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An adaptive physics-informed deep learning method for pore pressure prediction using seismic data

Petroleum Science 2024年第2期21卷 885-902页

作者： Xin Zhang Yun-Hu Lu Yan Jin mian Chen Bo Zhou State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China PetroChina Tarim Oilfield Company KorlaXinjiang841000China

Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum *** deep learning technique has been receiving more interest due to the great potential to deal with pore pressure ***,most of the traditional deep learning models are less efficient to address generalization *** fill this technical gap,in this work,we developed a new adaptive physics-informed deep learning model with high generalization capability to predict pore pressure values directly from seismic ***,the new model,named CGP-NN,consists of a novel parametric features extraction approach(1dCPP),a stacked multilayer gated recurrent model(multilayer GRU),and an adaptive physics-informed loss *** machine training,the developed model can automatically select the optimal physical model to constrain the results for each pore pressure *** CGP-NN model has the best generalization when the physicsrelated metricλ=0.5.A hybrid approach combining Eaton and Bowers methods is also proposed to build machine-learnable labels for solving the problem of few *** validate the developed model and methodology,a case study on a complex reservoir in Tarim Basin was further performed to demonstrate the high accuracy on the pore pressure prediction of new wells along with the strong generalization *** adaptive physics-informed deep learning approach presented here has potential application in the prediction of pore pressures coupled with multiple genesis mechanisms using seismic data.

关键词： Pore pressure prediction Seismic data 1d convolution pyramid pooling Adaptive physics-informed loss function High generalization capability

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Full-Scale Isogeometric Topology Optimization of Cellular Structures Based on Kirchhoff-Love Shells

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2479-2505页

作者： Mingzhe Huang Mi Xiao Liang Gao mian Zhou Wei Sha Jinhao Zhang State Key Lab of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China

Cellular thin-shell structures are widely applied in ultralightweight designs due to their high bearing capacity and strength-to-weight *** this paper,a full-scale isogeometric topology optimization(ITO)method based on Kirchhoff-Love shells for designing cellular tshin-shell structures with excellent damage tolerance ability is *** method utilizes high-order continuous nonuniform rational B-splines(NURBS)as basis functions for Kirchhoff-Love shell *** geometric and analysis models of thin shells are unified by isogeometric analysis(IGA)to avoid geometric approximation error and improve computational *** topological configurations of thin-shell structures are described by constructing the effective density field on the *** volume constraints are imposed in the proximity of each control point to obtain bone-like cellular *** facilitate numerical implementation,the p-norm function is used to aggregate local volume constraints into an equivalent global *** numerical examples are provided to demonstrate the effectiveness of the proposed *** simulation and comparative analysis,the results indicate that the cellular thin-shell structures optimized by the proposed method exhibit great load-carrying behavior and high damage robustness.

关键词： Cellular thin-shell structures isogeometric analysis full-scale topology optimization Kirchhoff–Love shells

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The current status and reflections on 3d in vitro modeling of liver metastasis in colorectal cancer

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 180-183页

作者： Bo Zhou Minghao Sun mian Yang Wei Cui Huayu Yang department of General Surgery Ningbo Medical Center Lihuili Hospital(The Affiliated Lihuili Hospital of Ningbo University)NingboChina department of Liver Surgery Peking Union Medical College Hospital(PUMCH)Peking Union Medical College(PUMC)&Chinese Academy of Medical Sciences(CAMS)BeijingChina

Colorectal cancer(CRC)ranks as the third most prevalent cancer worldwide and is identified as the second leading cause of cancer-related fatalities(1).The liver is the most common site for distant metastasis in CRC,with approximately 20%to 25%of newly diagnosed patients experiencing liver *** the disease progresses,this proportion can increase to as high as 50%(2),making it a primary cause of death in CRC patients.

关键词： Colorectal cancer(CRC) preclinical model 3d bioprinting chemotherapy predict

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Urban growth scenario projection using heuristic cellular automata in arid areas considering the drought impact

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Journal of Arid Land 2024年第4期16卷 580-601页

作者： TANG Xiaoyan FENG Yongjiu LEI Zhenkun CHEN Shurui WANG Jiafeng WANG Rong TANG Panli WANG mian JIN Yanmin TONG Xiaohua College of Surveying&Geo-Informatics Tongji UniversityShanghai 200092China Shanghai Key Laboratory of Space Mapping and Remote Sensing for Planetary Exploration Tongji UniversityShanghai 200092China

Arid areas with low precipitation and sparse vegetation typically yield compact urban pattern,and drought directly impacts urban site selection,growth processes,and future *** simulation and projection based on cellular automata(CA)models is important to achieve sustainable urban development in arid *** developed a new CA model using bat algorithm(BA)named bat algorithm-probability-of-occurrence-cellular automata(BA-POO-CA)model by considering drought constraint to accurately delineate urban growth patterns and project future scenarios of Urumqi City and its surrounding areas,located in Xinjiang Uygur Autonomous Region,*** calibrated the BA-POO-CA model for the drought-prone study area with 2000 and 2010 data and validated the model with 2010 and 2020 data,and finally projected its urban scenarios in *** results showed that BA-POO-CA model yielded overall accuracy of 97.70%and figure-of-merits(FOMs)of 35.50%in 2010,and 97.70%and 26.70%in 2020,*** inclusion of drought intensity factor improved the performance of BA-POO-CA model in terms of FOMs,with increases of 5.50%in 2010 and 7.90%in 2020 than the model excluding drought intensity *** suggested that the urban growth of Urumqi City was affected by drought,and therefore taking drought intensity factor into account would contribute to simulation *** BA-POO-CA model including drought intensity factor was used to project two possible scenarios(i.e.,business-as-usual(BAU)scenario and ecological scenario)in *** the BAU scenario,the urban growth dominated mainly in urban fringe areas,especially in the northern part of Toutunhe district,Xinshi district,and Midong *** exceptional and extreme drought areas as a spatial constraint,the urban growth was mainly concentrated in the"main urban areas-Changji-Hutubi"corridor urban pattern in the ecological *** results of this research can help to adjust urban planning and development *** mode

关键词： bat algorithm cellular automata(CA) probability-of-occurrence drought intensity algorithm-probability-of-occurrence-cellular automata(BA-POO-CA)model arid areas

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CURLY LEAF Regulates MicroRNA Activity by Controlling ARGONAUTE 1 degradation in Plants

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Molecular Plant 2020年第1期13卷 72-87页

作者： delfina A.Re d.mian a.cambiagno Agustin LArce Ariel HTomassi Marisol Giustozzi Paula Casati Federico dAriel Pablo A.Manavella lnstituto de Agrobiotecnologia del Litoral(CONICET-UNL) Catedra de Biologia Celulary MolecularFacultad de Bioquimica y Ciencias BiologicasUniversidad Nacional del Litoral3000 Santa FeArgentina Centro de Estudios Fotosinteticos y Bioquimicos(CEFOBI) Universidad Nacional de RosarioRosarioArgentina

CURLY LEAF ( CLF) encodes the methyltransferase subunit of the Polycomb Repressor Complex 2 (PRC2), which regulates the expression of target genes through H3K27 trimethylation. We isolated a new CLF mutant allele ( clf-78) using a genetic screen designed to identify microRNA (miRNA) deficient mutants. CLF mutant plants showed impaired miRNA activity caused by increased ubiquitination and enhanced degradation of ARGONAUTE 1 (AGO1) in specific tissues. Such CLF-mediated AGO1 regulation was evident when plants were exposed to UV radiation, which caused increased susceptibility of clf mutants to some UV-induced responses. Furthermore, we showed that CLF directly regulates FBW2, which in turn triggers AGO1 degradation in the clf mutants. Interestingly, AGO1 bound to a target appeared particularly prone to degradation in the mutant plants, a process that was exacerbated when the complex bound a non-cleavable target. Thus, prolonged AGO1–target interaction seems to favor AGO1 degradation, suggesting that non-cleavable miRNA targets may overcome translation inhibition by modulating AGO1 stability in plants.

关键词： CURLY LEAF ARGONAUTE Arabidopsis UV FBW2

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基于3d受限自组装构筑中空介孔氧化硅/碳复合微球

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高分子学报 2024年第5期55卷 604-613页

作者：王勉邓仁华朱锦涛华中科技大学化学与化工学院能量转换与存储材料化学教育部重点实验室材料化学与服役失效湖北省重点实验室武汉430074

发展简单、高效、可控的方法来制备中空介孔微球是介孔材料领域的研究热点.本工作结合嵌段共聚物的三维受限自组装(3d-CSA)和自模板碳化策略,建立了一种构筑中空介孔微球的新方法.首先,采用乳液-溶剂挥发法实现嵌段共聚物与全氟辛烷(PFO... 详细信息

发展简单、高效、可控的方法来制备中空介孔微球是介孔材料领域的研究热点.本工作结合嵌段共聚物的三维受限自组装(3d-CSA)和自模板碳化策略,建立了一种构筑中空介孔微球的新方法.首先,采用乳液-溶剂挥发法实现嵌段共聚物与全氟辛烷(PFO)在3d受限空间的分级组装,获得了核-壳结构微球,其中壳层由微相分离的嵌段共聚物构成.然后,在壳层的连续相选择性地复合氧化硅,既实现了无机框架的负载,又实现了对连续相聚合物链选择性交联.对复合微球进行煅烧处理后,实现了壳层连续相聚合物的选择性碳化,获得了中空介孔氧化硅/碳复合微球.本研究系统地阐述了核-壳型分级结构微球的形成机理和必备条件,研究了氧化硅前驱体添加量和嵌段共聚物分子量对中空介孔氧化硅/碳复合微球形貌的影响,为制备中空介孔微球材料提供了一种简便、可控的方法.

关键词：嵌段共聚物三维受限自组装中空微球介孔微球

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HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing

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Molecular Plant 2021年第3期14卷 426-439页

作者： d.mian a.cambiagno Axel J.Giudicatti Agustin L.Arce delfina Gagliardi Lei Li Wei Yuan derek S.Lundberg detlef Weigel Pablo A.Manavella Instituto de Agrobiotecnologı´a del Litoral(CONICET-UNL) Ca´tedra de Biologı´a Celular y MolecularFacultad de Bioquı´mica y Ciencias Biolo´gicasUniversidad Nacional del Litoral3000 Santa FeArgentina department of Molecular Biology Max Planck Institute for Developmental Biology72076 T€ubingenGermany

Post-transcriptional gene silencing mediated by microRNAs(miRNAs)modulates numerous developmental and stress response *** the last two decades,HASTY(HST),the ortholog of human EXPORTIN 5,was considered to be a candidate protein that exports plant miRNAs from the nucleus to the ***,we report that HST functions in the miRNA pathway independent of its cargo-exporting activity in *** found that Arabidopsis mutants with impaired HST shuttling exhibit normal subcellular distribution of ***,protein-protein interaction and microscopy assays showed that HST directly interacts with the microprocessor core component dCL1 through its N-terminal ***,mass spectrometry analysis revealed that HST also interacts independently of its N-terminal domain with the mediator complex subunit *** experiments revealed that HST could act as a scaffold to facilitate the recruitment of dCL1 to genomic MIRNA loci by stabilizing the dCL1-MEd37 complex,which in turn promotes the transcription and proper processing of primary miRNA transcripts(primiRNAs).Taken together,these results suggest that HST is likely associated with the formation of the miRNA biogenesis complex at MIRNA genes,promoting the transcription and processing of primiRNAs rather than the direct export of processed miRNAs from the nucleus.

关键词： microRNA gene silencing miRNA nuclear export HASTY miRNA biogenesis

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传统灶具造物智慧文化基因提取与设计路径探析

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吉林艺术学院学报 2024年第2期 4-13页

作者：郑勉勉刘洋张晴安徽工业大学安徽马鞍山243002

灶具作为中国人民最基本的生活资料,有制作食物的功能,对人类的生存和发展起着至关重要的作用。为传统灶具造物智慧的设计转化提供方法与路径,促进中国传统灶具文化的现代化传承和创新发展,基于文化基因理论,对其功能、形态、纹饰、材... 详细信息

灶具作为中国人民最基本的生活资料,有制作食物的功能,对人类的生存和发展起着至关重要的作用。为传统灶具造物智慧的设计转化提供方法与路径,促进中国传统灶具文化的现代化传承和创新发展,基于文化基因理论,对其功能、形态、纹饰、材质、色彩及文化寓意进行研究,绘制分析图谱进行可视化呈现。从中提取传统灶具造物智慧文化的功能、形态、纹饰、材质、色彩等显性基因与隐性基因,结合传统文化与现代产品设计审美需求,依据文化基因理论的排列组合、重组转换方法进行设计再造。以系列灯具、咖啡机、茶具产品的设计,验证基因提取方法的应用价值,得到基于文化基因理论的传统灶具造物智慧文化基因提取与产品创新设计方法。

关键词：传统灶具造物智慧文化基因设计路径产品创新

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纳洛酮治疗COPd呼吸衰竭肺性脑病的疗效分析

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中国现代药物应用 2024年第12期18卷 6-10页

作者：张勉滕州市中医医院 277599

目的探讨在慢性阻塞性肺疾病(COPd)呼吸衰竭肺性脑病的治疗中采用纳洛酮的应用效果。方法选取78例COPd呼吸衰竭肺性脑病患者,采用随机数字表法分为对照组[n=39,采取经鼻面罩双水平气道正压通气呼吸机(BiPAP)无创呼吸正压通气治疗]与研究... 详细信息

目的探讨在慢性阻塞性肺疾病(COPd)呼吸衰竭肺性脑病的治疗中采用纳洛酮的应用效果。方法选取78例COPd呼吸衰竭肺性脑病患者,采用随机数字表法分为对照组[n=39,采取经鼻面罩双水平气道正压通气呼吸机(BiPAP)无创呼吸正压通气治疗]与研究组(n=39,在对照组基础上联合使用纳洛酮治疗)。对比两组治疗效果,血气指标[血氧饱和度(SpO_(2))、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))],肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC],临床指标(呼吸衰竭纠正时间、感染控制窗出现时间、呼吸机使用时间、气管插管率及住院时间),炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)]。结果研究组治疗总有效率94.87%较对照组的74.36%高(Pd,均较对照组的(2.54±0.65)、(6.55±0.84)、(8.81±1.05)、(14.52±1.13)d短,气管插管率5.13%较对照组的23.08%低(Pd呼吸衰竭肺性脑病患者的治疗中采用纳洛酮能够降低机体炎性反应,改善患者的血气指标及肺功能,有效缓解患者的临床症状,减少气管插管率,可促进患者病情好转。

关键词：慢性阻塞性肺疾病呼吸衰竭肺性脑病纳洛酮血气指标治疗效果

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维生素d缺乏与高血压的相关性研究进展

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中国城乡企业卫生 2024年第8期39卷 40-43页

作者：张勉天津市红桥区西于庄街社区卫生服务中心全科天津300130

高血压是一种常见的心血管疾病,致残率、致死率均较高。维生素d是人体所必须的营养成分,能提高机体对Ca2+的吸收,从而进一步促进Ca2+沉积。维生素d缺乏会引起一系列疾病。机体中的7-脱氢胆甾醇会转化为维生素d3,转运至肝脏中,在羟化酶... 详细信息

高血压是一种常见的心血管疾病,致残率、致死率均较高。维生素d是人体所必须的营养成分,能提高机体对Ca2+的吸收,从而进一步促进Ca2+沉积。维生素d缺乏会引起一系列疾病。机体中的7-脱氢胆甾醇会转化为维生素d3,转运至肝脏中,在羟化酶作用下转化为25-羟维生素d[25(OH)d],结合蛋白到达肾脏部位,之后在1α-羟化酶作用下,生成骨化三醇(1,25-二羟维生素d),其可结合维生素d受体(一类配体依赖核转录因子),从而起到生物学效应,进而对基因转录产生影响。维生素d缺乏引起高血压疾病的可能机制包括:激活肾素-血管紧张素-醛固醇系统(RAAS)、甲状旁腺功能,影响机体的血管内皮细胞功能、增加胰岛素抵抗、上调一氧化氮合成酶、影响血管平滑肌细胞功能、血管动脉粥样硬化、钙化以及遗传基因。对于高血压人群,补充维生素d制剂能改善患者的不良心血管事件发生率,而补充维生素d对心血管死亡率研究较缺乏大样本量深入分析,因此临床上有待更多的试验数据进行深入研究。本文对维生素d缺乏与高血压的相关性研究进展进行综述,以期为高血压的治疗提供帮助。

关键词：维生素d缺乏高血压相关性钙离子不良心血管事件补充剂量

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