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dNA芯片-技术

德国医学 2000年第3期17卷 131-132页

作者： d.moradpour H.E.Blum 郝连杰 Medizinische Universittsklinik Freiburg Germany 同济医科大学附属同济医院

按人类基因组计划在2003年以前破译出全部人类遗传信息,为了如此大量序列信息在医学上有可能应用,以及整理出尚未明确功能的基因,要求迅速而且可靠的分析个体基因组序列和细胞以及组织特异性基因表达模式的方法。从这一点看来,dNA 芯片(... 详细信息

按人类基因组计划在2003年以前破译出全部人类遗传信息,为了如此大量序列信息在医学上有可能应用,以及整理出尚未明确功能的基因,要求迅速而且可靠的分析个体基因组序列和细胞以及组织特异性基因表达模式的方法。从这一点看来,dNA 芯片(chip)技术与 dNA 序列分析和聚合酶链反应相比较是一个进展,这进展使生物医学研究发生了根本性改变。

关键词： dNA芯片 dNA序列分析聚合酶链反应

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分子疾病模型——转基因和基因去除

德国医学 1999年第1期16卷 49-50页

作者： d.moradpour 郝连杰 Medizinische Klinik und Poliklinik der Universitt Hugstetter Str.55D-79106 FreiburgGermany 同济医科大学附属同济医院

将重组dNA-片段引入小鼠胚胎或者用高度精细的方法改变或灭活内源性细胞基因,并遗传给后代,从而可以在活体体内研究基因改变的后果,称为分子疾病模型。这种研究方法近年来为从基础上理解基因的功能和调控其产物作出了贡献。转基因(Trans... 详细信息

将重组dNA-片段引入小鼠胚胎或者用高度精细的方法改变或灭活内源性细胞基因,并遗传给后代,从而可以在活体体内研究基因改变的后果,称为分子疾病模型。这种研究方法近年来为从基础上理解基因的功能和调控其产物作出了贡献。转基因(Transgene)和“基因去除”(Knockout)-小鼠是多种医学重要疾病的致病机制和治疗精确而且可重复的模型,转基因和“基因去除”技术是现代分子遗传学和生物医学研究的标准项目。

关键词：疾病模型转基因基因去除分子遗传学

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慢性病毒性肝炎基因治疗策略

德国医学 1996年第3期13卷 123-126页

作者： H.E.Blum S.Wieland F.v.Weizscker W.-B.Offensperger S.Offensperger d.moradpour I.Chemin E.Walter 唐振亚 department of Medicine Ⅱ University of FreiburgHugstetter Str.55D-79106 FreiburgGermany 同济医科大学附属同济医院

中德一德中医学协会第11届联合年会于1996年9月在四川省成都市举行,这次年会的重点是交流中德双方近年来肝脏疾病研究成果以及临床经验。为迎接这次盛会,本刊特编译一期肝胆疾病专集,重点介绍近年来德国学者在肝脏疾病领域中的研究成果... 详细信息

中德一德中医学协会第11届联合年会于1996年9月在四川省成都市举行,这次年会的重点是交流中德双方近年来肝脏疾病研究成果以及临床经验。为迎接这次盛会,本刊特编译一期肝胆疾病专集,重点介绍近年来德国学者在肝脏疾病领域中的研究成果。德中医学协会理事长 Hpker 教授亲自为本刊收集挑选文章,做了大量仔细的工作。Freiburg 大学的 *** 教授、Tibingen 大学的 *** 教授和海德堡德国肿瘤研究中心的 *** 教授给本刊专门撰写了论文,为本期增色不少,在此表示衷心的感谢!今年2月29日至3月1日在香港举行第90次 Falk 研讨会,重点讨论了肝胆疾病研究的进展。全球肝胆疾病著名专家云集香港,作了精湛的报告,国内有200余位同道参加,受益非浅,为此本刊特将与会德国学者会上报告的论文摘要译出,以飨读者。德国医学以专集形式编译尚属首次,其目的是比较集中地介绍德国医学在某一方面的成就。由于受到资料来源的限制,可能很不全面,为此,深切盼望热忱于中德学术交流的德国学者们,能为本刊各专题撰写一些综合性的进展报道,谨此致以衷心的感谢!

关键词：病毒性肝炎基因治疗

Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen Thinh d.Le Phuong d.Nguyen Nga T.K.Le H.Nguyen-Xuan department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3d facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3d-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on the segmentation model,we propose an improved approach for extracting 3d facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3d printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3d bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3d.

关键词： 3d printing technology face reconstruction 3d segmentation 3d printed model

Numerical analysis of high‑speed railway slab tracks using calibrated and validated 3d time‑domain modelling

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Railway Engineering Science 2024年第1期32卷 36-58页

作者： A.F.Esen O.Laghrouche P.K.Woodward d.Medina‑Pineda Q.Corbisez J.Y.Shih d.P.Connolly Institute for High‑Speed Rail and System Integration University of LeedsLeeds LS29JTUK Institute for Infrastructure and Environment Heriot-Watt UniversityEdinburgh EH144ASUK Alstom Transport Saint‑OuenFrance Birmingham Centre for Railway Research and Education University of BirminghamBirmingham B152TTUK

Concrete slabs are widely used in modern railways to increase the inherent resilient quality of the tracks,provide safe and smooth rides,and reduce the maintenance *** this paper,the elastic performance of a novel slab trackform for high-speed railways is investigated using three-dimensional finite element modelling in *** is then compared to the performance of a ballasted ***,slab and ballasted track models are developed to replicate the full-scale testing of track *** the models are calibrated with the experimental results,the novel slab model is developed and compared against the calibrated slab track *** slab and ballasted track models are then extended to create linear dynamic models,considering the track geodynamics,and simulating train passages at various speeds,for which the Ledsgard documented case was used to validate the *** travelling at low and high speeds are analysed to investigate the track deflections and the wave propagation in the soil,considering the issues associated with critical *** train loading methods are discussed,and the most practical approach is retained and ***,correlations are made between the geotechnical parameters of modern high-speed rail and conventional *** is found that considering the same ground condition,the slab track deflections are considerably smaller than those of the ballasted track at high speeds,while they show similar behaviour at low speeds.

关键词： High-speed railways Slab track New ballastless track Ballasted track Critical speeds Finite element modelling Calibration of numerical models

Snapshot imaging of ultrashort electron bunches

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Light(Science & Applications) 2024年第7期13卷 1226-1228页

作者： Andreas döpp Ludwig-Maximilian-Universität München Am Coulombwall 185748GarchingGermany Max Planck Institut für Quantenoptik Hans-Kopfermann-Strasse 1Garching85748Germany

New measurements combine spatial and temporal information from optical transition radiation to estimate the three-dimensional structure of electron bunches from a laser wakefield accelerator.

关键词： ultrashort Snapshot electron

Influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 563-580页

作者： N.HUMNEKAR d.SRINIVASACHARYA department of Mathematics National Institute of TechnologyWarangal 506004TelanganaIndia

The influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel is *** darcyBrinkman model is used to characterize the fluid flow dynamics in porous *** analytical solutions are obtained for the unidirectional and completely developed *** on a normal mode analysis,the generalized eigenvalue problem under a perturbed state is *** eigenvalue problem is then solved by the spectral ***,the critical Rayleigh number with the corresponding wavenumber is evaluated at the assigned values of the other flow-governing *** results show that increasing the darcy number,the Lewis number,the dufour parameter,or the Soret parameter increases the stability of the system,whereas increasing the inclination angle of the channel destabilizes the ***,the flow is the most unstable when the channel is vertically oriented.

关键词： nanofluid inclined channel variable viscosity linear stability double dif-fusion porous medium

Improved Leap-frog Method for Time-domain Fault Location

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 670-674页

作者： Izudin džafić Rabih A.Jabr Faculty of Electrical Engineering University of SarajevoSarajevo 71000Bosnia and Herzegovina department of Electrical and Computer Engineering American University of BeirutBeirut 11072020Lebanon IEEE

The partial differential equation(PdE)solution of the telegrapher is a promising fault location method among time-domain and model-based *** research works have shown that the leap-frog process is superior to other explicit methods for the PdE ***,its implementation is challenged by determining the initial conditions in time and the boundary conditions in *** letter proposes two implicit solution methods for determining the initial conditions and an analytical way to obtain the boundary conditions founded on the signal *** results show that the proposal gives fault location accuracy superior to the existing leap-frog scheme,particularly in the presence of harmonics.

关键词： Fault location leap-frog partial differential equation time-domain analysis transmission line

The Effect of External Magnetic Field on Electron Scale Kelvin–Helmholtz Instability

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Research in Astronomy and Astrophysics 2024年第9期24卷 236-247页

作者： d.Tsiklauri Joule Physics Laboratory School of ScienceEngineering and EnvironmentUniversity of SalfordManchesterM54WTUK

We use particle-in-cell,fully electromagnetic,plasma kinetic simulation to study the effect of external magnetic field on electron scale Kelvin–Helmholtz instability(ESKHI).The results are applicable to collisionless plasmas when,e.g.,solar wind interacts with planetary magnetospheres or a magnetic field is generated in AGN *** find that as in the case of magnetohydrodynamic(MHd)KHI,in the kinetic regime,the presence of an external magnetic field reduces the growth rate of the *** the MHd case,there is a known threshold magnetic field for KHI stabilization,while for ESKHI this is to be analytically *** a kinetic analytical expression,we use several numerical simulation runs to establish an empirical dependence of ESKHI growth rate,Γ(B_(0))ω_(pe),on the strength of the applied external magnetic *** find the best fit is hyperbolic,Γ(B_(0))ω_(pe)=Γ_(0)ω_(pe)/(A+BB_(0)),where Γ_(0) is the ESKHI growth rate without an external magnetic field and B_(0)=B_(0)/B_(MHd)is the ratio of external and two-fluid MHd stability threshold magnetic field,derived *** analytical theory to back up this growth rate dependence on the external magnetic field is *** results suggest that in astrophysical settings where a strong magnetic field pre-exists,the generation of an additional magnetic field by the ESKHI is suppressed,which implies that nature provides a“safety valve”—natural protection not to“over-generate”magnetic field by the ESKHI ***,we find that our two-fluid MHd threshold magnetic field is the same(up to a factor √γ_(0))as the dC saturation magnetic field,previously predicted by fully kinetic theory.

关键词： instabilities magnetic fields plasmas Sun:heliosphere ISM:magnetic fields