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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George j.msheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi j.mes d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Proj.ct to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular j.nction Schwann cell

Turn-on fluorescence probe for selective detection of Hg(Ⅱ)by calixpyrrole hydrazide reduced silver nanoparticle: Application to real water sample

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Chinese Chemical Letters 2016年第5期27卷 731-737页

作者： Keyur d. Bhatt d.sha j. vyas Bharat A. Makwana Savan M. darj.e Vinod K. j.in Hemangini shah department of Chemistry C.U. Shah University Wadhwan 363030 India department of Chemistry School of Sciences Gujarat University Ahmedabad 380009 India

A simple and quick method for the synthesis of water dispersible stable silver nanoparticles has been developed. Calix[4]pyrrole octahydrazide （CPOH）, has been successfully used as a reducing as well as stabilizing agent for the synthesis of silver nanoparticles. CPOH-AgNps have been duly characterized by SPR, PSA, TEM and EdX-ray. The ability of CPOH-AgNps as selective and sensitive sensor for various ions （Pb（Ⅱ）, Cd（II）, Mn（Ⅱ）, Fe（Ⅲ）, Ni（Ⅱ）, Zn（Ⅱ）, Hg（Ⅱ）, Co（Ⅱ）, Cu（Ⅱ）） by colorimetry and spectrofluorimetry has been explored. CPOH-AgNps were found to be selective only for Hg（Ⅱ） ions. Nanomolar concentration of Hg（Ⅱ） ions can also be determined by spectrofluorimetry by increase in fluorescence intensity. Linear range of detection of Hg（Ⅱ） ions in water was found to be from 1nmol/L to mol/L. The method has been successfully applied for determination of Hg（Ⅱ） ions in ground water and industrial effluent waste water samples.

关键词： Calixpyrrole Silver nanoparticles Fluorescence study Colorimetric sensor Water samplesHg(Ⅱ) ions

A Processive Arabidopsis Formin Modulates Actin Filament dynamics in Association with Profilin

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Molecular Plant 2016年第6期9卷 900-910页

作者： sha Zhang Chang Liu j.aoj.ao Wang Zhanhong Ren Christopher j. Staiger Haiyun Ren Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education College of Life Science Beijing Normal University Beijing 100875 People'sRepublic of China department of Biological Sciences Purdue University Hansen Life Sciences Research Building West Lafayette IN 47907-2064 USA

Formins are conserved regulators of actin cytoskeletal organization and dynamics that have been impli- cated to be important for cell division and cell polarity. The mechanism by which diverse formins regulate actin dynamics in plants is still not well understood. Using in vitro single-molecule imaging technology, we directly observed that the FH1-FH2 domain of an Arabidopsis thaliana formin, AtFH14, processively at- taches to the barbed end of actin filaments as a dimer and slows their elongation rate by 90%. The attach- ment persistence of FH1-FH2 is concentration dependent. Furthermore, by use of the triple-color total internal reflection fluorescence microscopy, we found that ABP29, a barbed-end capping protein, com- petes with FH1-FH2 at the filament barbed end, where its binding is mutually exclusive with AtFH14. In the presence of different plant profilin isoforms, FH1-FH2 enhances filament elongation rates from about 10 to 42 times. Filaments buckle when FH1-FH2 is anchored specifically to cover slides, further indicating that AtFH 14 moves processively on the elongating barbed end. At high concentration, AtFH 14 bundles actin filaments randomly into antiparallel or parallel spindle-like structures; however, the FH1-FH2-mediated bundles become thinner and longer in the presence of plant profilins. This is the direct demonstration of a processive formin from plants. Our results also illuminate the molecular mechanism of AtFH14 in regulating actin dynamics via association with profilin.

关键词： processive formin profilin capping protein actin bundle TIRF microscopy single molecule

Emergence of magnetic order in kagome antiferromagnets

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Frontiers of physics 2019年第2期14卷 47-51页

作者： d. j. j. Farnell School of dentistry Cardiff UniversityCardiff CF14 /XYWales UK

Exotic quantum spin liquid (QSL) states and fractionalized quasiparticles in frustrated magnets are of much current interest in theoretical and experimental studies of quantum magnetism. The kagome-lattice Heisenberg antiferromagnet (KAFM) provides a possible realization of j.st such novel topological states of matter. The kagome lattice shown in Fig. 1 is one of eleven Archimedean lattices in two spatial dimensions, where the word kagome itself means uweave pattera" in j.panese.

关键词： magnetic order kagome antiferromagnets quantum spin liquid (QSL)

Convergence and exact solutions of spline finite strip method using unitary transformation approach

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Applied Mathematics and Mechanics(English Edition) 2011年第11期32卷 1407-1422页

作者： j. KONG d. THUNG division of Building Science and Technology City University of Hong Kong Hong Kong P. R. China School of Creative Media City University of Hong Kong Hong Kong P. R. China

The spline finite strip method （FSM） is one of the most popular numerical methods for analyzing prismatic structures. Efficacy and convergence of the method have been demonstrated in previous studies by comparing only numerical results with analytical results of some benchmark problems. To date, no exact solutions of the method or its explicit forms of error terms have been derived to show its convergence analytically. As such, in this paper, the mathematical exact solutions of spline finite strips in the plate analysis are derived using a unitary transformation approach （abbreviated as the U-transformation method herein）. These exact solutions are presented for the first time in open literature. Unlike the conventional spline FSM which involves assembly of the global matrix equation and its numerical solution, the U-transformation method decouples the global matrix equation into the one involving only two unknowns, thus rendering the exact solutions of the spline finite strip to be derived explicitly. By taking Taylor＇s series expansion of the exact solution, error terms and convergence rates are also derived explicitly and compared directly with other numerical methods. In this regard, the spline FSM converges at the same rate as a non-conforming finite element, yet involving a smaller number of unknowns compared to the latter. The convergence rate is also found superior to the conventional finite difference method.

关键词： spline finite strip U-transformation plate symmetry

On the radiogenic heat production of igneous rocks

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Geoscience Frontiers 2017年第5期8卷 919-940页

作者： d. Hasterok j. Webb department of Earth Sciences University of Adelaide North Terrace SA 5005 Australia Ramelius Resources Ltd. East Perth WA 6005 Australia

Radiogenic heat production is a physical parameter crucial to properly estimating lithospheric temperatures and properly understanding processes related to the thermal evolution of the Earth. Yet heat production is, in general, poorly constrained by direct observation because the key radiogenic elements exist in trace amounts making them difficulty image geophysically. In this study, we advance our knowledge of heat production throughout the lithosphere by analyzing chemical analyses of 108,103 igneous rocks provided by a number of geochemical databases. We produce global estimates of the average and natural range for igneous rocks using common chemical classification systems. Heat production increases as a function of increasing felsic and alkali content with similar values for analogous plutonic and volcanic rocks. The logarithm of median heat production is negatively correlated(r^2=0.98)to compositionally-based estimates of seismic velocities between 6.0 and 7.4 km s^(-1), consistent with the vast maj.rity of igneous rock compositions. Compositional variations for continent-wide models are also well-described by a log-linear correlation between heat production and seismic velocity. However, there are differences between the log-linear models for North America and Australia, that are consistent with interpretations from previous studies that suggest above average heat production across much of Australia. Similar log-linear models also perform well within individual geological provinces with^1000 samples. This correlation raises the prospect that this empirical method can be used to estimate average heat production and natural variance both laterally and vertically throughout the lithosphere. This correlative relationship occurs despite a direct causal relationship between these two parameters but probably arises from the process of differentiation through melting and crystallization.

关键词： Heat generation lgneous rocks Heat producing elements Continental lithosphere Seismic velocity density

Creep-induced redistribution of alloying elements in CZ1 zirconium alloys

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j.urnal of Materials Science & Technology 2024年第6期173卷 31-44页

作者： W.T.Lin Q.Y.Lv d.j.ao L.B.Zhang j.Tan G.sha j.Hu China Nuclear Power Technology Research Institute Shenzhen 518026China School of Material Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

Introducing minor alloying elements is an effective strategy to improve the corrosion and mechanical properties of zirconium alloys for nuclear *** in-reactor service,external environment and stress can affect the distribution of alloying elements,substantially changing the degradation process of zirconium *** date,there is a lack of in-depth understanding of the interaction between creep and microchemistry ***,we conducted systematic transmission electron microscopy(TEM)and atom probe tomography(APT)investigations to address creep-induced redistribution of alloying elements in CZ1(Zr-Sn-Nb-Fe-Cr-Cu)zirconium alloy with different initial ***,Fe,Sn,and Cu are found to co-segregate at grain *** higher the intermediate annealing temperature,the larger the Gibbsian interfacial excesses of solute elements *** further demonstrate that creep can reduce the excess value of Fe at grain boundaries due to the coarsening of Zr-Fe-Cr second phase particles via grain boundary and dislocation pipe *** the same time,the excess value of Sn is increased by diffusing from the matrix to grain ***,Cu as a minor element in the concentration range of 0.05-0.3 wt.%is found to segregate at dislocations to form the Cottrell atmosphere and develop Cu-rich nanoclusters for suppressing dislocation *** new understanding of the segregation and clustering of minor alloying elements provides guidance for developing zirconium alloys with enhanced creep resistance.

关键词： Zirconium alloy Thermal creep Grain boundary segregation dislocation segregation Cu-rich nanoclusters

Nonlinear response analysis and experimental verification for thin-walled plates to thermal-acoustic loads

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Chinese j.urnal of Aeronautics 2017年第6期30卷 1919-1930页

作者： Yundong sha j.an WANG Liaoning Key Laboratory of Advanced Test Technology for Aeronautical Propulsion System Shenyang Aerospace University Shenyang 110136 China

For large deflection strongly nonlinear response problem of thin-walled structure to thermal-acoustic load, thermal-acoustic excitation test and corresponding simulation analysis for clamped metallic thin-walled plate have been implemented. Comparing calculated values with experimental values shows the consistency and verifies the effectiveness of calculation method and model for thin-walled plate subj.cted to thermal-acoustic load. Then this paper further completes dynamic response calculation for the cross reinforcement plate under different thermalacoustic load combinations. Based on the obtained time-domain displacement response, analyses about structure vibration forms are mainly focused on three typical motions of post-buckled plate,indicating that the relative strength between thermal load and acoustic load determines j.mp forms of plate. The Probability spectrum density Functions（PdF） of displacement response were drawn and analyzed by employing statistical analysis method, and it clearly shows that the PdF of postbuckled plate exhibits bimodal phenomena. Then the Power Spectral density（PSd） functions were used to analyze variations of response frequencies and corresponding peaks with the increase of temperatures, as well as how softening and hardening areas of the plate are determined. In the last section, this paper discusses the change laws of tensile stress and compressive stress in pre/post buckling areas, and gives the reasons for N glyph trend of the stress Root Mean Square（RMS）.

关键词： Buckling Experimental verification Nonlinear response Power spectral density Probability spectrum densitySnap-through Thermal-acoustic load Thin-walled structure

The Friction and Wear Properties of CrN, Graphit-iC and dymon-iC Coatings in Air and under Oil-lubrication.

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材料热处理学报 2004年第05B期25卷 858-861页

作者： j. Stallard d.G Teer Teer Coatings Ltd Droitwich WorcestershireU.KTeer Coatings Ltd Droitwich WorcestershireU.K.

Hard ceramic coatings such as TiN and CrN are very successful and are widely used in improving the performance of cutting and forming tools, but they are less successful in providing protection for general machine components, such as gears and engine parts. The development of low-friction wear resistant coatings that can run dry or in a minimum amount of oil is becoming increasingly important to this industry. Two recently developed carbon-based coatings Graphit-iC? and dymon-iC, which are shown to exhibit very high sliding wear resistance and low friction in dry conditions, are compared to a CrN coating under oil lubricated conditions. Long term pin-on-disc tests using a chrome steel counterface ball were carried out on coated HSS test samples. All the coatings performed well at very high applied contact pressures, exceeding 1.5 GPa, but the Graphit-iC? and dymon-iC coatings also exhibited the desirable characteristic of protecting the counterface material. Reasons for this behaviour are discussed.

关键词： dLC 润滑油摩擦性能磨损性能涂层