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Acute phase reactants, challenge in the near future of animal production and veterinary medicine

Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2005年第10期6卷 941-947页

作者： GRUYS E. ,TOUSSAINT M.J.M. ,UPRAGARIN N. ,VAN EdEREN A.M. ,AdEWUYI A.A. ,CANdIANI d. ,NGUYEN T.K.A. ,SAbECKIENE (bALCIUTE) J. department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands department of Farm Resources and Production Medicine Faculty of Veterinary Medicine Kasetsart University Nakhon Pathom Thailand department of Veterinary Morphophysiology University of Torino Italy department of Embryo Transfer and Reproduction the National Institute of Animal Husbandry Hanoi Vietnam department of Infectious diseases Lithuanian Veterinary Academy Kaunas Lithuania)

The future of acute phase proteins (APPs) in science is discussed in this paper. Many functions and associated pathological processes of APPs are unknown. Extrahepatic formation in local tissues needs attention. Local serum amyloid A (SAA) formation may be involved in deposition of AA-amyloid induced by conformational change of SAA resulting in amyloid formation, having tremendous food safety implications. Amyloidogenesis is enhanced in mouse fed beta pleated sheet-rich pro- teins. The local amyloid in joints of chicken and mammary corpora amylacea is discussed. differences in glycosylation of glycoproteins among the APPs, as has been shown for α1-acid glycoprotein, have to be considered. More knowledge on the reactivity patterns may lead to implication of APPs in the diagnostics and staging of a disease. Calculation of an index from values of several acute phase variables increases the power of APPs in monitoring unhealthy individuals in animal populations. Vaccinations, just as infections in eliciting acute phase response seem to limit the profitability of vaccines because acute phase reactions are contraproductive in view of muscle anabolism. Interest is focused on amino acid patterns and vitamins in view of dietary nutrition effect on sick and convalescing animals. When inexpensive methodology such as liquid phase methods (nephelometry, turbidimetry) or protein array technology for rapid APPs measurement is available, APPs have a future in routine diagnostics. Specific groups of patients may be screened or populations monitored by using APPs.

关键词： Acute phase protein Amino acid Joint Mammary gland Mastitis Serum amyloid A (SAA) Vitamin A

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bioactivity‑Guided Isolation of Totarane‑derived diterpenes from Podocarpus neriifolius and Structure Revision of 3‑deoxy‑2α‑hydroxynagilactone E

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Natural Products and bioprospecting 2019年第2期9卷 157-163页

作者： P.Annécie benatrehina Wei-Lun Chen Austin A.Czarnecki Steven Kurina Hee-byung Chai daniel d.Lantvit Tran N.Ninh Xiaoli Zhang djaja d.Soejarto Joanna E.burdette A.douglas Kinghorn L.Harinantenaina Rakotondraibe division of Medicinal Chemistry and Pharmacognosy The Ohio State UniversityCollege of PharmacyColumbusOHUSA Center for biostatistics The Ohio State UniversityColumbusOHUSA College of Pharmacy University of Illinois at ChicagoChicagoILUSA John G.Searle Herbarium of the Field Museum of Natural History ChicagoILUSA Institute of Ecology and biological Resources Vietnam Academy of Science and Technology HanoiHanoiVietnam

bioactivity-guided phytochemical investigation of Podocarpus neriifolius ***.(Podocarpaceae)has led to the isolation of one new(2)and three known(1,3,and 4)b-type podolactones,along with three totarane-type diterpenes(5-7).Their structures were determined by interpretation of High Resolution ElectroSpray Ionization Mass Spectrometry(HRESIMS)and 1d and 2d NMR data,and comparison with the values reported in the *** structure of compound 1,previously identifed as 3-deoxy-2α-hydroxynagilactone E(8),was revised as its 2β-epimer,which has been reported recently as a new *** of the isolates were evaluated for their antiproliferative activity against a panel of four human cancer cell lines,namely,ovarian(OVCAR3),breast(MdA-Mb-231),colon(HT-29),and melanoma(MdA-Mb-435),and compounds 1 and 3 were found to be cytotoxic with IC_(50) values in the low micromolar range for most of the cell lines *** major compound,inumakilactone A(3),was further tested in vivo using the HT-29,MdA-Mb-435,and OVCAR3 cells in a murine hollow fber model,for the frst time.

关键词： Podocarpus neriifolius Nagilactone G-2β-O-β-d-glucoside Hollow fber assay 3-deoxy-2αhydroxynagilactone E Antiproliferative b-type podolactone

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Geochemistry and Heavy Metal Levels in the Sediments of the Port of Santa bárbara de Samana, dominican Republic

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Journal of Geoscience and Environment Protection 2021年第4期9卷 195-205页

作者： Ramón delanoy Misael díaz Asencio darlin Rodriguez Ministry of Higher Education Science and Technology Institute of Physics Autonomous University of Santo Domingo Santo Domingo Dominican Republic division of Oceanology Ensenada Center for Scientific Research and Higher Education Ensenada México department of Physics Autonomous University of Santo Domingo Santo Domingo Dominican Republic

In the Port of Santa bárbara de Samana, chemical residues, organic matter and heavy metals from domestic activities are deposited together in the waters and sediments. The analysis of the sediments by X-ray fluorescence of four extracted and sectioned cores showed that concentrations of trace metals such as Nickel, Chromium, Lead and Mercury were present at various depths, exceeding Limits of Toxicity (PEL) for marine sediments according to National Oceanic and Atmospheric Administration (NOAA) and Canadian Council of Ministers of the Environment (CCME). Cadmium presented values above the toxicity threshold (TEL) in its minimum values and in its maximum values they exceeded the PEL value. While the Zinc and Copper values were low in all sections and lower than TEL. The analysis of the loss by ignition and the dating with lead 210 due to excess of the C4 core, showed a sudden change in the organic matter content and sedimentation rate. The superficial sediments show that unlike the deeper ones, the heavy metal content is lower, as well as that they do not represent a risk to the ecosystem by not exceeding toxicity levels.

关键词： Sediment Heavy Metal Port of Samana X-Ray Fluorescence Mercury

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主要煤炭开采巷道工程的稳定性方向

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陕西煤炭 1985年第3期 52-60页

作者： b.N.WHITTAKER C.J.bONSALL d.G.bRANCH S.S.KAPUSNIAK 毛光宁煤炭科学院

前言在英国约克郡的塞尔比和利沙斯特郡的阿斯福比正在建设新的煤矿。较大范围的巷道掘进活动或者正在施工,或者已提出设计,组成了这些煤炭开采开发的整体。这些巷道要求具有很好的稳定性,在相当软弱的石炭纪煤系地层中服务年限达到80年... 详细信息

前言在英国约克郡的塞尔比和利沙斯特郡的阿斯福比正在建设新的煤矿。较大范围的巷道掘进活动或者正在施工,或者已提出设计,组成了这些煤炭开采开发的整体。这些巷道要求具有很好的稳定性,在相当软弱的石炭纪煤系地层中服务年限达到80年,在某些情况下可能更长些。在这些工程中,通常

关键词：巷道壁威尔森变形带煤炭开采岩石变形主要巷道

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COMPUTER SIMULATION OF REdUCTIVE bACK-EXTRACTION OF MACRO LEVEL PLUTONIUM IN CENTRIFUGAL EXTRACTORS

COMPUTER SIMULATION OF REDUCTIVE BACK-EXTRACTION OF MACRO LE...

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International Solvent Extraction Conference 2005

作者： Shekhar Kumar Sudhir b.Koganti Reprocessing R＆d division Reprocessing Group Indira Gandhi Centre for Atomic Research Kalpakkam 603102 India Reprocessing R＆d division Reprocessing Group Indira Gandhi Centre for Atomic Research Kalpakkam 603102 India

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Topology Optimization of 3d Structures with design dependent Loads

Topology Optimization of 3D Structures with Design Dependent...

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The Fourth World Congress of Structural and Multidisciplinary Optimization

作者： Velaja b.Hammer Niels Olhoff Institute of Mechanical Engineering Aalborg University Denmark Institute of Mechanical Engineering Aalborg University Denmark

＜正＞This work presents a generalization of topology optimization of linearly elastic continuum structures to problems involving loadings that depend on the design. 2d as well as 3d structures are considered. Minimum compliance is chosen as the design objective, assuming the boundary conditions and the total structural volume within the admissible design domain to be given, and the topology optimization is based on the usage of a SIMP material model, whose volume density parameter in each finite element plays the role of a design variable. The design sensitivities, including the sensitivities of the loads, are derived analytically.

关键词： Topology optimization design dependent loads analytical sensitivity analysis.

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Reply to discussion on "A generalized three-dimensional failure criterion for rock masses"

Reply to Discussion on "A generalized three-dimensional fail...

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第13届全国岩石动力学学术会议

作者： Ashok Jaiswal b.K.Shrivastva department of Mining Engineering Indian Institute of Technology(Banaras Hindu University)Varanasi 221005India

General:Jaiswal and Shrivastva(2012) proposed the mathematical formulations,*** J-S criterion for converting generalized H-b failure criterion into 3d smooth convex failure criterion at deviatoric *** J-S strength criterion is in two versions:uniform and variable extension *** has been observed from the analysis that at uniform extension ratio,the required strength parameters are only UCS and m(other parameters such as L,a,b and c are related with m).In the case of variable extension ratio,extra parameter f is required along with UCS and ***,it has minimal strength parameters compared to You strength criterion,Further-

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Khami Reservoir Evaluation Using 3d-Geostatical Modeling, Mansuri Oil Field, dezful Embayment, Iran

Khami Reservoir Evaluation Using 3D-Geostatical Modeling, Ma...

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International Conference on Computer Science and Information Technology(ICCSIT’2011);International Conference on Electrical,Electronics and Civil Engineering(ICEECE’2011);International Conference on Mechanical,Production and Automobile Engineering(ICMPAE’2011);International Conference on Humanities,Geography and Economics(ICHGE’2011);International Conference on Chemical,Ecology and Environmental Sciences(ICCEES’2011);International Conference on Medical,biological and Pharmaceutical Sciences (ICMbPS’2011)

作者： b. Soleimani M. Rajabzadeh department of Shahid Chamran University the Geology department of Shahid Chamran University

The Mansuri petroleum oil field located in the dezful Embayment consisted of three reservoirs: Asmari, bangestan and Khami. Of these, Khami reservoir is in exploratory stage. To construct 3-d structural and petrophysical models of this reservoir, Reservoir Modeling System Software using geophysical information, lithological study, and well logs data was applied. The structural model indicates a very gentle anticline without any fracturing pattern. based on the seismic and well logs data, the reservoir zonation reviewed and divided into 11 zones. Geostatic and petrophysical models of these zones associated with different data analysis at the exploratory well sites were used to define the reservoir properties. They are predicting that the best situation of possible commercial production wells is in the western part of the oil field, especially in 5 th zone of the reservoir. It is estimated the in-situ oil volume of the reservoir, reserve of the Khami reservoir had been 402 mbbl in this oil field.

关键词： 3d-Geostatical Modeling Khami Reservoir dezful Embayment Mansuri oil field

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小分子化合物与dNA嵌插作用的研究——不同酰胺侧链对结合强度的影响

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北京医科大学学报 1992年第2期24卷 147-149页

作者：杨铭王夔 d.W.boykin W.d.Wilson 北京医科大学天然药物及仿生药物国家重点实验室美国乔治亚州立大学化学系

本文报道不同侧链萘并噻吩类化合物(a、b、c)的合成及其与dNA的结合。粘度测定及光谱研究表明化合物与dNA以嵌插络合的方式结合。通过紫外、可见光谱法测定了3个化合物与dNA络合的表观稳定常数。结果表明,随着侧链的增长,化合物与dNA结... 详细信息

本文报道不同侧链萘并噻吩类化合物(a、b、c)的合成及其与dNA的结合。粘度测定及光谱研究表明化合物与dNA以嵌插络合的方式结合。通过紫外、可见光谱法测定了3个化合物与dNA络合的表观稳定常数。结果表明,随着侧链的增长,化合物与dNA结合的强度逐渐减弱。通过微量热实验数据对小分子化合物与dNA结合的本质进行了初步分析。

关键词：萘并噻吩酰胺侧链嵌插络合 dNA

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西秦岭新生代钾霞橄黄长岩的地球化学及其岩浆源区性质

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岩石学报 2008年第2期24卷 238-248页

作者：董昕赵志丹莫宣学喻学惠张宏飞李冰 d. J. dEPAOLO 中国地质大学地质过程与矿产资源国家重点实验室中国地质大学地球科学与资源学院北京100083 中国地质大学地质过程与矿产资源国家重点实验室中国地质大学地球科学学院武汉430074 中国地质科学院地球物理地球化学勘查研究所河北廊坊065000 伯克利加利福尼亚大学美国伯克利CA94720

西秦岭礼县地区新生代钾霞橄黄长岩具有贫SiO_2和Al_2O_3,富CaO、Mgo、TiO_2及K_2O+Na_2O的特征,矿物组合中除橄榄石、辉石外,普遍含有霞石、黄长石、白榴石和磁铁矿等矿物。火山岩的∑REE为97.82×10^(-6)～639.1×10^(-6)。岩石以强... 详细信息

西秦岭礼县地区新生代钾霞橄黄长岩具有贫SiO_2和Al_2O_3,富CaO、Mgo、TiO_2及K_2O+Na_2O的特征,矿物组合中除橄榄石、辉石外,普遍含有霞石、黄长石、白榴石和磁铁矿等矿物。火山岩的∑REE为97.82×10^(-6)～639.1×10^(-6)。岩石以强烈富集大离子亲石元素(LILE,如Rb、ba、K、Sr)和高场强元素(HFSE,如Nb、Th、Ta、P、Zr、Hf等)为特征具有Pb和Ti的负异常。火山岩具有相对高的^(143)Nd/^(144)Nd比值(0.512007～0.512130,ε^(Nd)=+3.4～+5.8)和相对低的^(87)Sr/^(86)Sr比值(0.703374～0.704726)。^(206)Pb/^(204)Pb、^(207)Pb/^(204)Pb和^(208)Ph/^(204)Ph的比值范围分别为18.088～19.112,15.476～15.626和38.071～39.680。岩石的微量元素和Sr、Nd和Pb同位素特征显示其与洋岛玄武岩(OIb)的地球化学特征相似。源区组成显示了亏损地幔端元dM、HIMU端元和富集地幔端元EMII这三种地球化学端元混合的特征。

关键词：钾霞橄黄长岩地球化学岩浆源区新生代西秦岭

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