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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 7-8页

作者： Farina A. LeShane E.S. Romero R. d.w. bianchi 高雪莲 division of Genetics Tufts-New England Medical Center Box 394 750 Washington St Boston MA 02111 United States Dr

Objective: This study was conducted to determine whether there is a relationship between the concentration of fetal cell-free dNA in maternal serum and the duration of pregnancy in women who are at high risk for preterm delivery because of either preterm labor or preterm premature rupture of the membranes. Study design: Sera were collected and frozen from 71 women with a male fetus. Maternal serum fetal cell-free dNA concentration was measured.w.th the use of real-time polymerase chain reaction amplification of dYS1. Fetal cell-free dNA concentrations were converted to multiples of the median. The following groups were studied: group 1: women with preterm labor and intact membranes who were delivered at ≥ 36 weeks of gestation (n = 21); group 2: women with preterm labor who were delivered at weeks of gestation (n = 29); and group 3: women with preterm premature rupture of the membranes in labor (n = 20) or not in labor (n = 1) who were delivered prematurely ( weeks of gestation). Kaplan-Meier and Cox regression analyses were used to analyze the relationship between fetal cell-free dNA concentrations and the likelihood of preterm delivery. Results: A cut-off value for fetal cell-free dNA of 1.82 multiples of the median was chosen for analysis. The cumulative rate of early preterm delivery ( weeks of gestation) was significantly higher for women with fetal cell-free dNA concentrations of ≥ 1.82 multiples of the median than those with fetal cell-free dNA concentrations below this cut-off (45% [95% CI, 36% - 74% ] vs 18% [95% CI, 11% - 25% ]; P = .008]. The cumulative rate of preterm delivery ( weeks of gestation) was also significantly higher at ≥ 1.82 multiples of the median (73% [95% CI, 52% - 93% ] vs 66% [95% CI, 54% - 79% ]; P = .02). After adjustment for covariates, Cox analysis showed that fetal cell-free dNA at ≥ 1.82 multiples of the mechanisms of disease that are associated.w.th a mean hazard rate of delivery of 1.57 (P = .005). Conclusion

关键词：自然早产母体血清胎儿细胞 dNA 早产高危孕妇男性胎儿胎膜早破回归分析法共变量研究设计

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母体体重与妊娠中期母体循环中游离胎儿dNA水平负相关

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 48-49页

作者： wataganara T. Peter I. Messerlian G.M. d.w. bianchi 杨晓梅 division of Genetics Department of Pediatrics Tufts-New England Medical Center 750 Washin gton Street Boston MA 02111 United States Dr.

OBJECTIVE: Clinical applications of the analysis of cellfree fetal dNA in ma te rnal plasma and serum are expanding. However, use of fetal dNA during prenatal s creening requires knowledge of variables that might affect its levels in the mat ernal circulation. we conducted this study to estimate the effect of selected de mographic factors on fetal dNA levels in the first and second trimesters of preg nancy. METHOdS: we developed a database that included fetal dNA levels and clini cal information, such as maternal age, ethnicity, weight, and smoking history. w e measured fetal dNA levels in maternal plasma and serum using real-time quanti tative polymerase chain reaction amplification of a Y chromosome specific sequen ce. The fetal dNA data from fresh first trimester plasma and previously frozen s econd trimester serum samples were analyzed separately. Fetal dNA levels were ad justed according to gestational age and storage time and then analyzed in associ ation with the demographic factors. RESULTS: In the first trimester group, no si gnificant association between maternal age, weight, ethnic background, or smokin g and plasma fetal dNA lev els was observed. In the second trimester group, a significant inverse correla tion between maternal weight and serum fetal dNA level was demonstrated (r = -0 .26, P = .007). This was especially prominent when the mothers weighed more than 170 lb (P = .001). Maternal age, ethnicity, and smoking were not significantly associated.w.th the second trimester serum fetal dNA levels. CONCLUSION: Fetal d NA levels are affected by maternal weight in the second trimester. A correction for this effect may be needed in larger-scale studies or for future clinical ap plications that measure cell-free fetal nucleic acids in maternal circulation.

关键词：妊娠中期负相关 dNA 产前筛查妊娠早期血浆样本临床信息人口统计学储存时间联合分析

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse w.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented.w.th a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received.w.ekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received.w.ekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated.w.th adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

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Probing Cu diffusion Barrier Layers on Porous Low-dielectric-Constant Films by Posireonium Annihilation Lifetime Spectroscopy

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Chinese Physics Letters 2005年第11期22卷 2906-2909页

作者：胡一帆 SUN Jia-Ning Gidley d.w. department of Physics Huazhong University of Science and Technology Wuhan 430074 department of Physics University of Michigan Ann Arbor MI 48109 USA

Two kinds of Cu diffusion barrier layers, sealed films and capped films, on nanoporous low-dielectric-constant films are investigated by positronium annihilation lifetime spectroscopy （PALS）. we have found that the minimum thickness of Ta to form an effective diffusion barrier is affected by the pore size. The films with large pores require thick barrier layers to form effective diffusion barriers. In addition, a possible ultra-thin diffusion barrier, i.e. a plasma-induced densification layer, has also been investigated. The PALS data confirm that a porous low-dielectric-constant thin film can be shrunk by exposure to plasma. This shrinkage is confined to a surface layer of collapsed pores and forms a dense layer. The dense layer tends to behave as Ps （positronium） diffusion barriers. Indeed, the controlled thin “skin” layer could prevent Cu diffusion into the underlying dielectrics.

关键词： THIN-FILMS

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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

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SCALING PROPERTIES OF INTERFACES IN CRYSTALS UNdER NONEQUILIBRIUM CONdITIONS

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Acta Metallurgica Sinica(English Letters) 1997年第5期10卷 415-418页

作者： Shi, d.w. Huang, J.Y. Long, Q.w. Inst of Metal Research Chinese Acad of Sciences Shenyang China

An equation of Langevin type was proposed to describe the interface evolution in crystals under nonequilibrium conditions (such as in Cu-Fe or Cu-Co system upon ball milling). The scaling properties (H) of this equation is in good agreement with the Monte Carlo simulations described by Bellon and Averback. In this equation the volume diffusion and interface diffusion are all important and this is consistent with some experimental results.

关键词： Ball milling Binary alloys Crystals Mathematical models Nanostructured materials Surface roughness

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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead department of Surgery University of TorontoTorontoONCanada donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged.w.th important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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