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Iris manipulation during phacoemulsification:intraoperative and postoperative complications

International Journal of Ophthalmology(English edition) 2021年第5期14卷 676-683页

作者： Eric R.Williams Jennifer L.Patnaik d.claire miller Anne M.Lynch Richard S.davidson Malik Y.Kahook Leonard K.Seibold department of Ophthalmology Sue Anschutz-Rodgers Eye CenterUniversity of Colorado School of MedicineAuroraCO 80045USA

AIM:To quantify intraoperative and postoperative complications in complex phacoemulsification cataract extraction(phacoemulsification)with iris manipulation compared to non-complex and complex phacoemulsification without iris ***:All phacoemulsification cases at the University of Colorado between January 1,2014,and June 30,2017 were *** criteria for the primary outcome of intraoperative complications were planned combination surgery and eyes with less than 28 d *** criteria for the secondary outcomes of postoperative complications were unplanned additional surgery,and chronic steroid eye drop use prior to *** including sex,race/ethnicity,surgery length,visual acuity,intraoperative and postoperative complications,and intraocular pressures(IOP)were collected and analyzed utilizing general linear and Logistic regression ***:The medical records of 5772 eyes were reviewed(500 complex without iris manipulation,367 with iris manipulation).The number of any intraoperative complication in the complex with iris manipulation and complex without iris manipulation groups was 15(4.1%)and 26(5.2%),respectively,compared to 41(0.8%)in the non-complex *** inflammation was found in 135(2.8%)non-complex cases,20(4.1%)complex cases without iris manipulation,and 20(5.6%)complex cases with iris *** adjusted odds ratio of postoperative inflammation in phacoemulsification with iris manipulation compared to non-complex was 2.3(95%CI:1.3-4.0,P=0.005).The rate of IOP spikes>10 mm Hg was significantly greater in cases with iris manipulation(P=0.001).CONCLUSION:Complex cases have more intraoperative ***,only complex cases with iris manipulation led to increase rates of postoperative inflammation and IOP spikes>10 mm Hg.

关键词： phacoemulsification iris manipulation inflammation

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Importance of Viral disease in dairy Cow Fertility

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Engineering 2020年第1期6卷 26-33页

作者： d.claire Wathes Chike F.Oguejiofor Carole Thomas Zhangrui Cheng Royal Veterinary College Hatfield AL97TAUK Faculty of Veterinary Medicine University of NigeriaNsukka 410001Nigeria

Many viral diseases are endemic in cattle populations worldwide. The ability of many viruses to cross the placenta and cause abortions and fetal malformations is well understood. There is also significant evidence that viral infections have additional actions in dairy cows, which are reflected in reduced conception rates. These effects are, however, highly dependent on the time at which an individual animal first contracts the disease and are less easy to quantify. This paper reviews the evidence relating to five viruses that can affect fertility, together with their potential mechanisms of action. Acute infection with non-cytopathic bovine viral diarrhea virus (BVdV) in mid-gestation increases abortion rates or causes the birth of persistently infected calves. BVdV infections closer to the time of breeding can have direct effects on the ovaries and uterine endometrium, which cause estrous cycle irregularities and early embryo mortality. Fertility may also be reduced by BVdV-induced immunosuppression, which increases the susceptibility to bacterial infections. Bovine herpesvirus (BHV)-1 is most common in pre-pubertal heifers, and can slow their growth, delay breeding, and increase the age at first calving. Previously infected animals subsequently show reduced fertility. Although this may be associated with lung damage, ovarian lesions have also been reported. Both BHV-1 and BHV-4 remain latent in the host following initial infection and may be reactivated later by stress, for example associated with calving and early lactation. While BHV-4 infection alone may not reduce fertility, it appears to act as a co-factor with established bacterial pathogens such as Escherichia coli and Trueperella pyogenes to promote the development of endometritis and delay uterine repair mechanisms after calving. Both Schmallenberg virus (SBV) and bluetongue virus (BTV) are transmitted by insect vectors and lead to increased abortion rates and congenital ***-8 also impairs t

关键词： Bovine viral diarrhea virus Bovine herpesvirus-1 Bovine herpesvirus-4 Schmallenberg virus Bluetongue virus Immunosuppression Embryo mortality

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Associations of self-reported and device-assessed physical activity with fatigue,quality of life,and sleep quality in adults living with and beyond cancer

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Journal of Sport and Health Science 2023年第6期12卷 664-673,F0003页

作者： Phillippa Lally Natalie Ella miller claire Lawrence Rebecca J Beeken Abigail Fisher department of Behavioural Science and Health University College LondonLondon WC1E 6BTUK department of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Health Sciences Leeds LS29NLUK

Background Greater physical activity is associated with improved outcomes in people living with and beyond ***,most studies in exercise oncology use self-reported measures of physical *** have explored agreement between self-reported and device-based measures of physical activity in people living with and beyond *** study aimed to describe physical activity in adults affected by cancer across self-reported and device-assessed activity,to explore levels of agreement between these measures in terms of their utility for categorizing participants as meeting/not meeting physical activity guidelines,and to explore whether meeting guidelines is associated with fatigue,quality of life,and sleep *** A total of 1348 adults living with and beyond cancer from the Advancing Survivorship Cancer Outcomes Trial completed a survey assessing fatigue,quality of life,sleep quality,and physical *** Godin-Shephard Leisure-Time Physical Activity Questionnaire was used to calculate a Leisure Score Index(LSI)and an estimate of moderate-to-vigorous physical activity(MVPA).Average daily steps and weekly aerobic steps were derived from pedometers worn by *** The percentage of individuals meeting physical activity guidelines was 44.3%using LSI,49.5%using MVPA,10.8%using average daily steps,and 28.5%using weekly aerobic ***(Cohen'sκ)between self-reported and pedometer measures ranged from 0.13(LSI *** daily steps)to 0.60(LSI ***).After adjusting for sociodemographic and health-related covariates,meeting activity guidelines using all measures was associated with not experiencing severe fatigue(odds ratios(ORs):1.43–1.97).Meeting guidelines using MVPA was associated with no quality-of-life issues(OR=1.53).Meeting guidelines using both self-reported measures were associated with good sleep quality(ORs:1.33–1.40).Conclusion Less than half of all adults affected by cancer are meeting physical activity guidelines,

关键词： Cancer survivorship Fatigue Physical activity Quality of life SleepTagedAPTARAEnd

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Chronic kidney disease and the skeleton

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Bone Research 2014年第4期2卷 205-217页

作者： Paul d miller Colorado Center for Bone Research LakewoodCO.USA

Fractures across the stages of chronic kidney disease （CKd） could be due to osteoporosis, some form of renal osteodystrophy defined by specific quantitative histomorphometry or chronic kidney disease-mineral and bone disorder （CKd-MBd）. CKd-MBd is a systemic disease that links disorders of mineral and bone metabolism due to CKd to either one or all of the following： abnormalities of calcium, phosphorus, parathyroid hormone or vitamin d metabolism; abnormalities in bone turnover, mineralization, volume, linear growth or strength; or vascular or other soft-tissue calcification. Osteoporosis, as defined by the National Institutes of Health, may coexist with renal osteodystrophy or CKd-MBd. differentiation among these disorders is required to manage correctly the correct disorder to reduce the risk of fractures. While the World Health Organization （WHO） bone mineral density （BMd） criteria for osteoporosis can be used in patients with stages 1-3 CKd, the disorders of bone turnover become so aberrant by stages 4 and 5 CKd that neither the WHO criteria nor the occurrence of a fragility fracture can be used for the diagnosis of osteoporosis. The diagnosis of osteoporosis in stages 4 and 5 CKd is one of the exclusion--excluding either renal osteodystrophy or CKd- MBd as the cause of low BMd or fragility fractures. differentiations among the disorders of renal osteodystrophy, CKd-MBd or osteoporosis are dependent on the measurement of specific biochemical markers, including serum parathyroid hormone （PTH） and/or quantitative bone histomorphometry. Management of fractures in stages 1-3 CKd does not differ in persons with or without CKd with osteoporosis assuming that there is no evidence for CKd-MBd, clinically suspected by elevated PTH, hyperphosphatemia or fibroblast growth factor 23 due to CKd. Treatment of fractures in persons with osteoporosis and stages 4 and 5 CKd is not evidence-based, with the exception of post-hoc analysis suggesting efficacy and safety of specific o

关键词： CKd GFR PTH MBd

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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Anion structural effects on interaction of rare earth element ions with dowex 50W X8 cation exchange resin

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Journal of Rare Earths 2018年第8期36卷 879-890页

作者： duane d.miller Ranjani Siriwardane dustin Mcintyre U.S. department of Energy National Energy Technology Laboratory AECOM

The effect of the anion in the original rare earth element（REE） solution on the reversible ion exchange of Ce nitrate and Ce sulfate with the dowex 50 W X8 was investigated using attenuated total reflection infrared（ATR-IR） spectroscopy, continuous flow reactor studies coupled with inductively coupled plasma mass spectroscopy（ICP-MS）, and density functional theory（dFT）. The simulated IR spectrum at the dFT B3 LYP/6-31 G（d） level was compared to the experimental results to characterize the IR spectrum, molecular interactions, and bonding of the ion exchanged species. The continuous liquid flow reactor studies show a capacity of 0.72 mmol/g sorbent for the Ce nitrateand 0.96 mmol/g sorbent for the Ce sulfate with the dowex 50 W X8. The flow reactor studies reveal the type of solute anion（SO_4^（（2-）） or NO_3^（（-））） associated with the REE during cation exchange significantly affects the sorption capacity of the dowex 50 W X8 ion exchange resin. The calculated REE binding energy（BE） and the dFT optimized structures suggest that the differences in sorption capacity is the result of the formation of different types of partially ionexchanged Ce_2^（（3＋））2 SO_4^（（2-）） and Ce^（（3＋）） 3 NO_3^（（-））. These results suggest that the solute anion affects the equilibrium constants of the dowex resin by the formation of a charged layer capable of retaining the counterion. Modifying the sulfonic acid site（H＋） in the dowex 50 W X8 with the NH_4~＋ counterion does not affect the sorption capacity and retention times of the Ce nitrate and Ce sulfate species. These results suggest that the counterions and co-ions having a finite size, may limit access to the dowex sulfonate active site where the type of REE cation as a nitrate or sulfate in solution may significantly modify the sorption capacity of the ion exchange resin. Similar results are obtained during sorption with nitrates and sulfates of Sm and Yb.

关键词： Ion exchange dowex Anion effects Rare earth metal sorption

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Impaired lysosomes in the retinal pigment epithelium play a central role in the degeneration of the neuroretina

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Neural Regeneration Research 2023年第12期18卷 2697-2698页

作者： Rebecca d.miller J.Arjuna Ratnayaka Clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthamptonUK

Lysosomes are highly dynamic, single membranebound compartments that are critical for maintaining cellular homeostasis. These organelles, which appear to vary between 200 nm–1 μm in diameter, originate from the maturation of endocytic vesicles and via the enrichment of newly synthesized lysosomal proteins in the trans-Golgi network.

关键词： critical dynamic degeneration

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