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Multitarget thiol-Activated tetrapyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer therapy

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CCS Chemistry 2024年第3期6卷 783-797页

作者： Xue-Quan Zhou Selda Abyar Imma Carbo-Bague Lan Wang Sebastian türck Maxime ASiegler Uttara Basu Ingo Ott Rongfang Liu Adriaan PIJzerman Sylvestre Bonnet Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055 Leiden Institute of Chemistry Leiden University2333 CC Leiden department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6 Institute of Medicinal and Pharmaceutical Chemistry Technische Universität Braunschweig38106 Braunschweig department of Chemistry Johns Hopkins UniversityBaltimoreMaryland 21218 division of drug discovery&Safety Leiden Academic Centre for Drug ResearchLeiden University2333 CC Leiden

Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase(trxR)inhibition,which disturbs the redox balance of cancer ***,in this model,the role of the ligand(s)coordinated to gold is often *** this work,we present a series of tetrapyridyl Au(Ⅲ)complexes that exhibit thiol-induced release of a Au(Ⅰ)ion and a tetrapyridyl *** formation of a free Au(Ⅰ)center is responsible for the expected trxR ***,the released ligand,which was visible in cells due to its intense blue fluorescence,showed excellent binding properties to the hERG potassium ***,these ligands ended up in the lysosomes,resulting in significant lysosome ***,the Au(Ⅲ)complexes presented in this work showed broad-spectrum anticancer properties,both in hypoxic 2d monolayers and 3d tumor *** suggest that the interaction of the released Au(Ⅰ)center and the tetrapyridyl ligand with two different protein targets may combine into prodrugs that overcome hypoxia-induced drug deactivation.

关键词： anticancer Au(Ⅲ)complexes enzyme inhibtion potassium channel affinity lysosome damage cell imaging prodrug

Structural effects induced by dialysis-based purification of carbon nanomaterials

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Nano Materials Science 2024年第4期6卷 475-483页

作者： A.d.Veloso A.M.Ferraria A.M.Botelho do Rego A.S.Viana A.J.S.Fernandes A.J.Fielding R.A.Videira M.C.Oliveira CQ-VR and Chemistry department University of Trás-os-Montes e Alto Douro BSIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa Centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physics department University of AveiroCampus de Santiago Faculty of Science Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUIMtE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking structures of small nanoparticles （d ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic resonance （EPR） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na+ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon Surface functionalization NMR XPS Hydrophilic carbon Paramagnetic

Cryptographic Lightweight Encryption Algorithm with dimensionality Reduction in Edge Computing

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Computer Systems Science & Engineering 2022年第9期42卷 1121-1132页

作者： d.Jerusha t.Jaya CSI Institute of technology NagercoilIndia

Edge Computing is one of the radically evolving systems through generations as it is able to effectively meet the data saving standards of consumers,providers and the workers. Requisition for Edge Computing based items havebeen increasing tremendously. Apart from the advantages it holds, there remainlots of objections and restrictions, which hinders it from accomplishing the needof consumers all around the world. Some of the limitations are constraints oncomputing and hardware, functions and accessibility, remote administration andconnectivity. there is also a backlog in security due to its inability to create a trustbetween devices involved in encryption and decryption. this is because securityof data greatly depends upon faster encryption and decryption in order to transferit. In addition, its devices are considerably exposed to side channel attacks,including Power Analysis attacks that are capable of overturning the *** space and the ability of it is one of the most challenging tasks. toprevail over from this issue we are proposing a Cryptographic LightweightEncryption Algorithm with dimensionality Reduction in Edge Computing. thet-distributed Stochastic Neighbor Embedding is one of the efficient dimensionality reduction technique that greatly decreases the size of the non-linear data. thethree dimensional image data obtained from the system, which are connected withit, are dimensionally reduced, and then lightweight encryption algorithm isemployed. Hence, the security backlog can be solved effectively using thismethod.

关键词： Edge computing(e.g) dimensionality reduction(dr) t-distributed stochastic neighbor embedding(t-sne) principle component analysis(pca)

StCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov d.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.t.Chao d.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng t.G.Cheng J.P.dai L.Y.dai X.C.dai d.dedovich A.denig I.denisenko J.M.dias d.Z.ding L.Y.dong W.H.dong V.druzhinin d.S.du Y.J.du Z.G.du L.M.duan d.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.t.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong t.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou t.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.t.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li d.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li t.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.t.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin d.X.Lin X.S.Lin B.J.Liu C.W.Liu d.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu t.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo t.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde d.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin t.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

the superτ-charm facility(StCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** StCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** StCF project in China is under development with an extensive R&d *** document presents the physics opportunities at the StCF,describes conceptual designs of the StCF detector system,and discusses future plans for detector R&d and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity StCF detector conceptual design

前言:青藏高原及其周边综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 911-914页

作者：沈树忠丁林朱茂炎王向东邓涛南京大学地球科学与工程学院关键地球物质循环前沿科学中心内生金属成矿机制研究国家重点实验室南京210023 中国科学院青藏高原研究所青藏高原地球系统全国重点实验室北京100101 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学地球与行星科学学院北京100049 中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物演化与人类起源重点实验室北京100044

青藏高原研究对揭示地史时期全球构造、古地理、生物与环境等的演化都具有举足轻重的作用.文章介绍了“青藏高原及其周边综合地层、生物群与古地理演化”专辑的组织背景、主要内容和期望目标,同时总结了本专辑成果相比第一次青藏高原科... 详细信息

青藏高原研究对揭示地史时期全球构造、古地理、生物与环境等的演化都具有举足轻重的作用.文章介绍了“青藏高原及其周边综合地层、生物群与古地理演化”专辑的组织背景、主要内容和期望目标,同时总结了本专辑成果相比第一次青藏高原科考报告的显著进展.

关键词：期望目标生物群全球构造生物与环境青藏高原周边

Mechanical and thermal postbuckling of FGM thick circular cylindrical shells reinforced by FGM stiffener system using higher-order shear deformation theory

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Applied Mathematics and Mechanics(English Edition) 2017年第1期38卷 73-98页

作者： d.V.dUNG H.t.tHIEM Faculty of Mathematics Mechanics and InformaticsVietnam National UniversityHanoi 100000Vietnam

the postbuckling of the eccentrically stiffened circular cylindrical shells made of functionally graded materials （FGMs）, subjected to the axial compressive load and external uniform pressure and filled inside by the elastic foundations in the thermal environments, is investigated with an analytical method. the shells are reinforced by FGM stringers and rings. the thermal elements of the shells and stiffeners in the fundamental equations are considered. the equilibrium and nonlinear stability equations in terms of the displacement components for the stiffened shells are derived with the third-order shear deformation theory and Leckhniskii smeared stiffener technique. the closed-form expressions for determining the buckling load and postbuckling load-deflection curves are obtained with the Galerkin method. the effects of the stiffeners, the foundations, the material and dimensional parameters, and the pre-existent axial compressive and thermal load are considered.

关键词： stiffened cylindrical shell functionally graded material (FGM) postbuck- ling elastic foundation analytical

A New Proof for Congruent Number’s Problem via Pythagorician divisors

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Advances in Pure Mathematics 2024年第4期14卷 283-302页

作者： Léopold dèkpassi Keuméan François Emmanuel tanoé UFR Mathematics and Computer Science F&#233lix Houphou&#235t Boigny University Abidjan Cote d&#8217Ivoire

Considering Pythagorician divisors theory which leads to a new parameterization, for Pythagorician triplets ( a,b,c )∈ ℕ 3∗ , we give a new proof of the well-known problem of these particular squareless numbers n∈ ℕ ∗ , called congruent numbers, characterized by the fact that there exists a right-angled triangle with rational sides: ( A α ) 2 + ( B β ) 2 = ( C γ ) 2 , such that its area Δ= 1 2 A α B β =n;or in an equivalent way, to that of the existence of numbers U 2 , V 2 , W 2 ∈ ℚ 2∗ that are in an arithmetic progression of reason n;Problem equivalent to the existence of: ( a,b,c )∈ ℕ 3∗ prime in pairs, and f∈ ℕ ∗ , such that: ( a−b 2f ) 2 , ( c 2f ) 2 , ( a+b 2f ) 2 are in an arithmetic progression of reason n;And this problem is also equivalent to that of the existence of a non-trivial primitive integer right-angled triangle: a 2 + b 2 = c 2 , such that its area Δ= 1 2 ab=n f 2 , where f∈ ℕ ∗ , and this last equation can be written as follows, when using Pythagorician divisors: (1) Δ= 1 2 ab= 2 S−1 d e ¯ ( d+ 2 S−1 e ¯ )( d+ 2 S e ¯ )=n f 2;Where ( d, e ¯ )∈ ( 2ℕ+1 ) 2 such that gcd( d, e ¯ )=1 and S∈ ℕ ∗ , where 2 S−1 , d, e ¯ , d+ 2 S−1 e ¯ , d+ 2 S e ¯ , are pairwise prime quantities (these parameters are coming from Pythagorician divisors). When n=1 , it is the case of the famous impossible problem of the integer right-angled triangle area to be a square, solved by Fermat at his time, by his famous method of infinite descent. We propose in this article a new direct proof for the numbers n=1 (resp. n=2 ) to be non-congruent numbers, based on an particular induction method of resolution of Equation (1) (note that this method is efficient too for general case of prime numbers n=p≡a ( ( mod8 ) , gcd( a,8 )=1 ). to prove it, we use a classical proof by induction on k , that shows the non-solvability property of any of the following systems ( t=0 , corresponding to case n=1 (resp. t=1 , corresponding to case n=2 )): ( Ξ t,k ){ X 2 + 2 t ( 2 k Y ) 2 = Z 2 X 2 + 2

关键词： Prime Numbers-diophantine Equations of degree 2 & 4 Factorization Greater Common divisor Pythagoras Equation Pythagorician triplets Congruent Numbers Inductive demonstration Method Infinite descent BSd Conjecture

Model with strong γ_4 t-violation

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Chinese Physics C 2008年第12期32卷 939-944页

作者： R. Friedberg t. d. Lee Physics department Columbia University New York NY 10027 U.S.A. China Center of Advanced Science and technology (CCASt/World Lab.) P.O. Box 8730

eAbstract We extend the t violating model of the paper on ＂Hidden symmetry of the CKM and neutrinomapping matrices＂ by assuming its t-violating phases X↑ and X↓ to be large and the same, with X = X↑ = X↓. In this case, the model has 9 real parameters： at, α↑,β↑,ξ↑,η↑t for the t-quark sector, α↓,β↓,ξ↓,η↓, for the sector and a common X- We examine whether these nine parameters are compatible with ten observables： the six quark masses and the four real parameters that characterize the CKM matrix （i.e., the Jarlskog invariant and three Eulerian angles）. We find.t.at this is possible only if the t violating phase X is large, between -120^o to -135^o. In this strong t violating model, the smallness of theJarlskog invariant 3 × 10^-5 ismainly accounted for by the large heavy quark masses, with mc/mt〈ms/mb≈0.02, as well as the near completeoverlap of t and b quark, with （c｜b）=-0.04.

关键词： Jarlskog invariant CKM matrix strong γ4 t-violation

dispersion of Axisymmetric Longitudinal Waves in A Bi-Material Compound Solid Cylinder Made of Viscoelastic Materials

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Computers, Materials & Continua 2016年第2期51卷 105-143页

作者： S.d.Akbarov t.Kocal t.Kepceler department of Mechanical Engineering Yildiz Technical UniversityYildiz Campus34349BesiktasIstanbulTurkey Institute of Mathematics and Mechanics of the National Academy of Sciences of Azerbaijan 37041BakuAzerbaijan department of Marine Engineering Operations Yildiz Campus34349 BesiktasIstanbulTurkey

the paper studies the dispersion of axisymmetric longitudinal waves in the bi-material compound circular cylinder made of linear viscoelastic *** investigations are carried out within the scope of the piecewise homogeneous body model by utilizing the exact equations of linear *** corresponding dispersion equation is derived for an arbitrary type of hereditary operator and the algorithm is developed for its numerical *** numerical results are obtained for the case where the relations of the constituents of the cylinder are described through fractional exponential *** influence of the viscosity of the materials of the compound cylinder on the wave dispersion is studied through the rheological parameters which indicate the characteristic creep time and long-term values of the elastic constants of these *** curves are presented for certain selected dispersive and non-dispersive attenuation cases under various values of the problem parameters and the influence of the aforementioned rheological parameters on these curves is *** a result of the numerical investigations,in particular,it is established.t.at in the case where the rheological parameters of the components of the compound cylinder are the same,the viscosity of the layers’materials causes the axisymmetric wave propagation velocity to decrease.

关键词： Characteristic creep time Viscoelastic material Wave dispersion Bi-material compound solid cylinder Wave attenuation