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中华口腔医学杂志 1957年第3期5卷 261-267页

作者： d.e.ross 江勋

一、诊断腮腺肿瘤的诊断通常是不困难的,但腮腺内和其周围的某些病理改变也会使肿瘤的诊断发生了困难。在耳周部发生的皮脂囊肿和包含囊肿常易造成误诊。必须注意在腮腺的周围、深部,甚致在腮腺的实质内有许多淋巴结,因此我

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Light sheet microscope scanning of biointegrated microlasers for localized refractive index sensing

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Photonics Research 2024年第8期12卷 1673-1680页

作者： ross C.COWIe MARCeL SCHUBeRT SUPA School of Physics and AstronomyUniversity of St AndrewsSt AndrewsUK Humboldt Centre for Nano and Biophotonics Department of ChemistryUniversity of CologneCologneGermany

Whispering gallery mode(WGM)microlasers are highly sensitive to localized refractive index changes allowing to link their emission spectrum to various chemical,mechanical,or physical *** recently found applications in biological studies within single cells,in three-dimensional samples such as multicellular spheroids,or in ***,detailed studies of biological samples also need to account for the structural heterogeneity of tissues and live animals,therefore requiring a combination of high-resolution microscopy and laser ***,we design and construct a light sheet fluorescence microscope with a coupled spectrometer for use in microlaser studies for combined high-resolution,high-speed imaging and WGM spectral *** light sheet illumination profile and the decoupled geometry of excitation and emission hereby directly affect the lasing and sensing properties,mainly through geometric constraints and by light coupling *** demonstrate the basic working principle of microlaser spectroscopy under light sheet excitation and measure the absolute refractive index within agarose and in zebrafish tail muscle *** further analyze the light coupling conditions that lead to the occurrence of two separate oscillation *** so-called cross modes can be scanned around the entire microlaser surface,which allows to estimate a surface-averaged refractive index profile of the microlaser environment.

关键词： refractive index excitation

Performance analysis of deep borehole heat exchangers for decarbonization of heating systems

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deep Underground Science and engineering 2024年第3期3卷 349-357页

作者： Andreas e.d.Lund department of electrical engineering and Automation Aalto UniversityEspooFinland

Meeting the climate change mitigation targets will require a substantial shift from fossil to clean fuels in the heating *** pumps with deep borehole exchangers are a promising solution to reduce *** the thermal behavior of deep borehole exchangers(dBHes)ranging from 1 to 2 km was analyzed for various heat flow profiles.A strong correlation between thermal energy extraction and power output from dBHes was found,also influenced by the heating profile *** operating time over the year typically resulted in higher energy production,while shorter one yielded higher average thermal power output,highlighting the importance of the choice of heating strategy and system design for optimal performance of *** breaks in operation for regenerating the borehole,for example,with waste heat,proved to be favorable for the performance yielding an overall heat output close to the same as with continuous extraction of *** results demonstrate the usefulness of deep boreholes for dense urban areas with less available *** the heat production from a single dBHe in Finnish conditions ranges from half up to even a few GWh a year,the technology is best suitable for larger heat loads.

关键词： clean energy deep borehole exchangers energy transition geothermal heat ground-coupled heat pump

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Converting TRex-RGB green-channel data to 557.7 nm auroral intensity:Methodology and initial results

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earth and Planetary Physics 2024年第1期8卷 258-274页

作者： Jun Liang d.M.Gillies e.Spanswick e.F.donovan University of Calgary CalgaryT2N 1N4Canada

The recently deployed Transition Region explorer(TRex)-RGB(red-green-blue)all-sky imager(ASI)is designed to capture“true color”images of the aurora and *** the 557.7 nm green line is usually the brightest emission line in visible auroras,the green channel of a TRex-RGB camera is usually dominated by the 557.7 nm *** this rationale,the TRex mission does not include a specific 557.7 nm imager and is designed to use the RGB green-channel data as a proxy for the 557.7 nm *** this study,we present an initial effort to establish the conversion ratio or formula linking the RGB green-channel data to the absolute intensity of 557.7 nm auroras,which is crucial for quantitative uses of the RGB *** illustrate two approaches:(1)through a comparison with the collocated measurement of green-line auroras from the TRex spectrograph,and(2)through a comparison with the modeled green-line intensity according to realistic electron precipitation flux measurements from low-earth-orbit satellites,with the aid of an auroral transport *** demonstrate the procedures and provide initial results for the TRex-RGB ASIs at the Rabbit Lake and Lucky Lake *** RGB response is found to be *** conversion ratios or formulas between RGB green-channel data and the green-line auroral intensity are given and can be applied immediately by TRex-RGB data *** methodology established in this study will also be applicable to the upcoming SMILe ASI mission,which will adopt a similar RGB camera system in its deployment.

关键词： TRex RGB green-line aurora auroral transport model

The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： d A Baghdasaryan V A Harutynyan e M Kazaryan H A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

The effect of Retinoic Acid on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens

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Infectious Microbes & diseases 2024年第2期6卷 65-73页

作者： Alexandra Stream ross Corriden Simon döhrmann Richard L.Gallo Victor Nizet ericka L.Anderson division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San Diego School of MedicineLa JollaCaliforniaUSA department of dermatology University of California San Diego School of MedicineLa JollaCaliforniaUSA Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San DiegoLa JollaCaliforniaUSA

Vitamin A and its biologically active derivative,retinoic acid(RA),are important for many immune ***,in particular,is essential for the development of immune cells,including neutrophils,which serve as a front-line defense against *** vitamin A deficiency has been linked to higher susceptibility to infections,the precise role of vitamin A/RA in host-pathogen interactions remains poorly ***,we provided evidence that RA boosts neutrophil killing of methicillin-resistant Staphylococcus aureus(MRSA).RA treatment stimulated primary human neutrophils to produce reactive oxygen species,neutrophil extracellular traps and the antimicrobial peptide cathelicidin(LL-37).Because RA treatment was insufficient to reduce MRSA burden in an in vivo murine model of skin infection,we expanded our analysis to other infectious *** did not affect the growth of a number of common bacterial pathogens,including MRSA,escherichia coli K1 and Pseudomonas aeruginosa;however,RA directly inhibited the growth of group A Streptococcus(GAS).This antimicrobial effect,likely in combination with RA-mediated neutrophil boosting,resulted in substantial GAS killing in neutrophil killing assays conducted in the presence of ***,in a murine model of GAS skin infection,topical RA treatment showed therapeutic potential by reducing both skin lesion size and bacterial *** findings suggest that RA may hold promise as a therapeutic agent against GAS and perhaps other clinically significant human pathogens.

关键词： retinoic acid neutrophil bacterial infection Staphylococcus aureus group A Streptococcus neutrophil extracellular traps antimicrobial peptide cathelicidin

Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications

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Bone Research 2024年第1期12卷 1-19页

作者： Xiwei Fan Antonia Rujia Sun Reuben S.e.Young Isaac O.Afara Brett R.Hamilton Louis Jun Ye Ong ross Crawford Indira Prasadam Centre for Biomedical Technologies Queensland University of TechnologyBrisbaneQLDAustralia School of Mechanical Medical&Process EngineeringQueensland University of TechnologyBrisbaneQLDAustralia Central Analytical Research Facility Queensland University of TechnologyBrisbaneQLDAustralia Molecular Horizons University of WollongongWollongongNSWAustralia department of Technical Physics University of Eastern FinlandKuopioFinland School of electrical engineering and Computer Science Faculty of EngineeringArchitecture and Information TechnologyUniversity of QueenslandBrisbaneQLDAustralia Centre for Microscopy and Microanalysis University of QueenslandBrisbaneQLDAustralia The Prince Charles Hospital BrisbaneQLDAustralia

Osteoarthritis(OA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose *** presents diverse clinical phenotypes and distinct molecular endotypes,including inflammatory,metabolic,mechanical,genetic,and synovial ***,innovative technologies are needed to support the development of effective diagnostic and precision therapeutic *** analysis of bulk OA tissue extracts has limitations due to technical constraints,causing challenges in the differentiation between various physiological and pathological phenotypes in joint *** issue has led to standardization difficulties and hindered the success of clinical *** insights into the spatial variations of the cellular and molecular structures in OA tissues,encompassing dNA,RNA,metabolites,and proteins,as well as their chemical properties,elemental composition,and mechanical attributes,can contribute to a more comprehensive understanding of the disease *** resolved biology enables biologists to investigate cells within the context of their tissue microenvironment,providing a more holistic view of cellular *** advances in innovative spatial biology techniques now allow intact tissue sections to be examined using various-omics lenses,such as genomics,transcriptomics,proteomics,and metabolomics,with spatial *** fusion of approaches provides researchers with critical insights into the molecular composition and functions of the cells and tissues at precise spatial ***,advanced imaging techniques,including high-resolution microscopy,hyperspectral imaging,and mass spectrometry imaging,enable the visualization and analysis of the spatial distribution of biomolecules,cells,and *** these molecular imaging outputs to conventional tissue histology can facilitate a more comprehensive characterization of disease *** review summarizes the rec

关键词： insight Spatial enable

Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： K.d.James J.e.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTeCs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTeC heterogeneity by examining the mechanisms by which mTeCs mimic the peripheral self[1].

关键词： medullary eliminate restricted

Roadmapping Roadmapping:Strategic planning for roadmapping systems

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Frontiers of engineering Management 2024年第3期11卷 516-527页

作者： Robert PHAAL Clemens CHASKeL Ricardo GONZALeZ Nakazawa Jonathan ross Institute for Manufacturing University of CambridgeCambridgeCB30FSUK

Roadmapping is a well-established technique in the context of innovation and strategy,with the potential to support organizations address the complex transformative challenges facing humanity in the 21st *** is enabled by its systems-based architecture and visual form of roadmaps,supporting communication and reduction of information asymmetries in complex sociotechnical *** paper focuses on an adaptation of the roadmapping method to support strategic planning for roadmapping systems in organizations,addressing implementation *** represents a novel application of roadmapping to business processes and systems,demonstrating the flexibility of the roadmapping approach.A workshop template(‘R2’)and process for supporting the roadmapping of roadmapping systems is presented,developed and refined through a series of six industrial cases,and illustrated with an application example in the additive manufacturing sector.

关键词： roadmapping strategic planning innovation management

Simple collective model for nuclear chiral mode

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Frontiers of physics 2024年第2期19卷 1-5页

作者： R.V.Jolos e.A.Kolganova d.R.Khamitova Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia dubna State University 141982 DubnaMoscow RegionRussia

A simple semi-analytical collective model that takes into account the limitations of the variation interval of the collective variable is suggested to describe the chiral dynamics in triaxial odd−odd nuclei with a fixed particle−hole *** collective Hamiltonian is constructed with the potential energy obtained using the postulated ansatz for the wave function symmetric with respect to chiral *** diagonalizing the collective Hamiltonian the wave functions of the lowest states are obtained and the evolution of the energy splitting of the chiral doublets in transition from chiral vibration to chiral rotation regime is demonstrated.

关键词： collective model nuclear chiral