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Utility of plasma d-dimer for diagnosis of venous thromboembolism after hepatectomy

World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto d.isuke tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido Tetsuo Ajiki Takumi Fukumoto division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUNd Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized that monitoring plasma d-dimer could be useful in the early diagnosis of VTE after *** To evaluate the utility of monitoring plasma d-dimer levels in the early diagnosis of VTE after *** The medical records of patients who underwent hepatectomy at our institution between January 2017 and december 2020 were retrospectively *** were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower *** factors,including demographic data and perioperative d-dimer values,were compared between the two *** operating characteristic curve analysis was performed to determine the d-dimer cutoff *** and multivariate analyses were performed using logistic regression analysis to identify significant *** In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The d-dimer levels on postoperative days(POd)1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma d-dimer levels on POd 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after *** Monitoring of plasma d-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication d-dimer Early diagnosis Venous thromboembolism

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Plasma depletions lasting into daytime during the recovery phase of a geomagnetic storm in May 2017:Analysis and simulation of GPS total electron content observations

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Earth and Planetary Physics 2021年第5期5卷 427-434页

作者： Yuichi Otsuka Atsuki Shinbori Takuya Sori Takuya tsugawa Michi Nishioka Joseph d.Huba Institute for Space-Earth Environmental Research Nagoya UniversityNagoyaJapan National Institute of Information and Communications Technology TokyoJapan Syntek Technologies FairfaxVAUSA

This paper reports that plasma density depletions appearing at middle latitudes near sunrise survived until afternoon on 29 May 2017 during the recovery phase of a geomagnetic *** analyzing GPS data collected in Japan,we investigate temporal variations in the horizontal two-dimensional distribution of total electron content(TEC)during the geomagnetic *** SYM-H index reached-142 n T around 08 UT on 28 May *** depletions extending up to approximately 38°N along the meridional direction appeared over Japan around 05 LT(LT=UT+9 hours)on 29 May 2017,when TEC rapidly increased at sunrise due to the solar extreme ultraviolet(EUV)*** TEC depletions appeared sequentially over Japan for approximately 8 hours in sunlit *** 06 LT on 29 May,when the plasma depletions first appeared over Japan,the background TEC was enhanced to approximately 17 TECU,and then decreased to approximately 80%of the TEC typical of magnetically quiet *** conclude that this temporal variation of background plasma density in the ionosphere was responsible for the persistence of these plasma depletions for so long in *** using the Naval Research Laboratory:Sami2 is Another Model of the Ionosphere(SAMI2),we have evaluated how plasma production and ambipolar diffusion along the magnetic field may affect the rate of plasma depletion *** shows that the plasma density increases at the time of plasma depletion appearance;subsequent decreases in the plasma density appear to be responsible for the long-lasting persistence of plasma depletions during *** plasma density depletion in the top side ionosphere is not filled by the plasma generated by the solar EUV productions because plasma production occurs mainly at the bottom side of the ionosphere.

关键词： plasma bubble GPS ionosphere ionospheric irregularity SAMI2

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Bone Scan Index Is a Prognostic Factor for Breast Cancer Patients with Bone Metastasis Being Treated with Zoledronic Acid

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Open Journal of Radiology 2015年第3期5卷 149-158页

作者： Yukinori Okada Tatsuyuki Abe Yasuo Nakajima Itsuko Okuda Brandon d. Lohman Yoshihide Kanemaki Yasuyuki Kojima Kouichirou tsugawa department of Radiology St. Marianna University School of Medicine Kawasaki Japan department of diagnostic Radiology International University of Health and Welfare Mita Hospital Tokyo Japan department of Radiology Breast and Imaging Center St. Marianna University School of Medicine Kawasaki Japan department of Surgery Division of Breast and Endocrine Surgery St. Marianna University School of Medicine Kawasaki Japan

Bone scan index (BSI) has been used to quantify the spread of bone metastasis and be a prognostic indicator in prostate cancer with bone metastases. However, the utility of BSI in breast cancer patients with bone metastasis has not been yet established. We retrospectively reviewed 57 female breast cancer patients with osteoblastic/lytic combined type bone metastases and treated with zoledronic acid after bone metastasis was identified. Serial bone scintigrams were taken at the time of bone metastasis detection and during the 6- and 12-month follow-ups. The scintigrams were analyzed by BONE NAVITM version 1 and the BSI value was calculated. Additionally, serum cancer antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) were measured. The patients were divided in 2 distinct groups—group A representing all follow-up BSI values ≤ initial BSI values and group B representing all follow-up BSI values ≥ initial BSI values. The interval changes of CA15-3 and CEA were divided in the same fashion. Kaplan-Meier method and log-rank test revealed that the overall survival rate was significantly greater in group A than those of group B after 6 months (p = 0.011) and 12 months (p = 0.016). Univariate analysis revealed that the overall survival rate was significantly greater in group A than those of group B, after a 6 month period (Hazard Ratio [HR] 5.841;95% confidence interval [CI] 1.248 - 27.34;p = 0.025) and 12 month period (HR: 4.22;95% CI 1.17615.15;p = 0.027). Multivariate analysis demonstrated that BSI changes after 6 and 12 months trended toward significance regarding parameters affecting survival rate (age and CA15-3) with a HR = 12.760 (95%CI 1.8110 - 89.850) at 6 months with a p = 0.010 and a HR = 5.0640 (95%CI 1.0590 - 24.220) at 12 months with a p = 0.042. BSI changes after 6 and 12 months appear to be a prognostic factor in breast cancer patients with bone metastasis treated with zoledronic acid.

关键词： Bone Scintigraphy Bone Scan Index Zoledronic Acid Overall Survival Rate

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美国低收入人群实行平价医疗法案医疗救助扩展计划与心血管病危险因素改变的相关性

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中华高血压杂志 2021年第3期29卷 279-279页

作者：袁源(摘译) 练桂丽(审校) Gotanda H Kominski GF Elashoff d tsugawa Y 不详

在群体水平实行平价医疗法案(affordable care act, ACA)的医疗救助扩展是否可改善心血管病危险因素目前证据有限。该研究旨在从国家层面评估美国ACA医疗救助扩展计划施行最初的3年间,低收入人群实行ACA医疗救助扩展与心血管病危险因素... 详细信息

在群体水平实行平价医疗法案(affordable care act, ACA)的医疗救助扩展是否可改善心血管病危险因素目前证据有限。该研究旨在从国家层面评估美国ACA医疗救助扩展计划施行最初的3年间,低收入人群实行ACA医疗救助扩展与心血管病危险因素改变的相关性。

关键词：医疗救助低收入人群心血管病危险因素平价医疗法案群体水平 ACA care 相关性

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