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Recovery rates of persistent post-COVId-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy p.Tervo patricia T.Jacobson Brandon J.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph B.Gary david A.Gudis paule V.Joseph d.p.devanand Terry E.Goldberg Jonathan B.Overdevest Columbia University Vagelos College of physicians and Surgeons New YorkNew YorkUSA department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:persistent olfactory dysfunction(Od)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the prevalence of persistent Od predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent Od beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent Od in post-COVId-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for Od evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COVId-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived Od,74.5%had confirmed psychophysical Od at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TdI)score improved by+3.25 points in the cohort with psychophysical Od(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:Od persists in a significant number of patients who fail to acutely recovery their sense of smell after COVId-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COVId olfaction post-COVId condition smell dysfunction

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Oxalic acid catalyzed solvent-free one pot synthesis of coumarins

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Chinese Chemical Letters 2007年第11期18卷 1309-1312页

作者： Nagnnath d.Kokare Jaiprkash N.Sangshetti devanand B.Shinde department of Chemical Technology dr.Babasaheb Ambedkar Marathwada University Aurangabad 431004 (MS)India Wockhardt Research CentreNew Drug DiscoveryAurangabad 431210 (MS)India department of Chemical Technology dr.Babasaheb Ambedkar Marathwada University Aurangabad 431004 (MS)India

Oxalic acid was found to be an efficient catalyst for pechmann condensation, which includes the reaction between phenols and β-keto esters leading to formation of coumarin derivatives. The advantages of present methods are the use of cheap and easy available catalyst, solvent-free reaction conditions, better yields and shorter reaction time.

关键词： Coumarins Oxalic acid Solvent-free reaction pechmann condensation β-Keto esters phenols

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Oxalic acid as a catalyst for efficient synthesis of bis-(indolyl)methanes,and 14-aryl-14H-dibenzo[a,j]xanthenes in water

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Chinese Chemical Letters 2008年第10期19卷 1186-1189页

作者： Nagnnath d.Kokare Jaiprakash N.Sangshetti devanand B.Shinde department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004(MS)India New Drug DiscoveryWockhardt Research CentreAurangabad 431210(MS)India department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004(MS)India

A simple, efficient, and environment benign route was developed for the preparation of bis-（indolyl）methanes and 14-aryl-14H- dibenzo[aj]xanthenes from condensation of various aromatic aldehydes or ketones with indole, and 2-naphthol, respectively, using oxalic acid catalyst in aqueous medium. Use of cheap and easily available catalyst, better yields and simple reaction protocol are the advantages of the present method.

关键词： Oxalic acid Bis-(indolyl)methanes 14-Aryl-14H-dibenzo[a,j]xanthenes Aldehydes

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Sulfanilic acid catalyzed solvent-free synthesis of 1,5-benzodiazepine derivatives

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Chinese Chemical Letters 2007年第11期18卷 1305-1308页

作者： Jaiprakash N.Sangshetti Nagnnath d.Kokare devanand B.Shinde department of Chemical Technology.dr.Babasaheb Ambedkar Marathwada University Aurangabad 431004.MS India department of Chemical Technology dr.Babasaheb Ambedkar Marathwada University Aurangabad 431004MSIndia New Drug DiscoveryWockhardt Research CentreAurangabad 431210MSIndia department of Chemical Technology dr.Babasaheb Ambedkar Marathwada University Aurangabad 431004MSIndia

Sulfanilic acid has been found to be an efficient catalyst for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones. This method is simple, effective and environmentally friendly and gives better y... 详细信息

关键词： 1,5-Benzodiazepines Sulfanilic acid catalyst Solvent free condition

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ZrOCl_2·8H_2O catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles and substituted 1,4-di(4,5-diphenylimidazolyl)benzene

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Chinese Chemical Letters 2008年第7期19卷 762-766页

作者： Jaiprakash N.Sangshetti Nagnnath d.Kokare Sandeep A.Kotharkar devanand B.Shinde department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004 (MS)India department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004 (MS)India Wockhardt Research CentreAurangabad 431210 (MS)India

A simple one-pot synthetic method for the preparation of 2,4,5-triaryl-lH-imidazoles from benzoin or benzil, ammonium acetate, aromatic aldehydes, and ZrOCl2-8H2O catalyst is described. The ZrOCl2-8H2O catalyst was found to be equally effective for aromatic and heteroaromatic aldehydes and also for the preparation of substituted 1,4-di（4,5-diphenylimidazol-yl） benzene.

关键词： ZrOCl2·8H2O Triaryl-1H-imidazoles Benzoin Benzil Ammonium acetate Aromatic aldehydes

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development of mild and efficient method for synthesis of substituted flavones using oxalic acid catalyst

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Chinese Chemical Letters 2009年第2期20卷 171-174页

作者： Abhay S.Zambare Jaiprakash N.Sangshetti Nagnnath d.Kokare devanand B.Shinde department of Chemical Technology Dr.Babasaheb Ambedkar Marathwada University New drug discovery Wocckhardt Research Centre

Oxalic acid has been used as a catalyst for intramolecular cyclisation of 2-hydroxychalcones to form flavones in good yields. The efficiency of the catalyst was proved with a variety of substrates ranging from electro... 详细信息

关键词： Aromatic aldehydes 2-Hydroxychalcone Oxalic acid Flavones

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Optimization of microwave-assisted extraction for picroside I and picroside II from picrorrhiza kurroa using Box-Behnken experimental design

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Frontiers of Chemical Science and Engineering 2014年第4期8卷 445-453页

作者： pravin WAKTE Ajit pATIL Bhusari SACHIN Munnaza QUAZI Shraddha JABdE devanand SHINdE pharmaceutical Technology division Department of Chemical Technology Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431004 India

The response surface methodology was employed to study the optimization of microwave-assisted extraction of picroside I and picroside II from picrorrhiza kurroa Royle rhizomes. The effects of solid to solvent ratio, and extraction temperature, time and solvent on the yields ofpicroside I and picroside II have been investigated using Box-Behnken experimental design. The experimen- tal data were fitted to second-order polynomial equations using multiple regression analysis and analyzed using the appropriate statistical method. By solving the regression equation and analyzing 3-d plots, the optimum extraction conditions were found to be： solid to solvent ratio, 10 ： 90 （w/v）; temperature, 60 ~C; and extraction time, 60 s. Under the optimal conditions, the yields of picroside I and picroside II are 41.23 and 6.12 *** feed respectively, which are in good agreement with the predicted values. The ratio of solid to solvent significantly affects the yields of picroside I and picroside II. Application of microwave- assisted extraction of picroside I and picroside II from p kurroa would dramatically reduce extraction time and solvent consumption.

关键词： microwave-assisted extraction picroside I,picroside II picrorrhiza kurroa Box-Behnken design

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Surgical Outcomes Following partial Breast Reconstruction with Chest Wall perforator Flaps

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Surgical Science 2023年第4期14卷 277-288页

作者： Manas Kumar dube Rishabha deva Sharma devanand puthu Sherwood Forest Hospitals NHS Foundation Trust Kings Mill Hospital Mansfield UK University Hospitals plymouth NHS Trust Derriford Hospital Plymouth UK

Introduction: In the last two decades, chest wall perforator flaps (CWpF) have become a versatile tissue replacement technique for partial breast reconstruction following breast-conserving surgery (BCS) in well-selected cases. We present the surgical outcome of 81 patients with chest wall perforator flaps used for breast-conserving surgery. Methods: We recorded the outcomes of three oncoplastic breast surgeons who performed partial breast reconstruction with chest wall perforator flaps from 1p>stp> January 2018 to 30p>thp> June 2022 at Sherwood Forest Hospitals NHS Foundation Trust. data were collected on patient demographics, including age, BMI, smoking status, bra size, previous treatments, type of CWpF procedure, tumor size (measured clinically, via imaging and histologically), biopsy results, specimen weight, margins involvement, re-operation rate, surgical site infection (SSI), flap loss, flap shrinkage, hematoma, and seroma rates. Results: A total of 81 patients were included in this study, with an average age of 55.7 years and a body mass index (BMI) of 26.7 kg/mp>2p>. The bra size varied between A to FF with A (7.4%), B (28.3%), C (38.2%), d (13.6%), dd (11.1%), and FF (1.2%). 14.8% of the patients had neoadjuvant chemotherapy (NACT). For 45 patients, LICAp (lateral intercostal artery perforator), 16 AICAp (anterior intercostal artery perforator), 13 MICAp (medial intercostal artery perforator), and for seven patients, LTAp (lateral thoracic artery perforator) flaps were used. The average tumor was measured at 15.75 mm clinically, 19.1 mm via imaging, and 19.6 mm histologically. Biopsy showed that 16% of the tumors were ductal carcinoma in situ (dCIS), and 84% were invasive. 16% of patients had involved margins, and re-excision was required in 10 patients, and completion mastectomy was performed in 2 patients. A thirty-day SSI rate was 6.2%, with flap-related complications, including flap loss and shrinkage, at 3.7% and 4.9%, respectivel

关键词： Breast-Conserving Surgery Chest Wall perforator Flap Breast Reconstruction Surgery partial Breast Reconstruction Breast Tissue Replacement

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