检索结果-南通市图书馆

A proton-catalyzing prodrug for PdT and glycolysis inhibition-synergistic therapy of tumor in spatiotemporal dimensions

引用

Science China Chemistry 2024年第9期67卷 3162-3178页

作者： Miao Li Xueying Sun Xiuqin Ma yang Tan Xiaoyi Jin yi Wang Fan yang Qian Li Honglei zhan.Xiaojun Peng School of Biological Engineering Dalian Polytechnic UniversityDalian 116034China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

The reactive oxygen species(ROS)generation from photosensitizer in photodynamic therapy(PdT)is limited by tumor *** type-I photosensitizers,e.g.,sulfur-substituted nile blue,still rely on oxygen as the main center for transferring electrons to generate *** off the pathway of oxygen consumption in tumor can help photosensitizers overcome the limitation of low oxygen,in order to efficiently generate more *** is known that glycolysis inhibitor 3-bromopyruvic acid(3-BP),which could specially target mitochondria,can provide more oxygen by inhibiting oxidative ***,we successfully designed and synthesized a new 3-BP-coupled sulfur-substituted nile blue as prodrug(nBBP)for chemical/photodynamic synergistic *** results indicated that the protons in tumor catalyzed the hydrolysis of nBBP,inhibited photoinduced electron transfer between 3-BP and the photosensitizer in nBBP and further assisted the photosensitizer to be localized in mitochondria,utilizing local oxygen as much as possible and kill tumor cells more ***,the glycolysis inhibition-induced autophagy was combined with PdT-induced autophagy,which could promote the deaths of tumor *** other remedies exploiting nanomaterials,this construction method of nBBP achieves the efficient synergy of photodynamic therapy and glycolysis inhibition,stronger than their theoretical addition,in spatiotemporal *** study provides not only a highly efficient platform for tumor therapy but also a design approach for prodrugs with synergistic effects.

关键词： photodynamic therapy prodrug glycolysis inhibition autophagy tumor synergistic therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1257-1282页

作者： Zhao Wang Heng zhan. Zhen Gao Zihao Sang Erik de Clercq Christophe Pannecouque dongwei Kang Peng zhan.Xinyong Liu department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Rega Institute for Medical Research Laboratory of Virology and ChemotherapyK.U.LeuvenLeuven B-3000Belgium China-Belgium Collaborative Research Center for Innovative Antiviral drugs of Shandong Province Jinan 250012China Suzhou Research Institute Shandong UniversitySuzhou 215123China

With our continuous endeavors in seeking potent anti-HIV-1 agents,we reported here the discovery,biological characterization,and druggability evaluation of a class of nonnucleoside reverse transcriptase *** fully explore the chemical space of the nnRTI-binding pocket,novel series of dihydrothiopyrano[3,2-d]pyrimidines were developed by employing the structure-based design *** of the derivatives were endowed with prominent antiviral activities against HIV-1 wild-type and resistant strains at nanomolar *** them,compound 23h featuring the aminopiperidine moiety was identified as the most potent inhibitor,with EC50values ranging from 3.43 to 21.4 nmol/***,for the challenging double-mutants F227L+V106A and K103n+y181C,23h exhibited 2.3-to 14.5-fold more potent activity than the first-line drugs efavirenz and ***,the resistance profiles of 23h achieved remarkable improvement compared to efavirenz and *** binding target of 23h was further confirmed to be HIV-1 reverse *** modeling studies were also performed to elucidate the biological evaluation results and give guidance for the optimization ***,no apparent inhibition of the major CyP450 enzymes and hERG channel was observed for *** importantly,23h was characterized by good pharmacokinetic properties and excellent safety in ***,23h holds great promise as a potential candidate for its effective antiviral efficacy and favorable drug-like profiles.

关键词： HIV-1 Reverse transcriptase dihydrothiopyrano[3,2-d]pyrimidine Antiviral agent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hierarchically Macroporous Zeolite ZSM-5 Microspheres for Efficient Catalysis

引用

Chemical Research in Chinese Universities 2024年第4期40卷 704-711页

作者： ZHEnG Mingdan CHEn ya LIU zhan.LyU Jiamin yE Bo SUn Ming-Hui CHEn Li-Hua SU Bao-Lian State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070P.R.China Laboratory of Inorganic Materials Chemistry(CMI) University of Namur5000NamurWalloniaBelgium

Hollow zeolite microspheres have recently attracted much attention for their applications in catalysis,microreactors and ***,we present hierarchically structured zeolite ZSM-5 microspheres with unique,abundant macropores that allow more efficient use for *** hierarchically macroporous zeolite ZSM-5 microspheres are synthesized under the assistance of water/oil emulsions and using polystyrene nanospheres as *** zeolite microsphere is assembled by uniform hollow zeolite *** large inner cavities and thin zeolite shells lead to smaller diffusion channel and higher improved accessibility to active sites,contributing to high catalytic performance in the catalytic conversion of benzyl alcohol in *** novel zeolite microspheres with impressive performance will be applied to numerous other industrial catalytic reactions.

关键词： Hierarchically porous structure Hollow structure Microsphere Zeolite ZSM-5 Alkylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polymer-supported chiral palladium-based complexes as efficient heterogeneous catalysts for asymmetric reductive Heck reaction

Green Synthesis and Catalysis

引用

Green Synthesis and Catalysis 2024年第2期5卷 102-107页

作者： Hui zhan. Bing Xu Liejin Zhou zhan.Ming zhan. Junliang zhan. College of Marine Ecology and Environment Shanghai Ocean University999 Hucheng Ring RoadShanghai 201306China department of Chemistry Fudan University2005 Songhu RoadShanghai 200438China Graduate School of Pharmaceutical Sciences Tohoku UniversitySendai 980-8578Japan Fudan zhan.jiang Institute Shanghai 201203China

Heterogeneous asymmetric catalysis is an important strategy for the industrial production of chiral ***,we reported a polymer-bound Xu-Phos-derived palladium catalyst that shows good performance in heterogeneous asymmetric reductive Heck reaction of allyl aryl *** heterogeneous catalyst was easily prepared by efficient immobilization of the sulfonamide phosphine ligand(Xu-Phos)in the cross-linked polystyrene via copolymerization,and exhibits similar catalytic activity and enantioselectivity to that of the homogeneous ***,the heterogeneous catalyst system is proved to be easily recovered and reused several times without losing catalytic activity obviously.

关键词： Heterogeneous catalysis Recoverability Palladium Hydroarylation Asymmetric catalysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory

引用

neuroscience Bulletin 2024年第2期40卷 147-156页

作者： Minghong Su Kejia Hu Wei Liu yunhao Wu Tao Wang Chunyan Cao Bomin Sun Shikun zhan.Zheng ye Institute of Psychology Chinese Academy of SciencesBeijing 100101China department of Psychology University of Chinese Academy of SciencesBeijing 100049China department of neurosurgery Center for Functional NeurosurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of neuroscience Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China

The prefrontal cortex and hippocampus may support sequential working memory beyond episodic memory and spatial *** stereoelectroencephalography(SEEG)study investigated how the dorsolateral prefrontal cortex(dLPFC)interacts with the hippocampus in the online processing of sequential *** patients with epilepsy(eight women,age 27.6±8.2 years)completed a line ordering task with SEEG recordings over the dLPFC and the *** showed longer thinking times and more recall errors when asked to arrange random lines clockwise(random trials)than to maintain ordered lines(ordered trials)before recalling the orientation of a particular ***,the ordering-related increase in thinking time and recall error was associated with a transient theta power increase in the hippocampus and a sustained theta power increase in the dLPFC(3–10 Hz).In particular,the hippocampal theta power increase correlated with the memory precision of line ***,theta phase coherences between the dLPFC and hippocampus were enhanced for ordering,especially for more precisely memorized ***,the theta band dLPFC→hippocampus influence was selectively enhanced for ordering,especially for more precisely memorized *** study suggests that theta oscillations may support dLPFC-hippocampal interactions in the online processing of sequential information.

关键词： Sequential working memory Hippocampus dorsolateral prefrontal cortex Theta oscillations Stereoelectroencephalography(SEEG) Phase coherence Granger causality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive evaluation of an ionic liquid based deep purification process for nH_(3)-containing industrial gas

引用

Journal of Environmental Sciences 2024年第2期136卷 698-708页

作者： Guoxiong zhan.Fei Cao Jianjun Chen Zhen Chen yuanmeng duan Fei Chang Shaojuan Zeng yinge Bai Zengxi Li Xiangping zhan. Junhua Li State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Sino-danish College University of Chinese Academy of SciencesBeijing 100049China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China College of Chemical and Engineering University of Chinese Academy of SciencesBeijing 100049China

Ammonia(nH_(3))emission has caused serious environment issues and aroused worldwide *** emerging ionic liquid(IL)provides a greener way to efficiently capture nH_(3).This paper provides rigorous process simulation,optimization and assessment for a novel nH_(3)deep purification process using *** process was designed and investigated by simulation and optimization using ionic liquid[C_(4)im][nTF_(2)]as *** objective functions,total purification cost(TPC),total process CO_(2)emission(TPCOE)and thermal efficiency(ηeff)were employed to optimize the absorption *** simulation and optimization results indicate that at same purification standard and recovery rate,the novel process can achieve lower cost and CO_(2)emission compared to benchmark *** process optimization,the optimal functions can achieve 0.02726$/nm~3(TPC),311.27 kg CO_(2)/hr(TP-COE),and 52.21%(ηeff)for enhanced ***,compared with conventional process,novel process could decrease over$3 million of purification cost and 10000 tons of CO_(2)emission during the life *** results provide a novel strategy and guidance for deep purification of nH_(3)capture.

关键词： nH_(3) Capture Process Ionic Liquid Process Simulation Process Optimization deep purification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Pairing Analysis Improvement of Magnetized Structure in Electromagnetic Bulging Process in Case of Tube with Field Shaper

引用

Journal of Electromagnetic Analysis and Applications 2024年第4期16卷 43-67页

作者： Blaise Kevine Lenz Soronga zhan.ian zhan.Jing Liu Jonas Asamoah Mohamed Bangali Bangura Matala Makiese n’kodia Kambani Chrionie Md Jobayer Hossain yongdong Chen Program debugging and design department Guangdong Lyric Robot Automation Co. Ltd Huizhou China Electrical and Automation department China Three Gorges University Yichang China Electronic department Power Electronic Research Center University of Kent Giles Ln Canterbury UK Program debugging department Guangdong Lyric Robot Automation Co. Ltd. Huizhou China Electrical and Computer Engineering department South China University of Technology Guangzhou China World Standardization Certification and Testing Group (Shenzhen) Co. Ltd. Shenzhen China Electrical Engineering-Power System Mapon University Kindu Democratic Republic of Congo department of Economy Managment School of Management Computer and Telecomunication Rabbat Marocco Materials Visual Calibration department Guangdong Lyric Robot Automation Co. Ltd. Huizhou China Program design department Guangdong Lyric Robot Automation Co. Ltd. Huizhou China

In the current practical science, the accuracy in the formability of metal alloys being the goal when using electromagnetic forming (EMF) technology, which is a high-speed processing technology that uses Lorentz forces to achieve plastic deformation of sheet metal;according to the previous analysis, the results have shown that in most cases, the Lorentz force acting on the workpiece (metal) is not uniform, there are uneven axial deformations of the metal plates which prevent the rapid advancement of today’s technology. In this article, we presented some advanced analyzes which will lead us to improve the technical solution for the problems of non-uniform axial deformations of the metals in the traditional tube electromagnetic forming technology (EMF). A field shaper is used as a practical forming tool to influence the magnetic field and magnetic pressure distribution, thereby improving the forming ability and result during the electromagnetic forming (EMF) process and we see that induced eddy current control is realized by changing the structural parameters of the magnetic field shaper;which improves the strength and controllability of the magnetic force that acts on the workpiece;thereby a greater radial magnetic pressure can be achieved with field shaper than the case without it;the field shaper regulates the electromagnetic force, the distribution of the magnetic pressure decreases, and the uniform force area of the tube increases which effectively enhances the uniform range of the pipe electromagnetic bulging and the electromagnetic induction coupling between the coil and the metallic workpiece is generally required to produce the Lorentz forces. Using COMSOL Multiphysics® simulation software helped us to accurately represent the real world, simulating multiple physical effects that happened in this model during the process.

关键词： Electromagnetic Forming Field Shaper Lorentz Force Magnetic Pressure distribution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rice planting acceleration of the activation and loss of soil iron in the red soil region of southern China

引用

Soil Ecology Letters 2024年第2期6卷 179-187页

作者： San’an nie Jie Fan ningxiang Ouyang Hao Sheng yangzhu zhan. Xiong yan zhan.yu College of Resources Hunan Agricultural UniversityChangsha410125China School of Economic Geography Hunan University of Finance and EconomicsChangsha410205China Zunyi normal University Zunyi563006China

Rice planting decreased total iron but increased active *** activation varied greatly among different paddy soils but not in woodland *** soil iron was mainly affected by pH,SOC and particle *** decrease of soil Fe wa... 详细信息

关键词： paddy soil iron forms parent material rice planting Fe activation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

dissolved organic matter accelerates microbial degradation of 17 alpha-ethinylestradiol in the presence of iron mineral

引用

Journal of Environmental Sciences 2024年第5期139卷 364-376页

作者： Huan He Min Shi Xiaoxia yang Juhong zhan.yanting Lin Ziwei Guo Zhicheng Liao Chaochao Lai Xiaomin Ren Bin Huang Xuejun Pan Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China yunnan Provincial Key Lab of Soil Carbon Sequestration and Pollution Control Kunming 650500China Research Institute for Environmental Innovation(Suzhou)Tsinghua Suzhou 215163China

dissolved organic matter(dOM)and iron minerals widely existing in the natural aquatic environment can mediate the migration and transformation of organic ***,the mechanism of interaction between dOM and iron minerals in the microbial degradation of pollutants deserves further *** this study,the mechanism of 17 alphaethinylestradiol(EE2)biodegradation mediated by humic acid(HA)and three kinds of iron minerals(goethite,magnetite,and pyrite)was *** results found that HA and iron minerals significantly accelerated the biodegradation process of EE2,and the highest degradation efficiency of EE2(48%)was observed in the HA-mediated microbial system with pyrite under aerobic ***,it had been demonstrated that hydroxyl radicals(HO·)was the main active substance responsible for the microbial degradation of ***·is primarily generated through the reaction between hydrogen peroxide secreted by microorganisms and Fe(II),with aerobic conditions being more *** presence of iron minerals and HA could change the microbial communities in the EE2 biodegradation *** findings provide new information for exploring the migration and transformation of pollutants by microorganisms in iron-rich environments.

关键词： dissolved organic matter Iron mineral 17 alpha-ethinylestradiol Biodegradation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

damage characteristics of fused silica under low-temporal coherence light

引用

High Power Laser Science and Engineering 2024年第3期12卷 77-83页

作者： Chong Shan Lingbao Kong Fujian Li yong Cui Lailin Ji Quan Zheng daxing Rao Ruijing He Xiaohui Zhao yuanan Zhao zhan.Sui Shanghai Engineering Research Center of Ultra-precision Optical Manufacturing School of Information Science and TechnologyFudan UniversityShanghaiChina Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghaiChina Key Laboratory of High Power Laser Materials Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina

The damage characteristics of fused silica were investigated under low-temporal coherence light(LTCL).It was found that the laser-induced damage threshold(LIdT)of fused silica for the LTCL was lower than that of the single longitudinal mode pulse laser,and for the LTCLs,the LIdTs decrease with the increasing of laser bandwidth,which is not consistent with the temporal spike *** is due to the nonlinear self-focusing effect and multi-pulse accumulation *** specific reasons were analyzed based on theoretical simulation and experimental *** research work is helpful and of great significance for the construction of high-power LTCL devices.

关键词： laser-induced damage threshold low-temporal coherence light nonlinear self-focusing effect temporal spike

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：