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Single-cell RNA sequencing in juvenile idiopathic arthritis

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Genes & diseases 2024年第2期11卷 633-644页

作者： Xiwen luo Xuemei Tang department of Rheumatology and Immunology Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Child Infection and Immunity Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China

Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children,with onset before age 16 and lasting for more than 6 *** is a highly heterogeneous condition with various consequences for health and quality of *** some JIA patients,early detection and intervention remain *** a result,further investigation of the complex and unknown mechanisms underlying JIA is *** in technology now allow us to describe the biological heterogeneity and function of individual cell populations in *** this review,we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis.

关键词： Juvenile idiopathic arthritis Macrophage Macrophage activation syndrome Monocyte Single-cell RNA sequencing Synoviocyte T cell

Combination of diketone and PAO to achieve macroscale oil-based superlubricity at relative high contact pressures

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Friction 2024年第5期12卷 869-883页

作者： Shaonan dU Chenhui ZHANG Zhi luo State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing100084China Beijing National Laboratory of Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing100190China

1-(4-ethylphenyl)-nonane-1,3-dione(0206)is an oil-soluble liquid molecule with rod-like *** this study,the chelate(0206-Fe)with octahedral structure was prepared by the reaction of ferric chloride and 1,*** experimental results show that when using 0206 and a mixed solution containing 60%0206-Fe and 40%0206(0206-Fe(60%))as lubricants of the steel friction pairs,superlubricity can be achieved(0.007,0.006).But their wear scar diameters(WSd)were very large(532µm,370µm),which resulted in the pressure of only 44.3 and 61.8 MPa in the contact areas of the friction *** 0206-Fe(60%)was mixed with PAO6,it was found that the friction coefficient(COF)decreased with increase of 0206-Fe(60%)in the *** the ratio of 0206-Fe(60%)to PAO6 was 8:2(PAO6(20%)),it exhibited better comprehensive tribological properties(232.3 MPa).Subsequent studies have shown that reducing the viscosity of the base oil in the mixed solution helped to reduce COF and increased *** the COF,contact pressure,and running-in time,it was found that the mixed lubricant(Oil3(20%))prepared by the base oil with a viscosity of 19.7 mPa·s(Oil3)and 0206-Fe(60%)exhibited the best tribological properties(0.007,161.4 MPa,3,100 s).

关键词： diketone oil-based lubricants chelate superlubricity

Facile synthesis of intra-nanogap enhanced Raman tags with different shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun Fan Brian T.Scarpitti Zhewen luo Abigail E.Smith Jian Ye Zachary d.Schultz department of Chemistry and Biochemistry The Ohio State UniversityColumbusOhio 43210USA School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell ***,creating stable,reproducible,and strong SERS signals remains challenging due to the potential interference from surrounding chemicals and locating SERS-active analytes into hot-spot ***,we developed a straightforward approach to synthesize intra-gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBT)as a reporter molecule within these gaps to avoid outside *** made three kinds of intra-gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which the nanorods based intra-gap nanoparticles exhibit the highest SERS *** advantage of our method is the ease of preparation of high-yield and stable intra-gap nanoparticles characterized by a short incubation time(10 min)with 4-NBT and quick synthesis without requiring an additional step to centrifuge for the purification of core *** intense localized field in the synthesized hot spots of these plasmonic gap nanostructures holds great promise as a SERS substrate for a broad range of quantitative optical applications.

关键词： hot spot engineering surface enhanced Raman scattering intra-gap nanoparticles 4-nitrobenzenethiol

Study on the tribological properties of metal rolling bearing under lubrication with diketone lubricants

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Science China(Technological Sciences) 2024年第7期67卷 2003-2017页

作者： dU ShaoNan ZHANG ChenHui luo Zhi State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Beijing National Laboratory of Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

In this article, 1-(4-ethylphenyl)-nonane-1,3-dione(0206) was prepared by Claisen condensation. By mixing 0206, chelate, and base oil in a ratio of 3.2:4.8:2, a diketone lubricant(PAO=14(20%)) that can achieve superlubricity was prepared and applied to bearing lubrication experiments. The experimental results show that when the bearing was lubricated by base oil, the friction coefficient(COF) and temperature rise decreased with the decrease of the viscosity of PAO. When PAO=14(20%) was used as the lubricant, the COF of the bearing was the lowest(0.001), and the wear morphology was comparable to that of the bearing lubricated with commercial lubricant. Compared with the base oil with the same viscosity, it is found that the COF and temperature rise of the bearing lubricated by PAO=14(20%) were lower under any experimental conditions. And when the amount of lubricant added was 10 μL, the COF of the bearing lubricated by PAO=14(20%) reached a very low value(0.0004).Bearing ball surface analysis identified the formation of diketone adsorption films. Combined with the previous PAO=14(20%)superlubricity mechanism, it was considered that the occurrence of tribochemical reaction and the bearing effect of chelates were the main reasons for the existence of ultra-low friction coefficient and low wear. In addition, when there were polar molecules in the lubricant, they were adsorbed on the metal surface through tribochemical reactions, resulting in many irregular pits on the surface.

关键词： superlubricity diketone chelate tribochemical recations bearing lubrication

Achieving Synergistic Improvement in dielectric and Energy Storage Properties of All-Organic Poly(Methyl Methacrylate)-Based Copolymers Via Establishing Charge Traps

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Energy & Environmental Materials 2024年第2期7卷 308-319页

作者： Guanghu He Huang luo Chuanfang Yan Yuting Wan dang Wu Hang luo Yuan Liu Sheng Chen Key Laboratory of Polymeric Materials and Application Technology of Hunan Province College of ChemistryXiangtan UniversityXiangtan 411105China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Guangdong University of Petrochemical Technology Maoming 525000China

How to achieve synergistic improvement of permittivity(ε_(r))and breakdown strength(E_(b))is a huge challenge for polymer ***,for the first time,theπ-conjugated comonomer(MHT)can simultaneously promote theε_(r)and E_(b)of linear poly(methyl methacrylate)(PMMA)*** PMMA-based random copolymer films(P(MMA-co-MHT)),block copolymer films(PMMA-b-PMHT),and PMMA-based blend films were prepared to investigate the effects of sequential structure,phase separation structure,and modification method on dielectric and energy storage properties of PMMA-based dielectric *** a result,the random copolymer P(MMA-coMHT)can achieve a maximumε_(r)of 5.8 at 1 kHz owing to the enhanced orientation polarization and electron *** electron injection and charge transfer are limited by the strong electrostatic attraction ofπ-conjugated benzophenanthrene group analyzed by the density functional theory(dFT),the discharge energy density value of P(MMA-co-PMHT)containing 1 mol%MHT units with the efficiency of 80%reaches15.00 J cm^(-3)at 872 MV m^(-1),which is 165%higher than that of pure *** study provides a simple and effective way to fabricate the high performance of polymer dielectrics via copolymerization with the monomer of P-type semi-conductive polymer.

关键词： dielectric capacitor electrical properties energy density polymer dielectric semiconductor polymer

Cell replacement with stem cell-derived retinal ganglion cells from different protocols

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Neural Regeneration Research 2024年第4期19卷 807-810页

作者： Ziming luo Kun-Che Chang Spencer Center for Vision Research Byers Eye InstituteStanford University School of Medicine department of Ophthalmology Louis J.Fox Center for Vision RestorationUniversity of Pittsburgh School of Medicine department of Neurobiology Center of NeuroscienceUniversity of Pittsburgh School of Medicine

Glaucoma,characterized by a degenerative loss of retinal ganglion cells,is the second leading cause of blindness *** is currently no cure for vision loss in glaucoma because retinal ganglion cells do not regenerate and are not replaced after *** stem cell-derived retinal ganglion cell transplant is a potential therapeutic strategy for retinal ganglion cell degenerative *** this review,we first discuss a 2d protocol for retinal ganglion cell differentiation from human stem cell culture,including a rapid protocol that can generate retinal ganglion cells in less than two weeks and focus on their transplantation ***,we discuss using 3d retinal organoids for retinal ganglion cell transplantation,comparing cell suspensions and *** review provides insight into current knowledge on human stem cell-derived retinal ganglion cell differentiation and transplantation,with an impact on the field of regenerative medicine and especially retinal ganglion cell degenerative diseases such as glaucoma and other optic neuropathies.

关键词： cell clumps cell suspension cell transplantation differentiation direct-induced protocol glaucoma optic neuropathy regenerative medicine retinal ganglion cell retinal organoids stem cells

HetNets Under decoupled Uplink and downlink Access with UE Random discontinuous Transmission: Local delay and Energy Efficiency

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China Communications 2024年第3期21卷 205-216页

作者： Zhang Yue Zheng Fuchun luo Jingjing School of Electronic and Information Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

due to the limited uplink capability in heterogeneousnetworks (HetNets), the decoupled uplinkand downlink access (dUdA) mode has recently beenproposed to improve the uplink performance. In thispaper, the random discontinuous transmission (dTX)at user equipment (UE) is adopted to reduce the interferencecorrelation across different time slots. By utilizingstochastic geometry, we analytically derive themean local delay and energy efficiency (EE) of an uplinkHetNet with UE random dTX scheme under thedUdA mode. These expressions are further approximatedas closed forms under reasonable *** results reveal that under the dUdA mode, there isan optimal EE with respect to mute probability underthe finite local delay constraint. In addition, with thesame finite mean local delay as under the coupled uplinkand downlink access (CUdA) mode, the HetNetsunder the dUdA mode can achieve a higher EE witha lower mute probability.

关键词： decoupled uplink and downlink access(dUdA) heterogeneous networks(HetNets) random discontinuous transmission(dTX) stochastic geometry

GIS-based prediction method of shallow landslides induced by heavy rainfall in large mountainous areas

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Journal of Mountain Science 2024年第5期21卷 1534-1548页

作者： luo Xiaoxiong LI Congjiang ZHOU Jiawen State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China College of Water Resource and Hydropower Sichuan UniversityChengdu 610065China

Rainwater runoff that does not infiltrate the soil during heavy rainfall may increase slope instability. The effect of runoff is usually neglected in conventional rainfall-induced slope failure analysis to simplify the model. To analyze the effect of runoff on slope stability, this study simultaneously simulated the effects of surface runoff and rainfall infiltration on bank slopes in the Three Gorges Reservoir Area. A shallow slope failure method that can be used to analyze runoff was proposed based on the modified Green-Ampt model, the simplified Saint-Venant model, and the infinite slope model. In this model, the modified Green–Ampt model was used to estimate the rainfall infiltration capacity and the wetting front depth. The eight-flow(d8) method and the simplified Saint-Venant model were selected to estimate the distribution of runoff. By considering the wetting front depth as the slip surface depth, the factor of safety of the slope could be determined using the infinite slope stability model. A comparison of the different models reveals that runoff can escalate the instability of certain slopes, causing stable slopes to become unstable. Comparison of the unstable areas obtained from the simulation with the actual landslide sites shows that the model proposed in this study can successfully predict landslides at these sites. The slope instability assessment model proposed in this study offers an alternative approach for estimating high-risk areas in large mountainous regions.

关键词： Rainfall-induced landslide Surface runoff Infiltration Geographic Information System Landslide susceptibility

Homoclinic Solutions for a Class of Perturbed Fractional Hamiltonian Systems with Subquadratic Conditions

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1177-1196页

作者： Ying luo Fei GUO Yan LIU School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin300354P.R.China

In this paper,we consider the following perturbed fractional Hamiltonian systems{td_(∞)^(α)(_(-∞)d_(t)^(α)u(t))+L(t)u(t)=■_(u)W(t,u(t))+■(u)G(t,u(t)),t∈R,u∈H^(α)(R,R^(N)),whereα∈(1/2,1],L∈C(R,R^(N×N))is symmetric and not necessarily required to be positive definite,W∈C1(R×R^(N,R))is locally subquadratic and locally even near the origin,and perturbed term G∈C1(R×R^(N,R))maybe has no parity in *** the perturbed method improved by the authors,a sequence of nontrivial homo clinic solutions is obtained,which generalizes previous results.

关键词： Perturbed fractional Hamiltonian systems subquadratic condition perturbed method homoclinic solutions multiplicity