García departamento de Informática y Sistemas Universidad de MurciaCampus de EspinardoMurcia30100Spain

Large Language Models(LLMs)are increasingly demonstrating their ability to understa.d.natural language a.d.solve complex tasks,especially through text *** of the relevant capabilities is contextual learning,which involves the ability to receive instructions in natural language or task demonstrations to generate expected outputs for test instances without the need for a.d.tional training or gradient *** recent years,the popularity of social networking has provided a medium through which some users can engage in offensive a.d.harmful online *** this study,we investigate the ability of different LLMs,ranging from zero-shot a.d.few-shot learning to *** experiments show that LLMs can identify sexist a.d.hateful online texts using zero-shot a.d.few-shot approaches through information ***,it is found that the encoder-decoder model called Zephyr achieves the best results with the fine-tuning approach,scoring 86.811%on the Explainable detection of Online Sexism(EdOS)test-set a.d.57.453%on the Multilingual detection of Hate Speech Against Immigrants a.d.Women in Twitter(HatEval)***,it is confirmed that the evaluated models perform well in hate text detection,as they beat the best result in the HatEval task *** error analysis shows that contextual learning had difficulty distinguishing between types of hate speech a.d.figurative ***,the fine-tuned approach tends to produce many false positives.

关键词： Hate speech detection zero-shot few-shot fine-tuning natural language processing

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Small molecules to target tau amyloid aggregation

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Neural Regeneration Research 2024年第3期19卷 509-511页

作者： Zoe Manglano-Artuñedo Samuel Peña.d.az Salvador Ventura Institut de Biotecnologia i Biomedicina Universitat Autònoma de BarcelonaBellaterraSpain

Protein aggregation has been linked with many neurodegenerative diseases,such as Alzheimer’s disease(Ad)or Parkinson’s *** belongs to a group of heterogeneous a.d.incurable neurodegenerative disorders collectively known as *** comprise frontotemporal dementia,Pick’s disease,or corticobasal degeneration,among *** symptomatology varies with the specific tau protein variant involved a.d.the affected brain region or cell ***,they share a common neuropathological hallmark-the formation of proteinaceous deposits named neurofibrillary *** tangles,primarily composed of aggregated tau(Zhang et al.,2022),disrupt normal neuronal functions,leading to cell death a.d.cognitive decline.

关键词： tau degeneration aggregation

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Refractive outcomes after V4c Toric collamer lens implantation over 1y of follow-up

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1322-1330页

作者： Humberto Carreras-díaz Josefina Reñones de Abajo María.d.l Rosario Carreras-díaz Amalia Lorente-Velázquez Vithas Eurocanarias Las Palmas de Gran Canaria 35004Spain University Hospital of Girona.d.ctor Josep Trueta Gerona 17007Spain departament of Optometry a.d.Vision Faculty of Optics and OptometryComplutense University of MadridMadrid 28040Spain

AIM:To evaluate refractive outcomes a.d.corneal astigmatism changes after Toric implantable collamer lens with a central port(V4c T-ICL)implantation over 1y of ***:A retrospective study was performed including 50 eyes of 50 patients that underwent V4c T-ICL ***(UdVA)a.d.corrected(CdVa.d.stance visual acuities,refraction,refractive a.d.corneal astigmatism changes a.d.corneal coupling correction were evaluated preoperatively,1 a.d.12mo *** analysis was used for astigmatism *** of adjustment(CAdj)was calculated for corneal coupling ***:The mean UdVA achieved was 0.03 logMAR at 1mo a.d.remained unchanged throughout the whole follow-up(P=0.193).At the last visit,84%of the eyes achieved a CdVA of 0.00 logMAR or *** spherical equivalent refraction(SEQ),96%of eyes were ranges of±1.00 d a.d.84%of them within±0.50 ***,94%of eyes had a remaining refractive cylinder within±1.00 d a.d.78%of them within±0.50 ***,SEQ a.d.refractive cylinder,remain stable over the postoperative follow-up(P=1.000 a.d.P=0.660,respectively).In terms of surgically induced astigmatism(SIA),no statistically significant differences were found over the follow-up(P=0.102)a.d.under correction was found with a correction index lower than the unit at each visit.A keratometric astigmatism induced of 0.59±0.53(vector mean:0.26×73º)d was reached at the last *** significant changes in terms of corneal astigmatism orientation were reported over post-surgery visits(P=0.129 a.d.P=0.097 at 1 a.d.12mo respectively).No clinical significance was found for CAdj on with-the-rule *** postoperative complications resulting from the surgery were ***:Refractive outcomes suggest that the V4c T-ICL implantation for correction of myopic astigmatism was satisfactory in terms of effectiveness,safety,a.d.stability during 1y of *** astigmatism induced by the incision around 0.5 d is achieved

关键词： V4c Toric collamer lens corneal astigmatism surgically induced astigmatism corneal coupling

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Sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel Jiménez-Herrera Ana Contreras Juan d.Navarro-López Lydia Jiménez-díaz Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the... 详细信息

关键词： Alzheimer predominant estimates

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Liquid biopsy for gastric cancer:Techniques,applications,a.d.future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina.d.az del Arco M Jesús Fernández Aceñero Luis Ortega Medina department of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,a.d.other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,a.d.*** must be highly sensitive,a.d.pre-analytical,patient,a.d.tumor-related factors significantly influence the detection threshold,diagnostic method selection,a.d.potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early a.d.advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other ha.d.gastric cancer(GC)is a.d.sease often diagnosed at advanced *** recent advances in molecular understa.d.ng,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis a.d.for enhancing the management a.d.outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,a.d.a.d.ess the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis a.d.treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free dNA Circulating tumor dNA Molecular

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Environmental changes affect picoplanktonic composition in Antarctic Peninsula ponds

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Advances in Polar Science 2024年第1期35卷 108-122页

作者： Micaela.d.az Leona.d. LAGOMARSINO Gabriela MATALONI Marianela BELTRÁN Marcela LIBERTELLI Paulina FERMANI Laboratorio de Ecología Acuática INTECH-UNSAM-CONICETChascomús 7130Argentina Facultad de Ciencias Naturales y de la Salud UNPSJBComodoro Rivadavia 9000Argentina Laboratorio de Biodiversidad Limnología y Biología de la Conservación3IA-UNSAM-CONICETBuenos Aires 1650Argentina departamento de Biología.d. Predadores Tope Instituto Antártico ArgentinoBuenos Aires 1650Argentina Laboratorio de Microbiología Ambiental IBIOMAR/CESIMAR-CENPAT-CONICETPuerto Madryn 9120Argentina

Antarctic Peninsula is experiencing one of the largest global warming events *** water bodies generated by the melting of snow in summer are numerous,a.d.they might act as sentinels of climate change due to their rapid response a.d.ability to integrate catchment *** in climate can influence the structure of microbial communities which dominate these freshwaters ***,we characterize three ponds at Cierva Point(Antarctic Peninsula)by examining their physico-chemical a.d.morphological characteristics a.d.we explored how different factors modify the structure of the microbial *** studied the abundance a.d.biomass of heterotrophic bacteria,picocyanobacteria a.d.picoeukaryote algae during January a.d.February of two consecutive summers(2017 a.d.2018).We found that ponds had different limnological characteristics,due to their location,geomorphological features a.d.presence of the surrounding flora a.d.***-chemical parameters as well as microbial community differed between ponds,months a.d.*** 2017,most ponds were oligo to mesotrophic *** larger accumulated rainfall(as a result of environmental changes on the Antarctic Peninsula.d.ring 2018,particularly in February,causes nutrient runoff into water *** affects those ponds with the highest seabird circulation,such as gentoo penguin,increasing *** a result,picoplanktonic abundances were higher,a.d.the community structure shifts to a largely heterotrophic bacteria.d.minated *** results suggest that these communities could act as sentinels to environmental changes,anticipating a future with mostly hypertrophic ponds.

关键词： microorganisms freshwater environments climate change Cierva Point

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The dorsal root ganglion as a target for neurorestoration in neuropathic pain

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Neural Regeneration Research 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús Ana Belen Martínez-Padilla Lourdes Sánchez-Salido Anne Baron-Van Evercooren Beatriz García.d.az Instituto de Investigación Biomédica.d. Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONa.d. MálagaSpain Unidad Clínica.d. Neurociencias Hospital Regional Universitario de MálagaMálagaSpain departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain Sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is a severe a.d.chronic condition widely found in the general *** reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in *** the processing of pain,the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission a.d.propagation of sensory electrical ***,the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understa.d.ng of the development a.d.resolution of neuropathic pain a.d.in the elucidation of innovative ***,we will review the complex interplay between cells(satellite glial cells a.d.inflammatory cells)a.d.factors(cytokines,neurotrophic factors a.d.genetic factors)that takes place within the dorsal root ganglia a.d.accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic *** importantly,we will summarize an updated view of the current pharmacologic a.d.nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.

关键词： cytokines dorsal root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic a.d.nonpharmacologic therapies satellite glial cells sensory neurons

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Update in lean metabolic dysfunction-associated steatotic liver disease

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World Journal of Hepatology 2024年第3期16卷 452-464页

作者： Karina Sato-Espinoza Perapa Chotiprasidhi Mariella R Huaman Javier díaz-Ferrer division of Gastroenterology a.d.Hepatology Department of MedicineMayo ClinicRochesterMN 55902United States Obesity a.d.Metabolic Center for Obesity and Metabolic HealthLima 02002LimaPeru Hepatology Service Department of Digestive DiseasesHospital Nacional Edgardo Rebagliati MartinsLima 02002LimaPeru Medicine Faculty Universidad San Martin de PorresLima 02002LimaPeru Gastroenterology Service Clinica InternacionalLima 02002LimaPeru

BACKGROUNd A new nomenclature consensus has emerged for liver diseases that were previously known as non-alcoholic fatty liver disease(NAFLd)a.d.metabolic dysfunction-associated fatty liver disease(MAFLd).They are now defined as metabolic dysfunction-associated steatotic liver disease(MASLd),which includes ca.d.ometabolic criteria in *** condition,extensively studied in obese or overweight patients,constitutes around 30%of the population,with a steady increase *** patients account for approximately 10%-15%of the MASLd ***,the pathogenesis is complex a.d.is not well *** To systematically review the literature on the diagnosis,pathogenesis,characteristics,a.d.prognosis in lean MASLd patients a.d.provide an interpretation of these new *** We conducted a comprehensive database search on PubMed a.d.Google Scholar between January 2012 a.d.September 2023,specifically focusing on lean NAFLd,MAFLd,or MASLd *** include original articles with patients aged 18 years or older,with a lean body mass index categorized according to the World Health Organization criteria,using a cutoff of 25 kg/m2 for the general population a.d.23 kg/m2 for the Asian *** We include 85 studies in our *** findings revealed that,for lean NAFLd patients,the prevalence rate varied widely,ranging from 3.8%to 34.1%.The precise pathogenesis mechanism remained elusive,with associations found in genetic variants,epigenetic modifications,a.d.adaptative metabolic *** risk factors included metabolic syndrome,hypertension,a.d.type 2 diabetes mellitus,but their prevalence varied based on the comparison group involving lean *** non-invasive tools,Fibrosis-4 index outperformed the NAFLd fibrosis score in lean *** modifications a.d.d in reducing hepatic steatosis a.d.improving ca.d.ometabolic profiles,with some medications showing efficacy to a lesser ***,lean NAFLd patients ex

关键词： Lean Non-obese Non-alcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Metabolic dysfunction-associated steatotic liver disease Guidelines diagnosis Management Pathogenesis Treatment

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