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Mapping nighttime PM2.5 from VIIRS dNB using a linear mixed effects model

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Mapping nighttime PM2.5 from VIIRS DNB using a linear mixed ...

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

第十三届全国气溶胶会议

作者： d.fu X.Xia M.duan X.Zhang X.Li J.Wang LAGEO Institute of Atmospheric PhysicsChinese Academy of Sciences College of Earth Sciences University of Chinese Academy of Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological disasters Nanjing University of Information Science&Technology School of Atmospheric Sciences Plateau Atmosphere and Environment Key Laboratory of Sichuan ProvinceChengdu University of Information Technology National Satellite Meteorological Center China Meteorological Administration department of Chemical and Biochemical Engineering Center for Global and Regional Environmental Studiesand Informatics InitiativeThe University of Iowa

Estimation of particulate matter with aerodynamic diameter less than 2.5 μm(PM) from daytime satellite aerosol products is widely reported in the literature, however, remote sensing nighttime PM from space is very *** shows a distinct diurnal cycle and PM concentration at 1:00 local standard time(LST) has a linear correlation coefficient(R) of 0.80 with daily-mean ***, estimation of nighttime PM is required for fully understanding of temporal variation of PM and its effects on air *** data from the day/Night Band(dNB) of the Visible Infrared Imaging Radiometer Suite(VIIRS) and hourly PM data at 35 stations in Beijing, a mixed effects model has been developed to estimate nighttime PM from nighttime light radiance measurements based on the assumption that the dNB-PM relationship is constant spatially but varies ***-validation showed that the model developed using all stations could predict PM with mean determination coefficient(R) of 0.87± 0.12, 0.83±0.10, 0.87± 0.09, 0.83± 0.10 in spring, summer, autumn and *** analysis showed that the best model performance was achieved in urban stations with average crossvalidation R of *** rural stations, dNB light signal was likely contaminated by lunar illuminance that resulted in relatively poor estimation of *** fixed and random parameters of the mixed effects model in urban stations differed from those in suburban stations, which indicated that the assumption of the mixed effects model should be carefully evaluated when the method was used at a regional scale.

关键词： VIIRS/dNB the mixed effects model nighttime PM 2.5

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao dong fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted.functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

Uncovering the internal structure of five-fold twinned nanowires through 3d electron diffraction mapping

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Chinese Physics B 2020年第6期29卷 517-531页

作者： Xin fu GRINM Group Corporation Limited National Analysis and Testing Center for Nonferrous Metals and Electronic MaterialsBeijing 101400China Guobiao(Beijing)Testing&Certification Co. Ltd.Beijing 101400China China United Test&Certification Co. Ltd.Beijing 101400China General Research Institute for Nonferrous Metals Beijing 100088China

Five-fold twinned nanostructures are intrinsically strained or relaxed by extended defects to satisfy the space-filling *** both of metallic and semiconductor five-fold twinned nanostructures show inhomogeneity in their cross-sectional strain distribution,the evident strain concentration at twin boundaries in the semiconductor systems has been found in contrast to the metallic ***,a problem is raised how the chemical bonding characteristics of various five-fold twinned nanosystems affects their strain-relieving defect *** using three-dimensional(3d)electron diffraction mapping methodology,the intrinsic strain and the strain-relieving defects in a pentagonal Ag nanowire and a star-shaped boron carbide nanowire,both of them have basically equal radial twin-plane width about 30 nm,are nondestructively *** non-uniform strain and defect distribution between the five single crystalline segments are found in both of the five-fold twinned *** intensity fine structure analysis for the boron carbide five-fold twinned nanowire indicates the presence of high-density of planar defects which are responsible for the accommodation of the intrinsic angular ***,for the Ag five-fold twinned nanowire,the star-disclination strain field is still present,although is partially relieved by the formation of localized stacking fault layers accompanied by partial *** analysis suggests that the variety in the strain-relaxation ways for the two types of five-fold twinned nanowires could be ascribed to the large difference in shear modulus between the soft noble metal Ag and the superhard covalent compound boron carbide.

关键词： five-fold twinnining elastic strain structural relaxation electron diffraction mapping

Effect of geometric parameters and grazing incidence on magnetic polaritons excited in 1d multi-groove gratings

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Science China(Technological Sciences) 2021年第8期64卷 1589-1598页

作者： Su ChengShuai fu CeJi LTCS and department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China

In this paper,effect of geometric parameters and grazing incidence on excitation of magnetic polaritons(MPs)in a 1d multigroove grating with different groove depths made of silver was *** results reveal that when the distance between grooves is sufficiently small,the resonance wavelengths of MPs excited in the grooves of unequal depths exhibit red shift with decrease of the distance,contrary to the case with equal groove *** shift of the MP resonance wavelengths was explained with the LC circuit ***,it was found that the resonance wavelengths of MPs depend linearly on the groove depths except when the difference between the groove depths is *** the grooves have equal depths,a large drop of the absorptance can occur due to the interaction and cancellation of the electric field vectors in the region between the ***,the results show that when a TM wave is at grazing incidence,MPs can be excited simultaneously in the grooves at a blue-shifted wavelength due to reduction of the effective capacitance,resulting in a dramatic enhancement of the ***,the results in this work may provide useful guidance in the design of wavelength-selective absorbers based on MPs.

关键词： multi-groove grating magnetic polaritons absorptance LC circuit model

Sharp Observability Inequalities for the 1-d Plate Equation with a Potential

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Chinese Annals of Mathematics,Series B 2012年第1期33卷 91-106页

作者： Xiaoyu fu College of Mathematics Sichuan UniversityChengdu 610064China department of Mathematics Indian Institute of TechnologyBombayMumbai 400076India

This paper deals with the problem of sharp observability inequality for the 1-d plate equation wtt ＋ wxxxx ＋ q（t, x）w = 0 with two types of boundary conditions w = wxx = 0 or w = wx = 0, and q（t, x） being a suitable potential. The author shows that 2 the sharp observability constant is of order exp（C｜｜q｜｜^2/7∞） for ｜｜q｜｜∞〉 1. The main tools to derive the desired observability inequalities are the global Carleman inequalities, based on a new point wise inequality for the fourth order plate operator.

关键词： Observability inequality Plate equation Point-wise estimate Carlemanestimate

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for disease Control and Prevention GuiyangGuizhou ProvinceChina department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

de novo synthesis of atropisomeric benzofurans via Cu/SPdO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang fu-Min Zhang Ai-Jun Ma Bao du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPdO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang daniel fu Alison N.deVore Marisol Lauffer Nilufer S.Atasoy deniz Atasoy Rory A.Fisher department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)