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Practical issues concerning tear protein assays in dry eye

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Eye and Vision 2014年第1期1卷 34-45页

作者： Sharon d.souza Louis Tong Narayana Nethralaya Superspeciality Eye Hospital and Post Graduate Institute BangaloreKarnatakaIndia. Singapore Eye Research Institute 11Third Hospital AvenueSingapore 168751Singapore. Singapore National Eye Center SingaporeSingapore. duke-NUS Graduate Medical School SingaporeSingapore. Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore.

dry eye is a common clinical condition diagnosed by cumulative evidence of symptoms and *** new treatments in dry eye are either expensive,invasive,have potential for side effects,or are not easily *** severe dry eye,the ideal modality of treatment to begin with is often not clear as specific molecular disturbances are not evident from just examination of clinical *** the effects of ongoing treatment is not straight forward since there is lack of agreement between clinical signs and *** is a need to have more objective methods of selecting treatment for dry eye and monitoring the effect of ***,there are many new technologies applied to the discovery of tear biomarkers,for e.g.,mass spectrometry based proteomics techniques and multiplex assays such as the bead-based sandwich indirect immunofluorescent *** proteins assays have even been made available as point-of-care *** review focuses on the evidence for the involvements of tear proteins in dry eye,possible changes in tear concentrations with therapy and the strength of evidence regarding dry eye *** remains to be done in terms of developing office-based assays and ascertaining their reliability,but current evidence suggests that tear proteins have a role in the clinical practice of dry eye.

关键词： Human dry eye Review Tear Proteomics Biomarker

The role of gut microbiota in the gut-brain axis:current challenges and perspectives

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Protein & Cell 2013年第6期4卷 403-414页

作者： Xiao Chen Roshan d.souza Seong-Tshool Hong BdRd Research Institute JINIS Biopharmaceuticals Inc948-9 DunsanBongdongWanjuChonbuk 565-902South Korea department of Microbiology and Genetics and Institute for Medical Science Chonbuk National University Medical SchoolJeonju 561-712South Korea

Brain and the gastrointestinal(GI)tract are intimately con-nected to form a bidirectional neurohumoral communica-tion *** communication between gut and brain,knows as the gut-brain axis,is so well established that the functional status of gut is always related to the condi-tion of *** researches on the gut-brain axis were traditionally focused on the psychological status affecting the function of the GI ***,recent evidences showed that gut microbiota communicates with the brain via the gut-brain axis to modulate brain development and behavioral *** recent fi ndings on the new role of gut microbiota in the gut-brain axis implicate that gut microbiota could associate with brain functions as well as neurological diseases via the gut-brain *** elucidate the role of gut microbiota in the gut-brain axis,precise identification of the composition of microbes constituting gut microbiota is an essential ***,identifi cation of microbes constituting gut microbiota has been the main technological challenge currently due to massive amount of intestinal microbes and the diffi culties in culture of gut *** methods for identifi ca-tion of microbes constituting gut microbiota are depend-ent on omics analysis methods by using advanced high tech ***,we review the association of gut microbiota with the gut-brain axis,including the pros and cons of the current high throughput methods for identi-fi cation of microbes constituting gut microbiota to eluci-date the role of gut microbiota in the gut-brain axis.

关键词： gut microbiota the gut-brain axis central nervous system high throughput methods next-generation sequencings

Changes in calcium accumulation and utilization efficiency and their impact on recycling,immobilization,and export across the oil palm cycle

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Oil Crop Science 2024年第3期9卷 143-150页

作者： Ismael de Jesus Matos Viégas Luma Castro de souza Eric Victor de Oliveira Ferreira Milton Garcia Costa Glauco André dos Santos Nogueira Vitor Resende do Nascimento Candido Ferreira de Oliveira Neto Capanema Campus Federal Rural University of the Amazon(UFRA)Av.Barao de CapanemaCaixa D'agua5514-6434ParaBrazil Center of Agricultural and Environmental Sciences Federal University of Maranhao(UFMA)ChapadinhaBR-222km 04SNBoa Vista65500000MaranhaoBrazilc Capitao Poço Campus Federal Rural University of the Amazon(UFRA)Tv.Pau AmareloS/n-Vila Nova68650-000Capitao PoçoParaBrazil department of Soil Science Sao Paulo State University(Unesp)School of Agricultural and Veterinarian SciencesJaboticabalVia de Acesso Prof.Paulo Donato CastelaneCastellane-S/N-Vila Industrial14884-900Sao PauloBrazil Institute of Agricultural Sciences(ICA) Federal Rural University of the Amazon(UFRA)Estr.Principal da Ufra2150Curio-Utinga66077-580BelemParaBrazil

Effective calcium(Ca)management is crucial for optimizing oil palm cultivation and enhancing crop *** study aimed to gain insights into the dynamics of Ca concentration,accumulation,exportation,immobilization,and recycling in various oil palm organs relative to plant *** experiment was conducted at the Agropalma enterprise site in the northeastern region of Para State,Brazil,evaluating seven plant age treatments:2,3,4,5,6,7,and 8 years *** a completely randomized design with four *** results demonstrated an age-related increase in Ca concentration in petioles,rachis,arrows,male inflorescences,peduncles,and ***,Ca accumulation exhibited an upward trend in all organs with progressing plant ***,the study revealed an enhanced Ca use efficiency across all plant organs in correlation with the age of oil palm *** findings underscore the dynamic nutritional demands of oil palm,influencing Ca immobilization,cycling,and export throughout its developmental stages.

关键词： Elaeis guineensis Jacq Ca cycling Ca export Ca immobilization Ca use efficiency Plant nutrition Amazon

Physico-chemical characterization of acid base disorders in patients with COVId-19:A cohort study

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World Journal of Nephrology 2024年第2期13卷 16-23页

作者： Sergio Pinto de souza Juliana R Caldas Marcelo Barreto Lopes Marcelo Augusto duarte Silveira Fernanda Oliveira Coelho Igor Oliveira Queiroz Pedro domingues Cury Rogério da Hora Passos department of Nephrology Hospital São RafaelSalvadorBA 41253190Brazil department of Nephrology D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Faculty of Medicine Escola Bahiana de Medicina e Saúde Pública-EBMSPSalvadorBA 40290000Brazil department of Intensive Care D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Hospital São Rafael D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil department of Intensive Care Unit Hospital Israelita Albert EinsteinSao PauloSP 05652900Brazil

BACKGROUNd Acid-base imbalance has been poorly described in patients with coronavirus disease 2019(COVId-19).Study by the quantitative acid-base approach may be able to account for minor changes in ion distribution that may have been over-looked using traditional acid-base analysis *** a cohort of critically ill COVId-19 patients,we looked for an association between metabolic acidosis surrogates and worse clinical outcomes,such as mortality,renal dialysis,and length of hospital *** To describe the acid-base disorders of critically ill COVId-19 patients using Stewart’s approach,associating its variables with poor *** This study pertained to a retrospective cohort comprised of adult patients who experienced an intensive care unit stay exceeding 4 days and who were diagnosed with severe acute respiratory syndrome coronavirus 2 infection through a positive polymerase chain reaction analysis of a nasal swab and typical pulmonary involvement observed in chest computed tomography *** and clinical data were obtained from electronic *** variables were compared using Fisher’s exact *** data were presented as median and interquartile *** Mann-Whitney U test was used for *** In total,211 patients were *** mortality rate was 13.7%.Overall,149 patients(70.6%)presented with alkalosis,28 patients(13.3%)had acidosis,and the remaining 34 patients(16.2%)had a normal arterial pondus *** those presenting with acidosis,most had a low apparent strong ion difference(SId)(20 patients,9.5%).Within the group with alkalosis,128 patients(61.0%)had respiratory *** non-survivors were older,had more comorbidities,and had higher Charlson’s and simplified acute physiology score *** did not find severe acid-base imbalance in this *** analyzed Stewart’s variables(effective SId,apparent SId,and strong ion gap and the effect of albumin,lactate,phosphorus,and chloride)were not d

关键词： COVId-19 Physicochemical approach Acid-base status Critically ill patients Acute respiratory syndrome

Sentence,Phrase,and Triple Annotations to Build a Knowledge Graph of Natural Language Processing Contributions—A Trial dataset

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Journal of data and Information Science 2021年第3期6卷 6-34页

作者： Jennifer d.souza Sören Auer TIB Leibniz Information Centre for Science and Technology HannoverGermany

Purpose:This work aims to normalize the NLPCONTRIBUTIONS scheme(henceforward,NLPCONTRIBUTIONGRAPH)to structure,directly from article sentences,the contributions information in Natural Language Processing(NLP)scholarly articles via a two-stage annotation methodology:1)pilot stage-to define the scheme(described in prior work);and 2)adjudication stage-to normalize the graphing model(the focus of this paper).design/methodology/approach:We re-annotate,a second time,the contributions-pertinent information across 50 prior-annotated NLP scholarly articles in terms of a data pipeline comprising:contribution-centered sentences,phrases,and triple *** this end,specifically,care was taken in the adjudication annotation stage to reduce annotation noise while formulating the guidelines for our proposed novel NLP contributions structuring and graphing ***:The application of NLPCONTRIBUTIONGRAPH on the 50 articles resulted finally in a dataset of 900 contribution-focused sentences,4,702 contribution-information-centered phrases,and 2,980 surface-structured *** intra-annotation agreement between the first and second stages,in terms of F1-score,was 67.92%for sentences,41.82%for phrases,and 22.31%for triple statements indicating that with increased granularity of the information,the annotation decision variance is *** limitations:NLPCONTRIBUTIONGRAPH has limited scope for structuring scholarly contributions compared with STEM(Science,Technology,Engineering,and Medicine)scholarly knowledge at ***,the annotation scheme in this work is designed by only an intra-annotator consensus-a single annotator first annotated the data to propose the initial scheme,following which,the same annotator reannotated the data to normalize the annotations in an adjudication ***,the expected goal of this work is to achieve a standardized retrospective model of capturing NLP contributions from scholarly *** would entail a larger initiati

关键词： Scholarly knowledge graphs Open science graphs Knowledge representation Natural language processing Semantic publishing

Experimental and computational validation of a scaled train tunnel model using modal analysis

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Frontiers of Mechanical Engineering 2013年第4期8卷 420-428页

作者： Janice B.d.souza Sangarapillai KANAPATHIPILLAI School of Mechanical and Manufacturing Engineering The University of New South Wales

Acoustic engineers are faced with the challenge of minimising reverberation time in their designs so as to contribute to the health and well-being of those traveling by train and those on the *** the problem is easy to identify,it is not as simple to *** acoustical environment of a train tunnel is complex,with a variety of noise contributing factors such as train announcements,speech of commuters,ventilation systems,electrical equipment and wheel and rail *** a result,there is some difficulty in modeling the complete acoustic environment with computational or acoustic first *** this study,an experimental rig was constructed to model the acoustic behavior within a *** modal properties for the 300 Hz to 1500 Hz range,including resonances and mode shapes were identified and were shown to successfully correspond to theoretical results and a computational model created in COMSOL using Finite Element Analysis.

关键词： reverberation time acoustic environment modal properties resonances

Breccia-cored columnar rosettes in a rubbly pahoehoe lava flow,Elephanta Island,deccan Traps,and a model for their origin

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地学前缘：英文版 2017年第6期8卷 1299-1309页

作者： Hetu Sheth Ishita Pal Vanit Patel Hrishikesh Samant Joseph d.souza department of Earth Sciences Indian Institute of Technology Bombay(IITB) Institute of Geophysics and Planetary Physics Scripps Institution of OceanographyUniversity of California San Diego department of Geology St.Xavier's College

Rubbly pahoehoe lava flows are abundant in many continental flood basalts including the deccan ***,structures with radial joint columns surrounding cores of flow-top breccia(FTB),reported from some deccan rubbly pahoehoe flows,are yet unknown from other basaltic provinces.A previous study of these deccan "breccia-cored columnar rosettes" ruled out explanations such as volcanic vents and lava tubes,and showed that the radial joint columns had grown outwards from cold FTB inclusions incorporated into the hot molten *** the highly vesicular(thus low-density)FTB blocks might have sunk into the flow interiors has remained a *** we describe a new example of a deccan rubbly pahoehoe flow with FTB-cored rosettes,from Elephanta Island in the Mumbai *** that(1)thick rubbly pahoehoe flows probably form by rapid inflation(involving many lava injections into a largely molten advancing flow),and(2)such flows are transitional to 'a'a flows(which continuously shed their top clinker in front of them as they advance),we propose a model for the FTB-cored *** suggest that the deccan flows under study were shedding some of their FTB in front of them as they advanced and,with high-eruption rate lava injection and inflation,frontal breakouts would incorporate this FTB rubble,with thickening of the flow carrying the rubble into the flow *** implies that,far from sinking into the molten interior,the FTB blocks may have been rising,until lava supply and inflation stopped,the flow began solidifying,and joint columns developed outward from each cold FTB inclusion as already inferred,forming the FTB-cored *** rubbly pahoehoe flows which began recycling most of their FTB became the 'a'a flows of the deccan.

关键词： Rubbly pahoehoe Columnar jointing Flow-top breccia Volcanism Flood basalt deccan Traps

Bacterial extracellular vesicle applications in cancer immunotherapy

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Bioactive Materials 2023年第4期22卷 551-566页

作者： Kanika Suri Anisha d.souza di Huang Aashray Bhavsar Mansoor Amiji department of Bioengineering College of EngineeringNortheastern UniversityBostonMA02115USA department of Pharmaceutical Sciences School of PharmacyNortheastern UniversityBostonMA02115USA Massachusetts Eye and Ear Infirmary Harvard Medical SchoolBostonMA20115USA department of Chemical Engineering College of EngineeringNortheastern UniversityBostonMA02115USA

Cancer therapy is undergoing a paradigm shift toward immunotherapy focusing on various approaches to activate the host immune *** research to identify appropriate immune cells and activate anti-tumor immunity continues to expand,scientists are looking at microbial sources given their inherent ability to elicit an immune *** extracellular vesicles(BEVs)are actively studied to control systemic humoral and cellular immune responses instead of using whole microorganisms or other types of extracellular vesicles(EVs).BEVs also provide the opportunity as versatile drug delivery *** mammalian EVs,BEVs have already made it to the clinic with the meningococcal vaccine(Bexsero®).However,there are still many unanswered questions in the use of BEVs,especially for chronic systemically administered *** this review,we address the opportunities and challenges in the use of BEVs for cancer immunotherapy and provide an outlook towards development of BEV products that can ultimately translate to the clinic.

关键词： Cancer immunotherapy Bacterial extracellular vesicles Membrane vesicles Outer membrane vesicles Mammalian extracellular vesicles

A novel ZnO/reduced graphene oxide and Prussian blue modified carbon paste electrode for the sensitive determination of Rutin

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Science China Chemistry 2019年第2期62卷 262-270页

作者： Ozma J d.souza Ronald J Mascarenhas Ashis K Satpati Basavanakote M Basavaraja Research and development Centre Bharathiar University Electrochemistry Research Group Department of Chemistry St.Joseph's College Analytical Chemistry division Bhabha Atomic Research Centre Anushakthi Nagar Trombay department of Chemistry PES University

A carbon paste modified sensor based on a novel composite of zinc oxide nanoparticles deposited on reduced graphene oxide(ZnO-rGrO) and Prussian blue(PB) was drop-cast(ZnO-rGrO-PB/MCPE) for the sensitive estimation of Rutin(Rtn) at pH *** high surface area of ZnO-rGrO and electrocatalytic property of PB promotes the oxidation of Rtn. Field emission scanning electron microscope(FE-SEM) and energy-dispersive X-ray spectroscopy(EdX) techniques were employed to confirm the deposition of ZnO-rGrO and PB on carbon paste electrode(CPE). The ability of ZnO-rGrO-PB/MCPE in charge transfer at the interface was investigated using electrochemical impedance spectroscopy(EIS). The heterogeneous rate constant(ks) and the charge transfer coefficient(α) have been calculated as 6.08 s^(-1) and 0.74 respectively. This sensor showed a wide linear response for Rtn from 7.0×10^(-8)to 7.0×10^(-6) M and 7.0×10^(-6) to 1.0×10^(-4) M with a limit of detection(2.05±0.04)×10^(-8) M(S/N=3). The application of ZnO-rGrO-PB/MCPE was found in the analysis of Rtn in fruit juice samples using standard addition method. This sensor showed good reproducibility, stability, selectivity and sensitivity.

关键词： Rutin zinc oxide nanoparticles reduced graphene oxide Prussian blue modified carbon paste electrode ascorbic acid