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Metabolomics for the diagnosis of bladder cancer: A systematic review

Asian Journal of Urology 2024年第2期11卷 221-241页

作者： Herney Andrés García-Perdomo Angélica María dávila-raigoza Fernando Korkes division of Urology/Urooncology Department of SurgerySchool of MedicineUniversidad del ValleCaliColombia UrOGIV research Group School of MedicineUniversidad del ValleCaliColombia Urologic Oncology Division of UrologyABC Medical SchoolSao PauloBrazil

Objective: Metabolomics has been extensively utilized in bladder cancer (BCa) research, employing mass spectrometry and nuclear magnetic resonance spectroscopy to compare various variables (tissues, s.r.m, blood, and urine). This study aimed to identify potential biomarkers for early BCa ***: A search s.r.tegy was d.signed to identify clinical trials, des.r.ptive and analytical obs.r.ational studies from databases such as Medline, Embase, Cochrane Central register of Controlled Trials, and Latin American and Caribbean Literature in Health sciences. Inclusion criteria comprised.studies involving BCa tissue, s.r.m, blood, or urine profiling using widely adopted metabolomics techniques like mass spectrometry and nuclear magnetic resonance. Primary outcomes included des.r.ption of metabolites and metabolomics profiling in BCa patients and the association of metabolites and metabolomics profiling with BCa diagnosis compared to control patients. The risk of bias was assessed using the Quality Assessment of studies of diagnostic ***: The search s.r.tegy yielded 2832 studies, of which 30 case-control studies were included. Urine was predominantly used as the primary sample for metabolite identification. risk of bias was often unclear inpatient selection, blinding of the index test, and reference standard assessment, but no applicability concerns were obs.r.ed. Metabolites and metabolomics profiles associated with BCa diagnosis were identified in glucose, amino acids, nucleotid.s, lipids, and aldehyd.s ***: The identified metabolites in urine included citric acid, valine, tryptophan, taurine, aspartic acid, uridine, ribose, phosphocholine, and carnitine. Tissue samples exhibited elevated levels of lactic acid, amino acids, and lipids. Consistent findings across tissue, urine, and s.r.m samples.r.vealed downregulation of citric acid and upregulation of lactic acid, valine, tryptophan, taurine, glutamine, aspartic acid, uridine, rib

关键词： Metabolite Metabolomics Bladder cancer Metabolomics.r.file

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Further investigation on the fusion of ^(6)Li with ^(209)Bi target at near-barrier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.r.Cortes 胡世鹏钱建强 d.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 J.J.Valiente-dobón d.Testov M.Mazzocco A.Gozzelino C.Parascandolo d.Pierroutsakou M.La Commara A.Goasduff d.Bazzacco d.r.Napoli F.Galtarossa F.recchia A.Illana s.Bakes I.Zanon s.Aydin G.de Angelis M.siciliano r.Menegazzo s.M.Lenzi J.L.Ferreira J.rangel s.r.an Akkoyun L.F.Canto J.Lubian school of Physics Beihang UniversityBeijing 100191China sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced.study in Nuclear Energy&safety Shenzhen UniversityShenzhen 518060China shenzhen Key Laboratory of research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly dipartimento di fisica As.r.nomia dell'Universita di padova PadovaItaly state Key Laboratory of radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Minis.r. of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly dipartimento di Farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly department of Natural and Mathematical sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics division Argonne National LaboratoryLemont-ILUSA departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete and incomplete fusion cross sections for ^(6)Li+^(209)Bi were meas.r.d using the in-beamγ-ray method around the Coulomb *** cross sections of(deuteron captured)incomplete fusion(ICF)products were re-quantified experimentally for this.r.action *** results.r.veal that the ICF cross section is equivalent to that of complete fusion(CF)above the Coulomb barrier and dominant near or below the Coulomb barrier.A theoretical calculation based on the continuum dis.r.tized coupled channel(CdCC)method was performed for the aforementioned CF and ICF cross sections;the result is consistent with the *** universal fusion function(UFF)was also compared with the meas.r.d CF cross section for different barrier parameters,demons.r.ting that the CF suppression factor is significantly influenced by the choice of potential,which can reflect both dynamic and.static effects of breakup on the fusion process.

关键词： cross section incomplete fusion suppression factor weakly bound nuclei

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single atom Cu-N-C catalysts for the electro-reduction of CO_(2) to CO assessed by rotating ring-d.sc electrode

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Journal of Energy Chemis.r. 2024年第1期88卷 169-182,I0004页

作者： s.Pérez-rodríguez M.Gutiérrez-roa C.Giménez-rubio d.ríos.r.iz P.Arévalo-Cid M.V.Martínez-Huerta A.Zitolo M.J.Lázaro d.sebastián Instituto de Carboquímica(CsIC) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de Catálisis y Petroleoquímica(CsIC) Marie Curie 228049 MadridSpain synchrotron sOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical CO_(2) reduction reaction(CO_(2)rr) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped carbon xerogel(Cu-N-C) are successfully developed varying the copper amount and the nature of the copper precurs.r. for the efficient CO_(2)rr. The electrocatalytic performance of Cu-N-C materials is assessed by a rotating ring-d.sc electrode(rrdE), technique still rarely explored for CO_(2)rr. For comparison, products are also characterized by online gas chromatography in a H-cell. The as-synthesized Cu-NC catalysts are found to be active and highly CO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 M KHCO_(3), while H_(2) from the competitive water reduction appears at larger overpotentials(-0.9 V vs. rHE). The optimum copper acetate-derived catalyst containing Cu-N_(4) moieties exhibits a CO_(2)-to-CO turnover frequency of 997 h^(-1) at -0.9 V vs. rHE with a H_(2)/CO ratio of 1.8. These results demons.r.te that rrdE configuration can be used as a feasible approach for identifying electrolysis products from CO_(2)rr.

关键词： Cu-N-C Carbon xerogel rotating ring d.sc electrode Carbon dioxide reduction reaction Carbon monoxide

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Temperature and s.r.cture meas.r.ments of heavy-ion-heated diamond using in situ X-ray diagnostics

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Matter and radiation at Extremes 2024年第4期9卷 80-89页

作者： J.Lutgert P.Hesselbach M.schorner V.Bagnoud r.Belikov P.drechsel B.Heus.r.O.sHumphries P.Katrik B.Lindqvist C.Qu r.redmer d.riley G.schaumann s.schumacher A.Tauschwitz d.Varentsov K.Weyrich X.Yu B.Zielbauer Zs.Major P.Neumayer d.Kraus Institut fur Physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GsI Helmholtzzentrum fur schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum dresden-rossendorf Bautzner Landstr.40001328 DresdenGermany European XFEL GmbH Holzkoppel 422869 SchenefeldGermany Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany state Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helmholtz Institut Jena Frobelstieg 307743 JenaGermany

We present in situ meas.r.ments of spectrally resolved X-ray scattering and X-ray diffraction from monocrystalline diamond.samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic s.r.cturalintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction meas.r.ments show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the Facility for Antiproton andIon research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense s.r.cture

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Tilted global solar irradiance in Bahrain:an experimental study

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Clean Energy 2024年第2期8卷 27-34页

作者： N.Vasilikos C.Georgantopoulou H.Alajaimi s.H.Almajed M.Ahmed d.Mathioulakis school of Mechanical Engineering Bahrain PolytechnicIsa TownPO Box 33349Kingdom of Bahrain school of Mechanical Engineering National Technical University of AthensHeroon Polytechniou 7 StZografos 15773AthensGreece

In the present work,tilted global solar irradiance data are presented and analysed,meas.r.d for a period of 1 year on the campus of Bahrain Polytechnic,Kingdom of Bahrain,from both a fixed photovoltaic panel and a moving one via a two-axis solar *** fixed panel faces south with an angle of 26°with respect to the horizontal,coinciding with the local geographical *** second panel is moved by two motors,controlled by a global positioning system and.suitable software so that the sun’s.r.ys are perpendicular to the panel s.r.ace.A pyranometer is installed on each panel,recording the tilted global solar irradiance,stored by using a data *** analysis of the data obtained.shows a 33%solar energy gain on an annual basis for the moving panel(2780 versus 2088 kWh/m^(2) on the fixed panel).More importantly,in June,when the energy demand in Bahrain is elevated due to the increased residential cooling loads,the solar energy received by the moving panel is 54.7%higher compared with that of the fixed *** a percentage basis,the increase in solar energy from the moving panel is profound in the early morning and late evening ***,the reduction in the solar energy received by the fixed panel from May to June does not appear in the moving panel because of the adjustable orientation of the *** the year,the mean daily solar power varies between 0.37 and 0.56 kW/m^(2) for the fixed panel,and 0.45 and 0.70 kW/m^(2) for the moving *** winter,solar energy fluctuations are elevated due to erratic weather conditions that present a peak standard deviation of 28%of the corresponding *** data presented are useful for potential solar investments in Gulf countries.

关键词： tilted.solar irradiance renewable energy solar tracking photovoltaic Gulf Cooperation Council Countries

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Effect of coenzyme Q10 supplementation on post-vitrification mouse embryo development

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Asian pacific Journal of reproduction 2024年第3期13卷 126-132页

作者： Anisa-Annur s Wan-Hafizah WJ Nor-Ashikin MNK Muhammad-Zaki r Faculty of Pharmacy and Health sciences Royal College of Medicine PerakUniversiti Kuala Lumpur30450 IpohPerakMalaysia Maternofetal and Embryo research Group Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia

Objective:To investigate the effects of coenzyme Q10(CoQ10)supplementation on post-vitrification embryo development and gross ***:Balb/c mouse embryos were cultured in potassium simplex optimised medium(KsOM)with varying CoQ10 concentrations[0(control),20,40,and 60μM].The most effective CoQ10 concentration(40μM)was selected for subsequent post-vitrification morphology *** were randomly divided into four groups:Group A(non-vitrified without CoQ10),Group B(non-vitrified with CoQ10),Group C(vitrified without CoQ10),and Group d(vitrified with CoQ10),followed by vitrification at the 8-cell *** rates and development until the blastocyst stage were evaluated through morphological examinations using AsEBIr's system,d.stinguishing normal and abnormal ***:supplementation of 40μM CoQ10 significantly increased blastocyst formation(95%)compared to the control group(92%),20μM(62%),and 60μM(56%)(Prification,Group d exhibited a significant increase in blastocyst formation(92%)compared to Group C(82%)(Prphological assessments indicated.superior embryo quality in Group B over Group d during the cleavage stage,morula,and blastocyst(Psions:CoQ10 supplementation exhibits promising potential to enhance preimplantation embryo development,increase blastocyst formation rates,and improve embryo quality *** offers a promising approach to mitigate oxidative s.r.ss on embryos,potentially improving overall assisted reproductive technology outcomes.

关键词： Coenzyme Q10 Antioxidant Embryo development Vitrification Morphology Assisted reproductive technology

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Effect of Ta_(2)O_(5)nanoparticles on bioactivity,composition,s.r.cture,in vitro and in vivo behavior of PEO coatings on Mg-alloy

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Journal of Magnesium and Alloys 2024年第6期12卷 2360-2379页

作者： d.V.Mashtalyar I.M.Imshinetskiy V.V.Kashepa K.V.Nadaraia M.A.Piatkova A.I.Pleshkova K.A.Fomenko A.Yu.Ustinov s.L.sinebryukhov s.V.Gnedenkov Institute of Chemis.r. Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eastern Federal University Vladivostok690950Russia regional Clinical dermatovenerological d.spens.r. Vladivostok690033Russia

The present study investigates the physical and chemical characteristics,behavior in vitro and in vivo,and biocompatibility of coatings containing Ta_(2)O_(5),which are obtained by plasma electrolytic oxidation(PEO)on MA8 magnesium *** obtained coatings demons.r.te in vivo biocompatibility and in vitro *** to the base PEO coating,the layers containing Ta_(2)O_(5)facilitate the development of apatite in simulated body fluid.suggesting that the inclusion of nanoparticles improves bioactivity of the *** was found that incorporation of Ta_(2)O_(5)nanoparticles increases.r.ughness and porosity of the formed layers by increasing particle concentration in electrolytes for the PEO process contributing to sufficient soft tissue ingrowth in *** on in vivo studies,these coatings also provide favorable tissue response and minimal inflammatory reaction in comparison with the bare magnesium alloy due to protection of living tissues from deleterious corrosion events of magnesium implant such as local alkalization and intense hydrogen *** results obtained in the present study concluded biocompatibility,tissue integration of the PEO coatings containing Ta_(2)O_(5)nanoparticles making them a promising protective layer for biodegradable magnesium implants.

关键词： Plasma electrolytic oxidation Bioactive coatings Tantalum pentoxide simulated body fluid.sBF) Apatite formation Histology

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Model dependent analysis of ■→■ decays in beyond.standard model

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Chinese Physics C 2024年第9期48卷 86-99页

作者： s.Mahata M.Mandal H.Mahapatra s.Biswas s.sahoo department of Physics National Institute of Technology Durgapur

Motivated by the recent experimental results of branching fractions for ■→■ decays,which deviate from their sM predictions,we hve investigated these decays in W' model and.scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→■ *** recent experimental results of branching fractions for semileptonic d meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： $ W' $ boson charm decay flavour changing charged current new physics scalar leptoquark

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Interfacial s.r.ss engineering toward enhancement of ferroelectricity in Al doped HfO_(2)thin films

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Chinese Physics B 2024年第9期33卷 637-643页

作者： s X Chen M M Chen Y Liu d W Cao G J Chen department of Microelectronics Jiangsu UniversityZhenjiang 212013China department of Physics Jiangsu UniversityZhenjiang 212013China Guangdong–Hong Kong–Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversityFoshan 528225China

Ferroelectric HfO_(2)has attracted much attention owing to its superior ferroelectricity at an ultra-thin thickness and good compatibility with si-based complementary metal-oxide-semiconductor(CMOs)***,the crystallization of polar orthorhombic phase(o-phase)HfO_(2)is less competitive,which greatly limits the ferroelectricity of the as-obtained ferroelectric HfO_(2)thin ***,the crystallization of o-phase HfO_(2)can be thermodynamically modulated via interfacial s.r.ss *** this paper,the growth of improved ferroelectric Al doped HfO_(2)(HfO_(2):Al)thin films on(111)-oriented.si subs.r.te has been *** analysis has suggested that nonpolar monoclinic HfO_(2):Al grown on(111)-oriented.si subs.r.te suffered from a s.r.ng compressive s.r.in,which promoted the crystallization of(111)-oriented o-phase HfO_(2)in the as-grown HfO_(2):Al thin *** addition,the in-plane lattice of(111)-oriented.si subs.r.te matches well with that of(111)-oriented o-phase HfO_(2),which further thermally stabilizes the o-phase HfO_(2).Accordingly,an improved ferroelectricity with a remnant polarization(2P_(r))of 26.7C/cm^(2) has been *** results shown in this work provide a simple way toward the preparation of improved ferroelectric HfO_(2)thin films.

关键词： improved ferroelectricity interfacial s.r.ss engineering compressive s.r.in HfO_(2)

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rotating effects on the photoionization cross-section of a 2d quantum ring

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Communications in Theoretical Physics 2024年第10期76卷 153-159页

作者： Carlos Magno O Pereira Frankbelson d.s s Azevedo Luís Fernando C Pereira Edilberto O silva departamento de Física Universidade Federal do Maranh?o

In this article, we investigate the nonrelativistic quantum motion of a charged particle within a rotating frame, taking into account the Aharonov–Bohm(AB) effect and a uniform magnetic field. Our analysis entails the derivation of the equation of motion and the corresponding radial equation to des.r.be the system. solving the resulting radial equation enables us to determine the eigenvalues and eigenfunctions, providing a clear expression for the energy levels. Furthermore,our numerical analysis highlights the substantial influence of rotation on both energy levels and optical properties. specifically, we evaluate the photoionization cross-section with and without the effects of rotation. To elucidate the impact of rotation on the photoionization process of the system, we present graphics that offer an appealing visualization of the intrinsic nature of the physics involved.

关键词： Aharonov-Bohm effect photoionization cross-section quantum ring rotating effect

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