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Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

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Neural regeneration research 2021年第3期16卷 482-488页

作者： Monica L.Acosta Mohd N.Mat Nor Cindy X.Guo Odunayo O.Mugisho frazer P.Coutinho Ilva d.rupenthal Colin r.Green School of Optometry and Vision Science University of AucklandAucklandNew Zealand Faculty of Medicine Universiti Sultan Zainal AbidinTerengganuMalaysia department of Ophthalmology University of AucklandAucklandNew Zealand Buchanan Ocular Therapeutics Unit Department of OphthalmologyAucklandNew Zealand New Zealand National Eye Centre University of AucklandAucklandNew Zealand Centre for Brain research Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Brain research New Zealand–rangahau roro Aotearoa AucklandNew Zealand

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of *** of these compounds are now in clinical trials,but for many of them,the literature is inconclusive about the molecular effect on the tissue,despite evidence of functional *** the different channel types has distinct physiological and pathological implications and this review describes current knowledge of connexin and pannexin protein channels,their function as channels and possible mechanisms of the channel block effect for the latest therapeutic *** summarize the evidence implicating pannexins and connexins in disease,considering their homeostatic versus pathological roles,their contribution to excesive ATP release linked to disease onset and progression.

关键词： connexin gap junction gap19 hemichannel pannexin retina tonabersat

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支持外观造型创新设计的计算机辅助设计环境

计算机辅助设计与图形学学报 2003年第10期15卷 1258-1262页

作者：刘弘刘希玉唐明晰 John Hamilton frazer 山东师范大学计算机科学系济南250014 香港理工大学设计学院设计技术研究中心

介绍一个计算机辅助设计环境 ,该环境利用进化计算及可视化技术生成二维草图及三维图像 ,以支持设计人员的创新设计用一个艺术设计实例介绍了该环境所采用的基于树结构的遗传算法 ,实例用一般的数学表达式生成艺术品底座外形 ,用复合... 详细信息

介绍一个计算机辅助设计环境 ,该环境利用进化计算及可视化技术生成二维草图及三维图像 ,以支持设计人员的创新设计用一个艺术设计实例介绍了该环境所采用的基于树结构的遗传算法 ,实例用一般的数学表达式生成艺术品底座外形 ,用复合函数表达式生成艺术花卉的三维图像实例表明 :文中方法能够生成一些有创意的解。

关键词：工业设计外观造型创新设计计算机辅助设计可视化产品设计

The OryzaSNP Project-SNP discovery in diverse rice

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分子植物育种 2007年第2期5卷 246-247页

作者： K. McNally r. Bruskiewich d. Mackill d. Weigel K. frazer K. Childs r. Buell J. Leach H. Leung International rice research Institute DAPO Box 7777 Metro Manila Philippines Max Planck Institute for developmental Biology D-72076 Tübingen Germany Perlegen Sciences Inc. 2021 Stierlin Court Mountain View CA 94043 USA The Institute for Genomic research 9712 Medical Center Dr. Rockville MD 20850 USA Bioagricultural Sciences and Pest Management Colorado State UniversityFt. Collins CO 80523 USA

The OryzaSNP project (http://***) is undertaking SNP discovery across the entire rice genome for 20 diverse varieties (McNally et al., 2006). These varieties include representatives from the indica, tropical

关键词：低聚物序列稻子单倍体种植技术

Concurrent multi-peak Bragg coherent x-ray diffraction imaging of 3d nanocrystal lattice displacement via global optimization

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npj Computational Materials 2023年第1期9卷 1579-1590页

作者： Siddharth Maddali Travis d.frazer Nazar delegan Katherine J.Harmon Sean E.Sullivan Marc Allain Wonsuk Cha Alan dibos Ishwor Poudyal Saugat Kandel Youssef S.G.Nashed F.Joseph Heremans Hoydoo You Yue Cao Stephan O.Hruszkewycz Materials Science division Argonne National LaboratoryLemontIL 60439USA Center for Molecular Engineering Argonne National LaboratoryLemontIL 60439USA Aix-Marseille Univ CNRSCentrale MarseilleInstitut FresnelMarseilleFrance X-ray Science division Argonne National LaboratoryLemontIL 60439USA Center for Nanoscale Materials Argonne National LaboratoryLemontIL 60439USA Mathematics&Computer Science division Argonne National LaboratoryLemontIL 60439USA Pritzker School of Molecular Engineering University of Chicago5640 South Ellis AvenueChicagoIL 60637USA SLAC National Accelerator Laboratory Menlo ParkCAUSA

In this paper we demonstrated a method to reconstruct vector-valued lattice distortion fields within nanoscale crystals by optimization of a forward model of multi-reflection Bragg coherent diffraction imaging(Mr-BCdI)*** method flexibly accounts for geometric factors that arise when making BCdI measurements,is amenable to efficient inversion with modern optimization toolkits,and allows for globally constraining a single image reconstruction to multiple Bragg peak *** is enabled by a forward model that emulates the multiple Bragg peaks of a Mr-BCdI experiment from a single estimate of the 3d crystal *** present this forward model,we implement it within the stochastic gradient descent optimization framework,and we demonstrate it with simulated and experimental data of nanocrystals with inhomogeneous internal lattice *** find that utilizing a global optimization approach to Mr-BCdI affords a reliable path to convergence of data which is otherwise challenging to reconstruct.

关键词： optimization coherent lattice

安徽某酸性矿山废水库嗜酸菌的分离、鉴定及基因组功能分析

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安徽某酸性矿山废水库嗜酸菌的分离、鉴定及基因组功能分析

作者： BANdA JOSEPH frazer（卓赛福）中国地质大学(北京)

学位级别：硕士

酸性矿山水(acid mine drainage,AMd)是人类矿业活动的主要污染物之一,pH通常在3.5以下,并含有高浓度的金属离子,危害十分严重。在酸性矿山废水的形成过程中,嗜酸菌发挥着至关重要的催化作用。因此,要理解酸性矿山废水的形成机制及演化... 详细信息

酸性矿山水(acid mine drainage,AMd)是人类矿业活动的主要污染物之一,pH通常在3.5以下,并含有高浓度的金属离子,危害十分严重。在酸性矿山废水的形成过程中,嗜酸菌发挥着至关重要的催化作用。因此,要理解酸性矿山废水的形成机制及演化过程,控制酸性矿山废水的产生,针对性的治理其污染,就需要我们真正认识酸性矿山废水区域内关键嗜酸菌的生理性质及适应机制。为此,本研究采集了安徽某铁矿的酸性矿山废水样品,从中分离纯化出了3株嗜酸菌,系统研究了其生理生化性质,并从基因组水平上分析了其适应极端环境的分子机制。主要的研究成果如下:1.从pH为3.01的酸性矿山废水中分离纯化出了3株嗜酸细菌,经16S r rNA基因测序和系统发育分析,确定它们分别为ralstonia ***、ralstonia ***和Acidocella ***。2.株细菌均为化能异养嗜酸菌。ralstonia *** pH生长范围为3.0-7.0,最适pH为3.0-4.5,最适度为30℃,可在0-5%的Na Cl环境中生长。ralstonia *** pH生长范围为2.0-6.5,最适pH为3.0-5.0,最适温度为30℃,可在0-5%的Na Cl环境中生长。Acidocella *** pH生长范围为2.5-6.0,最适pH为3.0-3.5,最适温度为35℃,可在0-3%的Na Cl环境中生长。3.株细菌均可耐受高浓度的耐重金属,但性能有一定差异。ralstonia ***对Zn的耐受性最强,耐受浓度高达10000 mg/L,对Cu、Cd、Ni的耐受浓度分别为1000 mg/L、1000 mg/L、150 mg/L。ralstonia ***对Cd的耐受性最强,达2000 mg/L,但对Cu、Zn、Ni都较为敏感,耐受浓度分别为50mg/L、200 mg/L、15 mg/L。Acidocella ***对Zn的耐受性最强,高达15000 mg/L,对Cd、Cu、Ni的耐受能力也很强,分别为2000 mg/L、1000mg/L、500 mg/L。4.基因组学研究表明,这3株细菌具有类似的适应机制。3株细菌均含有丰富的去饱和酶基因(des A、OLE1、ErG3),可以通过调节细胞膜的组分保持对H+的不渗透性。基因组中编码H+-ATPase(Ntp I)的基因也很丰富,可向细胞外主动泵出H+,从而保持细胞内的中性环境。5.株细菌含有丰富的重金属抗性基因,例如钴-锌-镉外排系统(Czc d)和阳离子转运ATPase(Znt A)等,通过这些酶的作用,可将Zn、Ni、Cd、Co、Cu、Hg等二价金属主动排放的细胞外。细胞膜上的砷转运蛋白Acr3则使细菌具有了抗砷的性能。Cation/multidrug efflux transporter(Acr B)可以帮助细菌消除重金属等多种有毒物质的抑制作用

关键词：酸性矿山废水嗜酸细菌适应机制全基因组测序重金属

A Comparison of the Clinical and Molecular diagnosis of Herpes Simplex Keratitis

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Open Journal of Ophthalmology 2014年第3期4卷 65-74页

作者： Victoria E. McGilligan Jonathan E. Moore Mohammad Tallouzi Sarah d. Atkinson Hugh O’Neill Susan Feeney Elena S. Novitskaya Anant Sharma Sunil Shah Jonathan A. Jackson david G. frazer Tara C. B. Moore Birmingham and Midland Eye Centre City Hospital Birmingham UK Centre for Molecular Biosciences University of Ulster Coleraine N. Ireland department of Ophthalmology Belfast Health and Social Care Trust The Royal Victoria Hospital Belfast N. Ireland department of Ophthalmology Moorfields at Bedford Hospital Bedford UK regional Virology Laboratory Belfast Health and Social Care Trust The Royal Victoria Hospital Belfast N. Ireland

Purpose: To compare the clinical and molecular diagnoses of Herpes Simplex Keratitis (HSK). Materials and Methods: Conjunctival swabs (after fluorescein and anaesthetic wash out) and detailed questionnaire data were obtained from 146 participants. Corneal rims and conjunctival epithelial cells were infected with Herpes Simplex Virus (HSV) type 1 or HSV2 and supernatant collected. HSV1;HSV2;Varicella Zoster Virus (VZV) and Adenovirus (AdV) dNA was assessed using two real time Polymerase Chain reaction (PCr) methods. results: Of the 146 participants recruited, 54 were clinically diagnosed with typical epithelial lesions and 38 with atypical epithelial lesions, 17 with old inactive HSK and 37 healthy volunteers. HSV1 dNA was detected in 28 (30%) of the 92 participants with clinically suspect HSK. Patients who presented with typical epithelial lesions had a higher positive rate (46%) than those who presented with atypical type lesions (8%), when using primers against the Glycoprotein (Gp) G region of the virus. When the same samples were retested with primers against the GpB region, the positive rate for the typical and atypical cases increased to 52% and 11% respectively. Antiviral use at the time of sampling reduced the rate of PCr positivity by 20% (p dV dNA was detected in 6% of the typical cases and 8% of the atypical cases. All control participants with no history of HSK were negative for HSV1 dNA. Sample quantity was confirmed by testing for housekeeping control genes, beta-actin and beta-2 macroglobulin. PCr results from in vitro control investigations of HSV1 and 2 infected corneal rims and conjunctival epithelial cells were 100% positive for infected and 100% negative for uninfected samples when assessed using both PCr methods. Conclusions: Clinical diagnosis of typical HSK is not always confirmed by PCr. Concomitant use of an antiviral reduces levels of PCr positivity. Given this and the findings that other ocular surface pathogens may mimic HSK pat

关键词： Herpes Simplex Keratitis PCr Antivirals Viralgenotype

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魔鬼的律师━为迷信辩护

1988年

作者： J.G.·弗雷泽(J.G. frazer)

来源：南通市图书馆图书汇雅图书（南通市图书馆... 评论

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T2加权梯度回波MrI所示大脑微量出血患者的认知功能障碍

作者： (美)迈克尔·L. 弗雷泽(Michael L. frazer)

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 31-31页

作者： Werring d.J. frazer d.W. Coward L.J. M.M. Brown 杜芳 department of Clinical Neurology Institute of Neurology University College London Queen Square London WC1N 3BG United Kingdom Prof.

Gradient echo T2. weighted MrI has high sensitivity in detecting cerebral mic robleeds, which appear as small dot like hypointense lesions. Microbleeds are s trongly associated with intracerebral haemorrhage, hypertension, lacunar stroke and ischaemic small vessel disease, and have generated interest as a marker of b leeding prone microangiopathy. Microbleeds have generally been considered to be clinically silent; however, since they are located in widespread cortical and b asal ganglia regions and are histologically characterized by tissue damage, we h ypothesized that they would cause cognitive dysfunction. We therefore studied pa tients with microbleeds (n = 25) and a nonmicrobleed control group (n = 30) matc hed for age, gender and intelligence quotient. To avoid the confounding effects of coexisting cerebrovascular disease, the groups were also matched for the exte nt of MrI visible white matter changes of presumed ischaemic origin, location o f cortical strokes, and for the proportion of patients with different stroke sub types (including lacunar stroke). A battery of neuropsychological tests was used to assess current intellectual function, verbal and visual memory, naming and p erceptual skills, speed and attention and executive function. Microbleeds were m ost common in the basal ganglia but were also found in frontal, parieto occipit al, temporal and infratentorial regions. There was a striking difference between the groups in the prevalence of executive dysfunction, which was present in 60 %of microbleed patients compared with 30%of non microbleed patients (P = 0.03 ). Logistic regression confirmed that microbleeds (but not white matter changes) were an independent predictor of executive impairment (adjusted odds ratio = 1. 32, 95%confidence interval 1.01 1.70, P = 0.04). Patients with executive dysfu nction had more microbleeds in the frontal region (mean count 1.54 versus 0.03; P = 0.002) and in the basal ganglia (mean 1.17 versus 0.32; P = 0.048). Ther

关键词： MrI T2加权梯度回波微出血认知损害脑血管病认知障碍心理学测验组织损害无症状