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Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes

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Journal of Animal Science and biotechnology 2013年第1期4卷 41-48页

作者： Logan b Smith Janelle M belanger Anita M Oberbauer department of Animal Science University of California

background： Fibroblast growth factor receptor 3 （FGFR3） inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate chondroyctes suggesting that FGFR3 reduces proliferative capacity, inhibits telomerase, and enhances senescence. Thyroid hormone （1-3） plays a role in cellular maturation of growth plate chondrocytes and a known target of T3 is FGFR3. The present study addressed whether reduced FGFR3 expression enhanced telomerase activity, mRNA expression of telomerase reverse transcriptase （TERT） and RNA component of telomerase （TR）, and chondrocyte proliferation, and whether the stimulation of FGFR3 by T3 evoked the opposite response. Results： Sheep growth-plate proliferative zone chondrocytes were cultured and transfected with siRNA to reduce FGFR3 expression; FGFR3 siRNA reduced chondrocyte FGFR3 mRNA and protein resulting in greater proliferation and increased TERT mRNA expression and telomerase activity （p 〈 0.0.5）. Chondrocytes treated with T3 significantly enhanced FGFR3 mRNA and protein expression and reduced telomerase activity （p 〈 0.05）; TERT and TR were not significantly reduced. The action of T3 at the growth plate may be partially mediated through the FGFR3 pathway. Conclusions： The results suggest that FGFR3 inhibits chondrocyte proliferation and reducing telomerase activity indicating an important role for telomerase in capacity during bone elongation. by down-regulating TERT expression sustaining chondrocyte proliferative

关键词： Chondrocytes Growth-plate Telomerase Fibroblast growth factor receptor 3 Thyroid hormone Sheep

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development of Ficus carica Linn leaves extract incorporated chitosan films for active food packaging materials and investigation of their properties

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Food bioscience 2022年第2期46卷 291-299页

作者： P.Yilmaz E.demirhan b.Ozbek Chemical Engineering department Yildiz Technical UniversityDavutpasa CampusEsenlerIstanbul34220Turkey

The serious problems caused by extensive usage of petroleum-based plastic materials led to investigating the comprehensive studies and developing active food packaging *** if the chitosan-based films are considered an attractive source,they exhibit some practical difficulties in developing active food packaging ***,Ficus carica Linn leaves extract(FLE),with the features of its cheapness,easy accessibility and superoxide anion radical scavenging activity,was incorporated into chitosan(CS)film at various concentrations(2%-6%w/w).To the best of our knowledge,this was the first time that FLE was utilized as a bioactive substance incorporated into chitosan films to develop eco-friendly,biodegradable,active food packaging *** results obtained revealed that FLE incorporation into chitosan films significantly improved the swelling,water solubility and opacity of neat chitosan *** and morphological analysis indicated that the films produced exhibited smooth structure with homogenous dispersion of *** mechanically,the addition of FLE resulted in a significant reduction in tensile strength while the elasticity of the films was ***,the antioxidant and biodegradability properties of neat chitosan films were enhanced *** was concluded that CS-FLE films appeared to be a capable and enhanced option for synthetic polymer-based food packaging *** on the analyses performed,further studies are suggested on the packaging application for various foods and to evaluate the possible interaction of packaging film materials with the compounds of the food products,to avoid possible negative effects.

关键词： Ficus carica Linn leaves extract Chitosan films Antioxidant activity Soil biodegradability Active food packaging materials

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Exploring the configuration space of elemental carbon with empirical and machine learned interatomic potentials

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npj Computational Materials 2023年第1期9卷 987-998页

作者： George A.Marchant Miguel A.Caro bora Karasulu Livia b.Pártay department of Chemistry University of WarwickCoventry CV47ALUK department of Chemistry and Materials Science Aalto University02150 EspooFinland

We demonstrate how the many-body potential energy landscape of carbon can be explored with the nested sampling algorithm,allowing for the calculation of its pressure-temperature phase *** compare four interatomic potential models:Tersoff,EdIP,GAP-20 and its recently updated version,*** evaluation is focused on their macroscopic properties,melting transitions,and identifying thermodynamically stable solid structures up to at least 100 *** phase diagrams of the GAP models show good agreement with experimental ***,we find that the models’description of graphite includes thermodynamically stable phases with incorrect layer *** adding a suitable selection of structures to the database and re-training the potential,we have derived an improved model—GAP-20U+gr—that suppresses erroneous local minima in the graphitic energy *** extreme high pressure nested sampling identifies two novel stable structures in the GAP-20 model,however,the stability of these is not confirmed by electronic structure calculations,highlighting routes to further extend the applicability of the GAP models.

关键词： carbon potential configuration

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用三维立体摄影测量技术测活猪后腿肉的体积(英文)

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实验力学 2007年第3期22卷 328-336页

作者：鞠向阳 J Paul Siebert N.J.b.McFarlane R.d.Tillett 英国Robert Gordon大学计算机系英国格拉斯哥大学计算机系英国Silsoe研究所光感技术组

研发了一高分辨率三维立体摄影测量系统,并成功地应用于扑捉活猪的三维形状以用于饲养猪的研究。为调查饲料和猪生长的关系,将32头猪分成高Lysine和低Lysine两饲料组观察。连续14周,每周用该系统拍摄猪的图像一次。该系统有三个立体摄影... 详细信息

研发了一高分辨率三维立体摄影测量系统,并成功地应用于扑捉活猪的三维形状以用于饲养猪的研究。为调查饲料和猪生长的关系,将32头猪分成高Lysine和低Lysine两饲料组观察。连续14周,每周用该系统拍摄猪的图像一次。该系统有三个立体摄影头,分别拍摄猪的侧面、背面和后腿面的立体图像。为重建猪的三维形状用以科学分析,我们研发了图像处理软件,包括相机标定、立体图像匹配和三维形状合成,并提出一种从每周测得的形状中提取每只猪每周后腿肉的体积的算法。实验证明该系统是精确和可靠的。

关键词：三维立体测量仪形状测量

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Assessing Conscientiousness and Identify Leadership Quality Using Temporal Sequence Images

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Intelligent Automation & Soft Computing 2023年第2期35卷 2003-2013页

作者： T.S.Kanchana b.Smitha Evelin Zoraida department of Computer Science Bharathidasan UniversityKhaja Mali CampusTiruchirappalliIndia

Human Facial expressions exhibits the inner *** the inner personality is performed through questionnaires during recruitment ***,the evaluation through questionnaires performs less due to anxiety,and stress during interview and prediction of leadership quality becomes a challenging *** the above problem,Temporal sequence based SENet architecture(TSSA)is proposed for accurate evaluation of personality trait for employing the correct person for leadership ***,SENet is integration with modern architectures for performance *** Proposed TSSA,face book facial images of a particular person for a period of one month and face images collect from different social environments and forms the sequential facial image database are analysed for personality trait *** a days,Facebook plays a vital role,where people express their emotions by posting images and updating their proﬁle *** TSSA method,50 Facebook temporal sequence of images of person with answered questionaries during the face image collection forms as a Temporal sequence image(TSI)database for prediction of the big Five personal-ity *** order to get precise prediction,we have analysed the face images that were posted in a period of one month and validated the result with the next month face images from face *** images for predicting the personality,where asked toﬁll the Questionnaires through Google Forms increase the accuracy in *** TSSA prediction results are utilized for assessment of a person’s conscientiousness for leadership quality *** study implements deep Learning algorithm with SENet architecture and compares with traditional *** the validation results the proposed TSSA method performs 96%of accuracy in conscientiousness prediction.

关键词： bigﬁve ocean deep learning set personality traits

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Seismo-ionospheric anomalies and implications from recent GNSS observations in India and South-East Asia

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Geodesy and Geodynamics 2016年第1期7卷 11-18页

作者： C.d. Reddy Indian Institute of Geomagnetism Navi Mumbai India

The lithosphere and the atmosphere/ionosphere, continuously exchange energy through various coupling mechanisms. Earthquake creates waves of energy, e.g. direct shock acoustic waves （SAWs） and Rayleigh wave induced acoustic waves （PAWs）. In the event of an earthquake occurring beneath the sea, atmospheric gravity waves {AGWs） are also generated. If the earthquake is large enough （Mw 〉 6）, SAWs, PAWs and AGWs induce detectable ionospheric plasma perturbations. Inferring the seismological information from these seismo-ionospheric manifestations is the subject that pertains to ionospheric seis- mology. both ground and satellite based advanced radio techniques are being used in monitoring ionospheric plasma perturbations. In this study, seismo-ionospheric anomalies and implications from recent GNSS observations in India and South-East Asia are dis- cussed, mainly pertaining to the following. （1） From the ionospheric plasma response to 2015 Nepal earthquake, the estimated group velocity for Andaman and Indian shield re- gions are 2100 ms i and 3900 ms-1 respectively and validated from ground measurements. （2） Atmospheric acoustic resonance at 4.0 mHz and a train of wave packet of TEC variation resulting from the beat phenomenon observed at the site ＇umlh＇ and （3） GNSS-based tsunami warning which is going to be promising tool in augmenting the existing tsunami warning systems.

关键词： Earthquake Tsunami Ionosphere GNSSTEC

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developmental transcription factors in age-related CNS disease: a phoenix rising from the ashes?

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Neural Regeneration Research 2016年第1期11卷 64-65页

作者： Robert b.White Meghan G.Thomas School of Anatomy Physiology & Human Biology The University of Western Australia Parkinson’s Centre School of Medical Sciences Edith Cowan University Experimental and Regenerative Neuroscience School of Animal BiologyThe University of Western Australia

Few would doubt that understanding the developmental landscape from which a mature neuron is derived is essential to understand its *** temporal and spatial position of a cell from the very earliest stages of developm... 详细信息

关键词： landscape earliest mature doubt exposed developmental substantia nigra hydroxylase dopamine

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Casting of microstructured shark skin surfaces and possible applications on aluminum casting parts

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China Foundry 2011年第1期8卷 62-65页

作者： Todor Ivanov Andreas bührig-Polaczek Uwe Vroomen Foundry Institute of RWTH Aachen University

Within the project "Functional Surfaces via Micro-and Nanoscaled Structures" which is part of the Cluster of Excellence "Integrative Production Technology" established and financed by the German Research Foundation (dFG),an investment casting process to produce 3-dimensional functional surfaces down to a structural size of 1μm on near-net-shape-casting parts has been *** common way to realize functional microstructures on metallic surfaces is to use laser ablation,electro discharge machining or micro *** handicap of these processes is their limited *** approach of this project to raise the efficiency is to use the investment casting process to replicate microstructured surfaces by moulding from a laser-microstructured grand master *** main research objective deals with the investigation of the single process steps of the investment casting process with regard to the moulding *** results concerning making of the wax pattern,suitability of ceramic mould and core materials for casting of an AlSi7Mg0.3 alloy as well as the knock-out behavior of the shells are *** using of the example of an intake manifold of a gasoline race car engine,a technical shark skin surface has been realized to reduce the drag of the intake *** intake manifold consists of an air-restrictor with a defined inner diameter which is microstructured with technical shark skin *** this reason the inner diameter cannot be drilled after casting and demands a very high accuracy of the casting part.A technology for the fabrication and demoulding of accurate microstructured castings are *** factors of different moulding steps of the macroscopic casting part as well as the microscopic riblet structure have been examined as well.

关键词： investment casting microstructured surfaces shark skin

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Review of micromachining of ceramics by etching

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中国有色金属学会会刊：英文版 2009年第B09期19卷 1-16页

作者： H.T.TING K.A.AbOU-EL-HOSSEIN H.b.CHUA School of Engineering and Science Curtin University of Technology (Sarawak Campus) department of Mechatronics Nelson Mandela Metr opolitan University

In the last two decades, there has been an enormous surge in interest in ceramic materials and, as a result, there have been significant advances in their development and applications. Their inherent properties, such as capability of operating at temperatures far above metals, high level of hardness and toughness, low coefficient of thermal expansion and high thermal conductivity rendered ceramics to be one of the leading engineering materials. Many research works have been conducted in the past few years on machining of advanced ceramics using different processing methods in order to obtain a better surface roughness, higher material removal rate and improved tool life. Micromachining using chemical etching is one of those methods that do not involve the problem of tool life and direct tool-work piece contact. However, only a few research works have been done on micromachining of ceramics using chemical etching. Hence, study of chemical machining of advanced ceramics is still needed as the process has found wide application in the industry because of its relative low operating costs. In this work, we summarize the recent progresses in machining of different types of advanced ceramics, material processing methods such as wet etching and dry etching, and finally the prospects for control of material removal rate and surface quality in the process of ceramic micromachining.

关键词：陶瓷材料化学蚀刻表面粗糙度机械加工过程陶瓷加工刀具寿命材料去除率高温作业

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Synthesis,structural and optical properties of SrZrO_3:Eu^(3+) phosphor

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Journal of Rare Earths 2014年第4期32卷 293-297页

作者： Sheetal V.b.Taxak Rajni Arora dayawati S.P.Khatkar department of Chemistry Maharshi Dayanand University department of Chemistry Government Post Graduate College

Eu3＋activated Sr1-xEuxZrO3 （x=0.01-0.04） phosphor with perovskite structure was successfully synthesized by using com-bustion method. The structure, morphology and optical properties of the material were characterized by X-ray diffraction, scanning electron microscopy and fluorescence spectrometry. The XRd results indicated that crystals of SrZrO3：Eu3＋belongs to tetragonal perovskite system. The phosphor could be effectively excited by UV light and the emission spectra results indicated that red-dish-orange luminescence of SrZrO3：Eu3＋due to magnetic dipole transition 5d0→7F1 at 593 nm was dominant. Thus, the prepared phosphor showed remarkable luminescent properties which find applications in field emission display （FEd） and plasma display panel （PdP） devices.

关键词： perovskite europium optical materials luminescence rare earths

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