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Anti-N-methyl-d-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations

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World Journal of Radiology 2024年第1期16卷 1-8页

作者： Bryce david Beutler Alastair E Moody Jerry Mathew Thomas Benjamin Phillip Sugar mark B Ulanja daniel Antwi-Amoabeng Lucas Anthony Tsikitas department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States department of Anesthesiology University of UtahSalt Lake CityUT 84132United States department of Internal Medicine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-d-aspartate receptor-associated encephalitis(NMdARE)is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic *** mechanism of pathogenesis remains incompletely understood,but is thought to be related to antibodies targeting the GluN1 subunit of the NMdA receptor with resultant downstream dysregulation of dopaminergic *** adults are most frequently affected;the median age at diagnosis is 21 *** is a strong female predilection with a female sex predominance of 4:*** often develops as a paraneoplastic process and is most commonly associated with ovarian ***,NMdARE has also been described in patients with small cell lung cancer,clear cell renal carcinoma,and other benign and malignant *** is based on correlation of the clinical presentation,electro-encephalography,laboratory studies,and *** tomography,positron emission tomography,and magnetic resonance imaging are essential to identify an underlying tumor,exclude clinicopathologic mimics,and predict the likelihood of long-term functional *** imaging may be of value for prognostication and to assess the response to *** may involve high-dose corticosteroids,intravenous immunoglobulin,and plasma ***,we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria,treatment regimens,and proposed pathogenetic mechanisms.

关键词： Anti-N-methyl-d-aspartate receptor-associated encephalitis Autoimmune encephalitis Encephalitis Ovarian teratoma Paraneoplastic syndrome Teratoma

Combining spatial modelling and radar to identify and protect avian migratory hot-spots

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Current Zoology 2014年第5期60卷 680-691页

作者： mark dESHOLM Rashpal GILL Thomas BOVITH Anthony d. FOX department of Bioscience Aarhus University Kalo Grenavej 14 8410 Ronde Denmark BirdLife denmark Vesterbrogade 140 1620 Copenhagen V Denmark Research department Danish Meteorological Institute Lyngbyvej 100 2100 Copenhagen O Denmark

Migrating landbirds are known to follow coast lines and concentrate on peninsulas prior to crossing water bodies, es- pecially during daylight but also at night, creating enhanced potential collision hazards with man-made objects. Knowing where these avian migration ＂hot-spots＂ occur in time and space is vital to improve flight safety and inform the spatial planning process （e.g. environmental assessments for offshore windfarms）. We developed a simple spatial model to identify avian migration hot- spots in coastal areas based on prevailing migration orientation and coastline features known, from visual and radar observations, to concentrate migrating landbirds around land masses. Regional scale model validation was achieved by combining nocturnal passerine movement data gathered from two tier radar coverage （long-range dual-polarization doppler weather radar and short- range marine surveillance radar） and standardised bird ringing. Applied on a national scale, the model correctly identified the ten most important danish coastal hot-spots for spring migrants and predicted the relative numbers of birds that concentrated at each site. These bird numbers corresponded well with historical observational data. Here, we provide a potential framework for the es- tablishment of the first three-dimensional avian airspace sanctuaries, which could contribute to more effective conservation of long-distance migratory birds [Current Zoology 60 （5）： 680-691, 2014].

关键词： Radar ornithology Migration Orientation Conservation Spatial model

Assessing the impact of conceptual mineral systems uncertainty on prospectivity predictions

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Geoscience Frontiers 2022年第6期13卷 182-207页

作者： mark d Lindsay Agnieszka M.Piechocka mark W Jessell Richard Scalzo Jeremie Giraud Guillaume Pirot Edward Cripps Commonwealth Scientific and Industrial Research Organisation Mineral Resources Australian Resources Research CentreWA 6151Australia Mineral Exploration Cooperative Research Centre Centre for Exploration TargetingSchool of Earth SciencesThe University of Western AustraliaPerthWA 6009Australia ARC Centre for data Analytics for Resources and Environments(dARE) Perth and SydneyAustralia University of Sydney School of Mathematics and StatisticsSydneyAustralia Universitéde Lorraine GeoRessourcesCNRS54000 NancyFrance The University of Western Australia Department of Mathematics and StatisticsPerthAustralia

The past two decades have seen a rapid adoption of artificial intelligence methods applied to mineral exploration. More recently, the easier acquisition of some types of data has inspired a broad literature that has examined many machine learning and modelling techniques that combine exploration criteria,or ’features’, to generate predictions for mineral prospectivity. Central to the design of prospectivity models is a ’mineral system’, a conceptual model describing the key geological elements that control the timing and location of economic mineralisation. The mineral systems model defines what constitutes a training set, which features represent geological evidence of mineralisation, how features are engineered and what modelling methods are used. Mineral systems are knowledge-driven conceptual models, thus all parameter choices are subject to human biases and opinion so alternative models are ***, the effect of alternative mineral systems models on prospectivity is rarely compared despite the potential to heavily influence final predictions. In this study, we focus on the effect of conceptual uncertainty on Fe ore prospectivity models in the Hamersley region, Western Australia. Four important considerations are tested.(1) Five different supergene and hypogene conceptual mineral systems models guide the inputs for five forest-based classification prospectivity models model.(2) To represent conceptual uncertainty, the predictions are then combined for prospectivity model comparison.(3)Representation of three-dimensional objects as two-dimensional features are tested to address commonly ignored thickness of geological units.(4) The training dataset is composed of known economic mineralisation sites(deposits) as ’positive’ examples, and exploration drilling data providing ’negative’sampling locations. Each of the spatial predictions are assessed using independent performance metrics common to AI-based classification methods and subjected to geological pl

关键词： Uncertainty Modelling Prospectivity Economic geology Geological plausibility Forest-based classification

Protecting miners from coal bursts during development above historic mine workings in Harlan County,KY

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International Journal of Mining Science and Technology 2021年第1期31卷 111-116页

作者： Christopher mark Mine Safety and Health Administration PittsburghPA 15236USA

In order to reach a large,untapped reserve of high-quality coal,d8 Cloverlick Mine proposed to mine a corridor nearly 600 m deep beneath the Benham Spur of Black Mountain,Kentucky’s highest peak.d8 Cloverlick Mine was extracting the Owl seam,but the corridor’s route lay approximately 20 m above century-old mine workings in the C–(darby)*** to the concern,three serious coal bursts had recently occurred in nearby Owl seam *** of the old workings seemed to indicate that the underlying C–seam had been fully ***,two of the coal bursts had occurred above areas where the C–Seam was also shown as mined *** Safety and Health Administration(MSHA)Technical Support therefore investigated the records of past mining to better understand the old mine *** conditions observed in current Owl seam workings were also compared with the maps of the old C–seam *** study concluded that the presence of hazardous underlying remnants could not be ruled *** mitigate the burst risk,d8 Cloverlick Mine adopted a strategy of stress probe drilling.A self-propelled coal drill was used to auger 11.5-m-long,small diameter holes in advance of *** each hole was drilled,the cuttings were measured to detect the presence of highly stressed *** the crossing was successfully completed without incident.

关键词： Coal bursts Underground mining Room-and-pillar destressing

Rapid range expansion predicted for the Common Grackle(Quiscalus quiscula)in the near future under climate change scenarios

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Avian Research 2021年第4期12卷 569-575页

作者： Peter Capainolo Utku Perktaş mark dEFellowes division of Vertebrate Zoology-department of Ornithology American Museum of Natural HistoryCentral Park West@79th StreetNew YorkNY 10024-5192USA People and Wildlife Research Group School of Biological SciencesUniversity of ReadingWhiteknightsReading RG66ASUK depart-ment of Biology(Zoology Section Biogeography Research Laboratory)Faculty of ScienceHacettepe UniversityBeytepe06800 AnkaraTurkey

Background:Climate change due to anthropogenic global warming is the most important factor that will affect future range distribution of species and will shape future biogeographic *** much effort has been expended in understanding how climate change will affect rare and declining species we have less of an understanding of the likely consequences for some abundant *** Common Grackle(Quiscalus quiscula;Linnaeus 1758),though declining in portions of its range,is a widespread blackbird(Icteridae)species in North America east of the Rocky *** study examined how climate change might affect the future range distribution of Common ***:We used the R package Wallace and six general climate models(ACCESS1-0,BCC-CSM1-1,CESM1-CAM5-1-FV2,CNRM-CM5,MIROC-ESM,and MPI-ESM-LR)available for the future(2070)to identify climatically suitable areas,with an ecological niche modelling approach that includes the use of environmental ***:Future projections suggested a significant expansion from the current range into northern parts of North America and Alaska,even under more optimistic climate change ***,there is evidence of possible future colonization of islands in the Caribbean as well as coastal regions in eastern Central *** most important bioclimatic variables for model predictions were Annual Mean Temperature,Temperature Seasonality,Mean Temperature of Wettest Quarter and Annual ***:The results suggest that the Common Grackle could continue to expand its range in North America over the next 50 *** research is important in helping us understand how climate change will affect future range patterns of widespread,common bird species.

关键词： Annual mean temperature Climate change Common Grackle Ecological niche modelling Range shift Seasonality

2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel Michael M.Todd Richard P.dutton Cynthia A.Lien Stuart A.Grant Joseph W.Szokol Lars I.Eriksson Myron Yaster mark d.Grant Madhulika Agarkar Anne M.Marbella Jaime F.Blanck Karen B.domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

Immunocamouflage of latex surfaces by grafted methoxypoly(ethylene glycol)(mPEG):Proteomic analysis of plasma protein adsorption

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Science China(Life Sciences) 2012年第3期55卷 191-201页

作者： LE Yevgeniya LI Li WANG dunCheng SCOTT mark d Canadian Blood Services Vancouver V6T 1Z3 Canada Centre for Blood Research University of British Columbia Vancouver V6T 1Z3 Canada department of Pathology and Laboratory Medicine University of British Columbia Vancouver V6T 1Z3 Canada

Grafting of methoxypoly(ethylene glycol)(mPEG) to cells and biomaterials is a promising non-pharmacological immunomodulation ***,due to the labile nature of cells,surface-plasma interactions are poorly understood;hence,a latex bead model was *** of beads resulted in a density and molecular weight dependent decrease in total adsorbed protein with a net reduction from(159.9±6.4) ng cm-2 on bare latex to(18.4±0.8) and(52.3±5.3) ng cm-2 on PEGylated beads(1 mmol L-1 of 2 or 20 kd SCmPEG,respectively).SdS-PAGE and iTRAQ-MS analysis revealed differential compositions of the adsorbed protein layer on the PEGylated latex with a significant reduction in the compositional abundance of proteins involved in immune system ***,the biological efficacy of immunocamouflaged cells and materials is mediated by both biophysical obfuscation of antigens and reduced surface-macromolecule interactions.

关键词： PEGylation immunocamouflage iTRAQ mass spectrometry polystyrene latex protein adsorption proteomics meth-oxypoly(ethylene glycol) polymer

Application and validation of a 3-d calcium,chloride,and sulfate model in Lake Okeechobee

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Ecological Processes 2014年第1期3卷 1-19页

作者： Kang-Ren Jin mark d Shafer Zhen-Gang Ji Lead Scientist South Florida Water Management DistrictP.O.Box 24680West Palm BeachFL 33416-4680USA Senior Environmental Engineer US Army Corps Engineers701 San Marco BlvdJacksonvilleFL 32207-8175USA Adjunct Professor Department of Civil EngineeringCatholic University of AmericaPangborn HallRoom G12WashingtonDC 20064USA

Introduction: The calibration, verification, and validation of calcium (Ca), chloride (Cl), and sulfate (SO_(4)) module ofthe Lake Okeechobee Environment Model (LOEM) was completed. The integrated model could simulate Ca, Cl, andSO_(4) concentrations and transport due to wind driven currents and waves from 1 Oct 1999 to 30 Sept 2009 in LakeOkeechobee. The enhanced model was also used to estimate lake water quality effects resulting from differentmanagement scenarios that include discharges from planned aquifer storage and recovery (ASR) ***: The fate and transport processes of Ca, Cl, and SO_(4) are controlled by their reactivity and their hydrodynamictransport. Reactivity includes chemical, biological, and bio-uptake processes (IJRSA 33:2233-2260, 2012). Hydrodynamictransport includes advection of water current, diffusion, and turbulent mixing within the water column. The depositionand resuspension on the water-sediment bed interface is also included. The mathematical equations for describing Ca,Cl, and SO_(4) substances, including heavy metal and total organic carbon (TOC), are ***: Both the statistical results and the time series comparisons indicate that the simulation of Ca, Cl, and SO_(4) aregenerally simulated well by the LOEM. The root mean square error over the variance rage is Cl dSO_(4) d SO_(4) concentrations in the lake were largely controlled by water temperature and lakeevaporation. Inflows to the lake can also have localized effects on chloride variations. Shallow water depth and highevaporation contribute to high Cl/Ca/ SO_(4) concentration in the lake.

关键词： Ca Cl SO_(4)modeling Lake Okeechobee Long-term simulation Environmental modeling

Genotype-by-environment interaction for grain yield among novel cowpea(Vigna unguiculata L.) selections derived by gamma irradiation

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The Crop Journal 2018年第3期6卷 306-313页

作者： Lydia Horn Hussein Shimelis Fatma Sarsu Learnmore Mwadzingeni mark d.Laing African Centre for Crop Improvement University of Kwa Zulu-Natal directorate of Research and Training Plant Production ResearchMinistry of AgricultureWater and Forestry Plant Breeding and Genetics Section Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture

This study determined the effects of genotype-by-environment(G × E) interaction and stability of yield among elite cowpea(Vigna unguiculata L.) selections derived by gamma irradiation. The study was conducted in Namibia at three selected sites: Bagani, Mannheim,and Omahenene, during 2014/2015 and 2015/2016. Thirty-four newly developed mutant genotypes and three local checks were evaluated using a randomized complete block design with three replications. Grain yield data were analyzed using the additive main effects and multiplicative interaction(AMMI) and the genotype main effect plus genotype-by-environment interaction(GGE) biplot methods. The AMMI and GGE biplot models explained 77.49% and 75.57% of total observed genotypic variation, *** and Omahenene were the environments best discriminating the test genotypes during 2014/2015 and 2015/2016, respectively. Four promising mutant genotypes: G9(Sh L3 P74), G10(Sh R3 P4), G12(Sh R9 P5), and G4(Sh L2 P4), showed wide adaptation and grain yields of 2.83, 2.06, 1.99, and 1.95 t ha^(-1), respectively. The novel mutant lines are useful genetic resources for production or future cowpea breeding programs in Namibia or similar environments.

关键词： AMMI Cowpea Genotype by environment interaction GGE biplot Mutants