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Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression,anxiety and psychosis

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World Journal of Psychiatry 2022年第2期12卷 308-322页

作者： Ana Paula Michelin Michael H J Maes Thitiporn Supasitthumrong Chusak Limotai Andressa Keiko Matsumoto Laura de Oliveira Semeão João Victor de Lima Pedrão Estefânia Gastaldello Moreira Buranee Kanchanatawan d.cio sabbatini barbosa Health Sciences Center State University of LondrinaLondrina 86038-440Brazil department of Psychiatry Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand department of Psychiatry Medical University of PlovdivPlovdiv 4004Bulgaria IMPACT Strategic Research Center Deakin UniversityGeelong 3220Australia Chulalongkorn Comprehensive Epilepsy Center of Excellence King Chulalongkorn Memorial HospitalThe Thai Red Cross SocietyBangkok 10330Thailand division of Neurology Department of MedicineFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand

BACKGROUNd Temporal lobe epilepsy(TLE)is the most common focal epilepsy subtype in adults and is frequently accompanied by depression,anxiety and *** in total paraoxonase 1(PON1)status may occur in TLE and these psychiatric *** To examine PON1 status,namely Q192R PON1 genotypes and PON1 enzymatic activities,in *** We recruited 40 normal controls and 104 TLE patients,27 without comorbidities and 77 with comorbidities including mood disorders(n=25),anxiety disorders(n=27)and psychosis(n=25).RESULTS Four-(chloromethyl)phenyl acetate hydrolysis(CMPAase)and arylesterase activities were significantly lower in TLE and mesial temporal sclerosis(MTS)with and without psychiatric comorbidities than those in normal *** areas under the receiver operating characteristic curve of CMPAase were 0.893(0.037)for TLE and 0.895(±0.037)for *** least squares path analysis showed that there were specific indirect effects of PON1 genotype on TLE severity(Pd psychopathology(Pdiated by lowered CMPAase activity,while arylesterase activity was not *** severity of TLE was significantly associated with psychopathology ***,PON1 CMPAase activity was inversely associated with Mini Mental State Examination *** The severity of TLE and comorbidities are to a large extent explained by reduced PON1 enzyme activities and by effects of the Q192R genotype,which are mediated by reduced CMPAase *** PON1 status plays a key role in the pathophysiology of TLE,MTS and psychiatric comorbidities by increasing the risk of oxidative ***1 enzyme activities are new drug targets in TLE to treat seizure frequency and psychiatric comorbidities.

关键词： Antioxidants Oxidative stress Neuroimmune Major depression Mood disorders Affective disorders

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Rainfall partitioning in young clonal plantations Eucalyptus species in a subtropical environment,and implications for water and forest management

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International Soil and Water Conservation Research 2021年第3期9卷 474-484页

作者： d.cio Oscar Cardoso Ferreto JoséMiguel Reichert Rosane barbosa Lopes Cavalcante Raghavan Srinivasan Soils department Universidade Federal de Santa Maria(UFSM).Avenida Romima 1000Santa MariaRSBrazil Instituto Tecnoldgico Vale.Rua Boaventura da Silva 955UmarizalBelemPABrazil department of Ecology and Conservation Biology Texas A&M University(TAMU)534 John Kimbrough Blvd.Room 305College StationTXUSA

different canopy characteristics of industrial eucalyptus may lead to differences in water evaporation and availability to *** study aims to understand rainfall partitioning in a young clonal plantation(age of 2-4.5 years)of three eucalyptus species by relating tree parameters:diameter at breast height,total height,and leaf area *** measured rainfall,throughfall,stemflow and litter interception,along with the tree *** eucalyptus trees had rainfall interception varying between 22 mm(for 178 mm of rainfall)and 42 mm(for 87 mm of te rainfall),throughfall between 106 mm(for 186 mm of rainfall)and 44 mm(for 74 mm of rainfall),and stemflow between 0.5 mm(for 92 mm of rainfall)and 1.4 mm(for 24 mm of rainfall).For the three species,rainfall interception varied between 12 and 48%,throughfall between 57 and 90%,and stemflow between 0.3 and 5.4%.The coefficient of determination between interception and rainfall was 0.76,indicating interception depends on other variables,possibly including antecedent rainfall,rainfall intensity,and *** decreased with a reduction in leaf area index caused by eucalyptus *** *** had 0.75 mm of throughfall per 1 mm of rainfall,whereas in *** and E saligna,these ratios were 0.71 and 0.68,*** in *** and *** had a higher positive relationship with the diameter at breast height of the trees,whereas in *** the highest relationship was with the *** results contribute to establishing management strategies,such as choosing suitable eucalyptus species to local climate,and to improve the synchronization of crop-demand versus soil-water-supply while maintaining streamflow to fulfill ecological and production needs.

关键词： Water balance Blue-green water Forest hydrology Rainfall interception Rainfall throughfall

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cAMP:A second messenger involved in the mechanism of midgut alkalinization in Lutzomyia longipalpis

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Insect Science 2022年第4期29卷 1059-1070页

作者： denise Barguil Nepomuceno Grasielle Caldas d’Ávila Pessoa Leonardo barbosa Koerich Marcos Horácio Pereira Mauricio Roberto Viana Sant'Anna Ricardo Nascimento Araújo Nelder Figueiredo Gontijo Laboratório de Fisiologia de Insetos Hematófagos Departamento de Parasitologia/ICBUniversidade Federal de Minas GeraisBelo HorizonteMGBrazil

The sand fly Lutzomyia longipalpis is the main vector of Leishmania infantum in the *** sand flies ingest sugar-rich solutions and blood,which are digested in the *** of nutrients is an essential function performed by digestive enzymes,which require appropriate physiological *** of the main aspects that influence enzymatic activity is the gut pH,which must be tightly *** second messengers are frequently involved in the coordination of tightly regulated physiological events,we investigated if the second messenger cAMP would participate in the process of alkalinization in the abdominal midgut of female *** midguts containing the indicator dye bromothymol-blue,cAMP stimulated the alkalinization of the midgut *** another technique based on the use of fluorescein as a pH indicator,we propose that cAMP is involved in the alkalinization of the midgut by activating HCO3-transport from the enterocyte's cytoplasm to the *** results strongly suggested that the carrier responsible for this process would be a HCO3−/Cl−antiporter located in the enterocytes’apical *** promotes the release of alkalinizing hormones in the hemolymph;however,when the enzyme adenylyl cyclase,responsible for cAMP production,was inhibited,we observed that the hemolymph from blood-fed ***’females did not stimulate midgut *** result indicated that hormone-stimulated alkalinization is mediated by *** the present study,we provide evidences that cAMP has a key role in the control of intestinal pH.

关键词： abdominal midgut alkalinization cAMP HCO_(3)^(-)/Cl^(-)antiport hormone Lulcomyia longipalpis

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Experimental and numerical characterization of 3d‑printed scaffolds under monotonic compression with the aid of micro‑CT volume reconstruction

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Bio-design and Manufacturing 2021年第2期4卷 222-242页

作者： R.Baptista M.F.C.Pereira A.Maurício d.Rechena V.Infante M.Guedes CdP2T Departamento de Engenharia MecanicaEscola Superior de Tecnologia de SetúbalInstituto Politécnico de Setúbal2910‑761 SetúbalPortugal CERENA DECivilInstituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais11049‑001 LisbonPortugal IdMEC Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais11049‑001 LisbonPortugal IPFN Instituto Superior TécnicoUniversidade de Lisboa1049‑001 LisbonPortugal CeFEMA Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais11049‑001 LisbonPortugal

Even when damaged by injury or disease bone tissue has the remarkable ability to *** this process is limited by large size bone defects,tissue engineering is responsible for restoring,maintaining or improving tissue *** are support structures,designed to be implanted in the damaged site,supporting mechanical loads and protecting the regenerating bone *** this paper,3d-printed PLA scaffolds with three different porosity values and two different geometries were experimentally and numerically ***-CT analysis showed that fused filament fabrication can be used to produce scaffolds with the desired porosity and 100%of interconnected *** monotonical compression,scaffolds apparent compressive modulus increased from 89 to 918 MPa,while yield stress increased from 2.9 to 27.5 MPa as porosity decreased from 70 to 30%.Open porosity decreased up to 8%on aligned scaffolds and 14%on staggered scaffolds,after compression,while scaffold’s surface-to-volume ratio highest reduction(7.48 to 4.55 mm−1)was obtained with aligned low porosity ***-CT volume reconstruction allowed for scaffold simplified numerical models to be built and *** agreement was found when predicting scaffold’s apparent compressive ***,it can be concluded that 3d printing is a viable scaffold manufacturing technique for trabecular bone replacement.

关键词： Scaffold Pore design Mechanical behavior Micro-CT analysis Finite element method

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Candidate genes for male and female reproductive traits in Canchim beef cattle

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Journal of Animal Science and Biotechnology 2018年第1期9卷 59-68页

作者： Marcos Eli Buzanskas daniela do Amaral Grossi Ricardo Vieira Ventura Flavio Schramm Schenkel Tatiane Cristina Seleguim Chud Nedenia Bonvino Stafuzza Luciana diniz Rola Sarah Laguna Conceio Meirelles Fabiana Barichello Mokry Maurício de Alvarenga Mudadu Roberto Hiroshi Higa Marcos Vinícius Gualberto barbosa da Silva Maurício Mello de Alencar Luciana Correia de Almeida Regitano danísio Prado Munari departamento de Zootecnia Universidade Federal da Paraíba(UFPB)AreiaParailba 58397-000Brazil Fast Genetics SaskatoonSK S7K 2K6Canada Beef Improvement Opportunities(BIO) GuelphON N1K 1ESCanada department of Animal and Poultry Science University of GuelphCentre for Genetic Improvement of Livestock(CGIL)GuelphON N1G 2W1Canada departamento de Ciencias Exatas Faculdade de Ci6ncias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil departamento de Zootecnia Nucleo de Pesquisa e Conservacao de CervMeosFaculdade de Ciencias Agrarias e VeterinariasUniversidade Estadual Paulista(Unesp)JaboticabalSao Paulo 14884 900Brazil department of Animal Science Federal University/of Lavras(UFLA)LavrasMinas Gerais 37200 000Brazil department of Genetics and Evolution Federa University of Sao Carlos(UFSCar)Sao CarlosSao Paulo 13565-905Brazil Embrapa Agricultural Informatics Campinas55o Paulo 13083 886Brazil Embrapa dairy Cattle Juiz de ForaMinas Gerais 36038 330Brazil Embrapa Southeast Livestock Sao CarlosSao Paulo 13560 970Brazil

Background： Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. data quality control was conducted resulting in 672,778 SNPs and 392 ***： Associated SNPs were observed for scrotal circumference at 420 d of age（435 SNPs）, followed by scrotal circumference at 210 d of age（12 SNPs）, age at first calving（six SNPs）, and age at second calving（four SNPs）. We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and ***： Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless,the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, al relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.

关键词： Animal breeding Composite breed Genome-wide association Genomic data Single nucleotide polymorphism

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Epidemiology of upper gastrointestinal symptoms in Brazil(Epi Gastro):A population-based study according to sex and age group

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World Journal of Gastroenterology 2014年第46期20卷 17388-17398页

作者： Maria do Rosário dias de Oliveira Latorre Aline Medeiros da Silva d.cio Chinzon Jaime N Eisig Telma RP dias-Bastos department of Epidemiology Faculty of Public HealthUniversity of S?o PauloS?o Paulo 01246-904Brazil Janssen-Cilag Farmacêutica Ltda. S?o Paulo 05501-900Brazil department of Gastroenterology Faculty of MedicineUniversity of S?o PauloS?o Paulo 05409-001Brazil

AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease(GERd)and dyspepsia in South ***:A telephone survey was conducted among adult owners of land-based telephones in S?o Paulo,Brazil,using previously validated computer-assisted sampling and survey *** Portugueselanguage survey included(1)sociodemographic characteristics(e.g.,weight,height,smoking)and comorbidities;(2)dietary habits;(3)presence of symptoms consistent with GERd or dyspepsia within the prior 3mo;and(4)use of medications and other therapies to manage *** were stratified post-hoc into three homogeneous geographical regions of S?o Paulo according to the Social Exclusion Indices of the districts and postal *** response data from each respondent were weighted by the numbers of adults and landline telephones in each *** analyses were weighted to account for sampling design and to be representative of the S?o Paulo population according to city census ***:Among 4570 households contacted,an adult from 3050(66.7%)agreed to *** nonresponse rate was 33.3%.The mean(SE)respondent age was 42.6(16.0)*** than half of all respondents were women(53.1%),aged 18 through 49 years(66.7%),married or cohabitating(52.5%),and/or above normal-weight standards(i.e.,35.3%overweight and 16.3%obese).A total of 26.5%of women were *** than 20%of respondents reported highly frequent symptoms consistent with GERd(e.g.,gastric burning sensation=20.8%)or dyspepsia(e.g.,abdominal swelling/distension=20.9%)at least once per *** of these symptoms were significantly(approximately 1.5-to 2.0-fold)higher among women than men but did not vary significantly as a function of advancing *** instance,14.1%of women reported that they experienced stomach burning(symptom of GERd)at least twice per week,compared to 8.4%of men(P=0.012 byχ2 test).A total of 15.7%of women reported that they experienced abdomi

关键词： dyspepsia Epidemiology Esophagus Gastroesophageal reflux Prevalence Stomach

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Splenic artery ligature associated with endoscopic banding for schistosomal portal hypertension

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World Journal of Gastroenterology 2014年第44期20卷 16734-16738页

作者： Renata Potonyacz Colaneri Fabrício Ferreira Coelho Roberto de Cleva Marcos Vinícius Perini Paulo Herman department of Gastroenterology University of S?o Paulo Medical School

AIM: To propose a less invasive surgical treatment for schistosomal portal hypertension.

关键词： Endoscopic banding Esophageal varices Portal hypertension Schistosomiasis Variceal bleeding

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Ecosystem services and legal protection of private *** or solution?

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Geography and Sustainability 2020年第3期1卷 173-180页

作者： Katažyna Mikša Marius Kalinauskas Miguel Inácio Eduardo Gomes Paulo Pereira Environmental Management Laboratory Mykolas Romeris UniversityVilnius LT-08303Lithuania Institute of International and European Union Law Mykolas Romeris UniversityVilnius LT-08303Lithuania

Ecosystem services(ES)delivery in quantity and quality are essential to improve human ***,often a considerable part of ES provisioning depends on the use of private land(e.g.,flood retention,carbon sequestration,water purification).In this context,the operationalization and implementation of ES concept may collide with legal property ***,it is essential to find constructive mechanisms to engage and encour-age private owners to implement sustainable land uses to reduce the onsite and offsite impacts of their *** paper aims to identify if ES delivery can be constrained by legal private land and how it can be *** is undeniable that land-use changes(e.g.,urbanization,agriculture intensification,and land abandonment)affect the territory’s capacity to deliver ES in quality and *** changes,especially land abandonment,are in-creasing the tradeoffs among ES(e.g.,between carbon sequestration and water yield).Land-use planning should consider these ***,incorporating ES into spatial plans is crucial for stakeholders to understand the impacts of land-use change in the loss of ES *** information can be transmitted through maps that communicate the message in a simplified *** owners can easily perceive the ES relevance that their land can provide if an understandable message is *** this can be a good solution,conflicts can appear even with the implementation of schemes such as Payment for ES(PES).PES is not always effective and can im-pose losses to farmers,disregard their cultural traditions,or not prevent poverty *** this context,it is crucial to consider local specificities to safeguard PES’s success,create a“win-win”and transform a problem into a *** owners’active participation in implementing sustainable practices or a determined land-use in their properties is vital to achieving global targets such as sustainable development goals.

关键词： Ecosystem services Law Private land Sustainability Land-use change

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Laparoscopic resection of primary retroperitoneal schwannoma:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4114-4121页

作者： Marcelo AF Ribeiro Jr Yasmin GB Elias Samara de S Augusto Paola R Néder Cássia TK Costa Andressa d Maurício Adriano P Sampaio Alexandre Z Fonseca General Surgery and Trauma department Catholic University of São Paulo–PUC-Sorocaba and Moriah HospitalSão Paulo 04083-002São Paulo CEPBrazil department of Surgery Medical SchoolSanto Amaro UniversitySão Paulo 04743-030São Paulo StateBrazil General Surgery and Trauma department Moriah HospitalSão Paulo 04083-002São Paulo StateBrazil

BACKGROUNd Schwannomas are rare,often benign,tumors deriving from Schwann cells that have low incidence in the retroperitoneal region(0.5%to 5%).Their diagnosis is hardly confirmed at early stage due to lack of specific features in signs,symptoms and imaging ***,it is necessary performing guided punch biopsy in order to identify *** removal is the treatment of choice due to its low sensitivity to radiation and *** SUMMARY Forty-seven years old female patient who was hospitalized for elective orthopedic procedure,without complications,evolved with severe pain in the lower limbs,thigh and gluteal region associated with neurogenic *** pain required magnetic resonance imaging(MRI)of the lumbar spine,which showed epidural collection with dural compression and massive heterogeneous perihepatic nodular *** surgical team opted for draining the collection,as well as requested an MRI of the abdomen and pelvis,whose analysis showed expansive lesion in the retroperitoneum,in close contact with the inferior vena cava and with the right renal vein.A guided puncture was performed for diagnostic clarification,which showed immunohistochemical profile compatible with *** selected treatment comprised retroperitoneum tumor resection in association with laparoscopic *** patient was discharged and remained stable after 4-mo follow-up;she remains under followup to check the need of cancer *** Schwannoma features requires surgical treatment based on laparoscopic resection,which often presents low relapse rates and optimistic prognosis.

关键词： Neurilemmoma Neoplasms Retroperitoneal space Laparoscopy Case report

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Time-Series Embeddings from Language Models:A Tool for Wind direction Nowcasting

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Journal of Meteorological Research 2024年第3期38卷 558-569页

作者： d.cio ALVES Fabio MENdONCA Sheikh Shanawaz MOSTAFA Fernando MORGAdO-dIAS University of Madeira Campus Universitário da Penteada9020-105FunchalPortugal Interactive Technologies Institute/Laboratory for Robotics and Engineering Systems and Agência Regional para o desenvolvimento da Investigação Tecnologia e InovaçãoEdif.Madeira TecnopoloCaminho da Penteada piso-29020-105FunchalPortugal

Wind direction nowcasting is crucial in various sectors,particularly for ensuring aviation operations and *** this context,the TELMo(Time-series Embeddings from Language Models)model,a sophisticated deep learning architecture,has been introduced in this work for enhanced wind-direction *** by using three years of data from multiple stations in the complex terrain of an international airport,TELMo incorporates the horizontal u(east-west)and v(north-south)wind components to significantly reduce forecasting *** a day with high wind direction variability,TELMo achieved mean absolute error values of 5.66 for 2-min,10.59 for 10-min,and 14.79 for 20-min forecasts,processed within a swift 9-ms/step *** degree-based analysis,in comparison,yielded lower performance,emphasizing the effectiveness of the u and v *** contrast,a Vanilla neural network,representing a shallow-learning approach,underperformed in all analyses,highlighting the superiority of deep learning methodologies in wind direction *** is an efficient model,capable of accurately forecasting wind direction for air traffic operations,with an error less than 20°in 97.49%of the predictions,aligning with recommended international *** model design enables its applicability across various geographical locations,making it a versatile tool in global aviation meteorology.

关键词： wind nowcasting wind components wind direction time series prediction deep learning

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