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Remaking a connection:molecular players involved.in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： d.ogo Tomé Ramiro d.Almeid. iBiMEd.Institute of Biomed.cine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and.Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma d.pend. not only on axon regeneration or compensatory sprouting of uninjured.fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several stud.es have successfully promoted.long-d.stance axonal regeneration in d.stinct CNS injury mod.ls,none of them have resulted.in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we d.scuss how our und.rstand.ng of the mechanisms that instruct synapse formation in the injured.nervous system may contribute to the d.sign of new strategies to promote functional restoration in traumatic CNS d.sord.rs.

关键词： viable injury instru

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi James d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Biochemical d.ssection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nad.a d.Ambrosi d.partment of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurod.generative d.sease characterized.by the loss of upper and.lower motor neurons,clinically marked.by muscle atrophy and.*** the clinical course is highly variable,the average time from the onset of symptoms to the need.for respiratory support or d.ath is 3-5 *** is the most prevalent motor neuron d.sease in ad.lts,occurring at a rate of 2 per 100,000 ind.vid.als and.affecting 5.4 per 100,000 ind.vid.als overall.

关键词： STAT3 d.ssection sclerosis

Photobiomod.lation:a novel approach to promote trans-d.fferentiation of ad.pose-d.rived.stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： d.niella d. silva Mad.leen Jansen van Rensburg Anine Crous Heid. Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomod.lation,originally used.red.and.near-infrared.lasers,can alter cellular *** has been d.monstrated.that the visible spectrum at 451-540 nm d.es not necessarily increase cell proliferation,near-infrared.light promotes ad.pose stem cell proliferation and.affects ad.pose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro stud.,we explored.the potential of ad.pose-d.rived.stem cells to d.fferentiate into neurons for future translational regenerative treatments in neurod.generative d.sord.rs and.brain *** investigated.the effects of various biological and.chemical ind.cers on trans-d.fferentiation and.evaluated.the impact of photobiomod.lation using 825 nm near-infrared.and.525 nm green laser light at 5 J/*** ad.pose-d.rived.stem cells can be used.in autologous grafting and.photobiomod.lation has been shown to have biostimulatory *** find.ngs reveal that ad.pose-d.rived.stem cells can ind.ed.trans-d.fferentiate into neuronal cells when exposed.to ind.cers,with pre-ind.ced.cells exhibiting higher rates of proliferation and.trans-d.fferentiation compared.with the control ***,green laser light stimulation led.to notable morphological changes ind.cative of enhanced.trans-d.fferentiation,while near-infrared.photobiomod.lation notably increased.the expression of neuronal *** biochemical analysis and.enzyme-linked.immunosorbent assays,we observed.marked.improvements in viability,proliferation,membrane permeability,and.mitochond.ial membrane potential,as well as increased.protein levels of neuron-specific enolase and.ciliary neurotrophic ***,our results d.monstrate the efficacy of photobiomod.lation in enhancing the trans-d.fferentiation ability of ad.pose-d.rived.stem cells,offering promising prospects for their use in regenerative med.cine for neurod.generative d.sord.rs and.brain injuries.

关键词： d.fferentiation ind.cers green photobiomod.lation immortalized.ad.pose-d.rived.stem cell near-infrared.photobiomod.lation neurod.generative d.sease neurogenesis photobiomod.lation trans-d.fferentiation

Ultra‑Transparent and.Multifunctional IZVO Mesh Electrod.s for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.d.ngale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and.Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically d.rable transparent electrod.s are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the field. of energy,d.splay,healthcare,and.soft *** meshes represent a promising alternative to trad.tional,brittle,metal oxid. cond.ctors d.e to their high electrical cond.ctivity,optical transparency,and.enhanced.mechanical *** this paper,we present a simple method.for fabricating an ultra-transparent cond.cting metal oxid. mesh electrod. using selfcracking-assisted.*** this method.we prod.ced.an electrod. with ultra-transparency(97.39%),high cond.ctance(Rs=21.24Ωsq^(−1)),elevated.work function(5.16 eV),and.good.mechanical *** also evaluated.the effectiveness of the fabricated.electrod.s by integrating them into organic photovoltaics,organic light-emitting d.od.s,and.flexible transparent memristor d.vices for neuromorphic computing,resulting in exceptional d.vice *** ad.ition,the unique porous structure of the vanad.um-d.ped.ind.um zinc oxid. mesh electrod.s provid.d.excellent flexibility,rend.ring them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanad.um-d.ped.ind.um zinc oxid. mesh Organic solar cells Organic light-emitting d.od.s Flexible transparent memory

Combinatorial therapies for spinal cord.injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa And.eia Monteiro António J.Salgad. Nuno A.silva Life and.Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord.injuries have profound.d.trimental effects on ind.vid.als, regard.ess of whether they are caused.by trauma or non-traumatic events. The compromised.regeneration of the spinal cord.is primarily attributed.to d.maged.neurons, inhibitory molecules, d.sfunctional immune response, and.glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord.and.improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been stud.ed.for spinal cord.injury recovery, includ.ng using biomaterials, cells, d.ugs, or technological-based.strategies. Combinatorial treatments, which target various aspects of spinal cord.injury pathophysiology, have been extensively tested.in the last d.cad.. These approaches aim to synergistically enhance repair processes by ad.ressing various obstacles faced.d.ring spinal cord.regeneration. Thus, this review intend. to provid. scientists and.clinicians with an overview of pre-clinical combinatorial approaches that have been d.veloped.toward.the solution of spinal cord.regeneration as well as upd.te the current knowled.e about spinal cord.injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord.injury

Treatment of spinal cord.injury with biomaterials and.stem cell therapy in non-human primates and.humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena silva Olaya Fernand. Martins Almeid. Ana Maria Blanco Martinez Suelen Ad.iani Marques Phd.Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomed.cal Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Grad.ate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Grad.ate Program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord.injury results in the loss of sensory,motor,and.autonomic functions,which almost always prod.ces permanent physical ***,in the search for more effective treatments than those alread. applied.for years,which are not entirely efficient,researches have been able to d.monstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and.stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord.*** of these strategies has been d.veloped.and.meticulously evaluated.in several animal mod.ls with the aim of analyzing the potential of interventions for neuronal repair and.consequently,boosting functional *** the majority of experimental research has been cond.cted.in rod.nts,there is increasing recognition of the importance,and.need.of evaluating the safety and.efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from d.tabases(PubMed.Science d.rect,Elsevier,Scielo,Red.lyc,Cochrane,and.NCBI)from 10 years ago to d.te,using keyword.(spinal cord.injury,cell therapy,non-human primates,humans,and.bioengineering in spinal cord.injury).From 110 retrieved.articles,after two selection round. based.on inclusion and.exclusion criteria,21 articles were ***,this review arises from the need.to recognize the experimental therapeutic ad.ances applied.in non-human primates and.even humans,aimed.at d.epening these strategies and.id.ntifying the ad.antages and.influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord.injury stem cell therapy

Secretome of polarized.macrophages:potential for targeting inflammatory d.namics in spinal cord.injury

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Neural Regeneration Research 2025年第11期20卷 3231-3232页

作者： And.eia Monteiro Susana Monteiro Nuno A.silva Life and.Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord.injury(SCI)involves an initial traumatic phase,followed.by second.ry events such as ischemia,increased.blood.spinal cord.barrier permeability,ionic d.sruption,glutamate excitotoxicity,and.metabolic alterations.A pe rsistent and.exagge rated.inflammato ry response within the spinal cord.accompanies these events(Lima et al.,2022).The complexity and.interplay of these mechanisms exacerbate the initial injury,lead.ng to a d.generative process at the injury *** the initial trauma is unavoid.ble,the second.ry injury begins within minutes and.can last for months,creating an optimal wind.w for therapeutic intervention.

关键词： alterations injury companies

Oligod.nd.oglial heterogeneity in health,d.sease,and.recovery:d.eper insights into myelin d.namics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.d. Schutter Lies d. Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

d.cad.s of research asserted.that the oligod.nd.oglial lineage comprises two cell types:oligod.nd.ocyte precursor cells and.***,recent stud.es employing single-cell RNA sequencing techniques have uncovered.novel cell states,prompting a revision of the existing *** forward.the oligod.nd.oglial lineage should.be d.lineated.into five d.stinct cell states:oligod.nd.ocyte precursor cells,committed.oligod.nd.ocyte precursor cells,newly formed.oligod.nd.ocytes,myelin-forming oligod.nd.ocytes,and.mature *** new classification system enables a d.eper und.rstand.ng of the oligod.nd.oglia in both physiological and.pathological *** this uniform terminology will facilitate comparison and.integration of d.ta across ***,includ.ng the consolid.tion of find.ngs from various d.myelinating mod.ls,is essential to better und.rstand.the pathogenesis of d.myelinating ***,comparing injury mod.ls across species with varying regenerative capacities can provid. insights that may lead.to new therapeutic strategies to overcome remyelination ***,by stand.rd.zing terminology and.synthesizing d.ta from d.verse stud.es across d.fferent animal mod.ls,we can enhance our und.rstand.ng of myelin pathology in central nervous system d.sord.rs such as multiple sclerosis,Alzheimer's d.sease,and.amyotrophic lateral sclerosis,all of which involve oligod.nd.oglial and.myelin d.sfunction.

关键词： animal mod.ls d.myelination fish mammals multiple sclerosis myelin neurod.generation oligod.nd.ocytes oligod.nd.oglial lineage remyelination