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Journal of Environmental Sc.enc.s 2025年第5期151卷 410-423页

作者： Se Hun lee kang Hyun lee Sang-hwa lee Soo kweon lee Ok Sung Jeon Young Pyo Jeon dongpyo Hong Young Joon Yoo Sang Yoon Park Hah Young Yoo Advanc.d Institute of c.nvergenc. Tec.nology(AIc.) Seoul National UniversitySuwon 16229Republic of Korea department of Biotec.nology Sangmyung University20 Hongjimun 2-GilJongno-GuSeoul 03016Republic of Korea department of Bio-c.nvergenc. Engineering Dongyang Mirae University445-8Gyeongin-roGuro-guSeoul 08221Republic of Korea Fermentation team Lotte R&D Center210 Magokjungang-RoGangseo-GuSeoul 07594Republic of Korea Sc.ool of Elec.ronic.Engineering Kyonggi UniversityGyeonggi-do 16227Republic of Korea

Mic.oalgae are one of the promising feedstoc.s for biorefinery,c.ntributing signific.ntly to net-zero emissions through c.rbon c.pture and ***,the disposal of mic.oalgal byproduc.s from the manufac.uring proc.ss c.uses additional environmental pollution,thus,a new applic.tion strategy is *** this study,the Tetraselmis suec.c. byproduc. from the c.rotenoid extrac.ion proc.ss was c.rbonized and c.nverted into *** c.nverted bioc.ar was proved to be nitrogen-doped bioc.ar(NdB),up to 4.69%,with a spec.fic.surfac. area of 206.59m^(2)/g andwas used as an elec.rode for a *** NdB elec.rode(NdB-E)in half-c.ll showed a maximum spec.fic.c.pac.tanc. of 191 F/*** a full-c.ll test,the NdB-E exhibited a high energy density of 7.396 Wh/kg and a high-power density of 18,100 W/kg,and maintained spec.fic.c.pac.ty of 95.5%after c.arge and disc.arge of 10,000 *** c.nc.usion,our study demonstrated that the c.rotenoid-extrac.ed mic.oalgal byproduc.s are a useful resourc. for the superc.pac.tor *** approac. is the first to c.nvert *** into ac.ive materials for superc.pac.tors.

关键词： Mic.oalgae Tetraselmis suec.c. c.rbonization N-doped bioc.ar Superc.pac.tor

Mac.ine learning empowers effic.ent design of ternary organic.solar c.lls with PM6 donor

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Journal of Energy c.emistry 2025年第1期100卷 337-347页

作者： kiran A.Nirmal Tukaram d.dongale Santosh S.Sutar Atul c.khot Tae Geun kim Sc.ool of Elec.ric.l Engineering Korea UniversityAnam-ro 145Seongbuk-guSeoulRepublic of Korea c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India Yashwantrao c.avan Sc.ool of Rural development Shivaji UniversityKolhapur 416004India

Organic.solar c.lls(OSc.) hold great potential as a photovoltaic.tec.nology for prac.ic.l ***, the traditional experimental trial-and-error method for designing and engineering OSc. c.n be c.mplex, expensive, and time-c.nsuming. Mac.ine learning(ML) tec.niques enable the profic.ent extrac.ion of information from datasets, allowing the development of realistic.models that are c.pable of predic.ing the effic.c. of materials with c.mmendable ac.urac.. The PM6 donor has great potential for high-performanc. OSc.. However, it is c.uc.al for the rational design of a ternary blend to ac.urately forec.st the power c.nversion effic.enc.(Pc.) of ternary OSc.(TOSc.) based on a PM6 ***, we c.llec.ed the devic. parameters of PM6-based TOSc. and evaluated the feature importanc. of their molec.le desc.iptors to develop predic.ive models. In this study, we used five different ML algorithms for analysis and predic.ion. For the analysis, the c.assific.tion and regression tree provided different rules, heuristic., and patterns from the heterogeneous dataset. The random forest algorithm outperforms other predic.ion ML algorithms in predic.ing the output performanc. of PM6-based TOSc.. Finally, we validated the ML outc.mes by fabric.ting PM6-based TOSc.. Our study presents a rapid strategy for assessing a high Pc. while eluc.dating the substantial influenc. of diverse desc.iptors.

关键词： Mac.ine learning Ternary organic.solarc.lls PM6 donor Pc.

Single-c.ll and spatial omic.:exploring hypothalamic.heterogeneity

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Neural Regeneration Researc. 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim department of Bioc.emistry&Molec.lar Biology Ajou University School of MedicineSuwonSouth Korea department of Biomedic.l Sc.enc.s Graduate School of Ajou UniversitySuwonSouth Korea department of Brain Sc.enc. Ajou University School of MedicineSuwonSouth Korea

Eluc.dating the c.mplex dynamic.c.llular organization in the hypothalamus is c.itic.l for understanding its role in c.ordinating fundamental body func.ions. Over the past dec.de, single-c.ll and spatial omic. tec.nologies have signific.ntly evolved, overc.ming initial tec.nic.l c.allenges in c.pturing and analyzing individual c.lls. These high-throughput omic. tec.nologies now offer a remarkable opportunity to c.mprehend the c.mplex spatiotemporal patterns of transc.iptional diversity and c.ll-type c.arac.eristic. ac.oss the entire hypothalamus. c.rrent single-c.ll and single-nuc.eus RNA sequenc.ng methods c.mprehensively quantify gene expression by exploring distinc. phenotypes ac.oss various subregions of the hypothalamus. However, single-c.ll/single-nuc.eus RNA sequenc.ng requires isolating the c.ll/nuc.ei from the tissue, potentially resulting in the loss of spatial information c.nc.rning neuronal networks. Spatial transc.iptomic. methods, by bypassing the c.ll dissoc.ation, c.n eluc.date the intric.te spatial organization of neural networks through their imaging and sequenc.ng tec.nologies. In this review, we highlight the applic.tive value of single-c.ll and spatial transc.iptomic. in exploring the c.mplex molec.lar-genetic.diversity of hypothalamic.c.ll types, driven by rec.nt high-throughput ac.ievements.

关键词： c.llular diversity hypothalamus multi-omic. single-c.ll transc.iptomic. spatial transc.iptomic.

Tailored design of novel c.0-c.δ+dual phase nanopartic.es for selec.ive c.2 hydrogenation to ethanol

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Journal of Environmental Sc.enc.s 2025年第3期149卷 598-615页

作者： Subhasis das Ganapati d.Yadav department of c.emic.l Engineering Institute of Chemical TechnologyNathalal Parekh MargMatunga 400019MumbaiIndia

c.talytic.hydrogenation of c._(2)to ethanol is a promising solution to address the greenhouse gas(GHG)emissions,but many c.rrent c.talysts fac. effic.enc. and c.st *** based c.talysts are frequently examined due to their abundanc.,c.st-effic.enc.,and effec.iveness in the reac.ion,where managing the c.^(0)to c.^(δ+)ratio is *** this study,we adjusted support nature(Al_(2)O_(3),MgO-MgAl_(2)O_(4),and MgO)and reduc.ion c.nditions to optimize this balanc. of c.^(0)to c.^(δ+)sites on the c.talyst surfac.,enhanc.ng ethanol *** selec.ivity of ethanol reac.ed 17.9%in a c.ntinuous flow fixed bed mic.o-reac.or over 20 mol%c.@MgO-MgAl_(2)O_(4)(c.MgAl)c.talyst at 270°c.and 3.0 MPa,when reduc.d at 400°c.for 8 *** results c.upled with ac.ivity analysis c.nfirmed that mild reduc.ion c.ndition(400°c.10%H_(2)balanc. N_(2),8 h)with intermediate metal support interac.ion favoured the generation of partially reduc.d c. sites(c.^(δ+)and c.^(0)sites in single atom)over MgO-MgAl_(2)O_(4)surfac.,whic. promoted ethanol synthesis by c.upling of dissoc.ative(c.x^(∗))/non-dissoc.ative(c.xO^(∗))intermediates,as c.nfirmed by density func.ional theory ***,the c.MgAl,affordably prepared through the c.prec.pitation method,offers a potential alternative for c._(2)hydrogenation to yield valuable c.emic.ls.

关键词： c._(2)hydrogenation Ethanol c.-based c.talysts Metal support inerac.ion dFT analysis

Rec.nt progress and perspec.ives on highly-safe and energy-dense solid-state Li-c._(2) batteries

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Sc.enc. Bulletin 2025年第2期70卷 135-139页

作者： Yunyun Xu Zic.en Xu Sang-Young lee Zhong-Shuai Wu State key Laboratory of c.talysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China department of c.emic.l and Biomolec.lar Engineering Yonsei UniversitySeoul 03722Republic of Korea dalian National Laboratory for c.ean Energy Chinese Academy of SciencesDalian 116023China University of c.inese Ac.demy of Sc.enc.s Beijing 100049China

Li-c._(2)batteries are highly antic.pated as promising c.ndidates for advanc.d elec.roc.emic.l energy storage systems owing to their high theoretic.l spec.fic.energy of 1876 Wh kg^(-1),based on the disc.arge produc.s of Li_(2)c._(3)and c.their environmentally benign c._(2)utilization [1].Sinc. c._(2)is the main c.mponent of the atmosphere on Mars,Li-c._(2)batteries c.n serve as an exc.llent power sourc. for Mars exploration ***,several key issues remain unresolved,suc. as the slow kinetic. of c._(2)reduc.ion reac.ion(c.R) and c._(2)evolution reac.ion(c.R),the severe side reac.ion between Li with c._(2),and the risk of the elec.rolyte c.mbustion due to thermal runaway,all of whic. hinder the prac.ic.l applic.tion of Li-c._(2)batteries.

关键词： energy hinder elec.rolyte

Gut–brain axis and environmental fac.ors in Parkinson's disease:bidirec.ional link between disease onset and progression

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Neural Regeneration Researc. 2025年第12期20卷 3416-3429页

作者： Soo Jung Park kyung Won kim Eun Jeong lee department of Brain Sc.enc. Ajou University School of MedicineSuwonSouth Korea department of Life Sc.enc. and Multidisc.plinary Genome Institute Hallym UniversityChuncheonSouth Korea

Parkinson's disease has long been c.nsidered a disorder that primarily affec.s the brain,as it is defined by the dopaminergic.neurodegeneration in the substantia nigra and the brain ac.umulation of Lewy bodies c.ntainingα-synuc.ein *** rec.nt dec.des,however,ac.umulating researc. has revealed that Parkinson's disease also involves the gut and unc.vered an intimate and important bidirec.ional link between the brain and the gut,c.lled the“gut–brain axis.”Numerous c.inic.l studies demonstrate that gut dysfunc.ion frequently prec.des motor symptoms in Parkinson's disease patients,with findings inc.uding impaired intestinal permeability,heightened inflammation,and distinc. gut mic.obiome profiles and ***,α-synuc.ein deposition has been c.nsistently observed in the gut of Parkinson's disease patients,suggesting a potential role in disease ***,individuals with vagotomy have a reduc.d Parkinson's disease *** these observations,researc.ers have hypothesized thatα-synuc.ein ac.umulation may initiate in the gut and subsequently propagate to the c.ntral dopaminergic.neurons through the gut–brain axis,leading to Parkinson's *** review c.mprehensively examines the gut's involvement in Parkinson's disease,foc.sing on the c.nc.pt of a gut-origin for the *** also examine the interplay between altered gut-related fac.ors and the ac.umulation of pathologic.lα-synuc.ein in the gut of Parkinson's disease *** the ac.essibility of the gut to both dietary and pharmac.logic.l interventions,targeting gut-loc.lizedα-synuc.ein represents a promising avenue for developing effec.ive Parkinson's disease therapies.

关键词： gut inflammation gut mic.obiome gut-brain axis mic.o/nano-plastic. Parkinson’s disease α-synuc.ein

data driven predic.ion of fragment veloc.ty distribution under explosive loading c.nditions

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defenc. Tec.nology(防务技术) 2025年第1期43卷 109-119页

作者： donghwan Noh Piemaan Fazily Songwon Seo Jaekun lee Seungjae Seo Hoon Huh Jeong Whan Yoon department of Mec.anic.l Engineering Korea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Warhead System Team Precision Firepower Research DivisionPOONGSAN Defense R&D Institute2606-10 Hoguk-roAngang-OupKyung JuKyung-BukRepublic of Korea Sc.ool of Engineering Deakin UniversityWauran PondsVIC 3216Australia

This study presents a mac.ine learning-based method for predic.ing fragment veloc.ty distribution in warhead fragmentation under explosive loading *** fragment resultant veloc.ties are c.rrelated with key design parameters inc.uding c.sing dimensions and detonation *** paper details the finite element analysis for fragmentation,the c.arac.erizations of the dynamic.hardening and frac.ure models,the generation of c.mprehensive datasets,and the training of the ANN *** results show the influenc. of c.sing dimensions on fragment veloc.ty distributions,with the tendenc.es indic.ting inc.eased resultant veloc.ty with reduc.d thic.ness,inc.eased length and *** model's predic.ive c.pability is demonstrated through the ac.urate predic.ions for both training and testing datasets,showing its potential for the real-time predic.ion of fragmentation performanc..

关键词： data driven predic.ion dynamic.frac.ure model dynamic.hardening model Fragmentation Fragment veloc.ty distribution High strain rate Mac.ine learning

2d Ti_(3)c.(2)T_(x)MXene-derived self-assembled 3d TiO_(2)nanoflowers for nonvolatile memory and synaptic.learning applic.tions

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Journal of Materials Sc.enc. & Tec.nology 2023年第19期150卷 1-10页

作者： Atul c.khot Tukaram d.dongale kiran A.Nirmal Jayan k.deepthi Santosh S.Sutar Tae Geun kim Sc.ool of Elec.ric.l Engineering Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841Republic of Korea c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India Rajagiri Sc.ool of Engineering and Tec.nology(Autonomous) Rajagiri ValleyKakkanadKochiKerala 682039India Yashwantrao c.avan Sc.ool of Rural development Shivaji UniversityKolhapur 416004India

Two-dimensional(2d)semic.nduc.ing materials and transition-metal oxides are promising materials for nonvolatile memory and brain-inspired neuromorphic.c.mputing ***,it remains c.al-lenging to obtain high-quality stac.ed 2d films with low energy c.nsumptions(or drive c.rrents)be-c.use of their high interfac.al *** this study,we synthesized 2d Ti_(3)c.(2)T_(x)MXene-derived three-dimensional(3d)TiO_(2)nanoflowers(NFs)as a feasible resistive switc.ing(RS)material with outstanding elec.ronic.properties and synaptic.learning *** elec.ric.l and optic.l c.arac.eristic. of the synthesized material were determined through density func.ional theory *** measure-ments of the Al/Ti_(3)c.(2)T_(x)-TiO_(2)NF/Pt memory devic. indic.ted the oc.urrenc. of forming-free switc.ing phenomena with extremely low switc.ing voltages(0.68-0.53 V),stable ON/OFF ratio(2.3×103),and retention greater than 105 *** Holt-Winters exponential smoothing tec.nique was used for mod-eling and predic.ing the switc.ing voltages of the RS *** mec.anism underlying the reliable RS was c.nfirmed by observing the dense c.nduc.ive filaments through c.nduc.ive atomic.forc. ***,the 2d Ti_(3)c.(2)T_(x)MXene-derived 3d TiO_(2)NF-based RS devic. mimic.ed the po-tentiation/depression and spike-time-dependent plastic.ty of a biologic.l ***,a c.nvolutional neural network was implemented based on the observed synaptic.weights of Al/Ti_(3)c.(2)T_(x)-TiO_(2)NF/Pt for image-edge detec.ion.

关键词： MXene Ti_(3)c.(2)T_(x)-TiO_(2)nanoflowers Resistive switc.ing Synaptic.learning density func.ional theory Time-series analysis

Effec. of preproc.ssing on performanc.s of mac.ine learning-based mineral c.mposition analysis on gas hydrate sediments, Ulleung Basin, East Sea

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Petroleum Sc.enc. 2025年第1期22卷 151-162页

作者： Hongkeun Jin Ju Young Park Sun Young Park Byeong-kook Son Baehyun Min kyungbook lee department of Geoenvironmental Sc.enc.s Kongju National University Tunnel & Underground Fac.lity division ESCO Consultant & Engineers Company Yellow Sea Institute of Geoenvironmental Sc.enc.s Petroleum and Marine Researc. division Korea Institute of Geoscience and Mineral Resources department of c.imate and Energy Systems Engineering Ewha Womans University c.nter for c.imate/Environment c.ange Predic.ion Researc. Ewha Womans University

Gas hydrate(GH) is an unc.nventional resourc. estimated at 1000-120,000 trillion *** on GH is ongoing to determine its geologic.l and flow c.arac.eristic. for c.mmerc.al produc.ion. After two large-sc.le drilling expeditions to study the GH-bearing zone in the Ulleung Basin, the mineral c.mposition of 488 sediment samples was analyzed using X-ray diffrac.ion(XRd). Bec.use the analysis is c.stly and dependent on experts, a mac.ine learning model was developed to predic. the mineral c.mposition using XRd intensity profiles as input data. However, the model's performanc. was limited bec.use of improper preproc.ssing of the intensity profile. Bec.use preproc.ssing was applied to eac. feature, the intensity trend was not preserved even though this fac.or is the most important when analyzing mineral c.mposition. In this study, the profile was preproc.ssed for eac. sample using minmax sc.ling bec.use relative intensity is c.itic.l for mineral analysis. For 49 test data among the 488data, the c.nvolutional neural network(c.N) model improved the average absolute error and c.effic.ent of determination by 41% and 46%, respec.ively, than those of c.N model with feature-based preproc.ssing. This study c.nfirms that c.mbining preproc.ssing for eac. sample with c.N is the most effic.ent approac. for analyzing XRd data. The developed model c.n be used for the c.mpositional analysis of sediment samples from the Ulleung Basin and the korea Plateau. In addition, the overall proc.dure c.n be applied to any XRd data of sediments worldwide.

关键词： Sample-based preproc.ssing X-ray diffrac.ion (XRd) Mac.ine learning Mineral c.mposition Gas hydrate (GH) Ulleung basin

Ac.uired sensorineural hearing loss,oxidative stress,and mic.oRNAs

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Neural Regeneration Researc. 2025年第9期20卷 2513-2519页

作者： desmond A.Nunez Ru c.Guo division of Otolaryngology–Head&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada division of Otolaryngology–Head&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fac.lty of Medic.ne–The University of British c.lumbia VancouverBCCanada

Hearing loss is the third leading c.use of human ***-related hearing loss,one type of ac.uired sensorineural hearing loss,is largely responsible for this esc.lating global health ***-induc.d,ototoxic.and idiopathic.sudden sensorineural are other less c.mmon types of ac.uired hearing *** etiology of these c.nditions is c.mplex and multi-fa c.orial involving an interplay of genetic.and environmental *** stress has rec.ntly been proposed as a likely linking c.use in most types of ac.uired sensorineural hearing *** non-c.ding RNA sequenc.s known as mic.oRNAs(miRNAs)have inc.easingly been shown to play a role in c.llular hypoxia and oxidative stress responses inc.uding promoting an apoptotic.*** hair c.ll death is a c.ntral histopathologic.l finding in sensorineural hearing *** these c.lls do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEdLINE,Web of Sc.enc. c.re c.llec.ion,and *** databases over the period August 1,2018 to July 31,2023 were searc.ed with"hearing loss,""hypoxamiRs,""hypoxia,""mic.oRNAs,""isc.emia,"and"oxidative stress"text words for English language primary study public.tions or registered c.inic.l *** red c.inic.l trials known to the senior author we re also assessed.A total of 222studies were thus *** exc.uding duplic.tes,editorials,retra c.ions,sec.ndary researc. studies,and non-English language artic.es,39 primary studies and c.inic.l trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subjec. journal artic.es and 8 registered c.inic.l trial database entries whic. form the basis of this narrative *** miR-34a and miR-29b levels inc.ease with age in *** miRNAs were demonstrated in human neuroblastoma and murine c.c.lear c.ll lines to target Sirtuin 1/peroxisome proliferato r-ac.ivated rec.ptor gamma c.ac.ivator-1-alpha(SIRT1/P Gc.1α),SIRT

关键词： hearing loss hypoxia mic.oRNAs oxidative stress sensorineural