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Trans.r.ptional reprogramming during human osteoclast differentiation identifies.r.gulators of osteoclast activity

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Bone research 2024年第1期12卷 180-198页

作者： Morten s.Hansen Kaja Madsen Maria Price Kent søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark department of Clinical research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and.systems.r.search(IMsr)and Centre for diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and receptors(COMPArE) Universities of Birmingham and NottinghamBirmingham B152TTUK department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark department of Orthopedic s.r.ery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany deutsches Zentrum Immuntherapie(dZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany steno diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone res.r.tion and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of trans.r.ptional reprogramming during human osteoclast *** were differentiated from Cd14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns cons.r.ed across *** patterns.r.vealed d.stinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on rNA from iliac crest biopsies and bone mineral density *** analyses.r.vealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific trans.r.ptional *** donor-specific expression patterns.r.vealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLr1,encoding LOX-1),that are predictive of the res.r.tive activity of mature *** expression of differentially expressed G-protein coupled receptors was s.r.ng during osteoclast differentiation,and these receptors are associated with bone mineral density sNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5Ar1),somatostatin receptor 2(ss.r.),and free fatty acid receptor 4(FFAr4/GPr120).Activating C5Ar1 enhanced osteoclast formation,while activating ss.r. decreased the res.r.tive activity of mature osteoclasts,and activating FFAr4 decreased both the number and res.r.tive activity of mature *** conclus

关键词： osteoclast programming identif

Model dependent analysis of d^(+)_(s)→η^(′)l+v_(l) decays in beyond.standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal H.Mahapatra s.Biswas s.sahoo department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental results of branching fractions for d^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sM predictions,we hve investigated these decays in W' model and.scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic d meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

Assessment of bisphenols in children's toy and baby products in the Middle East

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Emerging Contaminants 2024年第3期10卷 336-342页

作者： K.Martínez-Guijarro B.Gevao M.Porcelli s.Al-salem saif Uddin M.Bahloul H.Taqi M.Hajeyah d.Krishnan s.r.jagopalan A.Boota Environment Pollution and Climate Program Kuwait Institute for Scientific ResearchP.O.Box 23884SafatKuwait EPA Sierra Leone

A major concern from the scientific community has been raised.since evidence of Bisphenol A(BP-A)can leach out from the products where they are incorporated as well as its endocrine d.srupting effects obs.r.ed in animals and ***-A and.several related chemicals such as Bisphenol AP(BP-AP),Bisphenol B(BPeB),Bisphenol s(BPes),Bisphenol AF(BP-AF),Bisphenol(BPeP),Bisphenol Z(BP-Z)were analyzed in this ***-A and BP-s were the only bisphenols detected in the samples analyzed in this *** median(range;mean)concentrations of BP-A found in this study was 321 ng/g(11-200932;4893 ng/g).The analysis was carried out by sonicating 0.1 g of a cryo-milled.sample aliquot in methanol followed by UPLC-Ms/Ms *** concentrations of BP-A were found in several products labeled as BP-A free such as nursing bottles which are particularly problematic from the children's expos.r. point of *** study presents the first reliable bisphenols in children's toys and baby products commercialized in the Middle *** is,however,a need to continue monitoring these compounds,especially in low-cost toys,and the so-called BP-A-free products,which appear to have high levels of target contaminants and can pose an expos.r. risk for infants and children in the region.

关键词： Bisphenols Bisphenol A(BP-A) Bisphenol s(BPes) Children Toys

Advancements,s.r.tegies,and prospects of solid oxide electrolysis cells(sOECs):Towards enhanced performance and large-scale sustainable hydrogen production

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Journal of Energy Chemis.r. 2024年第7期94卷 688-715页

作者： Amina Lahrichi Youness El Issmaeli shankara s.Kalanur Bruno G.Pollet Green Hydrogen Lab(GH2Lab) Hydrogen Research Institute(HRI)Universitédu QuébecàTrois-Rivières(UQTR)3351 boulevard des ForgesTrois-RivièresQuébec G9A 5H7Canada

solid oxide electrolysis cells(sOECs.r.present a crucial s.r.de toward.sustainable hydrogen generation,and this.r.view explores their current scientific challenges,significant advancements,and potential for large-scale hydrogen *** sOEC technology,the application of innovative fabrication tech-niques,doping s.r.tegies,and advanced materials has enhanced the performance and durability of these systems,although degradation challenges persist,implicating the prime focus for future *** we provide in-depth analysis of the recent developments in sOEC technology,including Oxygen-sOECs,Proton-sOECs,and ***,Hybrid.sOECs,with their mixed ionic conducting electrolytes,demons.r.te superior efficiency and the concurrent production of hydrogen and *** with the capacity to harness waste heat,these advancements in sOEC technology present signif-icant promise for pilot-scale applications in *** review also highlights.r.markable achieve-ments and potential reductions in capital expenditure for future sOEC systems,while elaborating on the micro and macro aspects of sOECs with an emphasis on ongoing research for optimization and *** conclud.s with the potential of sOEC technology to meet various indus.r.al energy needs and its significant contribution considering the key research priorities to tackle the global energy demands,ful-fillment,and decarbonization efforts.

关键词： solid oxide electrolysis cells Proton-sOECs Oxygen-soECs Hybrid.sOECs Intermediate-high temperature electrolys.r. Hydrogenproduction

Classification of rings Associated with the Genus of Clean Graphs

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Algebra Colloquium 2024年第3期31卷 451-466页

作者： V.ramanathan C.selvaraj Aaqib Altaf s.Pirzada department of Mathematics Periyar UniversitySalem 636011Tamil NaduIndi department of Mathematics University of KashmirHazratbalSrinagarKashmirIndia

Let r be a ring(not necess.r.ly commutative)with identity 1 and let CL(r)be its clean *** this paper,we investigate the genus number of the compact riemann s.r.ace in which CL(r)can be embedded and explicitly determine all commutative rings.r.up to isomorphism)such that CL(r)has genus at most *** is shown that for any Artinian ring r,CL(r)is a projective graph if and only if r is isomorphic to ***,we determine all isomorphism classes of commutative rings whose clean graphs have crosscap two.

关键词： clean graph commutative ring planar graph genus crosscap

An in vitro demons.r.tion of a passive,acoustic metamaterial as a temperature sens.r.with mK resolution for implantable applications

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Microsystems & Nanoengineering 2024年第1期10卷 41-54页

作者： Lucrezia Maini Vicente Genovés.r.man Furrer Nikola Ces.r.vic Christofer Hierold Cosmin roman Micro-and Nanosystems Department of Mechanical and Process EngineeringETH ZurichTannenstrasse 38092 ZurichSwitzerland. Translational Cardiovascular Technology Department of Health Science and TechnologyETH ZurichLeopold-Ruzicka-Weg 48093 ZurichSwitzerland. Transport at Nanoscale Interfaces Swiss Federal Laboratories for Materials Science and TechnologyEMPAÜberlandstrasse 1298600 DübendorfSwitzerland department of Cardiothoracic and Vascular s.r.ery Deutsches Herzzentrum der Charite(DHZC)13353 BerlinGermany

Wireless medical sens.r. typically utilize electromagnetic coupling or ultrasound for energy transfer and.sens.r.*** transfer and management is a complex aspect that often limits the applicability of implantable sens.r.*** this work,we report a new passive temperature sensing scheme based on an acoustic metamaterial made of silicon embedded in a polydimethylsiloxane *** to other approaches,this concept is implemented without additional electrical components in situ or the need for a customized receiving unit.A standard ultrasonic transducer is used for this demons.r.tion to directly excite and collect the reflected *** metamaterial resonates at a frequency close to a typical medical value(5 MHz)and exhibits a high-quality *** the d.sign features of the metamaterial with the high-temperature sensitivity of the polydimethylsiloxane matrix,we achieve a temperature resolution of 30 *** value is below the current standard resolution required in infrared thermometry for monitoring postoperative complications(0.1 K).We fabricated.simulated,in vitro tested,and compared three acoustic sens.r.d.signs in the 29-43℃(~302-316 K)temperature *** this concept,we demons.r.te how our passive metamaterial sens.r.can open the way toward new zero-power smart medical implant concepts based on acoustic interrogation.

关键词： passive resolution utilize

Highly defective dark TiO_(2) Modified with Pt: Effects of Precurs.r.Nature and Preparation Method on Photocatalytic Properties

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Transactions of Tianjin University 2024年第2期30卷 198-209页

作者： E.d.Fakhrutdinova O.A.reutova T.A.Bugrova I.Yu.Ovsyuk L.s.Kibis O.A.stonkus d.B.Vasilchenko O.V.Vodyankina V.A.svetlychnyi National research Tomsk state University TomskRussia 634050 Novosibirsk state University NovosibirskRussia 630090 Boreskov Institute of Catalysis NovosibirskRussia 630090 Nikolaev Institute of Inorganic Chemis.r. NovosibirskRussia 630090

The study focused on the modification with platinum of dark defective titania obtained via pulsed las.r.ablation. Both the method of Pt introduction and the nature of the Pt precurs.r.were varied. All samples exhibited.similar phase compositions, specific s.r.ace areas, and Pt contents. High-resolution transmission electron microscopy coupled with pulsed CO ads.r.tion revealed increased d.spersity when photoreduction and the hydroxonitrate complex (Me _(4) N) _(2) [Pt _(2) (OH) _(2) (NO _(3) ) _(8) ] were used. The sample featured a high content of single-atom species and.subnano-sized Pt clusters. The X-ray photoelectron spectroscopy results showed that the photoreduction method facilitated the appearance of a larger number of Pt ^(2+) states, which appeared owing to the s.r.ng metal-support interaction (sMsI) eff ect of the transfer of electron density from the electron-saturated defects on the TiO _(2) s.r.ace to Pt ^(4+) . In the hydrogen evolution reaction, samples with a significant fraction of the Pt ^(2+) ionic component, capable of generating short-lived Pt^(0) single-atom sites under irradiation due to the sMsI eff ect, exhibited the highest photocatalytic activity. The 0.5Pt(C)/TiO_(2) -Ph sample exhibited the highest hydrogen yield with a quantum efficiency of 0.53, retaining its activity even after 8 h of operation.

关键词： dark(black)TiO_(2) Pulsed las.r.ablation Platinum reduction method Precurs.r.type Photocatalysis Hydrogen evolution reaction

Post-operative protein supplementation following orthopaedic s.r.ery: A systematic review

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sports Medicine and Health science 2024年第1期6卷 16-24页

作者： Andrew George Brendan M.Holderread Bradley s.Lambert Joshua d.Harris Patrick C.McCulloch Houston Method.st Orthopedics and.sports Medicine 6445 Main Street Suite 2300HoustonTX77030USA Houston Method.st Orthopedic Biomechanics.r.search Laboratory 6670 Bertner AveHoustonTX77030USA

decreased mechanical loading after orthopaedic s.r.ery pred.sposes patients to develop muscle *** purpose of this.r.view was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic s.r.ery.A systematic review was conducted according to the Preferred reporting Items for systematic reviews and MetaAnalysis(PrIsMA).PubMed(MEdLINE),Embase,scopus,and Web of science were searched for randomized controlled trials that assessed protein or amino acid.supplementation in patients undergoing orthopaedic *** investigators independently conducted the search using relevant Boolean *** outcomes included functional or physiologic meas.r.s of muscle atrophy or *** studies including 611 patients(224 males,387 females)were *** studies evaluated protein supplementation after ACL recons.r.ction(ACLr),3 after total hip arthroplasty(THA),5 after total knee arthroplasty(TKA),and 3 after s.r.ical treatment of hip *** supplementation showed beneficial effects across all types of *** primary benefit was a decrease in muscle atrophy compared to placebo as meas.r.d by muscle cross sectional *** authors also demons.r.ted improved functional meas.r.s and quicker achievement of rehabilitation *** supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLr,THA,TKA,and s.r.ical treatment of hip *** effects often correlate with improved functional meas.r.s and quicker achievement of rehabilitation *** research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.

关键词： Orthopaedic s.r.ery Protein supplementation systematic review Muscle atrophy

Experimental Investigation of Thermal Performance of Novel Finned radiators for Automotive Cooling system

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Journal of Thermal science 2024年第5期33卷 1726-1743页

作者： sINGH Hardeep TING david.s-K rEAdEr Graham EsHTIAGHI Nicky ICHIYANAGI Mitsuhisa sUZUKI Takashi Turbulence&Energy Laboratory University of WindsorWindsor N9B 3P4Canada Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia department of Engineering and Applied.sciences Sophia UniversityTokyo 102-8554Japan

This.r.search investigates innovative fin-type radiators for automobile engine cooling ***-channel and helical radiators,along with s.r.ight type,were analyzed for heat transfer characteristics under various *** uniqueness of this study is evident in the d.sign of microchannel and helical *** helical radiators,the inner rod features 4/8 helical-shaped water galleries,while the outer tube frame with embedded fins.r.mains *** contrast,the microchannel radiators have compact trapezoidal-shaped water galleries with separate fin ***,the novelty of the research is enhanced by the utilization of 3d printing technology in the manufacturing *** constant fin height analysis at varied water and air flow rate,Microchannel Water Air radiator with fin height 10.5 mm(MCWAr10.5)depicted a higher heat transfer rate amongst the *** comparison to s.r.ight Water Air radiator with fin height 9.5 mm(sWAr9.5),the heat transfer rate is 30.3%and 1.3 times ***,in constant fin s.r.ace area analysis,microchannel radiator(MCWAr3.2)illus.r.tes lower heat d.ssipation than Helical radiator(HWAr138)but higher than HWAr134 and s.r.ight radiator(sWAr6).The examination of pumping loss indicated that the Micro-channel radiator outperformed helical radiators due to its lower press.r. *** average press.r. loss for Micro-channel radiators was 0.74 kPa,making it 1.2 times higher than that of a s.r.ight radiator(0.62 kPa),indicating a better trade-off.

关键词： heat exchangers multi-channel helical heat exchanger heat transfer 3d printing