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Assessing tectonic influence on landscape evolution:case study of the Nandakini Watershed,Western Himalaya

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Journal of Mountain Science 2025年第2期22卷 666-680页

作者： Rakesh SINGH Pranati sahu Shalini KUMARI Vishal CHAUHAN department of Petroleum Engineering and Earth Sciences Graphic Era(Deemed to be University)Dehradun 248002India School of Basic and Applied Sciences SGRR UniversityDehradun 248001India Graphic Era Hill University Dehradun 248002India

Understanding the active tectonic processes in the Nandakini Watershed is imperative for evaluating geological hazards and seismic risks,as well as for informing land-use planning and natural resource management strategies in the *** geomorphology serves as a vital tool for characterizing recent tectonic *** research employs GIS techniques to elucidate tectonic activity and its influence on drainage patterns in the Nandakini Watershed,utilizing morphometric parameters derived from SRTM dEM *** indices are employed to assess the tectonic movement within drainage basins,capturing both areal and linear factors such as drainage density,texture,circulatory and bifurcation ratios,and stream length *** linear and areal morphometric indices are categorized into three classes representing varying degrees of active tectonic *** classifications are then utilized to compute the relative active tectonic index(IRAT).In addition,geomorphic parameters include hypsometric integral,stream length-gradient index,normalized steepness index,chi gradient index,and swath *** majority of the studied region is in an extremely high to moderately active tectonic ***-scale faults and thrusts within the basins are closely correlated with these zones that have been *** integrated methodology of GIS-based morphometric analysis and geomorphic study enables the identification of deformed landforms associated with ongoing tectonic ***,these results offer valuable insights for informing watershed management strategies and promoting sustainable land use planning initiatives.

关键词： Nandakini Watershed Morphotectonic indices Steepness indices Active tectonics Relative active tectonic index(IRAT)

QM/MM Based Study of Electronic Structure of Platinum dihalides

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Open Journal of Applied Sciences 2025年第1期15卷 305-328页

作者： Anil Kumar Soni Swati Vishnu Kumar sahu department of Chemistry Shia Post Graduate College Lucknow India Academy of Scientific and Innovative Research NPL Chemical and Food BND Division CSIR-National Physical Laboratory New Delhi India department of Chemistry Maharani Lal Kunwari Post Graduate College Balrmpur India

In this research work, atomic and molecular orbitals based analysis has been made to see electronic structure of platinum halides (platinum dichloride, platinum dibromide, platinum diiodide and platinum difluride). The geometry optimization and three dimensional (3d) modeling of the above mentioned species have been made on CAChe pro software. The results show: (i) The involvement of three p atomic orbitals is negligible as their summation values are very low in comparison to d orbital and considerably low with respect to s orbital. (ii) The study well support the Landis concepts of sdn-hybridation (here n = 1) as bond angle and contributions of s-orbital and d-orbital of Pt(II) are maximum with negligible contribution of p-orbitals. (iii) These halides also support the cloud-expanding effect with experimental data and also follow the nephelauxetic effect. The result is in good agreement with experiment results that covalent character increases in the order: PtI2 > PtBr2 > PtCl2 > PtF2. (iv) And thus the study will help to fine tune the existing complexes of these halides.

关键词： Platinum dhalides Mulliken Population Analysis sd-Hybridization Molecular Orbital diagram

Alcohol and alcoholism associated neurological disorders:Current updates in a global perspective and recent recommendations

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World Journal of Experimental Medicine 2025年第1期15卷 24-40页

作者： Prashanti sahu Henu Kumar Verma LVKS Bhaskar department of Zoology GGU BilaspurBilaspur 495009ChhattīsgarhIndia department of Lung Health and Immunity Helmholtz Zentrum MunichMunich 85764BayrenGermany department of Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattīsgarhIndia

Alcohol use disorder(AUd)is a medical condition that impairs a person's ability to stop or manage their drinking in the face of negative social,occupational,or health *** is defined by the National Institute on Alcohol Abuse and Alcoholism as a"severe problem".The central nervous system is the primary target of alcohol's adverse *** is crucial to identify various neurological disorders associated with AUd,including alcohol withdrawal syndrome,Wernicke-Korsakoff syndrome,Marchiafava-Bignami disease,dementia,and *** gain a better understanding of the neurological environment of alcoholism and to shed light on the role of various neurotransmitters in the phenomenon of alcoholism.A comprehensive search of online databases,including PubMed,EMBASE,Web of Science,and Google Scholar,was conducted to identify relevant *** neurotransmitters(dopamine,gammaaminobutyric acid,serotonin,and glutamate)have been linked to alcoholism due to a brain *** appears to be a complex genetic disorder,with variations in many genes influencing *** of these genes have been identified,including two alcohol metabolism genes,alcohol dehydrogenase 1B gene and aldehyde dehydrogenase 2 gene,which have the most potent known effects on the risk of *** degeneration and demyelination in people with AUd may be caused by neuronal damage,nutrient deficiencies,and blood brain barrier dysfunction;however,the underlying mechanism is *** review will provide a detailed overview of the neurobiology of alcohol addiction,followed by recent studies published in the genetics of alcohol addiction,molecular mechanism and detailed information on the various acute and chronic neurological manifestations of alcoholism for the Future research.

关键词： Alcohol Alcoholism Neurotransmitter Neurological disorders Alcohol metabolism

Tailored design of novel Co0-Coδ+dual phase nanoparticles for selective CO2 hydrogenation to ethanol

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Journal of Environmental Sciences 2025年第3期149卷 598-615页

作者： Subhasis das Ganapati d.Yadav department of Chemical Engineering Institute of Chemical TechnologyNathalal Parekh MargMatunga 400019MumbaiIndia

Catalytic hydrogenation of CO_(2)to ethanol is a promising solution to address the greenhouse gas(GHG)emissions,but many current catalysts face efficiency and cost *** based catalysts are frequently examined due to their abundance,cost-efficiency,and effectiveness in the reaction,where managing the Co^(0)to Co^(δ+)ratio is *** this study,we adjusted support nature(Al_(2)O_(3),MgO-MgAl_(2)O_(4),and MgO)and reduction conditions to optimize this balance of Co^(0)to Co^(δ+)sites on the catalyst surface,enhancing ethanol *** selectivity of ethanol reached 17.9%in a continuous flow fixed bed micro-reactor over 20 mol%Co@MgO-MgAl_(2)O_(4)(CoMgAl)catalyst at 270°C and 3.0 MPa,when reduced at 400°C for 8 *** results coupled with activity analysis confirmed that mild reduction condition(400°C,10%H_(2)balance N_(2),8 h)with intermediate metal support interaction favoured the generation of partially reduced Co sites(Co^(δ+)and Co^(0)sites in single atom)over MgO-MgAl_(2)O_(4)surface,which promoted ethanol synthesis by coupling of dissociative(CHx^(∗))/non-dissociative(CHxO^(∗))intermediates,as confirmed by density functional theory ***,the CoMgAl,affordably prepared through the coprecipitation method,offers a potential alternative for CO_(2)hydrogenation to yield valuable chemicals.

关键词： CO_(2)hydrogenation Ethanol Co-based catalysts Metal support ineraction dFT analysis

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

From Imperfection to Perfection: Advanced 3d Facial Reconstruction Using MICA Models and Self-Supervision Learning

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1459-1479页

作者： Thinh d.Le duong Q.Nguyen Phuong d.Nguyen H.Nguyen-Xuan CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Research on reconstructing imperfect faces is a challenging *** this study,we explore a data-driven approach using a pre-trained MICA(MetrIC fAce)model combined with 3d printing to address this *** propose a training strategy that utilizes the pre-trained MICA model and self-supervised learning techniques to improve accuracy and reduce the time needed for 3d facial structure *** results demonstrate high accuracy,evaluated by the geometric loss function and various statistical *** showcase the effectiveness of the approach,we used 3d printing to create a model that covers facial *** findings indicate that our method produces a model that fits well and achieves comprehensive 3d facial *** technique has the potential to aid doctors in treating patients with facial injuries.

关键词： 3d face reconstruction self-supervised learning face defect 3d printed prototypes

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Finding the balance: Modifying the cholesterol and steroidal glycoalkaloid synthesis pathway in tomato(Solanum lycopersicum L.) for human health, fruit flavor, and plant defense

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Horticultural Plant Journal 2025年第1期11卷 42-56页

作者： Vincenzo Averello IV Adrian d.Hegeman Changbin Chen department of Horticultural Science University of Minnesota1970 Folwell AvenueSt.PaulMN 55108USA School of Life Sciences Arizona State University427 E Tyler MalTempeAZ 85287USA

Unlike most plants, members of the genus Solanum produce cholesterol and use this as a precursor for steroidal glycoalkaloids. The production of the compounds begins as a branch from brassinosteroid biosynthesis, which produces cholesterol that is further modified to produce steroidal glycoalkaloids. during the cholesterol biosynthesis pathway, genetic engineering could alter the formation of cholesterol from provitamin d3(7-dehydrocholesterol) and produce vitamin d3. Cholesterol is a precursor for many steroidal glycoalkaloids, including a-tomatine and esculeoside A. Alpha-tomatine is consumed by mammals and it can reduce cholesterol content and improve LdL:HdL ratio. When there is a high a-tomatine content, the fruit will have a bitter flavor, which together with other steroidal glycoalkaloids serving as protective and defensive compounds for tomato against insect, fungal, and bacterial pests. These compounds also affect the rhizosphere bacteria by recruiting beneficial bacteria. One of the steroidal glycoalkaloids, esculeoside A increases while fruit ripening. This review focuses on recent studies that uncovered key reactions of the production of cholesterol and steroidal glycoalkaloids in tomato connecting to human health, fruit flavor, and plant defense and the potential application for tomato crop improvement.

关键词： Cholesterol Steroidal glycoalkaloids Tomato Biosynthesis a-tomatine Sterols Terpenoids Plant defense