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Efficacy of infliximab in acute severe ulcerative colitis:A single-centre experience

World Journal of Gastroenterology 2013年第7期19卷 1091-1097页

作者： Stephen J Halpin p John Hamlin d.niel p gree Lisa Warren Alexander C Ford Leeds Gastroenterology Institute St.James's University HospitalLeedsWest Yorkshire LS9 7TFUnited Kingdom Leeds Gastroenterology Institute St.James's University HospitalLeedsWest Yorkshire LS9 7TFUnited Kingdom r Leeds Institute of Molecular Medicine University of LeedsLeedsWest Yorkshire LS9 7TFUnited Kingdom

AIM:To suggest infliximab(IFX) is effective for acute severe ulcerative colitis,from real-life clinical ***:All patients receiving IFX for the treatment of acute severe ulcerative colitis in a single centre were *** were extracted from clinical records in order to assess response to IFX *** primary endpoint was colectomy-free survival,and secondary outcomes included glucocorticosteroid-free remission and safety,which was evaluated by recording deaths and adverse *** and clinical characteristics of those who underwent colectomy and those who were colectomy-free,both at discharge from their index admission,and during follow-up after an initial response to IFX were ***:Forty-four patients(16 females,mean age 36 years) received IFX between May 2006 and January 2012 for acute severe ulcerative *** median duration of follow-up post-first infusion was 396 d(interquartile range = 173-828 d).There were 21(47.7%) patients with p,10(22.7%) with 1 years to 2 years of follow-up,and 13(29.5%) with > 2 years of follow-up post-first infusion of ***,35(79.5%) responded to IFX,avoiding colectomy during their index admission,29(65.9%) were colectomyfree at last point of follow-up(median follow-up 396 d),and 25(56.8%) were in glucocorticosteroid-free remission at end of *** was one death from post-operative sepsis,20 d after a single IFX *** rates were generally lower among those "bridging" to *** 18 patients "bridged" to thiopurine therapy,17(94.4%) were colectomyfree,and 15(83.3%) were in glucocorticosteroid-free remission at study *** predictors of response were ***:IFX is effective for acute severe ulcerative colitis in real-life clinical ***-thirds of patients avoided colectomy,and more than 50% were in glucocorticosteroid-free remission.

关键词： Ulcerative colitis Severe Azathioprine Infliximab Remission

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dⅢ—d和JET中VH模式的研究

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国外核聚变与等离子体应用 1994年第5期 10-19页

作者： gree.,CM 青青

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Clinical significance of TGF-β₁ and β-glucuronidase synchronous detection in human pancreatic cancer

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Hepatobiliary & pancreatic diseases International 2002年第2期1卷 309-311页

作者： Yue H. Yang B. Zhang H. Zhu S.-d. du X.-J. Feng X.-L. Yu Z. Xia Y.-T. Yu J.-p. department of digestive diseases People's Hospital Wuhan University Wuhan 430071 China dept. of Liver and Biliary Surgery Gen. Hosp. Shenyang Military Region Shenyang 110016 China department of pathology Chinese Medical University Shenyang 110005 China

Objective: To investigate the relation of transfergrowth factor （TGF-β1） and β-glucuronidase （β-GCd） on the occurrence and progress of ***: The expression of TGF-β1 and β-GCd in thepancreatic cancer tissue and normal pancreatic tissuewas determined synchronously using ABC method ***: The percentage of TGF-β1 positive cells wassignificantly higher in pancreatic cancer tissue （43.8%±5.2%） than in adjacent pancreatic tissue （28.7%±3.6%, pdifferen-tiated and lymph nodes metastasis, the more over-ex-pression of TGF-β1. The percentage of β-GCd positivecells was also significantly higher in the pancreaticcancer tissue （62.5%±4.1%） than in the adjacentpancreatic tissue （33.5%±2.8%, pde-gree of over-expression of β-GCd was related to thedegree of cancer cells differentiation, but not to thelymph nodes metastasis. The expression of TGF-β1was significantly correlated with the expression of β-GCd in pancreatic cancer ***: The genesis of pancreatic cancer resultsfrom multi-factor, multi-step and multi-gene varia-tion. The synchronous detection of TGF-β1 and β-GCd helps to determine the malignant degree oftumors and the prognosis of patients with such disease.

关键词： pancreatic cancer transfer growth factor β1 β-glucuronidase

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金融发展与地区实体经济资本配置效率——来自省级工业行业数据的证据

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经济学（季刊） 2013年第1期12卷 527-548页

作者：李青原李江冰江春 Kevin X.d.Huang 武汉大学经济与管理学院国务院研究室宏观经济研究司美国范德比特大学经济系

本文基于实体经济运行的视角主要探讨了金融系统是否发挥了改善我国地区实体经济资本配置效率的功能。文章以1999—2006年间中国30个地区27个工业行业为样本,借助Wur-gler(2000)的资本配置效率估算模型,构建了非国有部门信贷比重等衡量... 详细信息

本文基于实体经济运行的视角主要探讨了金融系统是否发挥了改善我国地区实体经济资本配置效率的功能。文章以1999—2006年间中国30个地区27个工业行业为样本,借助Wur-gler(2000)的资本配置效率估算模型,构建了非国有部门信贷比重等衡量金融发展程度的指标,并运用系统广义矩面板估计方法等进行实证检验。结果显示:金融发展促进了中国地区实体经济资本配置效率的提高,同时当进一步考虑地方政府对银行信贷决策干预的影响时,地方政府的干预却会妨碍金融系统对中国地区实体经济资本配置效率改善功能的有效发挥。

关键词：金融发展政府干预地区实体经济资本配置效率

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