检索结果-南通市图书馆

Journal of Molecular Cell Biology 2022年第1期14卷 60-61页

作者： Xiaohua duan Hui Wang david d.ho Robert E.Schwartz Todd Evans Shuibing Chen department of Surgery Weill Cornell Medicine1300 York Ave.New YorkNY 10065USA State Key Laboratory of Oncogenes and Related Genes Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China Aaron diamond AIdS Research Center Columbia University Vagelos College of Physicians and SurgeonsNew YorkNY 10032USA division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medicine1300 York Ave.New YorkNY 10065USA department of Physiology Biophysics and Systems BiologyWeill Cornell Medicine1300 York Ave.New YorkNY 10065USA

Coronavirus disease 2019(COVId-19)has been an ongoing public health crisis since the end of 2019;besides vaccine development,there have been major research efforts focused on developing antiviral *** was the first US Food and drug Administration(FdA)-approved antiviral drug for ***,the FdA granted emergency use authorization(EUA)for three monoclonal antibody treatments,including sotrovimab or a combination of casirivimab and imdevimab,or bamlanivimab and etesevimab,each of which targets the coronavirus spike protein to block viral *** recently,Britain granted conditional authorization for the ribonucleoside analog molnupiravir,developed by Merck as a viral replication *** protease inhibitor PF-07321332 developed by Pfizer and boosted by ritonavir showed promising results in a phase III clinical trial,reducing the risk of hospitalization or death by 89%compared with placebo.

关键词： Pfizer Merck vaccine

direct 4d printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo Young Cho dong Hae ho Sae Byeok Jo Jeong ho Cho department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4d)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4d printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4d-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4d printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 398-414页

作者： Poornima d.E.Weerasinghe-Mudiyanselage Sohi Kang Joong-Sun Kim Sung-ho Kim hongbing Wang Taekyun Shin Changjong Moon department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the *** autoimmune encephalomyelitis(EAE)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in EAE *** the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase(11 days post-immunization,dPI)and chronic phase(28dPI).EAE-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic *** complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(dG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early ***,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and dG subregions in the early phase of EAE,but only reduced in the dG subregion during the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic ***,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC *** cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(ERK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the ERK-ARC pathway,indicating that this alteration may be associated with hi

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior Experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

Revealing the influence of in-situ formed LiCl on garnet/Li interface for dendrite-free solid-state batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第5期92卷 394-403页

作者： Seoyoon Shin Jinuk Lee Tae ho Shin Seokhee Lee Hydrogen Energy Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju-siGyeongsangnam-do 52851Republic of Korea department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea

Inadequate interfacial contact between lithium and solid-state electrolytes(SSEs)leads to elevated impedance and the growth of lithium dendrites,presenting significant obstacles to the practical viability of solid-state batteries(SSBs).To ameliorate interfacial contact,optimizing the surface treatment of SSEs has been widely ***,the formation of LiCl through acid treatment,an equally crucial factor impacting SSB performance,has received limited attention,leaving its underlying mechanism *** study aims to shed light on SSE characteristics following LiCl formation and the removal of Li_(2)CO_(3) through acid *** seek to establish quantifiable links between SSE surface structure and SSB performance,focusing on interfacial resistance,current distribution,critical current density(CCd),and lithium *** formation of LiCl,occurring as Li_(2)CO_(3) is removed through acid treatment,effectively mitigates lithium dendrite formation on SSE *** action inhibits electron injection and reduces the diffusion rate of Li ***,acid treatment transforms the SSE surface into a lithiophilic state by eliminating surface Li_(2)CO_(3).Consequently,the interfacial resistance between lithium and SSEs substantially decreases from 487.67 to 35.99Ωcm^(2) at 25°*** leads to a notably high CCd of 1.3 mA cm^(-2) and a significantly extended cycle life of 1,000 ***,in full SSBs incorporating LiCoO_(2)cathodes and acid-treated garnet SSEs,we observe exceptional cyclability and rate *** findings highlight that acid treatment not only establishes a fundamental relationship between SSE surfaces and battery performance but also offers an effective strategy for addressing interfacial challenges in SSBs.

关键词： Solid-statebatteries Acidtreatment Interfacial stability LiCl Surface modification

dual in-situ observation of tribochemical and morphological evolution of single-layer WS_(2)and multi-layer WS_(2)/C coatings

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第7期12卷 1580-1598页

作者： Yuzhen LIU Jae-ho HAN Shusheng XU Young Chan JUNG dae-Eun KIM State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China department of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264000China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264000China

The outstanding tribological performance of transition metal dichalcogenides(TMds)is attributed to their unique sandwich microstructure and low interlayer shear *** advantageous structure allows TMds to demonstrate exceptional friction reduction ***,the incorporation of TMds and amorphous carbon(a-C)in multi-layer structures shows excellent potential for further enhancing tribological and anti-oxidation *** carbon,known for its high ductility,chemical inertness,and excellent wear resistance,significantly contributes to the overall performance of these multi-layer *** gain an in-depth understanding of the tribological mechanism and evolution of TMds’multi-layer coatings,a dual in-situ analysis was carried out using a tribometer equipped with a 3d laser microscope and a Raman *** innovative approach allowed for a comprehensive evolution of the tribological,topographical,and tribochemical characteristics of both single-layer WS_(2)and multi-layer WS_(2)/C coatings in real *** findings from the dual in-situ tribotest revealed distinct failure characteristics between the single-layer WS_(2)coating and the multi-layer WS_(2)/C *** single-layer WS_(2)coating predominantly experienced failure due to mechanical removal,whereas a combination of mechanical removal and tribochemistry primarily influenced the failure of the multi-layer WS_(2)/C *** tribological evolution process of these two coatings can be classified into four stages on the basis of their tribological behavior:the running-in stage,stable friction stage,re-deposition stage,and lubrication failure *** stage represents a distinct phase in the tribological behavior of the coatings and contributes to our understanding of their behavior during sliding.

关键词： In-situ analysis multi-layer coating tribology tribochemistry

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混凝土的早期温度裂缝——工程实录

铁道建筑 1988年第9期 32-33页

作者： H.W.chung P.k.k.Lee d.ho 谢友均香港

在香港,由于铁路运输的电气化,大多数车站都已重建。典型的车站是两层的钢筋混凝土结构物,轨道铺设在底层地面,上面是候车大厅。候车大厅的楼板由预制板组成,而屋顶(包括候车大厅的天窗部分的屋顶)是现浇

关键词：混凝土无机非金属材料屋顶梁水化放热棍凝土

Optimization of the Use of Spherical Targets for Point Cloud Registration Using Monte Carlo Simulation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Geodesy and Geoinformation Science 2024年第2期 18-36页

作者： CHAN Ting On XIAO Hang XIA Linyuan LICHTI derek d. LI Ming ho dU Guoming School of Geography and Planning Sun Yat-sen University Guangdong Provincial Key Laboratory of Urbanization and Geo-Simulation Sun Yat-sen University Guangdong Provincial Engineering Research Center for Public Security and disasters Sun Yat-sen University department of Geomatics Engineering Schulich School of EngineeringUniversity of Calgary

Registrations based on the manual placement of spherical targets are still being employed by many professionals in the ***,the placement of those targets usually relies solely on personal experience without scientific evidence supported by numerical *** paper presents a comprehensive investigation,based on Monte Carlo simulation,into determining the optimal number and positions for efficient target placement in typical scenes consisting of a pair of *** demonstrates new check-up statistical rules and geometrical constraints that can effectively extract and analyze massive simulations of unregistered point clouds and their corresponding *** than 6×10～7 sets of the registrations were simulated,whereas more than IOO registrations with real data were used to verify the results of *** results indicated that using five spherical targets is the best choice for the registration of a large typical registration site consisting of two vertical facades and a ground,when there is only a box set of spherical targets *** a result,the users can avoid placing extra targets to achieve insignificant improvements in registration *** results also suggest that the higher registration accuracy can be obtained when the ratio between the facade-to-target distance and target-to-scanner distance is approximately 3:***,the targets should be placed closer to the scanner rather than in the middle between the facades and the scanner,contradicting to the traditional thought. Besides,the results reveal that the accuracy can be increased by setting the largest projected triangular area of the targets to be large.

关键词：

Inclusive quasielastic neutrino-nucleus scattering with energy density functional nuclear models

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第8期48卷 153-158页

作者： K.S.Kim Soonchul Choi Hana Gil Chang ho Hyun School of liberal arts and science korea aerospace universitygoyang 10540korea Center for exotic nuclear studies institute for basic sciencedaejeon 34126korea Center for extreme nuclear matters korea universityseoul 02841korea department of physics education daegu universitygyeongsan 38453korea

In this study,we calculated the inclusive charged-current neutrino-nucleus scattering from ^(40)Ar in the quasielastic *** explore the effect of uncertainties stemming from the nuclear structure,we used the KIdS(Korea-IBS-daegu-SKKU)nuclear energy density functional and Skyrme force models,namely SLy4,SkI3,and *** models were selected to have distinct behavior in terms of the density dependence of the symmetry energy and the effective mass of the *** the charged-current neutrino scattering,the single-and double-differential cross sections were calculated for various *** cross sections are reported as a function of the incident neutrino *** theoretical cross sections were compared with experimental data,and the roles of the effective mass and symmetry energy were investigated in terms of charged-current neutrino-nucleus scattering.

关键词： energy density functional neutrino-nucleus scattering symmetry energy effective mass of the nucleon

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 748-764页

作者： Ruonan Yan Chi-Tang ho Yanan Liu Shengnan Zhan Zufang Wu Xin Zhang department of Food Science and Engineering Ningbo UniversityNingbo 315211China department of Food Science Rutgers UniversityNew BrunswickNew Jersey 08901USA

The interaction between host circadian rhythm and gut microbes through the gut-brain axis provides new clues for tea polyphenols to improve host *** present research showed that oolong tea polyphenols(OTP)improved the structural disorder of the intestinal flora caused by continuous darkness,thereby modulating the production of metabolites related to pyruvate metabolism,glycolysis/gluconeogenesis,and tryptophan metabolism to alleviate the steady-state *** fecal microbiota transplantation from the OTP group,the single-cell transcriptomic analysis revealed that OTP significantly increased the number of hypothalamus cell clusters,up-regulated the number of astrocytes and fibroblasts,and enhanced the expression of circadian rhythm genes Cry2,Per3,Bhlhe41,Nr1d1,Nr1d2,dbp and Rorb in hypothalamic *** results confirmed that OTP can actively improve the intestinal environmental state as well as internal/peripheral circadian rhythm disorders and cognitive impairment,with potential prebiotic functional characteristics to notably contribute to host health.

关键词： Gut microbiota Circadian rhythm Oolong tea polyphenols Single-cell sequencing Metabolism

development of vehicle-recognition method on water surfaces using LidAR data:SPd^(2)(spherically stratified point projection with diameter and distance)

在线全文

学校读者我要写书评

暂无评论

defence Technology（防务技术） 2024年第6期36卷 95-104页

作者： Eon-ho Lee Hyeon Jun Jeon Jinwoo Choi Hyun-Taek Choi Sejin Lee The department of Mechanical Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea Ocean System Engineering Research division Korea Research Institute of Ships and Ocean Engineering(KRISO)Daejeon 34103Republic of Korea The division of Mechanical&Automotive Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea

Swarm robot systems are an important application of autonomous unmanned surface vehicles on water *** monitoring natural environments and conducting security activities within a certain range using a surface vehicle,the swarm robot system is more efficient than the operation of a single object as the former can reduce cost and save *** is necessary to detect adjacent surface obstacles robustly to operate a cluster of unmanned surface *** this purpose,a LidAR(light detection and ranging)sensor is used as it can simultaneously obtain 3d information for all directions,relatively robustly and accurately,irrespective of the surrounding environmental *** the GPS(global-positioning-system)error range exists,obtaining measurements of the surface-vessel position can still ensure stability during platoon *** this study,a three-layer convolutional neural network is applied to classify types of surface *** aim of this approach is to redefine the sparse 3d point cloud data as 2d image data with a connotative meaning and subsequently utilize this transformed data for object classification ***,we have proposed a descriptor that converts the 3d point cloud data into 2d image *** use this descriptor effectively,it is necessary to perform a clustering operation that separates the point clouds for each *** developed voxel-based clustering for the point cloud ***,using the descriptor,3d point cloud data can be converted into a 2d feature image,and the converted 2d image is provided as an input value to the *** intend to verify the validity of the proposed 3d point cloud feature descriptor by using experimental data in the ***,we explore the feasibility of real-time object classification within this framework.

关键词： Object classification Clustering 3d point cloud data LidAR(light detection and ranging) Surface vehicle