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中国检验检测 1981年第4期 52-53页

作者： d.petersen 薛家政

在测量仪器中使用微处理器,不仅能收到经济效果,而且为计量技术提供有利条件,给用户带来好处,并显著改善了仪器性能。微处理器的计算能力,能使被测值彼此之间或它们与任何给定常数之间进行运算。这样就可确定导出的和非直接可测的量(如... 详细信息

在测量仪器中使用微处理器,不仅能收到经济效果,而且为计量技术提供有利条件,给用户带来好处,并显著改善了仪器性能。微处理器的计算能力,能使被测值彼此之间或它们与任何给定常数之间进行运算。这样就可确定导出的和非直接可测的量(如功率=

关键词：微处理器测量仪器倒数值

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覆膜支架在经颈静脉门腔分流术中的应用

中华放射学杂志 2008年第8期42卷 830-834页

作者：赵剑波李彦豪 Kenneth J.Kolbeck Frederick S.Keller John A.Kaufman Robert E.Barton Bryan d.petersen 南方医科大学南方医院介入放射科广州510515 美国俄勒冈州健康生命科技大学dotter介入放射学研究所

目的评价经颈静脉肝内门腔分流术（TIPS）专用覆膜支架（Viatorr支架）在TIPS中的应用价值。方法回顾性分析37例在美国俄勒冈州健康生命科技大学dotter介入放射学研究所采用Viatorr支架行’nPs治疗的患者资料，随访时间为（15．2±9．... 详细信息

目的评价经颈静脉肝内门腔分流术（TIPS）专用覆膜支架（Viatorr支架）在TIPS中的应用价值。方法回顾性分析37例在美国俄勒冈州健康生命科技大学dotter介入放射学研究所采用Viatorr支架行’nPs治疗的患者资料，随访时间为（15．2±9．3）个月（3～42个月）。TIPS指征包括门静脉高压相关性的急慢性消化道出血，经药物及内镜治疗无效者17例；顽固性肝源性胸、腹水18例，***综合征2例。采用配对t检验比较手术前后门腔静脉压力差（PSG）的变化，以Kaplan-Meier曲线分析支架开通率。结果37例共置入41枚Viatorr支架，其中3枚直径为8mm，38枚为10mm，支架带膜长度为4～8cm，无相关手术并发症。PSG由术前的（22．4±8．4）mmHg（1mmHg=0．133kPa）降为（8．1±3．2）mmHg，差异有统计学意义（t=12．754，P〈0．01）。17例出血患者术后出血均停止，1例于术后17个月复发。18例严重顽固性腹水及肝性胸水患者中，4例术后腹水不消退，其余14例随访期间有2例腹水复发。2例（5．4％）发生分流道阻塞，Kaplan-Meier曲线分析结果显示1年的开通率为97．0％。术后1个月内无病死患者，2例分别于术后3个月及15个月死于多器官功能衰竭，晚期病死率为5．4％，死亡前1周内复查支架均通畅。肝移植患者5例（13．5％）。结论Viatorr支架能明显提高TIPS术后开通率，选择合适的支架，采用正确的释放技术能进一步提高疗效，但长期效果评价尚需验证。

关键词：高血压,门静脉支架放射学,介入性

Quantum state tomography from observable time traces in closed quantum systems

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Control Theory and Technology 2024年第2期22卷 222-234页

作者： Shuixin Xiao Yuanlong Wang Qi Yu Jun Zhang daoyi dong Ian R.petersen University of Michigan–Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai200240China School of Engineering The Australian National UniversityCanberraACT2601Australia Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing100190China Centre for Quantum Computation and Communication Technology(Australian Research Council) Centre for Quantum DynamicsGriffith UniversityBrisbaneQLD4111Australia School of Engineering and Technology University of New South WalesCanberraACT2600Australia

The task to estimate all the parameters of an unknown quantum state, also called quantum state tomography, is essential for characterizing and controlling quantum systems. In this paper, we utilize observable time traces to identify the initial quantum state of a closed quantum system, based on the state space approach in the control theory. In the informationally complete scenario, we show that with a linear regression estimation (LRE), the mean squared error (MSE) scales as , where N is the resource number. In the informationally incomplete scenario, we introduce regularization LRE to perform the state tomography task. We employ PBH test to demonstrate that closed quantum systems with only one observable are informationally incomplete and propose using observables, where d is the dimension of the quantum state, for informational completeness. Numerical examples demonstrate the effectiveness of our method.

关键词： Quantum state tomography Time trace Quantum system identification

Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis

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World Journal of Gastroenterology 2024年第10期30卷 1405-1419页

作者： Ye Tian Xin Li Xu Wang Si-Ting Pei Hong-Xin Pan Yu-Qi Cheng Yi-Chen Li Wen-Ting Cao Jin-dong ding petersen Ping Zhang International School of Public Health and One Health Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Medical Laboratory Science and Technology College Harbin Medical University-Daqing CampusDaqing 163000Heilongjiang ProvinceChina department of Laboratory diagnosis Qiqihar Tuberculosis Control CenterQiqihar 161000Heilongjiang ProvinceChina department of Public Health University of CopenhagenCopenhagen 1353Denmark department of Public Health University of Southern DenmarkOdense 5000Denmark

BACKGROUNd Ulcerative colitis is a chronic inflammatory disease of the colon with an unknown *** sphingomyelinase(alk-SMase)is specifically expressed by intestinal epithelial cells,and has been reported to play an anti-inflammatory ***,the underlying mechanism is still *** To explore the mechanism of alk-SMase anti-inflammatory effects on intestinal barrier function and oxidative stress in dextran sulfate sodium(dSS)-induced *** Mice were administered 3%dSS drinking water,and disease activity index was determined to evaluate the status of *** permeability was evaluated by gavage administration of fluorescein isothiocyanate dextran,and bacterial translocation was evaluated by measuring serum *** epithelial cell ultrastructure was observed by electron *** blotting and quantitative real-time reverse transcription-polymerase chain reaction were used to detect the expression of intestinal barrier proteins and mRNA,*** oxidant and antioxidant marker levels were analyzed using commercial kits to assess oxidative stress *** Compared to wild-type(WT)mice,inflammation and intestinal permeability in alk-SMase knockout(KO)mice were more severe beginning 4 d after dSS *** mRNA and protein levels of intestinal barrier proteins,including zonula occludens-1,occludin,claudin-3,claudin-5,claudin-8,mucin 2,and secretory immunoglobulin A,were significantly reduced on 4 d after dSS *** observations revealed progressive damage to the tight junctions of intestinal epithelial ***,by day 4,mitochondria appeared swollen and ***,compared to WT mice,serum malondialdehyde levels in KO mice were higher,and the antioxidant capacity was significantly *** expression of the transcription factor nuclear factor erythroid 2-related factor 2(Nrf2)in the colonic mucosal tissue of KO mice was significantly decr

关键词： Alkaline sphingomyelinase Intestinal mucosal barrier Antioxidant capacity dextran sulfate sodium-induced colitis nuclear factor erythroid 2-related factor 2

Utilizing melt crystallization fundamentals in the development of a new tabletting technology

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Frontiers of Chemical Science and Engineering 2014年第3期8卷 346-352页

作者： Ahmed ABOUZEId Sandra petersen Joachim ULRICH Martin Luther University Halle-Wittenberg Center for Engineering Science Thermal Process Engineering D-06099 Halle Germany

Increasing production effeciency and lowering costs are some of the many advantages melt crystallization technology offers over the conventional methodology of tabletting. A normal tablet consists of a pure shell or a coat and a separate core constituting the pharmaceutical active ingredient. Great emphasis is put on the purity of the shell since its purpose is to solely protect and deliver the active ingredient to its target. Melt crystallization is a purification （separation） process. It is discussed here for its ability to produce coated tablets, by separating the ＂coating＂ material from the ＂to be coated＂ material coming from one molten mixture. Molten drops of lutrol-ibuprofen mixture are produced using the drop forming technique. The subsequent analysis involves proving and quantifying the phase separation （coat purity）. The mechanism of a crystallizing drop is shown as direct evidence of the ongoing process. Moreover, solidified tablet batches are analyzed for the purity of their coating by measuring the ibuprofen concentration. This optimization process is carried out through multiple stages of development and condition enhancements in order to produce the most pure tablet coating. As a result, a trial showing an almost purely coated tablet is presented here.

关键词： phase separation melt crystallization tablets,process optimization

Importance of emulsions in crystallization --applications for fat crystallization

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 43-48页

作者： Sandra petersen K. CHALEEPA Joachim ULRICH Center for Engineering Science Thermal Process Engineering Martin Luther University Halle-Wittenberg D-06099 Halle (Saale) Germany

Emulsions and crystallization are two independent research topics which normally do not overlap although a combination of the two could be applicable to many areas. Here, the importance of emulsions in the field of fat crystallization is described. Three applications with industrial relevance were chosen for investigation： fat fractionation, the solidification of phase change materials and solid lipid nanoparticles. For fat fractionation and phase change materials, emulsification can be applied as a tool to improve the fat crystallization process, and thus the product quality of the crystallized fat. Furthermore, the use of emulsification creates new solid lipid nanoparticles in the application fields such as area of fat crystallization.

关键词： emulsion fat crystallization phase change material emulsion ffactionation emulsion solidification

A methodological framework for analyzing PPGIS data collected in 3d

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International Journal of digital Earth 2023年第1期16卷 3435-3455页

作者： Kamyar Hasanzadeh Nora Fagerholm Hans Skov-petersen Anton Stahl Olafsson department of Geography and Geology University of TurkuTurkuFinland department of Geosciences and Natural Resource Management University of CopenhagenCopenhagenDenmark

Public participation geographic information system(PPGIS)is a facilitated Volunteered Geographic Information approach and data collection method that aims to capture the spatial experiences of *** we experience the space around us three-dimensionally,altitude,as the third dimension,has been often absent from PPGis research and *** is largely because of the complexity of implementing surveys in 3d but can also be attributed to a lack of analytical preparedness for using such *** study complements 3d PPGIS data collected from a pilot study of the Aninkainen block in Turku,Finland with synthetic,*** manufactured,data to propose an analytical framework for the study of 3d PPGIS *** analytical framework divides methods based on the geographical scale into two groups:micro-and macro-scale *** this framework,we propose the use of geospatial metrics to analyze 3d PPGIS *** argue that while this multidisciplinary area of research is in its infancy,use of intuitive 3d adapted geometric and landscape metrics can help overcome some of complexities associated with use of this emerging participatory *** conclude by outlining the limitations and envisioning areas for future research.

关键词： 3d GIS landscape metrics PPGIS

End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients

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World Journal of Gastroenterology 2018年第41期24卷 4691-4697页

作者： Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T petersen Mark d Topazian Vinay Chandrasekhara Barham K Abu dayyeh division of Gastroenterology and Hepatology Mayo Clinic department of Gastroenterology Digestive Center for Diagnosis and Treatment division of Gastroenterology and Hepatology Georgetown University Medstar Washington Hospital Center

AIM To determine if end-stage renal disease (ESRd) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHOdS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of diseases 9^(th) Revision (ICd-9-CM). Included patients were divided into three groups: ESRd, chronic kidney disease (CKd), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICd-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression *** There were 492175 discharges that underwent ERCP during the 3 years. The ESRd and CKd groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRd group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP d was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP d had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP djusted mean difference (aMd) = 5.9 d (95% CI: 5.0-6.7 d, ~aP d higher hospitalization charges aMd = $+82064 (95%CI: $68221-$95906, ~aP d is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes.

关键词： End-stage renal disease Nationwide Inpatient Sample Endoscopic retrograde cholangiopancreatography

Realization Feature of Mesenchymal dermal Cells Tissue Engineering Construction Response in Granulating Wound Transplantation in Relation with Time-Frame

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Journal of Cosmetics, dermatological Sciences and Applications 2012年第3期2卷 126-129页

作者： Elena petersen Moscow Scientific Research Center of dermatovenerology and Cosmetology of Moscow City Moscow Russia

derma is progenitor cells sours, that are able to differentiate further in several mesodermal lineage and neural and endodermal lineage. Culture conditions, skin taking site and culture medium composition considerably contribute to it. Spheroid cultured mesenchymal dermal cells contribution to skin regeneration in granulating wound in rat model was estimated.

关键词： Brief Report 3d Cultivated Tissue Engineering Construction Skin Mesenchymal dermal Cells Sprouting Capillary-Like Structures

Quality assessment of graphene： Continuity, uniformity, and accuracy of mobility measurements

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Nano Research 2017年第10期10卷 3596-3605页

作者： david M. A. Mackenzie Jonas d. Buron Patrick R. Whelan José M. Carida Martin Bjergfelt Bironq Luo Abhay Shivayogimath Anne L. Smitshuysen Joachim d. Thomsen Timothy J. Booth Lene Gammelgaard Johanna Zultak Bjarke S. Jessen Peter Boggild dirch H. petersen department of Micro- and Nanotechnology Technical University of Denmark Orsteds Plads 345 B Kongens Lyngby 2800 Denmark Center for Nanostructured Graphene (CNG) Technical University of Denmark Kongens Lyngby 2800 Denmark

With the increasing availability of large-area graphene, the ability to rapidly and accurately assess the quality of the electrical properties has become critically important. For practical applications, spatial variability in carrier density and carrier mobility must be controlled and minimized. We present a simple framework for assessing the quality and homogeneity of large-area graphene devices. The field effect in both exfoliated graphene devices encapsulated in hexagonal boron nitride and chemical vapor-deposited （CVd） devices was measured in dual current-voltage configurations and used to derive a single, gate-dependent effective shape factor, t, for each device, β is a sensitive indicator of spatial homogeneity that can be obtained from samples of arbitrary shape. All 50 devices investigated in this study show a variation （up to tenfold） in β as a function of the gate bias. Finite element simulations suggest that spatial doping inhomogeneity, rather than mobility inhomogeneity, is the primary cause of the gate dependence of β, and that measurable variations of β can be caused by doping variations as small as 10^10 cm^-2. Our results suggest that local variations in the position of the dirac point alter the current flow and thus the effective sample shape as a function of the gate bias. We also found that such variations lead to systematic errors in carrier mobility calculations, which can be revealed by inspecting the corresponding β factor.

关键词： chemical vapor-deposited (CVd) graphene doping inhomogeneity electrical measurements van der Pauw hBN-encapsulated graphene finite element simulations Raman mapping