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Pharmacological insights into autophagy modulation in autoimmune diseases

Acta Pharmaceutica Sinica B 2021年第11期11卷 3364-3378页

作者： Ming-Yue Wu Er-Jin Wang du Feng Min Li Richard d.Ye Jia-Hong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 9999078China Key Laboratory of Protein Modification and degradation State Key Laboratory of Respiratory DiseaseCollege of Basic Medical ScienceGuangzhou Medical UniversityGuangzhou 510000China School of Pharmaceutical Sciences National and Local United Engineering Lab of Druggability and New Drugs EvaluationGuangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510000China Kobilka Institute of Innovative drug discovery School of Life and Health Sciencesthe Chinese University of Hong KongShenzhen 518000China

As a cellular bulk degradation and survival mechanism,autophagy is implicated in diverse biological ***-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus(SLE)and inflammatory bowel disease(IBd),indicating that autophagy dysregulation may be involved in the development of autoimmune diseases.A series of autophagy modulators have displayed protective effects on autoimmune disease models,highlighting the emerging role of autophagy modulators in treating autoimmune *** review explores the roles of autophagy in the autoimmune diseases,with emphasis on four major autoimmune diseases[SLE,rheumatoid arthritis(RA),IBd,and experimental autoimmune encephalomyelitis(EAE)].More importantly,the therapeutic potentials of small molecular autophagy modulators(including autophagy inducers and inhibitors)on autoimmune diseases are comprehensively analyzed.

关键词： Autophagy Autoimmune disease Systemic lupus erythematosus Inflammatory bowel disease Rheumatoid arthritis Experimental autoimmune encephalomyelitis Autophagy inducer Autophagy inhibitor

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Effective charge from lattice QCd

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Chinese Physics C 2020年第8期44卷 23-32页

作者： Z.-F.Cui J.-L.Zhang d.Binosi F.de Soto C.Mezrag J.Papavassiliou C.d.Roberts J.Rodríguez-Quintero J.Segovia S.Zafeiropoulos School of Physics Nanjing UniversityNanjing 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjing 210093China department of Physics Nanjing Normal UniversityNanjing 210023China European Centre for Theoretical Studies in Nuclear Physics and Related Areas Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy dpto.Sistemas Físicos Químicos y NaturalesUniv.Pablo de OlavideE-41013 SevillaSpain 6.IRFUCEAUniversitéParis-SaclayF-91191 Gif-sur-YvetteFrance department of Theoretical Physics and IFIC University of Valencia and CSICE-46100ValenciaSpain department of Integrated Sciences and Center for Advanced Studies in Physics Mathematics and Computation University of Huelva E-21071 HuelvaSpain Aix Marseille Univ Universitéde ToulonCNRSCPTMarseilleFrance

Using lattice configurations for quantum chromodynamics(QCd)generated with three domain-wall fermions at a physical pion mass,we obtain a parameter-free prediction of QCd’s renormalisation-group-invariant process-independent effective charge,α^(k2).Owing to the dynamical breaking of scale invariance,evident in the emergence of a gluon mass-scale,m0=0.43(1)GeV,this coupling saturates at infrared momenta:α^(0)/π=0.97(4).Amongst other things:α^(k2)is almost identical to the process-dependent(Pd)effective charge defined via the Bjorken sum rule;and also that Pd charge which,employed in the one-loop evolution equations,delivers agreement between pion parton distribution functions computed at the hadronic scale and *** diversity of unifying roles played byα^(k^2)suggests that it is a strong candidate for that object which represents the interaction strength in QCd at any given momentum scale;and its properties support a conclusion that QCd is a mathematically well-defined quantum field theory in four dimensions.

关键词： running coupling quantum chromodynamics dyson-Schwinger equations lattice field theory emer-gence of mass confinement

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Specific alterations of regional myocardial work in strength-trained athletes using anabolic androgenic steroids compared to athletes with genetic hypertrophic cardiomyopathy

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Journal of Sport and Health Science 2023年第4期12卷 477-485页

作者： Antoine Grandperrin Frédéric Schnell Erwan donal Elena Galli Christophe Hedon Olivier Cazorla Stéphane Nottin Avignon University LaPEC UPR 4278Avignon F-84000France Rennes University CHU RennesInsermLTSI-UMR 1099Rennes F-35000France Montpellier University PhyMedExpINSERMCNRSPhysiology and Experimental Heart and Muscle MedicineMontpellier 34295France

Background:Strength-trained athletes using anabolic androgenic steroids(AAS)have left ventricular(LV)hypertrophy and myocardial fibrosis that can lead to sudden cardiac death.A similar feature was described in athletes with hypertrophic cardiomyopathy(HCM),which complicates the diagnosis for *** this context,we aimed to compare the LV function of the 2 populations by measuring global and regional strain and myocardial work using speckle-tracking ***:Twenty-four strength-trained asymptomatic athletes using AAS(AAS-Athletes),22 athletes diagnosed with HCM(HCM-Athletes),and 20 healthy control athletes(Ctrl-Athletes)underwent a resting echocardiography to assess LV *** evaluated LV global and regional strains and myocardial work,with an evaluation of the constructive work(CW),wasted work,and work efficiency(WE).Results:Compared to Ctrl-Athletes,both AAS-Athletes and HCM-Athletes had a thicker interventricular septum,with maj ored values in *** strain was reduced in AAS-Athletes and even more in ***,global WE was significantly diminished in both AAS and HCM-Athletes(93%±2%in Ctrl-Athletes,90%±4%in AAS-Athletes,and 90%±5%in HCM-Athletes(mean±Sd);pd WE regional analysis showed specific alterations,with the basal septal segments preferentially affected in AAS-Athletes,and both septal and apical segments affected in ***:The regional evaluation of myocardial work reported specific alterations of the major LV hypertrophy induced by the regular use of AAS compared to the LV hypertrophy due to *** finding could help clinicians to differentiate between these 2 forms of pathological hypertrophy.

关键词： Anabolic androgenic steroids Hypertrophic cardiomyopathy Left ventricular function Myocardial work Speckle-tracking echocardiography

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Synthesis of RE-Ag,Al-RE-doped sol-gel glass and films for solar cells

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Journal of Rare Earths 2009年第4期27卷 671-674页

作者： A.V.Semchenko V.V.Sidsky V.Е.Gaishun d.L.Kovalenko W.Strek Francisk Skorina Gomel State University 246019 Sovetskaya st.104 Gomel Belarus Institute of Low Temperature and Structures Research PAN Okolna st.2 Wroclaw Poland

The paper dealt with the study of fluorescence properties of sol-gel systems doped with rate-earth ions and co-doped with silver. The general problem for these types of inorganic phosphors was a very low absorbance in the visible range. Therefore, a sensitizer of luminescence of the rare-earth ions should be selected and used. The sensitizer should possess a good absorbance in the visible range and strong interaction with the rare-earth ions. In this study silver ions were selected as the sensitizer.

关键词： sol-gel method sol-gel glass and film luminescence and its amplification rare-earth ions silver ions energy transfer

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Miscibility of Two Components in a Binary Mixture of 9-Phenyl Anthracene Mixed with Stearic Acid or Polymethyl Methacrylate at Air-Water Interface

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Chinese Physics Letters 2007年第5期24卷 1331-1334页

作者： P. K. Paul Md. N. Islam d. Bhattacharjee S. A. Hussain department of Physics Tripura University Suryamaninagar-799130 Tripura India

We report the miscibility characteristics of two components in a binary mixture of 9-phenyl anthracene （PA） mixed with stearic acid （SA） or polymethyl methacrylate （PMMA）. The behaviour of surface pressure versus area per molecule isotherms reveal that the area per molecule decreases systematically with increasing molefractions of PA. The characteristics of areas per molecule versus molefractions and collapse pressure vs molefraction indicate that various interactions involved among the sample and matrix molecules. The interaction scheme is found to change with the change in surface pressure and molefraction of mixing. Scanning electron microscopic study confirms the aggregation of PA molecules in the mixed films.

关键词： LANGMUIR-BLOdGETT-FILMS SPECTROSCOPIC CHARACTERIZATIONS MOLECULES SYSTEMS

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Hepatocellular carcinoma immunotherapy:The impact of epigenetic drugs and the gut microbiome

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Liver Research 2020年第4期4卷 191-198页

作者： Farzam Vaziri Steven d.Colquhoun Yu-Jui Yvonne Wan department of Pathology and Laboratory Medicine University of California DavisSacramentoCAUSA department of Surgery University of California DavisSacramentoCAUSA

The incidence of hepatocellular carcinoma(HCC)has been increasing for *** disease has now risen to become the sixth most common malignancy overall,while ranking as the third most frequent cause of cancer *** several surgical interventions and loco-regional treatment options are available,up to 80%of patients present with advanced disease not amenable to standard ***,traditional cytotoxic chemotherapeutic agents are notoriously ineffective and essentially play no role in the management of affected *** has led to an enormous need for more effective sys-temic therapeutic *** recent years,immunotherapy has emerged as a potentially viable and exciting new alternative for the treatment of *** the current immunotherapeutic options remain imperfect,various strategies can be employed to further improve their *** findings have revealed epigenetic modulation can be effective as a new approach for improving HCC *** the gut microbiome(gut-liver axis)can also be an interesting subject in this ***,we explore the latest insights into the role of immunotherapy treating HCC,both mono and in combination with other *** also focus on the impact of epigenetic drugs and the microbiome in the overall effectiveness of HCC immunotherapy.

关键词： Hepatocellular carcinoma(HCC) Immunotherapy Gut microbiota Epigenetic drugs Combination therapy

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飞行器围绕小行星的轨道运动(英文)

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宇航学报 2006年第5期27卷 961-964页

作者：胡维多 d.J.Scheeree 北京航空航天大学宇航学院北京100083 航空航天工程系

分析了飞行器围绕小行星轨道运动的特点,介绍了所建立的表述这一问题的理论基础。采用三种不同方法从几个侧面揭示了这一问题的本质特征。给出了所完成的研究这一问题的进展、结果和相互联系,其中包括轨道摄动、共振运动和周期轨道运动... 详细信息

分析了飞行器围绕小行星轨道运动的特点,介绍了所建立的表述这一问题的理论基础。采用三种不同方法从几个侧面揭示了这一问题的本质特征。给出了所完成的研究这一问题的进展、结果和相互联系,其中包括轨道摄动、共振运动和周期轨道运动。这一问题的核心和难点是轨道的稳定性问题。

关键词：轨道运动小行星摄动共振运动周期轨道

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Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma

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Liver Research 2020年第4期4卷 173-179页

作者： Tahereh Setayesh Steven d.Colquhoun Yu-Jui Yvonne Wan department of Pathology and Laboratory Medicine University of California DavisSacramentoCAUSA department of Surgery University of California DavisSacramentoCAUSA

Galectins(Gals)are evolutionarily conserved proteins that bind to b-galactoside containing *** expression of Gals is associated with the development,progression,and metastasis of different types of *** the 11 Gals identified in humans,the roles of Gal-1 and Gal-3 have been extensively investigated in various ***,we summarize the roles of overly expressed Gal-1 and Gal-3 in the pathogenesis of hepatocellular carcinoma(HCC).The overexpression of Gal-1 and Gal-3 correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,and poor prognosis.A potentially promising future treatment strategy for HCC may include the combination of immunotherapy with Gal-1 *** research is warranted to investigate targeting Gal-1 and Gal-3 for HCC treatment.

关键词： Galectin-1(Gal-1) Galectin-3(Gal-3) Liver cancer Hepatocellular carcinoma(HCC) Fibrosis Cirrhosis Non-alcoholic steatohepatitis(NASH) Metastasis Epithelial-mesenchymal transition(EMT)

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distribution Management Systems for Smart Grid:Architecture,Work Flows,and Interoperability

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 300-308页

作者： Rabih A.Jabr Izudin dzafic the department of Electrical and Computer Engineering American University of BeirutBeirut 11072020Lebanon the Faculty of Electrical Engineering University of SarajevoSarajevo 71000Bosnia and Herzegovina

The smart grid integrates advanced sensors,a two-way communication infrastructure,and high-performance computation-based *** distribution management systems for smart grid include several functions for manipulating legacy voltage control devices and distributed energy resources through closed-loop volt/var control,leading to wide-area regulation of voltages in the presence of fluctuating *** other primary distribution network analysis application is concerned with automatic fault location and service restoration following fault events,aiming to provide the grid with autonomous intelligence for *** technologies are vital to enable the computing applications of distribution networks,whether they work in centralized or distributed *** paper presents the state of the art in distribution management system architectures and modern workflows showing data exchange,practical parallel implementations designed to handle large amounts of data,in addition to communication standards that serve as interoperability *** demystifies the relationship between different functions developed independently by power system researchers and shows their operation as a complete system,thus placing them in a better context for future research and development.

关键词： Cyber security data communication power distribution networks self-healing software architecture voltage control.

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differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate

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International Journal of Oral Science 2023年第4期15卷 701-717页

作者： Maria B.Asparuhova Xiaoqing Song dominic Riedwyl Geert van Geest dieter d.Bosshardt Anton Sculean Laboratory of Oral Cell Biology School of Dental MedicineUniversity of BernBernSwitzerland department of Periodontology School of Dental MedicineUniversity of BernBernSwitzerland Interfaculty Bioinformatics Unit University of BernBernSwitzerland Robert K.Schenk Laboratory of Oral Histology School of Dental MedicineUniversity of BernBernSwitzerland

The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human ***-four CTGs belonging to anterior deep(Ad),anterior superficial(AS),posterior deep(Pd),and posterior superficial(PS)groups were subjected to RNA-Sequencing and their transcriptomes were analyzed *** correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts(HPFs)extracted from the CTGs.A clearly more pronounced location-dependent than depth-dependent difference between the grafts,with a minimal number of genes(4)showing no dependence on the location,was ***,endothelial,and monocytic cell migration was strongly(Pd by Ad-and ***,significantly increased expression of genes encoding C-C and C-X-C motif chemokine ligands as well as significantly(Pd p38 signaling suggested immunomodulatory phenotype for Ad-and *** growth factor gene expression and significantly activated(Pd Akt signaling in HPFs originating from A-CTGs implied their involvement in cell survival,proliferation,and *** collagen-rich expression profile contributing to high mechanical stability,increased osteogenesis-related gene expression,and strongly activated(Pd1/5/8 signaling characterized HPFs originating from *** present data indicate that in humans,differences between palatal CTGs harvested from different locations and depths appear to be location-rather than *** findings provide the basis for future personalization of the therapeutic strategy by selecting an optimal graft type depending on the clinical indications.

关键词： selecting characterizing showing

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