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Corneal collagen cross-linking in patients with keratoconus from the dresden protocol to customized solutions:theoretical basis

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 951-962页

作者： Ciro Caruso Luca d’Andrea Mario Troisi Michele Rinaldi Raffaele Piscopo Salvatore Troisi Ciro Costagliola Corneal Transplant Center Pellegrini HospitalVia Portamedina alla Pignasecca 41Napoli 80127Italy Eye Clinic Department of NeurosciencesReproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples 80131Italy Public Health department University of Naples Federico IINaples 80131Italy Salerno Hospital University Ophthalmologic UnitBaronissiCampania 84131Italy

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual *** therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced *** keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe *** consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks *** aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment ***,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

关键词： corneal collagen cross linking keratoconus custom fast protocol dresden protocol lambert-beer law Bunsen-roscoe law

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Interfacial stress engineering toward enhancement of ferroelectricity in Al doped HfO_(2)thin films

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Chinese Physics B 2024年第9期33卷 637-643页

作者： S X Chen M M Chen Y Liu d W Cao G J Chen department of Microelectronics Jiangsu UniversityZhenjiang 212013China department of Physics Jiangsu UniversityZhenjiang 212013China Guangdong–Hong Kong–Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversityFoshan 528225China

Ferroelectric HfO_(2)has attracted much attention owing to its superior ferroelectricity at an ultra-thin thickness and good compatibility with Si-based complementary metal-oxide-semiconductor(CMOS)***,the crystallization of polar orthorhombic phase(o-phase)HfO_(2)is less competitive,which greatly limits the ferroelectricity of the as-obtained ferroelectric HfO_(2)thin ***,the crystallization of o-phase HfO_(2)can be thermodynamically modulated via interfacial stress *** this paper,the growth of improved ferroelectric Al doped HfO_(2)(HfO_(2):Al)thin films on(111)-oriented Si substrate has been *** analysis has suggested that nonpolar monoclinic HfO_(2):Al grown on(111)-oriented Si substrate suffered from a strong compressive strain,which promoted the crystallization of(111)-oriented o-phase HfO_(2)in the as-grown HfO_(2):Al thin *** addition,the in-plane lattice of(111)-oriented Si substrate matches well with that of(111)-oriented o-phase HfO_(2),which further thermally stabilizes the o-phase HfO_(2).Accordingly,an improved ferroelectricity with a remnant polarization(2P_(r))of 26.7C/cm^(2) has been *** results shown in this work provide a simple way toward the preparation of improved ferroelectric HfO_(2)thin films.

关键词： improved ferroelectricity interfacial stress engineering compressive strain HfO_(2)

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PLCG2 Mutation in a Patient Presenting with Type 2 Autoimmune Hepatitis

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 685-687页

作者： Antoine Gardin Léa Gaigne Aude Magérus Frédéric Rieux-Laucat Emmanuel Jacquemin Pediatric Hepatology and Liver Transplantation Unit National Reference Centre for Inflammatory Diseases of the Bile Ducts and Autoimmune HepatitisFILFOIEERN RARE LIVERBicêtre HospitalAssistance Publique–Hôpitaux de ParisUniversity Paris-SaclayLe Kremlin-BicêtreFrance INSERM UMR 1193 HepatinovParis-Saclay UniversityOrsayFrance Laboratory of Immunogenetics of Pediatric Autoimmune diseases INSERM UMR 1163Imagine InstituteParis CitéUniversityParisFrance

The combination of defective immune tolerance and external triggers is thought to underlie the pathophysiology of autoimmune hepatitis.1,2 Some polymorphisms associated with susceptibility to autoimmune hepatitis have been reported,and some cases have been described in patients with monogenic primary immune deficiencies or systemic diseases.

关键词： autoimmune Autoimmune immune

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dynamic of Scalar Bosons in Aharonov-Bohm Magnetic Field

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Journal of Applied Mathematics and Physics 2024年第1期12卷 268-276页

作者： Frédéric d. Y. Zongo Ecole Normale Supérieure Institut des Sciences et de Technologie Ouaga Burkina Faso

We study the dynamic of scalar bosons in the presence of Aharonov-Bohm magnetic field. First, we give the differential equation that governs this dynamic. Secondly, we use variational techniques to show that the following Schrödinger-Newton equation: , where A is an Aharonov-Bohm magnetic potential, has a unique ground-state solution.

关键词： Scalar Boson Aharonov-Bohm Magnetic Field Schrödinger-Newton Equation Ground-State Solution

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Metabolomics for the diagnosis of bladder cancer: A systematic review

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Asian Journal of Urology 2024年第2期11卷 221-241页

作者： Herney Andrés García-Perdomo Angélica María dávila-Raigoza Fernando Korkes division of Urology/Urooncology Department of SurgerySchool of MedicineUniversidad del ValleCaliColombia UROGIV Research Group School of MedicineUniversidad del ValleCaliColombia Urologic Oncology Division of UrologyABC Medical SchoolSao PauloBrazil

Objective: Metabolomics has been extensively utilized in bladder cancer (BCa) research, employing mass spectrometry and nuclear magnetic resonance spectroscopy to compare various variables (tissues, serum, blood, and urine). This study aimed to identify potential biomarkers for early BCa ***: A search strategy was designed to identify clinical trials, descriptive and analytical observational studies from databases such as Medline, Embase, Cochrane Central Register of Controlled Trials, and Latin American and Caribbean Literature in Health Sciences. Inclusion criteria comprised studies involving BCa tissue, serum, blood, or urine profiling using widely adopted metabolomics techniques like mass spectrometry and nuclear magnetic resonance. Primary outcomes included description of metabolites and metabolomics profiling in BCa patients and the association of metabolites and metabolomics profiling with BCa diagnosis compared to control patients. The risk of bias was assessed using the Quality Assessment of Studies of diagnostic ***: The search strategy yielded 2832 studies, of which 30 case-control studies were included. Urine was predominantly used as the primary sample for metabolite identification. Risk of bias was often unclear inpatient selection, blinding of the index test, and reference standard assessment, but no applicability concerns were observed. Metabolites and metabolomics profiles associated with BCa diagnosis were identified in glucose, amino acids, nucleotides, lipids, and aldehydes ***: The identified metabolites in urine included citric acid, valine, tryptophan, taurine, aspartic acid, uridine, ribose, phosphocholine, and carnitine. Tissue samples exhibited elevated levels of lactic acid, amino acids, and lipids. Consistent findings across tissue, urine, and serum samples revealed downregulation of citric acid and upregulation of lactic acid, valine, tryptophan, taurine, glutamine, aspartic acid, uridine, rib

关键词： Metabolite Metabolomics Bladder cancer Metabolomicsprofile

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Temperature and structure measurements of heavy-ion-heated diamond using in situ X-ray diagnostics

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Matter and Radiation at Extremes 2024年第4期9卷 80-89页

作者： J.Lutgert P.Hesselbach M.Schorner V.Bagnoud R.Belikov P.drechsel B.Heuser O.SHumphries P.Katrik B.Lindqvist C.Qu R.Redmer d.Riley G.Schaumann S.Schumacher A.Tauschwitz d.Varentsov K.Weyrich X.Yu B.Zielbauer Zs.Major P.Neumayer d.Kraus Institut fur Physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GSI Helmholtzzentrum fur Schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany European XFEL GmbH Holzkoppel 422869 SchenefeldGermany Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helmholtz Institut Jena Frobelstieg 307743 JenaGermany

We present in situ measurements of spectrally resolved X-ray scattering and X-ray diffraction from monocrystalline diamond samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic structuralintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction measurements show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the Facility for Antiproton andIon Research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense structure

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data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“der Simulierte Mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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Nonlinear Coupling of Kinetic Alfvén Waves and Ion Acoustic Waves in the Inner Heliosphere

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Research in Astronomy and Astrophysics 2024年第10期24卷 141-158页

作者： Mani K.Chettri Vivek Shrivastav Rupak Mukherjee Nidhi Gaur R.P.Sharma Hemam d.Singh department of Physics Sikkim UniversityGangtokSikkimIndia dAV Public School Sector 14GurugramHaryanaIndia Plasma Simulation Laboratory Department of Energy Science and EngineeringIndian Institute of Technology DelhiDelhiIndia

We study the nonlinear coupling of kinetic Alfvén waves with ion acoustic waves applicable to the Earth’s radiation belt and near-Sun streamer belt solar wind using dynamical equations in the form of modified Zakharov *** simulations show the formation of magnetic field filamentary structures associated with density humps and dips which become turbulent at later times,redistributing the energy to higher *** magnetic power spectra exhibit an inertial range Kolmogorov-like spectral index value of-5/3 for k_(⊥)ρ_(i)d by a steeper dissipation range spectra with indices~-3 for the radiation belt case and~-4 for the nearSun streamer belt solar wind case,here k_(⊥)andρ_(i)represent the wavevector component perpendicular to the background magnetic field and the ion thermal gyroradius,*** quasilinear theory in terms of the Fokker-Planck equation in the region of wavenumber turbulent spectra,we find the particle distribution function flattening in the superthermal tail population which is the signature of particle energization and plasma heating.

关键词： Sun:chromosphere Sun:corona Sun:heliosphere

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Optimization of the Use of Spherical Targets for Point Cloud Registration Using Monte Carlo Simulation

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Journal of Geodesy and Geoinformation Science 2024年第2期7卷 18-36页

作者： CHAN Ting On XIAO Hang XIA Linyuan LICHTI derek d LI Ming Ho dU Guoming School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Urbanization and Geo-Simulation Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Engineering Research Center for Public Security and disasters Sun Yat-sen UniversityGuangzhou 510275China department of Geomatics Engineering Schulich School of EngineeringUniversity of CalgaryCalgary AB T2N 1N4Canada

Registrations based on the manual placement of spherical targets are still being employed by many professionals in the ***,the placement of those targets usually relies solely on personal experience without scientific evidence supported by numerical *** paper presents a comprehensive investigation,based on Monte Carlo simulation,into determining the optimal number and positions for efficient target placement in typical scenes consisting of a pair of *** demonstrates new check-up statistical rules and geometrical constraints that can effectively extract and analyze massive simulations of unregistered point clouds and their corresponding *** than 6×10^(7) sets of the registrations were simulated,whereas more than IOO registrations with real data were used to verify the results of *** results indicated that using five spherical targets is the best choice for the registration of a large typical registration site consisting of two vertical facades and a ground,when there is only a box set of spherical targets *** a result,the users can avoid placing extra targets to achieve insignificant improvements in registration *** results also suggest that the higher registration accuracy can be obtained when the ratio between the facade-to-target distance and target-to-scanner distance is approximately 3:***,the targets should be placed closer to the scanner rather than in the middle between the facades and the scanner,contradicting to the traditional thought. Besides,the results reveal that the accuracy can be increased by setting the largest projected triangular area of the targets to be large.

关键词： point cloud registration Monte Carlo simulation optimalization spherical target

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Paper Analytical device for the Colourimetric detection of Alkaline Phosphatase in Serum and Saliva

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Journal of Analysis and Testing 2024年第3期8卷 385-394页

作者： d.Alageswari A.Lakshmidevi P.E.Resmi P.V.Suneesh AarathiPradeep T.G.SatheeshBabu department of Chemistry Amrita School of Physical Sciences Coimbatore Amrita Vishwa Vidyapeetham Amrita Biosensor Research Lab Amrita School of Engineering Coimbatore Amrita Vishwa Vidyapeetham Amrita Biomedical Engineering Centre Amrita School of Engineering Coimbatore Amrita Vishwa Vidyapeetham

A paper analytical device (PAd) was developed for the colourimetric estimation of alkaline phosphatase (ALP). ALP catalyzes the hydrolysis of disodium phenyl phosphate (dSPP) to phenol, which then undergoes oxidative coupling with4-aminoantipyrine (4-AAP) producing a reddish brown-coloured quinone imine. The colourimetric reaction tested in solution has been translated onto a PAd for the point of care (PoC) testing of ALP. A uniform colour was obtained in 25 min with the introduction of ALP onto the reagent drop cast paper device. The images obtained by scanning the PAd were processed using ImageJ software. The colour intensity obtained by image processing was proportional to the concentration of ALP present in the sample. ALP in serum and saliva samples were tested using the PAd in the range of 0 to 528 U/L and0 to 187 U/L, respectively. The interference studies revealed that the PAd was selective to ALP in the presence of other biomolecules. The PAd exhibited a limit of detection (LOd) of 3.3 U/L and a sensitivity of 48.36 a.u/Log(U/L) for serum ALP and LOd of 1.69 U/L and a sensitivity of 28.5 a.u/Log (U/L) for salivary ALP. The PAd showed good agreement with the clinical methods for real samples.

关键词： Alkaline phosphatase Colourimetry ImageJ Paper analytical device Point of care testing

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