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Comparison of cross sectional optical coherence tomography images of elevated optic nerve heads across acquisition devices and scan protocols

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eye and Vision 2018年第1期5卷 163-171页

作者： Megh d.Patel Fareshta Khushzad Heather E.Moss department of Ophthalmology Stanford University2370 Watson Courtsuite 200Palo AltoCA 94303USA department of Neurology and Neurological Sciences Stanford University2370 Watson Courtsuite 200Palo AltoCA 94303USA

Background:Optic nerve head measurements extracted from optical coherence tomography(OCT)show promise for monitoring clinical conditions with elevated optic nerve *** aim of this study is to compare reliability within and between raters and between image acquisition devices of optic nerve measurements derived from OCT scans in eyes with varying degrees of optic nerve ***:Wide angle line scans and narrow angle radial scans through optic nerve heads were obtained using three spectral domain(Sd)OCT devices on 5 subjects(6 swollen optic nerves,4 normal optic nerves).Three raters independently semi-manually segmented the internal limiting membrane(ILM)and Bruch’s membrane(BM)on each scan using customized *** rater segmented each scan *** were qualitatively and quantitatively ***-rater,intra-rater and inter-device reliability was assessed for the optic nerve cross sectional area calculated from the ILM and BM segmentations using intraclass correlation coefficients and graphical ***:Line scans from all devices were qualitatively *** scans for which frame rate could not be adjusted were of lower ***-rater reliability for segmentation and optic nerve cross sectional area was better than inter-rater reliability,which was better than inter-device reliability,though all ICC exceeded *** was not impacted by the degree of optic nerve ***:Sd-OCT devices acquired similar quality scans of the optic nerve head,with choice of scan protocol affecting the *** image derived markers,variability between devices was greater than that attributable to inter and intra-rater differences.

关键词： Optic nerve head Optical coherence tomography Bruch’s membrane Inner limiting membrane Comparison

New Taxanes from the Leaves of Taxus cuspidata and ***

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层积结构对加拿大铁杉三层胶合木典型力学性能的影响

2008年中国药学会学术年会暨第八届中国药师周

作者： Manli ZHANG,1 Junqian LIU,2Changhong HUO,1 Qingwen SHI,1,* Yucheng GU3(1.School of Pharmaceutical Science,Hebei Medical University,361 Zhongshan East Road,050017,Shijiazhuang,HeBei Province 2.The First Hospital of Hebei Medical University,361 Zhongshan East Road,050017,Shijiazhuang,HeBei Province 3.Syngenta Jealott''s Hill International Research Centre,Bracknell,Berkshire RG42 6ey,UK)

OBJECTIVE:To study the constituents of Taxus cusipidata and *** ***:The constituents were extracted with methanol and isolated by column chromatography on silica gel,prep-TLC and *** structures were determined on the basis of 1d and 2d NMR as well as MS spectral *** method was used to evaluate the cytotoxicities of the three ***:Eight compounds were isolated and ***:Compounds 2,3,5-9 have not previously been reported from the titled *** 7 was a new taxane with a novel *** 8 showed weak growth inhibitory activities against T-98 and MM1-CB.

关键词： Taxus cuspidata T.canadensis Taxaceae,taxane diterpene MTT

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林业工程学报 2023年第1期8卷 59-65页

作者：卫佩行王建和郭叶莹子李昊张龙彭思江苏农林职业技术学院风景园林学院句容212400 西南林业大学材料科学与工程学院昆明650224 南京林业大学土木工程学院南京210037

以锯材为基本单元的正交胶合木(cross-laminated fimber, CLT)和平行胶合木(glue-laminated timber, GLT)是具有广阔应用前景的两种胶合木。为研究层积结构不同而引起的胶合木胶合性能和力学性能差异,选用No.2加拿大西部铁杉[(Tsuga can... 详细信息

以锯材为基本单元的正交胶合木(cross-laminated fimber, CLT)和平行胶合木(glue-laminated timber, GLT)是具有广阔应用前景的两种胶合木。为研究层积结构不同而引起的胶合木胶合性能和力学性能差异,选用No.2加拿大西部铁杉[(Tsuga canadensis L.) Carrière]在相同制备工艺条件(胶黏剂为单组分聚氨酯胶黏剂,施胶量为160 g/m^(2);冷压时间为1 h,冷压压力为1.0 MPa)下,并在同一大幅面压机上压制尺寸为4 300 mm×1 200 mm×105 mm的三层结构CLT和GLT板。依据LY/T 3039—2018、CSA O112.10-08、ANSI/APA PRG 320-2019与ASTM d198-15等国内外标准,测试CLT和GLT的胶层剪切强度、抗弯性能和抗剪性能。结果发现:干态条件下CLT的胶层剪切强度平均值为1.17 MPa,湿态条件(浸水真空-加压循环)下则降为0.83 MPa,而干态条件下GLT的胶层剪切强度为5.59 MPa,湿态条件下则降为3.47 MPa,由降幅可判定GLT胶合质量对环境湿度变化更为敏感;CLT和GLT梁四点面外弯曲时跨中截面应变沿高度方向基本上是均匀且对称的线性分布,由此可认为这两种胶合木梁在跨高比较大时受弯变形遵循平截面假定;CLT梁的抗弯弹性模量、抗弯强度、层间剪切强度分别为10 065.84,37.86和1.96 MPa,皆小于GLT梁的抗弯弹性模量、抗弯强度和层间剪切强度;比起GLT梁,CLT梁受弯破坏模式更为复杂,包含了沿木材年轮方向的滚动剪切破坏和纵横向层板之间的胶合界面破坏。上述试验研究和分析为这两种胶合木在工程中的应用提供了设计参考和理论依据。

关键词：层积结构正交胶合木平行胶合木胶合性能力学性能

Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-βinduced retinal pigmented epithelium degeneration

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1526-1534页

作者： Siddharth Narendran Felipe Pereira Praveen Yerramothu Ivana Apicella Shao-bin Wang Kameshwari Ambati Shuichiro Hirahara Younghee Kim Meenakshi Ambati Vidya L.Ambati Peirong Huang Akhil Varshney Yosuke Nagasaka Shinichi Fukuda Kirstie L.Baker Kenneth M.Marion Jan M.deussing Srinivas R.Sadda brad.ey d.Gelfand Jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA Aravind eye Care System MaduraiIndia departamento de Oftalmologia e Ciências Visuais Escola Paulista de MedicinaUniversidade Federal de São PauloSão PauloBrazil Center for digital Image Evaluation CharlottesvilleVAUSA doheny eye Institute Los AngelesLos AngelesCAUSA Molecular Neurogenetics Department of Stress Neurobiology and NeurogeneticsMax Planck Institute of PsychiatryMunichGermany department of Ophthalmology David Geffen School of MedicineUniversity of California–Los AngelesLos AngelesCAUSA department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(RPE)extracellular deposits characteristic of age-related macular degeneration(AMd),a common cause of global *** report that AβOs induce RPE degeneration,a clinical hallmark of geographic atrophy(GA),a vision-threatening late stage of AMd that is currently *** demonstrate that AβOs induce activation of the NLRP3 inflammasome in the mouse RPE in vivo and that RPE expression of the purinergic ATP receptor P2RX7,an upstream mediator of NLRP3 inflammasome activation,is required for AβO-induced RPE *** classes of small molecule inflammasome inhibitors—nucleoside reverse transcriptase inhibitors(NRTIs)and their antiretrovirally inert modified analog Kamuvudines—both inhibit AβOs-induced RPE *** findings crystallize the importance of P2RX7 and NLRP3 in a disease-relevant model of AMd and identify inflammasome inhibitors as potential treatments for GA.

关键词： degeneration activation upstream

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流感嗜血杆菌性流感引起的眼内炎

世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 53-54页

作者： Yoder d.M. Scott I.U. Flynn Jr. H.W. Miller d. 黎黎

To investigate the clinical settings, management strategies, antibiotic sensit ivities, and visual acuity outcomes for eyes with endophthalmitis caused by Haem ophilus influenzae. Retrospective, noncomparative, consecutive case series. The medical records were reviewed of all patients treated for culture proven H. inf luenzae endophthalmitis at a single institution between January 1, 1980, and dec ember 31, 2002. Visual acuity and antibiotic sensitivities. The study included 1 6 eyes of 16 patients with a median age of 68 years (range, 6 months-83 years) and a median follow up of 26 months (range, 2 months-15 years). Clinical setti ngs included post trabeculectomy (n=7), postcataract surgery (n=6), post pars plana vitrectomy (n=1), post secondary intraocular lens insertion (n=1), and po stsuture removal from an extracapsular cataract wound (n=1). Eleven (69%) cases were of delayed onset ( > 6 weeks from surgery/event), with a median interval b etween surgery/event and presentation with endophthalmitis of 18 months (range, 44 days-21 years); 5 (31%) cases were of acute onset (median, 6 days; range, 2 -14 days). Presenting visual acuity was hand movements or better in 7 (44%) ey es. A vitreous tap and inject was performed initially in 9 (56%) eyes, and a vi trectomy was performed initially in the remaining 7 (44%) eyes. All eyes receiv ed intravitreal antibiotics on the day of presentation, and 11 (69%) received i ntravitreal dexamethasone. In vitro testing of the H. influenzae isolates reveal ed that 14 of 16 (88%) were sensitive to vancomycin, ampicillin, and trimethopr im/sulfa methoxazole; 15 of 16 (94%) were sensitive to aminoglycosides (1 isol a te was resistant to gentamicin); and all were sensitive to cephalosporins, fluor oquinolones, and carbapenems. The organisms were sensitive to at least 1 of the initial antibiotics administered in all cases. Final visual acuity was 5/200 or better in 6 (38%) eyes, and 6 (38%) eyes had a final visual acuity of no light pe

关键词：流感嗜血杆菌眼内炎玻璃体切除抗生素敏感性晶状体囊外摘除小梁切除手术玻璃体切割术睫状体平坦部晶体植入临床病史

A Novel Taxane with An Unprecedented Skeleton from Taxus cuspidata Needles

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A Novel Taxane with An Unprecedented Skeleton from Taxus cus...

Two New Taxanes from Taxus cuspidata Needles and *** Rooted Cuttings

第九届全国中药和天然药物学术研讨会

作者： Shiping Chen~1 Sa Lv~1 Zuoping Li~2 Changhong Huo~2 Yongmin Zhao~3 Qingwen Shi~(2*) Yucheng Gu~4 1.depatment of Environmental Biochemistry Graduate School of Medicine,Chiba University,1-8-1,Inohana,Chuo-ku,Chiba 260-8670,Japan 2.department of Natural Product Chemistry,School of Pharmaceutical Sciences,Hebei Medical University,361 Zhongshan East Road,050017,Shijiazhuang,Hebei Province,P.R.China 3.School of Basic Medical Science,Hebei North University,zhangjiakou 075000,China 4.Jealott''s Hill International Research Centre,Syngenta,Berkshire,RG42 6ey,UK

＜正＞A novel metabolite with an unprecedented skeleton was isolated from the needles of Taxus *** structure was characterized as 2,7,9,10-tetraacetoxy-5,12-dihydroxy-11,12-secotaxa-4（20）-en-11, 13-dione（1）on the ... 详细信息

关键词： Taxus cuspidata Taxaceae needles isolation

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Two New Taxanes from Taxus cuspidata Needles and *** Rooted ...

Wide-field three-photon excitation in biological samples

第九届全国中药和天然药物学术研讨会

作者： Sa Lv~1 Shiping Chen~1 Changhong Huo~2 Yongmin Zhao~3 Qingwen Shi~(2*) Yucheng Gu~4 1.depatment of Environmental Biochemistry Graduate School of Medicine,Chiba University,1-8-1,Inohana,Chuo-ku,Chiba 260-8670,Japan 2.department of Natural Product Chemistry,School of Pharmaceutical Sciences,Hebei Medical University,361 Zhongshan East Road,050017,Shijiazhuang,Hebei Province,P.R.China 3.School of Basic Medical Science,Hebei North University,zhangjiakou 075000,China 4.Jealott''s Hill International Research Centre,Syngenta,Berkshire,RG42 6ey,UK

＜正＞A novel metabolite with an unprecedented hemiketal ring between C-13 and C-9 and a taxane with an amino-side chain on C-5 were isolated from the needles of Taxus cuspidata and rooted cuttings of Taxus canadensis,*** structure,s were characterized as 2,10-diacetoxy-5-cinnamoyloxy-11.1-dihydroxy-9,13-epoxide-taxa-4（20）-ene（1）and 7,9 ,10.1-tetraacetoxy-5-[3’-（N-formyl-N-methylamino）-3’-phenylpropanoyl]oxytaxa-4（20）,12-diene（2）on the basis of 1d-, 2d-NMR data *** spectra of 2 in CdCh solution revealed that 2 was composed of two epimers（2 and 3）in a ratio of 2:1 approximately.

关键词： Taxus cuspidata Taxus canadensis Taxaceae needles rooted cutting taxane isolation

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Light(Science & Applications) 2016年第1期5卷 65-73页

作者： Christopher J Rowlands demian Park Oliver T Bruns Kiryl d Piatkevich dai Fukumura Rakesh K Jain Moungi G Bawendi Edward S Boyden Peter TC So department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Media Lab Massachusetts Institute of TechnologyCambridgeMA 02139USA department of Chemistry Massachusetts Institute of TechnologyCambridgeMA 02139USA Edwin L.Steele Laboratories Department of Radiation OncologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA department of Brain and Cognitive Sciences McGovern Institute and MIT Center for Neurobiological EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139-4307USA department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

Three-photon wide-field depth-resolved excitation is used to overcome some of the limitations in conventional point-scanning two-and three-photon *** of chromophores as diverse as channelrhodopsins and quantum dots is shown,and a penetration depth of more than 700μm into fixed scattering brain tissue is achieved,approximately twice as deep as that achieved using two-photon wide-field *** with live animal experiments is confirmed by imaging the cerebral vasculature of an anesthetized mouse;a complete focal stack was obtained without any evidence of *** an additional validation of the utility of wide-field three-photon excitation,functional excitation is demonstrated by performing threephoton optogenetic stimulation of cultured mouse hippocampal neurons expressing a channelrhodopsin;action potentials could reliably be excited without causing photodamage.

关键词： biophotonics multiphoton microscopy optogenetics temporal focusing three-photon

Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization

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Signal Transduction and Targeted Therapy 2023年第3期8卷 905-907页

作者： Shao-bin Wang Yosuke Nagasaka dionne Argyle Ayami Nagasaka Praveen Yerramothu brad.ey dGelfand Jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

dear Editor,Vascular endothelial growth factor-A(VEGFA,also known as VEGF)is a critical angiogenic factor that regulates the physiological and pathological blood vessel growth.1 Increased abundance of VEGF in the eye underlies many forms of aberrant ocular angiogenesis and resultant vision loss,including in neovascular age-related macular degeneration(nvAMd),proliferative diabetic retinopathy(PdR).

关键词： degeneration ocular release