检索结果-南通市图书馆

Simplified Technique for Predicting Offshore Pipeline Expansion

在线全文

学校读者我要写书评

暂无评论

Journal of Marine Science and Application 2018年第1期17卷 68-78页

作者： J.H.Seo d.k.kim H.S.Choi S.Y.Yu k.S.Park Graduate School of Engineering Mastership Pohang University of Science and TechnologyPohang 37673Republic of Korea Ocean and Ship Technology Research Group Universiti Teknologi PETRONAS32610 Seri IskandarPerakMalaysia department of Civil and Environmental Engineering Universiti Teknologi PETRONAS32610 Seri IskandarPerakMalaysia Vietnam Construction Steel Solution Marketing Center POSCO Vietnam HoldingsHo Chi Minh City 700000Vietnam

In this study,we propose a method for estimating the amount of expansion that occurs in subsea pipelines,which could be applied in the design of robust structures that transport oil and gas from offshore *** begin with a literature review and general discussion of existing estimation methods and terminologies with respect to subsea *** to the effects of high pressure and high temperature,the production of fluid from offshore wells is typically caused by physical deformation of subsea structures,e.g.,expansion and contraction during the transportation *** severe cases,vertical and lateral buckling occurs,which causes a significant negative impact on structural safety,and which is related to on-bottom stability,free-span,structural collapse,and many other *** addition,these factors may affect the production rate with respect to flow assurance,wax,and hydration,to name a *** this study,we developed a simple and efficient method for generating a reliable pipe expansion design in the early stage,which can lead to savings in both cost and computation *** such,in this paper,we propose an applicable diagram,which we call the standard dimensionless ratio(SdR)versus virtual anchor length(LA)diagram,that utilizes an efficient procedure for estimating subsea pipeline expansion based on applied reliable *** this user guideline,offshore pipeline structural designers can reliably determine the amount of subsea pipeline expansion and the obtained results will also be useful for the installation,design,and maintenance of the subsea pipeline.

关键词： Pipe expansion HP/HT Thermal expansion Subsea pipeline

MR肝胆对比剂和细胞外对比剂对肝细胞癌的检出：肝胆期影像特征与无病生存期的关系

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2020年第1期 113-113页

作者： d.k.kim C.An Y.E.Chung J.Y.Choi J.S.Lim M.S.Park 徐文睿 department of Radiology Severance Hospital Research Institute of Radiological Science Yonsei University College of Medicine

对于肝细胞癌的检出,肝胆对比剂增强MRI的敏感性要高于细胞外对比剂增强MRI。目的通过分析肝癌根治性切除术后的无病生存率,比较行肝胆对比剂增强MRI

关键词：肝胆期 MRI 对比剂增强 MR 无病生存期影像特征肝细胞癌

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 293-309页

作者： kiran A.Nirmal Tukaram d.dongale Atul C.khot Chenjie Yao Nahyun kim Tae Geun kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： kiyoung kim department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLd)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLd are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a dNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and dNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLd,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： kiyoung kim department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea Bk21 FOUR kNU Creative BioResearch Group kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

大动脉炎:利用128层双源CTA评估其冠状动脉异常

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2014年第2期 160-160页

作者： E.J.kang S.M.kim Y.H.Choe G.Y.Lee k.N.Lee d.k.kim 高子晴 department of Radiology and Cardiovascular Imaging Center Samsung Medical CenterSungkyunkwan University School of Medicine

目的探讨冠状动脉CTA对大动脉炎(Takayasu arteritis,TA)合并冠状动脉病变的诊断价值及其与临床症状的相关性。材料与方法本研究经医院伦理委员会批准并免

关键词：冠状动脉异常临床症状相关性冠状动脉病变 CTA 双源

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi department of Brain Science Ajou University School of MedicineSuwonSouth Korea department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea department of Neurology Ajou University School of MedicineSuwonSouth Korea department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a dNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee kim Rudolph ETanzi Se Hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNdC5) in response to physical exercise. Studies reveal that irisin/FNdC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNdC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNdC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNdC5) irisin