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International Journal of Sediment Research 2021年第6期36卷 736-746页

作者： Sylvain Orseau Nicolas Huybrechts Pablo Tassi d.mien pham van bang Fabrice Klein Cerema Direction Technique Eau Mer et Fleuves Sorbonne Universités Université de Technologie de Compiégne CNRSFRE2012 RobervalCentre de Recherche Royallieu Electricité de France R&D Department Laboratoire d'Hydraulique Saint Venant (ENPC-EdF/R&d-CEREMA) 5. Centre Eau Terre et Environnement INRS-ETE 6. Grand Port Maritime de Bordeaux

In order to optimize ship navigation in the macrotidal Gironde Estuary, a recent project funded by the port of Bordeaux aims at better understand and forecast hydrodynamic and fine sediment transport within the estuary. In the framework of this project, a two-dimensional hydro-sedimentary model is built. The model includes hydrodynamic forcings, mixed-sediment transport, and consolidation processes. The harmonic analysis of the astronomical tides reveals a strong distortion of the tidal wave inducing the growth of overtide constituents and the non-significant effect of tide-surge interactions in annual-scale prediction. depending on hydrological conditions, river discharge can considerably alter the model accuracy due to the migration of the turbidity maximum zone modifying the bottom *** with measurements shows the ability of the model to reproduce suspended-sediment concentrations in the central Estuary. Sensitivity of the model to sediment features has also been discussed in regard of suspended-sediment concentrations and fluid mud deposits. The model will be further coupled with ship squat predictions and a morphodynamic model.

关键词： Sediment transport Numerical modeling Mixed sediment Gironde Estuary Opentelemac

Three-dimensional simulation of horseshoe vortex and local scour around a vertical cylinder using an unstructured finite-volume technique

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International Journal of Sediment Research 2020年第3期35卷 295-306页

作者： Wei Zhang Miguel Uh Zapata Xin Bai d.mien pham-van-bang Kim dan Nguyen Laboratory for Hydraulics Saint-Venant (LHSV ENPC-EDF R&D-Cerema)University Paris-Est CONACYT Centro de Investigacion en Matematicas A.C.(CIMAT)Unidad Merida 3. Laboratory for Hydraulics and Environment (LHE)Institut National de La Recherche ScientifiqueUniversite Du Quebec

A Large Eddy Simulation model is developed to simulate the hydrodynamics and scour process around a circular *** Navier-Stokes solver is based on the projection method and a second-order unstructured finite-volume method.A sigma-coordinate system is used to obtain an accurate representation of the evolution of the sediment-water *** erosion is simulated by solving the sediment continuity equation using a mass-conservating sand-slide algorithm and a bedload transport rate,which is based on a description of physical processes(Engelund & Freds(?)e,1976).Simulations of flow around a vertical cylinder for free-slip bed,rigid bed,and live-bed cases are *** mean velocity profile and shear stress validate the accuracy of this *** vortex and lee-wake vortex shedding structure are simulated,and the results are thoroughly discussed in *** formation and the temporal development of the scour hole and other topographic bed features are successfully *** current paper reports the first known investigation of both scour evolution and coherent structure using large-eddy simulation.

关键词： Non-hydrostatic flows Horseshoe vortex Wake region Scouring Bedload transport

Effect of self-weight consolidation on a hydro-sedimentological model for the Río de la Plata estuary

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International Journal of Sediment Research 2019年第5期34卷 444-454页

作者： Pablo Santoro Mónica Fossati Pablo Tassi Nicolas Huybrechts d.mien pham van bang Ismael Piedra-Cueva Instituto de Mecánica de los Fluidos e Ingeniería Ambiental Facultad de Ingeniería Universidad de la República Université Paris-Est Laboratory for Hydraulics Saint-Venant (ENPC-EDF/R& D-CEREMA) Electricity of France R&D Department Sorbonne Universités Université de Technologie de Compiègne FRE UTC-CNRS 3023 Roberval Centre de Recherche Royallieu Cerema Direction Technique Eau Mer et Fleuves Institut National de la Recherche Scientifique Centre-Eau Terre Environnement

The effect of the consolidation process on the morphodynamics and fine sediment dynamics of the Río de la Plata estuary is explored through a circulation-wave-sediment transport model. The consolidation model is calibrated based on settling column experimental data. different simulations are done in order to initialize the mud layer distribution and to investigate the impact of different erosion parameter assumptions on the modeled sediment dynamics. Finally a two-year simulation is done with and without the consolidation process and realistic hydrodynamic forcings. Considering the consolidation process, the model correctly reproduces measured vertical density profiles in the Montevideo Bay access channel. The simulated suspended sediment dynamics behavior in Montevideo Bay with the consolidation process provides a more realistic deposition pattern in regard to the dredging activities.

关键词： Cohesive sediment Self-weight consolidation Morphodynamics Numerical modeling

Assignment of the non-exchangeable proton resonances and conformational analysis of oligonucleotide dNA d(TTGGGGTT)by twodimensional nuclear magnetic resonance methods

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Chinese Journal of Chemistry 1990年第3期8卷 246-250页

作者： dONG,Yan-Hong TANG,Wen-Xia dAI,An-bang Coordination Chemistry Institute,Nanjing University,Nanjing 210008WU,Jia-Zhen Beijing Biophysics Institute,Academia Sinica,Beijing 100080van BOOM,J.H. REEdIJK,J. STRUIK,A.F. department of Chemistry,Gorlaeus Laboratories,Leiden University,Leiden,The Netherlands Coordination Chemistry Institute Nanjing University Nanjing 210008 Beijing Biophysics Institute Academia Sinica Beijing 100080 department of Chemistry Gorlaeus Laboratories Leiden University Leiden The Netherlands

Two-dimensional NMR study on the single-stranded octadeoxynucleotide,d(TT- GGGGTT)is *** of the base protons,the H1′,H2′ and H2″ protons were made by two-dimensional Nuclear Overhauser Enhancement Spectroscopy(NOESY)and two-dimensional homonuclear J-correlated Spectroscopy(COSY).The result indicates that the overall structure of the single-stranded d(TTGGGGTT)is a right-handed B-type helix.

关键词： Assignment of the non-exchangeable proton resonances and conformational analysis of oligonucleotide dNA d dNA

2009―2018年强直性脊柱炎研究现状的文献计量学分析

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第二军医大学学报 2020年第4期41卷 455-460页

作者：朱善邦冯新哲徐卫东海军军医大学(第二军医大学)长海医院关节骨病外科上海200433

目的了解强直性脊柱炎(AS)的研究状况和发展趋势,为后续研究提供参考依据。方法在Web of Science数据库中检索AS相关文献,使用科学引文索引扩展版提取分析数据,收入论著和综述2种文献类型。搜索使用的术语为:标题=ankylosing spondyliti... 详细信息

目的了解强直性脊柱炎(AS)的研究状况和发展趋势,为后续研究提供参考依据。方法在Web of Science数据库中检索AS相关文献,使用科学引文索引扩展版提取分析数据,收入论著和综述2种文献类型。搜索使用的术语为:标题=ankylosing spondylitis和发表年份=(2009―2018)和语言=English。对文献概况、国家和地区、机构、作者、文献来源出版物、文献研究方向、被引频次、影响因子、H指数和关键词等进行分析。结果共收入Web of Science数据库中2009―2018年发表的AS相关文献2759篇,发文量最多的国家是中国(612篇,22.18%),发文量最多的机构是荷兰莱顿大学(102篇,3.70%),发文量居首位的作者是荷兰莱顿大学的van der Heijde d(103篇,3.73%)。AS研究方向主要为风湿病学(1473篇,53.39%)、内科学(235篇,8.52%)、骨科学(195篇,7.07%),文献主要来源于Rheumatol Int。发文量居前10位的期刊2018年平均影响因子为4.420,发文量占文献总量的38.64%(1066/2759)。2759篇文献共被引用44772次(已排除自引30592次),平均每篇文章被引次数为16.23次。美国、德国和荷兰的H指数和被引次数均明显高于其他国家,H指数均为51,被引频次分别为11468、10132和9494次,分别占被引总次数的25.61%、22.63%和21.21%;中国虽然发文量最多,但是被引频次和H指数仅排在第6位(被引6478次,H指数为31)。运用VOSviewer软件分析发现,关键词主要集中于“发病机制相关”“遗传相关”“康复相关”“诊治相关”和“疾病相关”5个族群。结论2009―2018年AS有关文献发文量以中国、土耳其和美国最多。虽然中国的发文数量目前领先,但是文献质量与西方国家还存在差距。

关键词：强直性脊柱炎文献计量学引文 H指数 VOSviewer软件

结缔组织生长因子在大鼠移植肺急性排斥反应期的表达及意义

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中华胸心血管外科杂志 2007年第2期23卷 117-118页

作者：袁运长王电军尹邦良中南大学湘雅二医院胸心外科长沙410011

目的检测结缔组织生长因子（CTGF）在大鼠移植肺内的表达,并探讨其与移植肺纤维化关系。方法Wister大鼠15只为供体,Sd大鼠15只为受体,进行原位左肺移植,1周后取其中10例移植肺标本作为实验组;10例健康Wister大鼠肺标本作为对照组,采用... 详细信息

目的检测结缔组织生长因子（CTGF）在大鼠移植肺内的表达,并探讨其与移植肺纤维化关系。方法Wister大鼠15只为供体,Sd大鼠15只为受体,进行原位左肺移植,1周后取其中10例移植肺标本作为实验组;10例健康Wister大鼠肺标本作为对照组,采用免疫组化方法检测CTGF在肺组织中的表达,同时采用HE及van Gieson染色观察肺组织病理形态;并进行纤维化的半定量评分。结果移植肺组织内有大量炎性细胞浸润;肺间质纤维组织增生,部分肺泡组织破坏;CTGF在移植肺组织中有明显表达,而正常肺无表达。结论在肺移植术后的急性排斥反应期CTGF有明显表达,且可能参与移植肺纤维化的病理过程。

关键词：肺移植移植物排斥生长物质结缔组织转化生长因子β

结缔组织生长因子在大鼠移植心脏急性排斥反应期的表达(英文)

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中南大学学报（医学版） 2008年第5期33卷 425-431页

作者：袁运长夏振坤章庆春尹邦良中南大学湘雅二医院胸心外科长沙410011 广东省心血管病研究所广州510080

目的:检测结缔组织生长因子(connective tissue growth factor,CTGF)在大鼠移植心脏急性排斥期(acute rejection,AR)的表达,并探讨其与移植心脏心肌纤维化的关系。方法:取Wister大鼠16只作为供体,取Sd大鼠16只作为受体,进行腹部异位心... 详细信息

目的:检测结缔组织生长因子(connective tissue growth factor,CTGF)在大鼠移植心脏急性排斥期(acute rejection,AR)的表达,并探讨其与移植心脏心肌纤维化的关系。方法:取Wister大鼠16只作为供体,取Sd大鼠16只作为受体,进行腹部异位心脏移植,采用10 mg/(kg.d)环孢霉素A,40 mg/(kg.d)骁悉和3 mg/(kg.d)甲泼尼龙三联免疫抑制疗法,2周后取其中10例移植心脏标本作为实验组,10例健康Wister大鼠心脏标本作为对照组(normal heart,NH)。采用HE及van Gieson染色观察心肌病理形态、心脏血管狭窄程度;并进行纤维化的半定量评分。采用免疫组化半定量方法检测CTGF在心脏组织中的表达,并分析其与心肌纤维化的相关性。结果:移植心脏血管壁及心肌间质组织内有大量粒细胞浸润,呈典型的急性排斥反应期改变;移植心脏血管内膜及大量纤维组织增生,与正常对照组相比,差异有统计学意义(P<0.05);CTGF在移植心脏组织中有明显表达,且主要表达于血管壁及心肌损伤部位,而正常心脏无表达,CTGF灰度值为(AR vs NH:103.52±6.42 vs.182.61±8.72,P<0.05)。CTGF灰度值与移植心脏纤维化显著负相关(r=-0.734,P<0.01)。结论:CTGF在急性移植心脏组织中有明显表达且可能与移植心脏心肌纤维化相关。

关键词：急性排斥反应结缔组织生长因子纤维化心脏移植