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Understanding the Recovery of the Intervertebral disc:A Comprehensive Review of In Vivo and In Vitro Studies

Journal of Bionic Engineering 2024年第4期21卷 1919-1948页

作者： Faten Feki Fahmi zaïri Abderrahman Tamoud Melissa Moulart Rym Taktak nader Haddar Fahed zaïri Sfax University ENISMaterials Engineering and Environment Laboratory3038SfaxTunisia University of Lille IMT Nord EuropeJUNIAUniversity of ArtoisULR 4515-LGCgELaboratoire de Génie Civil et geo-Environnement59000LilleFrance PrediTwins Lab 59000LilleFrance Japet Medical device 59000LilleFrance Sfax University ENISLaboratory of Advanced Materials3038SfaxTunisia Ramsay Générale de Santé Hôpital PrivéLe Bois59000LilleFrance

Within the consistent daily rhythm of human life,intervertebral discs endure a variety of complex loads beyond the influences of gravity and muscle forces,leading to significant morphological changes(in terms of volume,area,and height)as well as biomechanical alterations,including an increase in disc stiffness and a decrease in intradiscal ***,the discs demonstrate an ability to regain their original morphological and biomechanical characteristics after a period of nocturnal *** preservation of normal disc function is critically dependent on this recovery phase,which serves to forestall premature disc *** phenomenon of disc recovery has been extensively documented through numerous in vivo studies employing advanced clinical techniques such as Magnetic Resonance Imaging(MRI),stadiometry,and intradiscal pressure ***,the findings from in vitro studies present a more complex picture,with reports varying between full recovery and only partial recuperation of the disc ***,research focusing on degenerated discs in vitro has shed light on the quantifiable impact of degeneration on the disc ability to *** dynamics within the disc are considered a primary factor in recovery,yet the disc intricate multiscale structure and its viscoelastic properties also play key *** elements interact in complex ways to influence the recovery mechanism,particularly in relation to the overall health of the *** objective of this review is to collate,analyze,and critically evaluate the existing body of in vivo and in vitro research on this topic,providing a comprehensive understanding of disc recovery *** understanding offers a blueprint for future advancements in medical treatments and bionic engineering solutions designed to mimic,support,and enhance the natural recovery processes of intervertebral discs.

关键词： Intervertebral disc Recovery In vivo vs.in vitro studies degeneration Viscoelastic effects Fluid dynamics

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Chebyshev polynomial-based Ritz method for thermal buckling and free vibration behaviors of metal foam beams

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 891-910页

作者： n.d.nGUYEn T.n.nGUYEn Faculty of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City 71309Viet Nam Faculty of Engineering and Technology Kien Giang UniversityChau Thanh 92000Viet Nam

This study presents the Chebyshev polynomials-based Ritz method to examine the thermal buckling and free vibration characteristics of metal foam *** analyses include three models for porosity distribution and two scenarios for thermal *** material properties are assessed under two conditions,i.e.,temperature dependence and temperature *** theoretical framework for the beams is based on the higher-order shear deformation theory,which incorporates shear deformations with higher-order *** governing equations are established from the Lagrange equations,and the beam displacement fields are approximated by the Chebyshev *** simulations are performed to evaluate the effects of thermal load,slenderness,boundary condition(BC),and porosity distribution on the buckling and vibration behaviors of metal foam *** findings highlight the significant influence of temperature-dependent(Td)material properties on metal foam beams'buckling and vibration responses.

关键词： Ritz method Chebyshev function buckling vibration metal foam beam higher-order beam theory(HOBT)

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Influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 563-580页

作者： n.HUMnEKAR d.SRInIVASACHARYA department of Mathematics National Institute of TechnologyWarangal 506004TelanganaIndia

The influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel is *** darcyBrinkman model is used to characterize the fluid flow dynamics in porous *** analytical solutions are obtained for the unidirectional and completely developed *** on a normal mode analysis,the generalized eigenvalue problem under a perturbed state is *** eigenvalue problem is then solved by the spectral ***,the critical Rayleigh number with the corresponding wavenumber is evaluated at the assigned values of the other flow-governing *** results show that increasing the darcy number,the Lewis number,the dufour parameter,or the Soret parameter increases the stability of the system,whereas increasing the inclination angle of the channel destabilizes the ***,the flow is the most unstable when the channel is vertically oriented.

关键词： nanofluid inclined channel variable viscosity linear stability double dif-fusion porous medium

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Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma Science and Technology 2024年第4期26卷 52-60页

作者： V.A.KRUPIn M.R.nURGALIEV A.R.nEMETS I.A.ZEMTSOV S.d.SUnTSOV T.B.MYALTOn d.S.SERGEEV n.A.SOLOVEV d.V.SARYCHEV d.V.RYJAKOV S.n.TUGARInOV n.n.nAUMEnKO national Research Centre“Kurchatov Institute” Moscow 123182Russia Bauman Moscow State Technical University Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JSC“SOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECRH power. The EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECRH regimes. discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

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Optimal combination of the correction model and parameters for the precision geometric correction of UAV hyperspectral images

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 173-184页

作者： Wenzhong Tian za Kan Qingzhan Zhao Ping Jiang Xuewen Wang Hanqing Liu College of Mechanical and Electrical Engineering Shihezi UniversityShihezi 832000XinjiangChina Research Center for Space Information Engineering Technology Shihezi 832000XinjiangChina XPCC division of national Remote Sensing Center of China Shihezi 832000XinjiangChina College of Information Science and Technology Shihezi UniversityShihezi 832000XinjiangChina

nowadays,with the rapid development of quantitative remote sensing represented by high-resolution UAV hyperspectral remote sensing observation technology,people have put forward higher requirements for the rapid preprocessing and geometric correction accuracy of hyperspectral *** optimal geometric correction model and parameter combination of UAV hyperspectral images need to be determined to reduce unnecessary waste of time in the preprocessing and provide high-precision data support for the application of UAV hyperspectral *** this study,the geometric correction accuracy under various geometric correction models(including affine transformation model,local triangulation model,polynomial model,direct linear transformation model,and rational function model)and resampling methods(including nearest neighbor resampling method,bilinear interpolation resampling method,and cubic convolution resampling method)were ***,the distribution,number,and accuracy of control points were analyzed based on the control variable method,and precise ground control points(GCPs)were *** results showed that the average geometric positioning error of UAV hyperspectral images(at 80 m altitude AGL)without geometric correction was as high as 3.4041 m(about 65 pixels).The optimal geometric correction model and parameter combination of the UAV hyperspectral image(at 80 m altitude AGL)used a local triangulation model,adopted a bilinear interpolation resampling method,and selected 12 edgemiddle distributed *** correction accuracy could reach 0.0493 m(less than one pixel).This study provides a reference for the geometric correction of UAV hyperspectral images.

关键词： geometric correction hyperspectral images unmanned aerial vehicle(UAV) ground control point(GCP)

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design and optimization of an airflow-vibration sieving device for the effective cleaning of cyperus esculentus *** mixture

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 77-88页

作者： Shan Chen Shiguan An za Kan Lidong Huang Hewei Meng Jiangtao Qi Huijie Peng College of Mechanical and Electrical Engineering Shihezi UniversityShihezi 832000XinjiangChina Engineering Research Center for Production Mechanization of Oasis Special Economic Crop Ministry of EducationShihezi 832000XinjiangChina Guilin Mike Machinery Co. LtdGuilin 541000GuangxiChina

The threshing mixture of Cyperus esculentus(Tiger nut)planted in sandy areas is complex during harvesting,and there are problems of high impurity rate and high cleaning loss rate of the *** this paper,the threshing mixture of Cyperus esculentus is taken as the research object,and the suspension speed of each component is measured to design an“airflow+vibration”sieving *** the vector polygon method to explore the law of motion of the vibrating sieve,establish the force model of the seeds on the sieve surface,and analyze the conditions for the seeds to penetrate the *** to the principle of seeds penetrating the sieve and long stalks not penetrating the sieve,the geometric model of sieve blades opening degree adjustment mechanism is *** of the conditions under which long stalks can be thrown out of the *** experiment bench of the cleaning device was built,and the evaluation indexes were the rate of seed impurity and the rate of cleaning loss of the device,and the crank speed,sieve blades opening degree and fan speed were used as the experiment factors to study the influence law of each influencing factor on the evaluation index through single-factor *** response surface methodology to find the optimal combination of working parameters of the cleaning *** verify the device’s application on the combine harvester to improve the effectiveness of the cleaning operation of the Cyperus esculentus combine harvester.

关键词： sand cultivation Cyperus esculentus wind sieve type cleaning device optimization

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design of Resilient Sensor networks Balancing Resilience and Efficiency

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International Journal of disaster Risk Science 2024年第1期15卷 107-115页

作者： Sergey n.Vecherin Kiril d.Ratmanski Luke Hogewood Igor Linkov Cold Regions Research and Engineering Laboratory Engineering Research and Development CenterHanoverNH 03755USA Environmental Laboratory Engineering Research and Development CenterVicksburgMS 39180USA

In recent years,the notion of resilience has been developed and applied in many technical areas,becoming exceptionally pertinent to disaster risk *** a disaster situation,accurate sensing information is the key to efficient recovery *** general,resilience aims to minimize the impact of disruptions to systems through the fast recovery of critical functionality,but resilient design may require redundancy and could increase *** this article,we describe a method based on binary linear programming for sensor network design balancing efficiency with *** application of the developed framework is demonstrated for the case of interior building surveillance utilizing infrared sensors in both twoand three-dimensional *** method provides optimal sensor placement,taking into account critical functionality and a desired level of resilience and considering sensor type and *** problem formulation,resilience requirements,and application of the optimization algorithm are described in *** of sensor locations with and without resilience requirements shows that resilient configuration requires redundancy in number of sensors and their intelligent *** tasks are successfully solved by the described method,which can be applied to strengthen the resilience of sensor networks by *** proposed methodology is suitable for large-scale optimization problems with many sensors and extensive coverage areas.

关键词： Binary linear programming Optimal sensor placement Redundant networks Resilience and efciency Resilient sensor networks

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Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury

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neural Regeneration Research 2024年第10期19卷 2119-2131页

作者： nikita Ollen-Bittle Austyn d.Roseborough Wenxuan Wang Jeng-liang d.Wu Shawn n.Whitehead department of Anatomy and Cell Biology Western UniversityLondonONCanada Schulich School of Medicine and dentistry Western UniversityLondonONCanada deparment of Clinical neurological Sciences Western UniversityLondonONCanada

Traumatic brain injury is followed by a cascade of dynamic and complex events occurring at the cellular level. These events include: diffuse axonal injury, neuronal cell death, blood-brain barrier break down, glial activation and neuroinflammation, edema, ischemia, vascular injury, energy failure, and peripheral immune cell infiltration. The timing of these events post injury has been linked to injury severity and functional outcome. Extracellular vesicles are membrane bound secretory vesicles that contain markers and cargo pertaining to their cell of origin and can cross the blood-brain barrier. These qualities make extracellular vesicles intriguing candidates for a liquid biopsy into the pathophysiologic changes occurring at the cellular level post traumatic brain injury. Herein, we review the most commonly reported cargo changes in extracellular vesicles from clinical traumatic brain injury samples. We then use knowledge from animal and in vitro models to help infer what these changes may indicate regrading cellular responses post traumatic brain injury. Future research should prioritize labeling extracellular vesicles with markers for distinct cell types across a range of timepoints post traumatic brain injury.

关键词： axonal injury biomarkers blood-brain barrier chronic traumatic encephalopathy extracellular vesicles glial activation neuroinflammation traumatic brain injury

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Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape

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neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney J.Rouse Victoria n.Jensen Coy d.Heldermon Lacerta Therapeutics AlachuaFLUSA University of Florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for *** results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological *** treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢ***-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential *** group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores n-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢB to that seen in healthy ***,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢB field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB n-acetyl-alpha-glucosaminidase newborn screening

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Polio eradication surveillance in Sri Lanka,2019-2023

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando n.S.Madarasinghe C.Rangana n.Weerasinghe d.C.U.d.Weligamage J.I.Abeynayake department of Medical Microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio Regional Reference Laboratory,Sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VdPV)surveillance at Polio Regional Reference Laboratory,Sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VdPV real time reverse transcriptase polymerase chain reaction(ITd/VdPV rRTPCR)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from Sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VdPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while Sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VdPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in children aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,ensuring timely reporting as per global ***:The Polio Regional Reference Laboratory,Sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VdPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication

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