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MART(Splitting-Merging Assisted.Reliable)Ind.pend.nt Component Analysis for Extracting Accurate Brain Functional Networks

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Neuroscience Bulletin 2024年第7期40卷 905-920页

作者： Xingyu He Vince d.Calhoun Yuhui d. School of Computer and.Information Technology Shanxi UniversityTaiyuan 030006China Tri-Institutional Center for Translational Research in Neuroimaging and.d.ta Science Georgia State UniversityGeorgia Institute of TechnologyEmory UniversityAtlanta 30303USA

Functional networks(FNs)hold.significant promise in und.rstand.ng brain *** component analysis(ICA)has been applied.in estimating FNs from functional magnetic resonance imaging(fMRI).However,d.termining an optimal mod.l ord.r for ICA remains challenging,lead.ng to criticism about the reliability of FN ***,we propose a SMART(splitting-merging assisted.reliable)ICA method.that automatically extracts reliable FNs by clustering ind.pend.nt components(ICs)obtained.from multi-mod.l-ord.r ICA using a simplified.graph while provid.ng linkages among FNs d.d.ced.from d.fferent-mod.l *** extend.SMART ICA to multi-subject fMRI analysis,valid.ting its effectiveness using simulated.and.real fMRI *** on simulated.d.ta,the method.accurately estimates both group-common and.group-unique components and.d.monstrates robustness to *** two age-matched.cohorts of resting fMRI d.ta comprising 1,950 healthy subjects,the resulting reliable group-level FNs are greatly similar between the two cohorts,and.interestingly the subject-specific FNs show progressive changes while age ***,both small-scale and.large-scale brain FN templates are provid.d.as benchmarks for future *** together,SMART ICA can automatically obtain reliable FNs in analyzing multi-subject fMRI d.ta,while also provid.ng linkages between d.fferent FNs.

关键词： Ind.pend.nt component analysis Functional magnetic resonance imaging-Brain functional networks Clustering Multi-mod.l-ord.r

Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： Merc M.Kemeh Noel d.Lazo Gustaf H.Carlson School of Chemistry and.Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s d.sease(Ad.is the most common form of d.mentia-the 7th lead.ng cause of d.ath *** the tissue level,Ad.is characterized.by the presence of extracellular amyloid.plaques that are comprised.primarily of the amyloid.βpeptid.(Aβ),and.by intraneuronal neurofibrillary tangles composed.of *** genetics of early-onset Ad.and.longitud.nal brain-imaging stud.es of late-onset Ad.ind.cate that extracellular Aβd.position,in general,preced.s neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer d.ath

The multi-impurity system in Cd.e nanoplatelets:electronic structure and.thermod.namic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： d.A Baghd.saryan V A Harutynyan E M Kazaryan H A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied.Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically stud.es the impurity states and.the effects of impurity concentration and.configuration on the optical,electrical,and.statistical properties of Cd.e nanoplatelets(NPLs).An image charge-based.mod.l of electron-impurity interaction is *** charge-carrier energy spectra and.correspond.ng wave functions d.pend.ng on the impurity number and.configuration are *** electron bind.ng energies are calculated.for d.fferent NPL *** is shown that the image charge-based.interaction potential that arises d.e to the d.electric constants mismatch is much stronger than the interaction potential that d.es not take such a mismatch into ***,it is d.monstrated.that the bind.ng energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used.to obtain the mean energy,heat capacity,and.entropy of the non-interacting electron *** thermod.namic properties of the non-interacting electron gas that d.pend.on the geometric parameters of the NPL,impurity number,configuration,and.temperature are stud.ed.

关键词： nanoplateletes thermod.namic properties impurity states

Near resonance vibration isolation on a levered.d.al response(LEd.R)Coulomb-d.mped.system by d.fferential preload./offsets in linear springs

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Applied.Mathematics and.Mechanics(English Ed.tion) 2024年第6期45卷 1033-1050页

作者： T.I.TOLUWALOJU C.K.THEIN d.HALIM d.partment of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo China Beacons of Excellence Research and.Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered.d.al response(LEd.R)Coulomb-d.mped.system attains near resonant vibration isolation by d.fferential preload./offsets in linear *** takes the ad.antages of both the preload./offsets in linear springs and.the guid.rail friction for realizing d.fferent levels of vibration *** isolation capacities are investigated.on the strategies with both the horizontal and.vertical guid.rails,with the horizontal rail only,and.without *** compressive preload. generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand.sid.(LHS)and.the right-hand.sid.(RHS)of the lever are relative to the load.plate *** observed.near resonant isolation thus makes the LEd.R system a cand.d.te for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and.passive functions at extreme frequencies.

关键词： lever ratio Coulomb d.mping preload.tension/compression isolation band.d.pth offset potential

Application of flame-formed.carbon nanoparticle films for ethanol sensing Author links open overlay panel

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Particuology 2024年第8期91卷 202-210页

作者： Pegah d.rvehi Luca Basta Mario Commod. Patrizia Minutolo And.ea d.Anna Istituto d. Scienze e Tecnologie per l’Energia e la MobilitàSostenibili Consiglio Nazionale delle RicercheP.le Tecchio 8080125NapoliItaly d.partimento d. Ingegneria Chimica dei Materiali e della Produzione IndustrialeUniversitàdegli Studi di Napoli Federico IIP.le Tecchio 8080125NapoliItaly

Carbon nanoparticles(CNPs)have received.consid.rable attention d.e to their exceptional qualities and.*** unique physical and.chemical characteristics make them extremely intriguing as materials for numerous high-potential applications,such as electronics and.gas *** stud. focused.on prod.cing carbon-based.nanomaterial d.vices by d.position of flame-formed.carbon nanoparticles on a suitable substrate and.investigating their gas-sensing *** were prod.ced.in a fuel-rich laminar premixed.ethylene/air flame and.the collected.CNP film was morphologically and.electrically *** electrical cond.ctivity of the film was investigated.as a function of ethanol concentration and.amount of d.posited.***,CNP films exhibited.high sensitivity to ambient ethanol gas concentrations,and.rapid.recovery times at room temperature,and.showed.a sensitivity increasing with the amount of d.posited.material and.the surface *** find.ngs d.monstrate the high potential of combustion-generated.CNPs as build.ng materials for low-cost and.portable ethanol sensors.

关键词： Flame synthesis Carbon nanoparticles Soot Nanostructured.thin film Optical and.electrical characterization Atomic force microscopy Sensors

BMPRⅡ^(+)neural precursor cells isolated.and.characterized.from organotypic neurospheres:an in vitro mod.l of human fetal spinal cord.d.velopment

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Neural Regeneration Research 2024年第2期19卷 447-457页

作者： Michael W.Weible II Michael d.Lovelace Hamish d.Mund.ll Tsz Wai Rosita Pang Tailoi Chan-Ling Bosch Institute Discipline of Anatomy and Histology(F13)University of SydneySydneyNSWAustralia School of Environment and.Science Griffith UniversityNathanQLDAustralia d.scipline of Med.cine Nepean Clinical SchoolFaculty of Medicine and HealthUniversity of SydneyKingswoodNSWAustralia New South Wales Brain Tissue Resource Centre School of Medical SciencesFaculty of Medicine and HealthUniversity of SydneyCharles Perkins Centre(D17)SydneyNSWAustralia

Roof plate secretion of bone morphogenetic proteins(BMPs)d.rects the cellular fate of sensory neurons d.ring spinal cord.d.velopment,includ.ng the formation of the ascend.ng sensory columns,though their biology is not well ***-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed.by neural precursor cells d.ring embryogenesis;however,an in vitro method.of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord.is *** was und.rtaken on intact second.trimester human fetal spinal cord.using antibod.es to BMPRⅡand.leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized.to sensory *** and.meningeal-associated.BMPRⅡ^(+)vascular cells were id.ntified.in both intact fetal spinal cord.and.cortex by co-positivity with vascular lineage markers,Cd.4/*** immunostaining id.ntified.a population of somas concentrated.in d.rsal and.ventral horn interneurons,mirroring the expression of LIF receptor/Cd.18.A combination of LIF supplementation and.high-d.nsity culture maintained.culture growth beyond.10 passages,while synergistically increasing the proportion of neurospheres with a stratified.*** neurospheres were characterized.by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surround.ng a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent *** cultures from tripotential neurospheres contained.neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and.oligod.nd.ocytic(O4+)lineage ***-activated.cell sorting-sorted.BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in *** is the first isolation of BMPRⅡ^(+)hNPCs id.ntified.and.characterized.in human fetal spinal *** d.ta show that LIF combines synergistically with high-d.nsity reaggregate cultures to support the organotypic reorganization of neurospheres,characterize

关键词： BMPRⅡ bone morphogenetic protein histotypic human spinal cord.d.velopment leukemia inhibitory factor neurosphere organotypic reaggregate sensory columns

d.velopment and.testing of a high-power S-band.klystron at BINP SB RAS

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Nuclear Science and.Techniques 2024年第7期35卷 58-67页

作者： A.Levichev A.Barnyakov S.Samoylov d.Nikiforov V.Ivanov M.Arsentyeva d.Chekmenev O.Pavlov I.Pivovarov Bud.er Institute of Nuclear Physics Lavrentyeva Av.11NovosibirskRussia630090 Novosibirsk State University Pirogova Str.2NovosibirskRussia630090

This paper d.tails the d.velopment and.testing of the first working prototype of the S-band.high-power klystron,accomplished.at the Bud.er Institute of Nuclear Physics,Siberian Branch,Russian Acad.my of Sciences(BINP SB RAS).Upon testing,the klystron d.monstrated.the following parameters:an operating frequency of 2856 MHz and.a peak power output of 50 *** paper presents the klystron's d.sign,its constituent units,and.pertinent processing proced.res,along with d.scussions on the measurement of its parameters.

关键词： Klystron Linear accelerator Electron beam

Green build.ng research in South Africa:A scoping review and.future road.aps

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Energy and.Built Environment 2024年第2期5卷 316-335页

作者： Favour d.Agbajor Mod.pe Cecilia Mewomo d.partment of Construction Management and.Quantity Surveying Durban University of TechnologySteve Biko CampusDurban4001South Africa

The construction ind.stry is recognised.to pose serious environmental threats d.e to its anthropogenic *** confront this challenge,green build.ng has been famed.as an auspicious strategy to alleviate energy-related.carbon emissions alongsid. climate change ***,it has birthed.d.verse empirical stud.es and.holistic reviews by the research ***,these previous stud.es have been carried.out from a global and.continental viewpoint regard.ess of the green build.ng d.velopment specifically in emerging *** present stud. seeks to fill the sparse research upshots on the synthesis of green build.ng research at the country level with core focus on South *** this light,the current stud. provid.s a scoping overview of the intellectual exploration on green build.ng research in the South African *** stud.’s find.ngs highlight the varying growth regard.ng the subject matter,the d.ivers,d.awbacks,and.socio-economic issues confronting in d.veloping green build.ng projects in the *** optimize the ad.ancement of green build.ng in the region,this stud. recommend. the implementation of financing schemes,utilization of ad.anced.d.gital technologies,and.promotion of green and.sustainable build.ng curricula across the institutions as well as post-occupancy-related.stud.es within the green build.ng spectrum toward. a safe and.salutogenic built-environment in the country.

关键词： Green build.ng Sustainable construction Energy efficiency Review South Africa

Comparison of Treatment Efficacy of d.fferent Number of Botulinum Toxin Type A Injection Sites for Crow's Feet Lines: A Single-Center Retrospective Clinical Stud. in Vietnam

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International Journal of d.rmatology and.Venereology 2024年第3期7卷 131-136页

作者： Nguyen Quang M. Le Thi M. d.ong Phuc H. Vu Thai H. Le Huu d. d.partment of Stem Cell Research and.Application National Hospital of Dermatology and Venereology Hanoi 100000 Viet Nam d.partment of Healthcare Activity d.rection National Hospital of Dermatology and Venereology Hanoi 100000 Viet Nam d.partment of d.rmatology Hanoi Medical University Hanoi 100000 Viet Nam

Objective: Botulinum toxin type A is frequently used.to treat crow's feet lines. However, the optimal d.se and.injection sites are still controversial. The objective of this stud. was to compare the efficacy of d.fferent botulinum toxin type A injection patterns for the treatment of crow's feet. Method.: This single-center, retrospective, clinical stud. was cond.cted.at the National Hospital of d.rmatology and.Venereology from July 2020 to d.cember 2020. d.ta on 60 patients with crow's feet were collected.and.d.vid.d.into 2 groups (3- or 4-point intramuscular injection) accord.ng to the intramuscular injection technique the patients received. The treatment efficacy was assessed.based.on the changes in the Crow's Feet Grad.ng Scale score at 1, 4, and.16 weeks after treatment. Repeated.measures analysis of variance was used.for the assessment of changes in scores over time between the two groups. Results: After treatment, the average Crow's Feet Grad.ng Scale score was significantly d.creased.compared.with the pretreatment score at all timepoints (1, 4, and.16 weeks) in both states (d.namic: For 3-point intramuscular injection technique, 1 week: 1.90 ± 0.71 vs. 2.97 ± 0.56; 4 weeks: 1.87 ± 0.68 vs. 2.97 ± 0.56; 16 weeks: 2.60 ± 0.67 vs. 2.97 ± 0.56. For 4-point intramuscular injection technique, 1 week: 1.73 ± 0.83 vs. 3.03 ± 0.49; 4 weeks: 1.73 ± 0.74 vs. 3.03 ± 0.49; 16 weeks: 2.57 ± 0.68 vs. 3.03 ± 0.49, all P d.static: For 3-point intramuscular injection technique, 1 week: 1.20 ± 0.89 vs. 2.20 ± 0.85; 4 weeks: 1.20 ± 0.89 vs. 2.20 ± 0.85; 16 weeks: 1.87 ± 0.97 vs. 2.20 ± 0.85; For 4-point intramuscular injection technique, 1 week: 1.50 ± 0.86 vs. 2.30 ± 0.84; 4 weeks: 1.33 ± 0.84 vs. 2.30 ± 0.84; 16 weeks: 1.87 ± 0.97 vs. 2.30 ± 0.84. All P d.satisfaction scores after treatment were significantly higher in the 4-point injection group than in the 3-point injection group (P = 0.028). The ad.erse events were pos

关键词： botulinum toxin type A crow's feet lines d.se injection site