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discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin4-yl)thieno[3,2-d]pyrimidin-4(3h)-one derivatives as an orally active antitumor agent

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Acta Pharmaceutica Sinica B 2024年第2期14卷 893-896页

作者： Mingwei Fu Min Ge Wanxiang yang Chunchen hu Xiaowei Li Yuanjiang Wang Shaohua Gou Pharmaceutical Research Center and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Jiangsu Province hi-Tech Key Laboratory for Biomedical Research Southeast UniversityNanjing 211189China Zenji Research Laboratories Nanjing 211189China

To the Editor:Kinase cell division cycle 7(CdC7),a cell division cycle protein,takes a vital role in mediating dNA ***7 complexes in the nucleus can phosphorylate the minichromosome maintenance complex(MCM)family members that bind to *** addition,CdC7 kinase,as a molecular switch regulating dNA replication,can mediate dNA damage signaling pathways to stimulate cell cycle termination as well as dNA *** have shown that CdC7 is overexpressed in many types of cancer cells,and its overexpression was related to poor patient survival,tumor grade,genetic instability,aneuploidy and so ***,CdC7 is a promising target for antitumor therapy.

关键词： Cell division cycle 7 dNA replication CdC7 inhibitor Anti-tumor

Construction of 2d/2d Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.Y.huang Z.yang S.Y.yang Z.h.dai Y.J.Liu J.h.Liao G.Y.Zhong Z.J.Xie Y.P.Fang S.S.Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2d)CdS nanosheets on 2d MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2d/2d structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Two-dimensional structure heterostructure Photothermal effect Photocatalyst hydrogen evolution

deep Insight of design,Mechanism,and Cancer Theranostic Strategy of Nanozymes

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Nano-Micro Letters 2024年第2期16卷 165-217页

作者： Lu yang Shuming dong Shili Gai dan yang he ding Lili Feng Guixin yang Ziaur Rehman Piaoping yang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China Yantai Research Institute Harbin Engineering UniversityYantai 264000People’s Republic of China Key Laboratory of Green Chemical Engineering and Technology of heilongjiang Province College of Material Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040People’s Republic of China department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan

Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale ***,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side ***,various nanozymes have been developed and used for tumor *** this review,more than 270 research articles are discussed systematically to present progress in the past five ***,the discovery and development of nanozymes are ***,classification and catalytic mechanism of nanozymes are ***,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical ***,synergistic theranostic strategy of nanozymes are ***,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.

关键词： Nanozymes Classification Prediction and design Catalytic mechanism Tumor theranostics

Luminescence regulation of Sb^(3+)in 0d hybrid metal halides by hydrogen bond network for optical anti-counterfeiting

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Opto-Electronic Advances 2024年第3期7卷 15-25页

作者： dehai Liang Saif M.h.Qaid Xin yang Shuangyi Zhao Binbin Luo Wensi Cai Qingkai Qian Zhigang Zang Key Laboratory of Optoelectronic Technology&Systems(Ministry of Education) Chongqing UniversityChongqing 400044China department of Physics&Astronomy College of SciencesKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia department of Chemistry and Chemical Engineering Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China department of Oil Army Logistics Academy of PLAChongqing 401311China

The Sb^(3+) doping strategy has been proven to be an effective way to regulate the band gap and improve the photophysical properties of organic-inorganic hybrid metal halides(OIhMhs).however,the emission of Sb^(3+) ions in OIhMhs is primarily confined to the low energy region,resulting in yellow or red *** date,there are few reports about green emission of Sb^(3+)-doped ***,we present a novel approach for regulating the luminescence of Sb^(3+) ions in 0d C_(10)h_(2)_(2)N_(6)InCl_(7)·h_(2)O via hydrogen bond network,in which water molecules act as agents for hydrogen ***^(3+)-doped C_(10)h_(2)2N_(6)InCl_(7)·h_(2)O shows a broadband green emission peaking at 540 nm and a high photoluminescence quantum yield(PLQY)of 80%.It is found that the intense green emission stems from the radiative recombination of the self-trapped excitons(STEs).Upon removal of water molecules with heat,C_(10)h_(2)_(2)N_(6)In_(1-x)Sb_(x)Cl_(7) generates yellow emis-sion,attributed to the breaking of the hydrogen bond network and large structural distortions of excited *** water molecules are adsorbed by C_(10)h_(2)_(2)N_(6)In_(1-x)Sb_(x)Cl_(7),it can subsequently emit green *** water-induced reversible emission switching is successfully used for optical security and information *** findings expand the under-standing of how the local coordination structure influences the photophysical mechanism in Sb^(3+)-doped metal halides and provide a novel method to control the STEs emission.

关键词： indium-based halides Sb^(3+)doping hydrogen bonding network optical anti-counterfeiting

Exploring one material for dual applications:A red-emitting Mg_(2)GeO_(4):Eu^(3+)nanophosphor for future generation energy efficient WLEds and dosimetric applications

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Journal of Rare Earths 2024年第10期42卷 1835-1845页

作者： Akshay Arjun G.P.darshan S.C.Sharma h.Nagabhushana d.V.Sunitha h.B.Premkumar department of Physics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied SciencesBengaluru560054India honorary Professor of Law and Forensic Materials Jain UniversityBengaluru560069India C.N.R.Rao Centre for Advanced Materials Tumkur UniversityTumkur572103India School of Applied Sciences(Physics) REVA UniversityBengaluru560064India

The envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are highly *** this in mind,a series of forsterite-structured Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors was synthesized via a solution combustion method using oxalyl dihydrazide as a *** X-ray diffraction patterns confirm the orthorhombic crystal system with a Puma space *** results clearly show irregularly shaped cluster-like structures with aggregation of the *** diffuse reflectance spectra,the optical energy band gap of the Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors was estimated and obtained to be~4.12-4.32 *** photoluminescence emission spectra exhibit intense peaks at^(5)79,589,610,661,and 707 nm,which are due to characteristic^(5)d_(0)→^(7)F_(0),^(5)d_(0)→^(7)F_(1),^(5)do→^(7)F_(2),^(5)d_(0)→^(7)F_(3)and^(5)d_(0)→^(7)F_(4)transitions of Eu^(3+)ions,*** Commission International de L'Eclairage color coordinates are gradually tuned from pale red(0.5980,0.4012)to a pure red(0.6385,0.3611)*** glow peaks showcase excellent super-linear response at low doses ofγ-irradiations,indicating that the prepared phosphor can be used in thermoluminescent personal dosimetry which is a biological tissue *** aforementioned results demonstrate that the prepared Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors are considered an excellent candidate for dual applications,i.e.,red component in future generation white-light-emitting diodes(WLEds)and personal dosimetric applications.

关键词： Nanophosphors Photoluminescence Thermoluminescence dosimetry Photometric properties Rare earths

Cognition on oxidation behavior of Ni-based superalloy Gh4742 when exposed to water vapor

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Journal of Materials Science & Technology 2024年第7期174卷 15-22页

作者： h.Xu S.F.yang E.h.Wang C.Y.Guo Y.S.Liu X.M.hou Y.L.Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The oxidation behavior of Ni-based superalloy Gh4742 exposed to water vapor was investigated at 900-1100℃for 50 h in Ar+20%h_(2)O,with Ar+20%O_(2)included for *** presence of h_(2)O is adverse to formation of continuous Cr_(2)O_(3)oxide layer but contributes to generation of big *** on this,Ni^(2+)and Co^(2+)are more easily to diffuse towards the outermost oxide layer(OOL),forming non-protective Ni-and Co-rich oxides with high *** leads to a higher weight gain in Ar+20%h_(2)O than that in Ar+20%O_(2).At elevated temperatures,the spallation of oxide scale occurs while the consumption of Cr is reduced in Ar+20%h_(2)O,and the contents of Ni-and Co-rich oxides at this moment are reduced in the *** oxidation mechanism was also discussed.

关键词： Gh4742 Superalloy h_(2)O diffusion Oxidation Mechanism

Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali yang Yu Liu En-yang Wang Jinbo Pang Shirong huang Thomas Gemming Jinshun Bi Alicja Bachmatiuk hao Jia Shu-Xian hu Chongyun Jiang hong Liu Gianaurelio Cuniberti Weijia Zhou Mark h Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany dresden Center for Intelligent Materials(GCL dCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2d)materials toolkit to assemble van der Waals *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for example,SnCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors were soaked in SnCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2d materials.

关键词： two-dimensional(2d)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

A mutation in TBXT causes congenital vertebral malformations in humans and mice

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Journal of Genetics and Genomics 2024年第4期51卷 433-442页

作者： Shuxia Chen Yunping Lei Yajun yang Chennan Liu Lele Kuang Li Jin Richard hFinnell Xueyan yang hongyan Wang Obstetrics and Gynecology hospital State Key Laboratory of Genetic Engineering at School of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200438China Shanghai Key Laboratory of Metabolic Remodeling and health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Center for Precision Environmental health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA MOE Key Laboratory of Contemporary Anthropology School of Life SciencesFudan UniversityShanghai 200438China department of Assisted Reproduction Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Children’s hospital Fudan University399 Wanyuan RoadShanghai 201102China

T-box transcription factor T(TBXT;T)is required for mesodermal formation and axial skeletal *** it has been extensively studied in various model organisms,human congenital vertebral malformations(CVMs)involving T are not well ***,we report a family with 15 CVM patients distributed across 4 *** affected individuals carry a heterozygous mutation,T c.596A>G(p.Q199R),which is not found in unaffected family members,indicating co-segregation of the genotype and *** vitro assays show that T p.Q199R increases the nucleocytoplasmic ratio and enhances its dNA-binding affinity,but reduces its transcriptional activity compared to the *** determine the pathogenicity of this mutation in vivo,we generated a Q199R knock-in mouse model that recapitulates the human CVM *** heterozygous Q199R mice show subtle kinked or shortened tails,while homozygous mice exhibit tail filaments and severe vertebral ***,we show that the Q199R mutation in T causes CVM in humans and mice,providing previously unreported evidence supporting the function of T in the genetic etiology of human CVM.

关键词： Congenital vertebral malformation TBXT T gene Loss-of-function mutation

Loss of the accessory chromosome converts a pathogenic tree-root fungus into a mutualistic endophyte

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Plant Communications 2024年第1期5卷 164-180页

作者： huanshen Wei Zhenhui Zhong Zhongfeng Li Yuwei Zhang Eva h.Stukenbrock Boping Tang Ningning yang Riccardo Baroncelli Long Peng Zhuo Liu Xinghua he Yuzhan yang Zhilin Yuan State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China Research Institute of Subtropical Forestry Chinese Academy of ForestryHangzhou 311400China State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Agriculture and Forestry UniversityFuzhou 350002China Environmental Genomics Christian-Albrechts University24118 KielGermany Max Planck Fellow Group Environmental Genomics Max Planck Institute for Evolutionary Biology24306 PlonGermany Jiangsu Key Laboratory for Bioresources of Saline Soils School of WetlandsYancheng Teachers UniversityYancheng 224002China department of Agricultural and Food Sciences(dISTAL) University of Bologna40127 BolognaItaly

Some fungal accessory chromosomes(ACs)may contribute to virulence in ***,the mecha-nisms by which ACs determine specific traits associated with lifestyle transitions along a symbiotic contin-uum are not *** we delineated the genetic divergence in two sympatric but considerably variable isolates(16B and 16W)of the poplar-associated fungus Stagonosporopsis *** identified a-0.6-Mb horizontally acquired AC in 16W that resulted in a mildly parasitic lifestyle in *** deletion of the AC(d16W)significantly altered the fungal ***,d16W was morphologically more similar to 16B,showed enhanced melanization,and established beneficial interactions with poplar plants,thereby acting as a dark septate *** sequencing(RNA-seq)analysis showed that AC loss induced the upregulation of genes related to root colonization and biosynthesis of indole acetic acid and *** observed that the AC maintained a more open status of chromatin across the genome,indicating an impressive remodeling of cis-regulatory elements upon AC loss,which potentially enhanced symbiotic *** demonstrated that the symbiotic capacities were non-host-specific through comparable experiments on Triticum–and Arabidopsis–fungus ***,the three isolates generated symbiotic interactions with a nonvascular *** summary,our study suggests that the AC is a suppressor of symbiosis and provides insights into the underlying mechanisms of mutualism with vascular plants in the absence of traits encoded by the *** speculate that AC-situ-ated effectors and other potential secreted molecules may have evolved to specifically target vascular plants and promote mild virulence.

关键词： dark septate endophytes effectors lifestyle transition root–fungus symbioses