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对首次细针穿刺活检无法得到明确诊断结果的甲状腺结节的处理:我们可以避免重复活检吗?

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国际医学放射学杂志 2014年第6期 576-577页

作者： T.j.T.Anderson M.K.Atalay d.j.grand G.L.Baird j.j.Cronan M.d.Beland 文凤 department of diagnostic Imaging Rhode Island Hospital593 Eddy StProvidenceRI 02903

摘要目的在首次细针穿刺活检结果不明的病人中,明确与恶性肿瘤相关的人口统计学和超声特征,以阐明重复细针穿刺活检、手术切除和超声随访在这类结节诊疗中发挥的

关键词：细针穿刺超声随访结节甲状腺粒子肉内分泌腺明确

101例肾肿瘤病人经皮射频消融术后肾晕轮征的发生率及其临床重要性

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国际医学放射学杂志 2009年第6期 590-591页

作者： T.C.Schirmang W.W.Mayo-Smith d.E.dupuy M.d.Beland d.j.grand 范文哲 department of diagnostic Imaging Rhode Island Hospital and arren Alpert Medical School of Brown University593 Eddy StProvidenceRI 02903USA

目的报道肾肿瘤病人经皮射频消融(radiofrequen-cy ablation,RFA)术后肾晕轮征的发生率及其临床重要性。材料与方法本回顾性研究遵照HIPAA规定,获得伦理委员会批准。101例病人共106个实性肾肿瘤行经皮RFA。3名经委员会认证的放射专家回... 详细信息

目的报道肾肿瘤病人经皮射频消融(radiofrequen-cy ablation,RFA)术后肾晕轮征的发生率及其临床重要性。材料与方法本回顾性研究遵照HIPAA规定,获得伦理委员会批准。101例病人共106个实性肾肿瘤行经皮RFA。3名经委员会认证的放射专家回顾性分

关键词：肾肿瘤 RFA 泌尿系肿瘤发生率晕轮病人

Kinetics of glyphosate and aminomethylphosphonic acid sorption onto montmorillonite clays in soil and their translocation to genetically modified corn

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journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： Meichen Wang Kelly j Rivenbark Timothy d Phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AMPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AMPA ***,clay-based sorption strategies for mixtures of GLP and AMPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AMPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(CM)and acid processed montmorillonite(APM)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APM inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AMPA in soils and plants.

关键词： Glyphosate AMPA Adsorption Soil remediation Plant Hydroponic system

Generalized polynomial chaos expansion by reanalysis using static condensation based on substructuring

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 819-836页

作者： d.LEE S.CHANG j.LEE department of Automotive Engineering Hanyang UniversitySeoul 04763Republic of Korea School of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea department of Mechanical Robotics and Energy EngineeringDongguk UniversitySeoul 04620Republic of Korea

This paper presents a new computational method for forward uncertainty quantification(UQ)analyses on large-scale structural systems in the presence of arbitrary and dependent random *** method consists of a generalized polynomial chaos expansion(GPCE)for statistical moment and reliability analyses associated with the stochastic output and a static reanalysis method to generate the input-output data *** the reanalysis,we employ substructuring for a structure to isolate its local regions that vary due to random *** allows for avoiding repeated computations of invariant substructures while generating the input-output data *** substructuring with static condensation further improves the computational efficiency of the reanalysis without losing ***,the GPCE with the static reanalysis method can achieve significant computational saving,thus mitigating the curse of dimensionality to some degree for UQ under high-dimensional *** numerical results obtained from a simple structure indicate that the proposed method for UQ produces accurate solutions more efficiently than the GPCE using full finite element analyses(FEAs).We also demonstrate the efficiency and scalability of the proposed method by executing UQ for a large-scale wing-box structure under ten-dimensional(all-dependent)random inputs.

关键词： forward uncertainty quantification(UQ) generalized polynomial chaos expansion(GPCE) static reanalysis method static condensation substructuring

Malargüe Site Remediation:A Successful Solution for Uranium Mill Tailings

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原子能科学技术 2024年第10期58卷 2088-2094页

作者： BARARI E díAZ j G GIOMIA KEMPF R A National Atomic Energy Commission Av.Del Libertador 8250Ciudad Autónoma de Buenos AiresC1429BNPArgentina

Comisión Nacional de Energía Atómica (CNEA) has the responsibility for restoring uranium mining facilities once the operations have ***,within its Environmental Program and in compliance with its legal responsibilities,decides to implement a restoration project for all sites related to the mining and processing of uranium *** Malargüe Site is located within the Province of Mendoza in the city of Malargü*** is the first site to successfully complete its *** activities consist of relocation of tailings to an engineering *** tailings management(encapsulation) and rehabilitation of the area was finished in june *** remediation alternative for the ore tailings was selected after conducting comparative studies and submitted the project to the society for *** objective of the encapsulation of the mineral tails is to isolate them from the environment,also proceeding with the decontamination and rehabilitation of the area (landscaping,post-closure monitoring and 20 years monitoring period).Encapsulation consisted of the construction of a containment cell for the mine tailings,to isolate them and prevent pollutants from entering the environment through the transfer *** clean the impacted areas,the soil was removed,it was incorporated into the encapsulation,and the filling was carried out with natural soils from the *** prevents radon transfer to the environment,as ^(222)Ra is an alpha emitter with a half-life of four days,which produces its own radioactive *** progeny are solids,and when a ^(222)Ra nucleus emits an alpha particle into the air,the resulting ^(218)Po nucleus,momentarily electrically charged,adheres to any dust *** prevents the discharge into the air containing radon and also containing dust particles charged with intensely radioactive radon *** tasks mentioned make it possible to decrease radon emanation,reduce radiological risks to the public and pre

关键词： remediation radionuclide transfer tailings encapsulation solution sustainable

Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： K.d.james j.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

减少CT结肠成像中的辐射剂量:降低管电压到100kV

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国际医学放射学杂志 2013年第3期 265-265页

作者： K.j.Chang d.B.Caovan d.j.grand W.Huda W.W.Mayo-Smith 宾锋利 department of diagnostic Imaging Warren Alpert Medical School of Brown UniversityRhode Island Hospital

目的将管电压从120kV减少到100kV,评估病人行CT结肠成像时辐射剂量、对比噪声比(CNR)以及三维影像质量受到的影响,并确定病人体型如何影响这些结果。材料与方法该回顾性研究符合HIPAA并经过机构审查委员会批准,纳入研究的为接受CT结肠... 详细信息

目的将管电压从120kV减少到100kV,评估病人行CT结肠成像时辐射剂量、对比噪声比(CNR)以及三维影像质量受到的影响,并确定病人体型如何影响这些结果。材料与方法该回顾性研究符合HIPAA并经过机构审查委员会批准,纳入研究的为接受CT结肠成像检查并免除知情同意书的63例连续的病人。对病人进行仰卧位(120kV)和俯卧位(100kV)扫描,其他扫描参数不变。用Wilcoxon配对符号秩检验对容积CT剂量指数(CTdIvol)、剂量长度乘积(dLP)、图像噪声、所选材料的衰减以及CNR进行比较。两位阅片者在不知管电压的情况下,对三维腔内影像质量进行独立评估。κ系数由阅片者之间协定计算。平均影像质量评分用Wilcoxon符号秩检验进行比较。根据病人的前后径对所有记录的数据进行分类以确定病人体型对结果的影响。结果将管电压从120kV降到100kV,结果使CTdIvol(PdLP(P<0.001)降低了16%,而影像噪声增加了32%(P<0.001),示踪液的平均衰减从395HU增至487HU(P<0.001)。不论什么体型的病人,示踪液的平均CNR基本没有改变(120kV时为17.1,100kV时为16.8;P=0.37)。三维影像质量略有下降,中位数得分从5(总分5)降至4(总分5)(P<0.001)。此研究在阅片者之间有很好的一致性。结论将管电压从120kV降至100kV使病人所受辐射剂量明显减少,但所有体型的病人的三维影像质量只有很小的下降。

关键词：管电压结肠成像辐射剂量 CT kV

Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape

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Neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney j.Rouse Victoria N.jensen Coy d.Heldermon Lacerta Therapeutics AlachuaFLUSA University of Florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for *** results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological *** treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢ***-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential *** group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores N-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢB to that seen in healthy ***,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢB field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB N-acetyl-alpha-glucosaminidase newborn screening

Generalized time-dependent generator coordinate method for induced fission dynamics

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Frontiers of physics 2024年第4期19卷 1-12页

作者： B.Li d.Vretenar T.Nikšić j.Zhao P.W.Zhao j.Meng State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Physics department Faculty of ScienceUniversity of Zagreb10000 ZagrebCroatia Center for Circuits and Systems Peng Cheng LaboratoryShenzhen 518055China

The generalized time-dependent generator coordinate method(Td-GCM)is extended to include pairing *** correlated GCM nuclear wave function is expressed in terms of time-dependent generator states and weight *** particle–hole channel of the effective interaction is determined by a Hamiltonian derived from an energy density functional,while pairing is treated dynamically in the standard BCS approximation with time-dependent pairing tensor and single-particle occupation *** the inclusion of pairing correlations,various time-dependent phenomena in open-shell nuclei can be described more *** model is applied to the description of saddle-to-scission dynamics of induced *** generalized Td-GCM charge yields and total kinetic energy distribution for the fission of 240Pu,are compared to those obtained using the standard time-dependent density functional theory(Td-dFT)approach,and with available data.

关键词： nuclear density functional theory generator coordinate method fission dynamics