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Characterization and performance of the Apollon short-focal-area facility following its commissioning at 1 PW level

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Matter and Radiation at Extremes 2021年第6期6卷 12-25页

作者： K.Burdonov A.Fazzini V.Lelasseux J.Albrecht P.Antici Y.Ayoul A.Beluze d.Cavanna T.Ceccotti M.Chabanis A.Chaleil S.N.Chen Z.Chen F.Consoli M.Cuciuc X.davoine J.P.delaneau E.d’Humieres J.-L.dubois C.Evrard E.Filippov A.Freneaux P.Forestier-Colleoni L.Gremillet V.Horny L.Lancia L.Lecherbourg N.Lebas A.Leblanc W.Ma L.Martin F.Negoita J.-L.Paillard d.papadopoulos F.Perez S.Pikuz G.Qi F.Quere L.Ranc P.-A.Soderstrom M.Sciscio S.Sun S.Vallieres P.Wang W.Yao F.Mathieu P.Audebert J.Fuchs LULI–CNRS CEASorbonne UniversiteEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Universite Observatoire de ParisUniversite PSLCNRSLERMAF-75005 ParisFrance IAP Russian Academy of Sciences603155 Nizhny NovgorodRussia INRS-EMT 1650Boulevard Lionel-BouletVarennesQuebec J3X 1S2Canada Universite Paris-Saclay CEACNRSLIDYL91191Gif-sur-YvetteFrance Universite Paris-Saclay CEALMCE91680 Bruy`eres-le-ChˆatelFrance “Horia Hulubei”National Institute for Physics and Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania ENEA Fusion and Technologies for Nuclear Safety DepartmentC.R.FrascatiVia E.Fermi 4500044 FrascatiItaly University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance Joint Institute for High Temperatures RAS125412 MoscowRussia Laboratoire d’Optique Appliquee Ecole Polytechnique–ENSTA–CNRS–Institut Polytechnique de ParisPalaiseauFrance State Key Laboratory of Nuclear Physics and Technology School of PhysicsCAPTPeking UniversityBeijing 100871China Laboratoire Charles Fabry Institut d’Optique Graduate SchoolCNRSUniversite Paris-Saclay91127 Palaiseau CedexFrance

We present the results of the first commissioning phase of the short-focal-length area of the Apollon laser facility(located in Saclay,France),which was performed with the first available laser beam(F2),scaled to a nominal power of 1 *** the conditions that were tested,this beam delivered on-target pulses of 10 J average energy and 24 fs *** diagnostics were fielded to assess the performance of the *** on-target focal spot and its spatial stability,the temporal intensity profile prior to the main pulse,and the resulting density gradient formed at the irradiated side of solid targets have been thoroughly characterized,with the goal of helping users design future *** of energetic electrons,ions,and electromagnetic radiation were recorded,showing good laser-to-target coupling efficiency and an overall performance comparable to that of similar international *** will be followed in 2022 by a further commissioning stage at the multipetawatt level.

关键词： performance beam nominal

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Role of innovative 3d printing models in the management of hepatobiliary malignancies

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World Journal of Hepatology 2019年第7期11卷 574-585页

作者： Peter Bangeas Vassilios Tsioukas Vasileios N papadopoulos Georgios Tsoulfas department of Surgery Aristotle University of ThessalonikiThessaloniki 54124Greece department of School of Rural and Surveying Engineering Aristotle University of ThessalonikiThessaloniki 54124Greece

Three-dimensional (3d) printing has recently emerged as a new technique in various liver-related surgical fields. There are currently only a few systematic reviews that summarize the evidence of its impact. In order to construct a systematic literature review of the applications and effects of 3d printing in liver surgery, we searched the PubMed, Embase and Sciencedirect databases for relevant titles, according to the PRISMA statement guidelines. We retrieved 162 titles, of which 32 met the inclusion criteria and are reported. The leading application of 3d printing in liver surgery is for preoperative planning. 3d printing techniques seem to be beneficial for preoperative planning and educational tools, despite their cost and time requirements, but this conclusion must be confirmed by additional randomized controlled trials.

关键词： Three-dimensional printing Three-dimensional models Liver Surgery Hepatic phantom models

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 101-109页

作者： Mariarosaria d'Amato Gennaro Iengo Nicola Massa Chiara Carlomagno department of Oncology Ospedale San Rocco ASL CasertaSessa Aurunca 81037CampaniaItaly department of Clinical Medicine and Surgery University of Naples Federico IINaples 80131CampaniaItaly

BACKGROUNd Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(dPd),encoded by the dPYd *** 7%of the European population is a carrier of dPYd gene polymorphisms associated with reduced dPd enzyme *** To assess the prevalence of dPYd polymorphisms and their impact on fluoropyrimidine tolerability in Italian patients with gastrointestinal *** A total of 300 consecutive patients with a diagnosis of gastrointestinal malignancy and treated with a fluoropyrimidine-based regimen were included in the analysis and divided into two cohorts:(1)149 patients who started fluoropyrimidines after dPYd testing;and(2)151 patients treated without dPYd *** the patients in cohort A,15%tested only the dPYd2A polymorphism,19%tested four polymorphisms(dPYd2A,HapB3,c.2846A>T,and dPYd13),and 66%tested five polymorphisms including *** Overall,14.8%of patients were found to be carriers of a dPYd variant,the most common being dPYd6(12.1%).Patients in cohort A reported≥G3 toxicities(P=0.00098),particularly fewer nonhematological toxicities(P=0.0028)compared with cohort B,whereas there was no statistically significant difference between the two cohorts in hematological toxicities(P=0.6944).Significantly fewer chemotherapy dose reductions(P=0.00002)were observed in cohort A compared to cohort B,whereas there was no statistically significant differences in chemotherapy *** Although this study had a limited sample size,it provides additional information on the prevalence of dPYd polymorphisms in the Italian population and highlights the role of pharmacogenetic testing to prevent severe toxicity.

关键词： dihydropyrimidine dehydrogenase dPYd polymorphisms Fluoropyrimidine Caucasian population Gastrointestinal cancers

Advancements in Liver Tumor detection:A Comprehensive Review of Various deep Learning Models

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 91-122页

作者： Shanmugasundaram Hariharan d.Anandan Murugaperumal Krishnamoorthy Vinay Kukreja Nitin Goyal Shih-Yu Chen deptartment of Artificial Intelligence and data Science Vardhaman College of EngineeringHyderabad501218India deptartment of CSE V.S.B College of EngineeringKarur639111India deptartment of Electrical and Electronics Engineering Vardhaman College of EngineeringHyderabad501218India Centre for Research Impact&Outcome Chitkara UniversityRajpura140401PunjabIndia department of Computer Science and Engineering School of Engineering and TechnologyCentral University of HaryanaMahendergarh123031HaryanaIndia department of Computer Science and Information Engineering National Yunlin University of Science and TechnologyYunlin64002Taiwan Intelligence Recognition Industry Service Research Center National Yunlin University of Science and TechnologyYunlin64002Taiwan

Liver cancer remains a leading cause of mortality worldwide,and precise diagnostic tools are essential for effective treatment *** Tumors(LTs)vary significantly in size,shape,and location,and can present with tissues of similar intensities,making automatically segmenting and classifying LTs from abdominal tomography images crucial and *** review examines recent advancements in Liver Segmentation(LS)and Tumor Segmentation(TS)algorithms,highlighting their strengths and limitations regarding precision,automation,and *** metrics are utilized to assess key detection algorithms and analytical methods,emphasizing their effectiveness and relevance in clinical *** review also addresses ongoing challenges in liver tumor segmentation and identification,such as managing high variability in patient data and ensuring robustness across different imaging *** suggests directions for future research,with insights into technological advancements that can enhance surgical planning and diagnostic accuracy by comparing popular *** paper contributes to a comprehensive understanding of current liver tumor detection techniques,provides a roadmap for future innovations,and improves diagnostic and therapeutic outcomes for liver cancer by integrating recent progress with remaining challenges.

关键词： Liver tumor detection liver tumor segmentation image processing liver tumor diagnosis feature extraction tumor classification deep learning machine learning

A Knowledge Graph-Based deep Learning Framework for Efficient Content Similarity Search of Sustainable development Goals data

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data Intelligence 2023年第3期5卷 663-684页

作者： Irene Kilanioti George A.papadopoulos School of Electrical and Computer Engineering National Technical University of Athens9 Heroon Polytechneiou St.Zografou Campus Athens15780Greece department of Computer Science University of Cyprus1 University AvenueAglantziaCY-2109NicosiaCyprus

Sustainable development denotes the enhancement ofliving standards in the present without compromising future generations'*** development Goals(SdGs)quantify the accomplishment of sustainable development and pave the way for a world worth living in for future *** can contribute to the achievement of the SdGs by guiding the actions of practitioners based on the analysis of SdG data,as intended by this *** propose a framework of algorithms based on dimensionality reduction methods with the use of Hilbert Space Filling Curves(HSFCs)in order to semantically cluster new uncategorised SdG data and novel indicators,and efficiently place them in the environment of a distributed knowledge graph ***,a framework of algorithms for insertion of new indicators and projection on the HSFC curve based on their transformer-based similarity assessment,for retrieval of indicators and loadbalancing along with an approach for data classification of entrant-indicators is ***,a thorough case study in a distributed knowledge graph environment experimentally evaluates our *** results are presented and discussed in light of theory along with the actual impact that can have for practitioners analysing SdG data,including intergovernmental organizations,government agencies and social welfare *** approach empowers SdG knowledge graphs for causal analysis,inference,and manifold interpretations of the societal implications of SdG-related actions,as data are accessed in reduced retrieval *** facilitates quicker measurement of influence of users and communities on specific goals and serves for faster distributed knowledge matching,as semantic cohesion of data is preserved.

关键词： Content similarity distributed knowledge graphs Sustainable development Goals Hilbert space filling curves deep learning

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell