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Baroreflex Control of Heart Rate in Mice Overexpressing Human SOd1: Functional Changes in Central and Vagal Efferent Components

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Neuroscience Bulletin 2019年第1期35卷 91-97页

作者： Jin Chen He Gu Robert d.Wurster Zixi cheng division of Neuroscience and division of Metabolic and Cardiovascular Sciences Burnett School of Biomedical SciencesCollege of MedicineUniversity of Central FloridaOrlandoFL 32816USA department of Cellular and Molecular Physiology Stritch School of MedicineLoyola UniversityMaywoodIL 60153USA

Excessive reactive oxygen species(ROS)(such as the superoxide radical) are commonly associated with cardiac autonomic dysfunctions. Though superoxide dismutase 1(SOd1) overexpression may protect against ROS damage to the autonomic nervous system, superoxide radical reduction may change normal physiological functions. Previously, we demonstrated that human SOd1(hSOd1) overexpression does not change baroreflex bradycardia and tachycardia but rather increases aortic depressor nerve activity in response to arterial pressure changes in C57 B6 SJL-Tg(SOd1)2 Gur/J mice. Since the baroreflex arc includes afferent, central, and efferent components, the objective of this study was to determine whether hSOd1 overexpression alters the central and vagal efferent mediation of heart rate(HR) responses. Our data indicate that SOd1 overexpression decreased the HR responses to vagal efferent nerve stimulation but did not change the HR responses to aortic depressor nerve(AdN)stimulation. Along with the previous study, we suggest that SOd1 overexpression preserves normal baroreflex function but may differentially alter the functions of the AdN, vagal efferents, and central components. While SOd1 overexpression likely enhanced AdN function and the central mediation of bradycardia, it decreased vagal efferent control of HR.

关键词： SOd1 Parasympathetic Baroreflex

An accurate determination of the Hubble constant from baryon acoustic oscillation datasets

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Science China(Physics,Mechanics & Astronomy) 2015年第9期58卷 103-108页

作者： cheng cheng HUANG QingGuo State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences University of the Chinese Academy of Sciences

Even though the Hubble constant cannot be significantly determined just by the low-redshift Baryon Acoustic Oscillation(BAO)data, it can be tightly constrained once the high-redshift BAO data are combined. We combined BAO data from 6d FGS, BOSS dR11 clustering of galaxies, Wiggle Z and z = 2.34 from BOSS dR11 quasar Lyman-α forest lines to get H0= 68.17+1.55-1.56 km s-1Mpc-1. In addition, we adopted the simultaneous measurements of H(z) and dA(z) from the two-dimensional two-point correlation function from BOSS dR9 CMASS sample and two-dimensional matter power spectrum from SdSS dR7 sample to obtain H0=(68.11±1.69) km s-1Mpc-1. Finally, combining all of the BAO datasets, we conclude that H0=(68.11±0.86) km s-1Mpc-1, a1.3% determination.

关键词： Hubble constant baryon acoustic oscillation large-scale structure

Predicting gas and shrinkage porosity in solidification microstructure:A coupled three-dimensional cellular automaton model

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Journal of Materials Science & Technology 2020年第14期47卷 91-105页

作者： cheng Gu Colin d.Ridgeway Emre Cinkilic Yan Lu Alan A.Luo department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA department of Integrated Systems Engineering The Ohio State UniversityColumbusOH 43210USA

Porosity formation during solidification of aluminum-based alloys,due to hydrogen gas and alloy shrinkage,has been a major issue adversely affecting the performance of solidification products such as castings,welds or additively manufactured components.A three-dimensional cellular automaton(CA)model has been developed,for the first time,to couple the predictions of hydrogen-induced gas porosity and shrinkage porosity during solidification microstructure evolution of a binary Al-Si *** CA simulation results are validated under various cooling rates by porosity measurements in an experimental wedge die casting using X-ray micro computed tomography(XMCT)*** validated porosity moel provides a critical link in integrated computation materials engineering(ICME)design and manufacturing of solidification products.

关键词： Solidification Cellular automaton Microstructure simulation Microporosity evolution

Identification methods for anomalous stress region in coal roadways based on microseismic information and numerical simulation

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International Journal of Mining Science and Technology 2017年第3期27卷 525-530页

作者： Liu Chao Li Shugang cheng cheng cheng Xiaoyu College of Safety Science and Engineering Xi'an University of Science & Technology Xi'an 710054 China Key Laboratory of Western Mine Exploitation and Hazard Prevention Ministry of Education Xi'an University of Science & Technology Xi'an 710054 China

It is believed that the microseismicity induced by mining effect and gas gradient disturbance stress is a precursor to the essential characteristics of roadway unstability. In order to effectively identify and evaluate the stability of coal roadways in the process of mine development and extraction, a microseismic monitoring system was deployed for the study of the stress evolution process, damage degree and distribution characteristics in the tailgate and headgate. The mine under study is the 62113 outburst working face of Xin Zhuangzi coalmine in Huainan mining area. The whole process of microfractures initiation,extension, interaction and coalescence mechanisms during the progressive failure processes of the coal rock within the delineated and typical event clusters were investigated by means of a two dimensional realistic failure process analysis code(RFPA2d-Flow). The results show that the microseismic events gradually create different-sized event clusters. The microseismicity of the tailgate is significantly higher than that of the headgate. The study indicates that the greater anomalous stress region matches the area where microfractures continuously develop and finally connect to each other and form a fissure *** to the mine layout and stress concentration, the ruptured area is mainly located on the left shoulder of the tailgate roof. The potential anomalous stress region of the coal roadway obtained by numerical simulation is relatively in good agreement with the trend of spatial macro evolution of coal rock microfractures captured by the microseismic monitoring system. The research results can provide important basis for understanding instability failure mechanism of deep roadway and microseismic activity law in complex geologic conditions, and it ultimately can be used to guide the selection and optimization of reinforcement and protection scheme.

关键词： Microseismic monitoring technology Numerical simulation Anomalous stress region Event clusters Microcracks

In Honor of the 80th Birthday of Professor WANG Fosong

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Science China Chemistry 2012年第5期55卷 643-645页

作者： Stephen Z. d. cheng the University of Akron

Professor Fosong Wang was born in Guangdong, China in 1933 and received his undergraduate education at Wuhan University between 1951 and 1955. Following graduation, he went to the Former Soviet Union to continue his graduate studies whereupon, in 1960, he received his Ph.d. in chemistry from the Institute of High Molecular Compounds of

关键词：生日化学研究所本科教育武汉大学松广东省研究生前苏联

光交联复合水凝胶支架中人牙髓干细胞的成骨/成牙分化能力

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中国组织工程研究 2025年第19期29卷 4022-4028页

作者：杨杜娟程梦可刘佳新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科新疆维吾尔自治区乌鲁木齐市830054 新疆维吾尔自治区口腔医学研究所新疆维吾尔自治区乌鲁木齐市830054

背景:甲基丙烯酸酐改性明胶(gelatin-methacryloyl,Gel-MA)与经处理牙本质基质(treated dentin matrix,TdM)在一定比例下经过紫外线交联后形成的复合水凝胶支架具有良好的孔隙率、机械性能、溶胀性能及生物降解率,这为临床上年轻恒牙的... 详细信息

背景:甲基丙烯酸酐改性明胶(gelatin-methacryloyl,Gel-MA)与经处理牙本质基质(treated dentin matrix,TdM)在一定比例下经过紫外线交联后形成的复合水凝胶支架具有良好的孔隙率、机械性能、溶胀性能及生物降解率,这为临床上年轻恒牙的牙髓再生提供了新的思路和方法。目的:探究1∶2质量比Gel-MA/TdM复合光交联水凝胶支架对人牙髓干细胞增殖能力及成骨/成牙本质分化能力的影响。方法:将第3代牙髓干细胞接种至1∶2质量比Gel-MA/TdM复合水凝胶支架中,采用CCK-8实验检测人牙髓干细胞在复合水凝胶支架中的增殖能力。将第3代牙髓干细胞接种至1∶2质量比Gel-MA/TdM复合水凝胶支架中并进行成骨诱导,采用碱性磷酸酶染色及茜素红染色观察矿化结节的形成情况,采用RT-PCR检测成牙相关因子(牙本质基质蛋白1、牙本质涎磷蛋白)和成骨相关因子(骨钙素、Runt相关转录因子2)的基因表达。结果与结论:①CCK-8检测结果显示,前7 d的牙髓干细胞增殖能力明显升高,第10天时速度减缓;②碱性磷酸酶染色及茜素红染色结果显示,Gel-MA/TdM复合水凝胶组牙髓干细胞的碱性磷酸酶活性及矿化结节生成强于单纯Gel-MA水凝胶组(PdM复合水凝胶组牙髓干细胞中牙本质基质蛋白1、牙本质涎磷蛋白、骨钙素、Runt相关转录因子2的基因表达量明显高于单纯Gel-MA水凝胶组(Pd基因表达量明显高于7 d(PdM复合水凝胶支架上的牙髓干细胞表现出较好的增殖能力,能够强化牙髓干细胞的成骨、成牙本质分化能力。

关键词：牙髓再生甲基丙烯酸酐改性明胶牙本质基质复合支架牙髓干细胞成骨成牙本质

Strategies for prevention and management of partial flap loss or fat necrosis in microvascular autologous breast reconstruction

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Plastic and Aesthetic Research 2023年第1期10卷 295-304页

作者： Gabriela d García Nores Angela cheng department of Surgery Division of Plastic and Reconstructive SurgeryEmory UniversityAtlantaGA 30322USA

Partial flap loss(skin involved)or fat necrosis following autologous breast reconstruction remains a dreaded postoperative complication despite significant advances in microsurgical *** strategies have been proposed in the preoperative and intraoperative period to prevent this complication ranging from preoperative imaging,intra-operative tissue perfusion assessment,appropriate perforator selection(location and number),maximizing inflow and outflow with additional anastomoses and/or pedicles,and minimizing ischemia *** management of partial flap loss(when there is skin involvement)and fat necrosis remains a challenge,with very little published data focusing on classification,timing,and *** intervention versus close observation may depend on multiple patient factors and the degree or volume of *** intervention options include hyperbaric oxygen therapy,fat aeration with a needle,liposuction,fat grafting,addition of another flap or implant,depending on the nature of the *** review summarizes the current evidence for each of these strategies to help the current surgeon understand their options in preventing and managing patients suffering from partial flap loss.

关键词： Partial flap loss fat necrosis prevention of fat necrosis

Special topic on soft matter science and technology

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Science China Chemistry 2018年第1期61卷 1-2页

作者： Wen-Bin Zhang Stephen Z.d.cheng Yong Cao Key Laboratory of Polymer Chemistry & Physics of Ministry of Education Center for Soft Matter Science and Engineering College of Chemistry and Molecular Engineering Peking University South China Advanced Institute of Soft Matter Science and Technology South China University of Technology State Key Laboratory of Luminescent Materials and devices South China University of Technology

Soft matter, as first proposed by de Gennes in 1991, describes a broad range of molecular systems exhibiting a large response to small foreign stimuli. Typically, it includes colloidal particles, amphiphiles, liquid crystals, polymers and others. The term ＂soft＂ originates from the common macroscopic properties of these systems and differentiates them from conventional ＂hard＂ materials. Over the past decades, the field of ＂soft matter＂ has progressed tremendously. Today, it is a truly multidisciplinary research endeavor bridging physics with chemistry and life science. There are many research activities all over the world that are solely devoted to the field of soft matter. In turn, the in-depth understanding of soft matter has promoted our sci- ence and technology and helped shaping our civilization as it is now.

关键词： Special topic soft matter science and technology

Fluconazole Susceptibility and Genotypic Heterogeneity of Oral Candida albicans Colonies from the Patients with Cancer Receiving Chemotherapy in China

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International Journal of Oral Science 2009年第3期1卷 156-162页

作者： Jing Sun cheng Qi Micheal d. Lafleur Qing-guo Qi department of Oral Medicine Key Lab of Oral biomedicine Shandong Province School of Stomatology Shandong University Jinan China The Secondary Hospital affiliated to Shandong University Jinan China Antimicrobial discovery Center and department of Biology Northeastern University Boston USA

Aim To identify heterogeneity of Candida albicans （C. albicans） isolated from the population with cancer in China by using identification medium, subculture molecular typing, and antifungal susceptibility test. Methodology Oral cheek mucosal specimens from 52 cancer patients receiving chemotherapy were cultured on CHROMagar CandidaTM plates for Candida identification. All the C. albicans colonies on the plates were subcultured and reconfirmed by API20C, then submitted to the antifimgal drug susceptibility test with fluconazole and molecular typing using randomly amplified polymorphic dNA-PCR （RAPd） with primers RSd6 and *** 54% （28/52） patients were oral yeast carriage in which C. albicans predominated. More than 7 C. albicans colonies were isolated from each of 12 patients （Group A）, while less than 5 colonies were isolated from each of 16 patients （Group B）. RSd6 and RSd12 were successful in eliciting 17 （A1-A17） and 2 （B1-B2） genotypes, respectively from among the 205 isolates. The two primers were combined to generate 21 genotypes. The C. albicans isolates obtained from the same patient and episode showed a diversity for fluconazole revealed by MIC50 and MIC90. Conclusion The heterogeneity of the C. albicans colonies isolated from the same patients can be detected. C. albicans with varied fluconazole susceptibility and genotypic characteristics may coexist in the same oral Candida population.

关键词： Candida albicans molecular typing chemotherapy antifungal susceptibility