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Isolation of Marine Actinomycetes from the Mangrove Swamps for Biotechnological Exploration

Journal of Life Sciences 2011年第12期5卷 1030-1036页

作者： Rajesh C. Patil Abhishek d. Mule Gajanan V. Mali Rajmahammad R. Tamboli Rahul M. Khobragade Sanjay K. Gaikwad Vasanti I. Katchi dhanashree Patil Bhavan＇s College Andheri （w） Mumbai 400058 India department of Microbiology M.B.S.K. Kanya Mahavidyalay Kadegaon Sagli 415304 India department of Microbiology M.U. Mahavidyalaya Udgir Latur 413512 India department of Microbiology Dr. Babasaheb Ambedkar Marathawada University Sub-campus Osmanabad 431001 India department of Cell ＆ Molecular Biology Rajiv Gandhi Institute of IT and Biotechnology Bharati Vidyapeeth Pune 411043 India Gopal krishna College Kolhapur 416011 India

The mangroves are specialized marine environments widely distributed along the coast lines, which support biologically diverse groups of organisms including microbes. The microorganisms present in this ecosystem contribute significantly in the food web of the tropical marine ecosystem. In the present investigation, Actinomycete isolates obtained from mangrove sediments have been studied for diversity as well as for their bioactive potential. Seven different Actinomycete isolates （MS 1-MS7） were obtained from the sediments collected from the mangrove swamps. The phylogenetic analysis of these isolates showed that out or seven isolates, 3 isolates belong to Streptomyces sp., which has bioactive potential as several bioactive metabolites have been isolated from this group. One bacterium showed genetic similarity with Corynebacterium sp.. The microbes from this group are used for very important industrial applications. Three Actinomycete isolates showed very low similarity with the reported strains from the gene bank. In suggests that, these cultures could be novel and further research work is warranted to prove this speculation. In antagonistic studies, three Actinomycete isolates showed promising results. This investigation highlights the importance of mangrove ecosystem as a rich source of diverse Actinomycete strains for biotechnological applications.

关键词： Actinomycetes mangrove swamps phylogenetic analysis bioactivity.

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Efficacy and Safety of Tinefcon^® Tablets in Subjects with Plaque Psoriasis: An Open Label, Non-Comparative, Multicenter, Phase IV Trial

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Journal of Cosmetics, dermatological Sciences and Applications 2016年第2期6卷 55-66页

作者： Somesh Sharma Kailash bhatia Meetesh Agarwal Sandesh Gupta Leelavathi Budamakuntla Sudhakar Grandhi Vinod Titarmare Sushil Pande Ranjan Rawal Aruna Samarth Rizwan Haq Vikrant Saoji d. V. S. Pratap L. M. Kansal d. G. Saple Shatrughan Sahay Parag Kalyani Puneet Goyal Sharmila Patil A. J. Kanwar Bhavesh Swarnakar Sujay Kulkarni Abhijeet Morde Hitesh Khandagale Yogesh dound Nitin Jadhav Sanjeev Hegde Murlidhara Padigaru Ashish C. Suthar Piramal Enterprises Limited Mumbai India bhatia Skin Center Bima Nagar Indore India Agrawal Path LAB Vijaynagar Indore India Skin & Laser Center Krishna Nagar New Delhi India diabetes and Shirdi Skin Care Centre Karnataka India Medipoint Hospitals Pvt. Ltd. Pentagon Research Pvt. Ltd. Pune India Skin Care Clinic Nagpur India NKP Salve Institute and Lata Mangeshkar Hospital Nagpur India department of dermatology Sheth VS General Hospital Ahmedabad India Sai Skin Care Clinic Hyderabad India Radiance Skin Care Clinic Nagpur India dr. Vikrant Saoji’s Clinic Ramdaspeth Nagpur India durgabai deshmukh Hospital & Research Center Hyderabad India Kansal Cosmetic & Skin Care Clinic Jaipur India dr. Saple’s Clinic Dadar (East) Mumbai India Sri Skin Care & Laser Clinic Lucknow UP India Ruby Hall Clinic Pune India Renova Skin & Laser Clinic Sector-9 Mansarovar Jaipur India dr. d. Y. Patil Medical College and Hospital Nerul Navi Mumbai India department of dermatology Venerology & Leprology Postgraduate Institute of Medical Education and Research Chandigarh India Swarnakar Superspeciality Centre Indore India Clinical Research and development Piramal Enterprises Limited Mumbai India

Importance: This post-marketing surveillance study was conducted to evaluate real-world information about the efficacy and safety of oral Tinefcon? tablets (Sphaeranthus indicus based) in plaque psoriasis patients. Materials and Methods: Patients aged at least 18 years and older with clinical diagnosis of plaque psoriasis, were enrolled in this open label, non-comparative, multicenter trial. All eligible subjects received four 700 mg Tinefcon? tablets/day for 12 weeks. The primary outcome measure was percent change in Psoriasis Area Severity Index (PASI) score from baseline to week 12. The secondary outcome measures were Physician Global Assessment (PGA), Nail Psoriasis Severity Index (NAPSI), Psoriatic Arthritis Evaluation and Gene Expression Profiling and Immunohistochemistry. Results: After completion of Tinefcon? treatment at 12 weeks, more than half of subjects (52%) achieved PASI 50 response;PASI 75 response was attained in 68 (23%) subjects and PASI 90 response in 22 (7%) subjects. Five subjects with severe psoriasis achieved PASI 90 without receiving any concomitant medication. Reduction in severity as assessed by PGA was observed in more than half of patients with moderate disease. Histopathological evaluation revealed that epidermal thickness was considerably reduced in 66% of subjects. The expression of inflammatory marker S100A9 protein was(meaningfully reduced in 60% patients with non-significant reduction of Keratin 10 protein expression. Gene expression analysis showed increase down regulation of SERPINB4;PI3 and KRT16 genes after a 12-week treatment period in subjects with higher PASI scores. Conclusion: Oral Tinefcon? tablets showed good efficacy and had a favorable safety profile in plaque psoriasis patients.

关键词： Psoriasis Tinefcon® Tablet Sphaeranthus indicus

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