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Neuroendocrine tumor metastatic to the orbit treated with radiotherapy

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World Journal of Gastrointestinal Oncology 2013年第8期5卷 177-180页

作者： Renata d'Alpino Peixoto Howard John Lim winson Y Cheung department of Medical Oncology BC Cancer Agency

Neuroendocrine tumors are rare neoplasms that infrequently metastasize to the *** that patients with these tumors may have prolonged survival despite dissemination,maintaining quality of life by providing early diagnosis and effective treatment to preserve vision and comfort is a fundamental *** report the case of a79-year old woman who presented with well-differentiated metastatic neuroendocrine tumor to the liver with no carcinoid syndrome and was started on intramuscular long-acting octreotide with disease *** years later she developed right-sided diplopia associated with mild eye discomfort,proptosis and *** magnetic resonance imaging showed a 2.1 cm mass in the right orbit and further biopsy confirmed a neuroendocrine tumor *** patient was treated with a four-week course of stereotactic radiotherapy to the right orbital metastasis(4000 cGy in 20 fractions)with minor conjunctivitis as the only side *** months later,she remains well with no visual loss.

关键词： Neuroendocrine tumor Carcinoid tumor Orbital metastases diplopia Radiotherapy

Paradigm shift in gastrointestinal surgery−combating sarcopenia with prehabilitation:Multimodal review of clinical and scientific data

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World Journal of Gastrointestinal Surgery 2021年第8期13卷 734-755页

作者： Frederick H Koh Jason MW Chua Joselyn LJ Tan Fung-Joon Foo winson J Tan Sharmini S Sivarajah Leonard Ming Li Ho Bin-Tean Teh Min-Hoe Chew division of Surgery Sengkang General HospitalSingapore 544886Singapore Institute of Molecular and Cell Biology Agency for Science Technology and ResearchSingapore 138673Singapore duke-NUS Graduate Medical School National Cancer Centre SingaporeSingapore 169610Singapore

A growing body of evidence has demonstrated the prognostic significance of sarcopenia in surgical patients as an independent predictor of postoperative complications and *** included an increased risk of total complications,major complications,re-admissions,infections,severe infections,30 d mortality,longer hospital stay and increased hospitalization expenditures.A program to enhance recovery after surgery was meant to address these complications;however,compliance to the program since its introduction has been less than *** the last decade,the concept of prehabilitation,or"pre-surgery rehabilitation",has been *** presurgical period represents a window of opportunity to boost and optimize the health of an individual,providing a compensatory"buffer"for the imminent reduction in physiological reserve *** results have been *** review the literature to critically review the utility of prehabilitation,not just in the clinical realm,but also in the scientific realm,with a resource management point-of-view.

关键词： Sarcopenia Prehabilitation Surgery Frailty Value Gastrointestinal surgery

Prediction of overall survival following colorectal cancer surgery in elderly patients

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World Journal of Gastrointestinal Surgery 2019年第5期11卷 247-260页

作者： Isaac Seow-En winson Jianhong Tan Sreemanee Raaj dorajoo Sharon Hui Ling Soh Yi Chye Law Soo Yeun Park Gyu-Seok Choi Wah Siew Tan Choong Leong Tang Min Hoe Chew department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore department of General Surgery Sengkang General HospitalSingapore 544886Singapore department of Pharmacy National University of SingaporeSingapore 117559Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Colorectal Cancer Center Kyungpook National University Chilgok HospitalKyungpook National University School of MedicineDaegu 702-210South Korea

BACKGROUNd With advanced age and chronic illness,the life expectancy of a patient with colorectal cancer(CRC)becomes less dependent on the malignant disease and more on their pre-morbid *** major surgery for these elderly patients can be *** accurate tool demonstrating post-operative survival probability would be useful for surgeons and their *** To integrate clinically significant prognostic factors relevant to elective colorectal surgery in the elderly into a validated pre-operative scoring *** In this retrospective cohort study,patients aged 70 and above who underwent surgery for CRC at Singapore General Hospital between 1 January 2005 and 31 december 2012 were identified from a prospectively maintained *** with evidence of metastatic disease,and those who underwent emergency surgery or had surgery for benign colorectal conditions were excluded from the *** primary outcome was overall 3-year overall survival(OS)following surgery.A multivariate model predicting survival was derived and validated against an equivalent external surgical cohort from Kyungpook National University Chilgok Hospital,South *** analyses were performed using Stata/MP Version *** A total of 1267 patients were identified for *** median post-operative length of stay was 8[interquartile range(IQR)6-12]d and median follow-up duration was 47(IQR 19-75)*** OS was 78(IQR 65-85)*** multivariate analysis,the factors significant for predicting overall mortality were serum albumindL,serum carcinoembryonic antigen≥20μg/L,T stage 3 or 4,moderate tumor cell differentiation or worse,mucinous histology,rectal tumors,and pre-existing chronic obstructive lung *** age alone was not found to be *** Korean cohort consisted of 910 *** Singapore cohort exhibited a poorer OS,likely due to a higher proportion of advanced *** the clinicopathologic di

关键词： Colorectal cancer surgery Elderly Overall survival Pre-operative prognostic score

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荔枝蒂蛀虫室内饲养技术的研究

昆虫天敌 2007年第4期29卷 160-165页

作者：曾赞安梁广文华南农业大学资源环境学院

室内试验结果表明,利用荔枝种仁作为食物成功饲养荔枝蒂蛀虫至完成一世代。荔枝蒂蛀虫在荔枝、龙眼鲜果表皮产卵量较高,10 d产卵数分别为88.33和179.33粒/处理。蒂蛀虫卵散产在特制收卵卡的凹陷处且呈规则排列。选荔枝种仁作为其食物,... 详细信息

室内试验结果表明,利用荔枝种仁作为食物成功饲养荔枝蒂蛀虫至完成一世代。荔枝蒂蛀虫在荔枝、龙眼鲜果表皮产卵量较高,10 d产卵数分别为88.33和179.33粒/处理。蒂蛀虫卵散产在特制收卵卡的凹陷处且呈规则排列。选荔枝种仁作为其食物,并注入清水保持种仁的湿度,荔枝蒂蛀虫在角度90～150°折纸内化蛹,化蛹率和羽化率分别为33.67%和94.06%。

关键词：荔枝蒂蛀虫饲养技术荔枝种仁

Critical appraisal of laparoscopic vs open rectal cancer surgery

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World Journal of Gastrointestinal Surgery 2016年第6期8卷 452-460页

作者： winson Jianhong Tan Min Hoe Chew Angela Renayanti dharmawan Manraj Singh Sanchalika Acharyya Carol Tien Tau Loi Choong Leong Tang department of Colorectal Surgery Singapore General Hospital Centre for Qualitative Medicine DUKE NUS Graduate Medical School

AIM:To evaluate the long-term clinical and oncological outcomes of laparoscopic rectal resection(LRR) and the impact of conversion in patients with rectal ***:An analysis was performed on a prospective database of 633 consecutive patients with rectal cancer who underwent surgical *** were compared in three groups:Open surgery(OP),laparoscopic surgery,and converted laparoscopic ***-term outcomes,long-term outcomes,and survival analysis were ***:Among 633 patients studied,200 patients had successful laparoscopic resections with a conversion rate of 11.1%(25 out of 225).Factors predictive of survival on univariate analysis include the laparoscopic approach(P = 0.016),together with factors such as age,ASA status,stage of disease,tumor grade,presence of perineural invasion and vascular emboli,circumferential resection margin d postoperative adjuvant *** survival benefit of laparoscopic surgery was no longer significant on multivariateanalysis(P = 0.148).Neither 5-year overall survival(70.5% vs 61.8%,P = 0.217) nor 5-year cancer free survival(64.3% vs 66.6%,P = 0.854) were significantly different between the laparoscopic group and the converted ***:LRR has equivalent long-term oncologic out c ome s w he n c ompare d t o *** c opic conversion does not confer a worse prognosis.

关键词： Rectal cancer Laparoscopic Outcomes Conversion Prognosis