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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Bacterial inactivation,dNA damage,and faster ATP degradation induced by ultraviolet disinfection

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 153-162页

作者： Chao Yang Wenjun Sun Xiuwei ao School of Environment Tsinghua UniversityBeijing 100084China

The efficacy of ultraviolet(UV)disinfection has been validated in numerous studies by using culturebased ***,the discovery of viable but non-culturable bacteria has necessitated the investigation of UV disinfection based on bacterial viability *** used quantitative polymerase chain reaction(qPCR)to investigate dNA damage and evaluated adenosine triphosphate(ATP)to indicate bacterial *** results of qPCR effectively showed the dNA damage induced by UV when using longer gene amplicons,in that sufficiently long amplicons of both 16S and gadA indicated that the UV induced dNA *** copy concentrations of the long amplicons of 16S and gadA decreased by 2.38 log/mL and 1.88 log/mL,respectively,after exposure to 40 mJ/cm^2 lowpressure *** UV exposure,the ATP level in the bacteria did not decrease *** it decreased gradually at a rate that was positively related to the UV *** low-pressure UV,this rate of decrease was slow,but for medium pressure UV,this rate of decrease was relatively high when the UV fluence reached 40 mJ/cm^*** the same UV fluence,the ATP level in the bacteria decreased at a faster rate after exposure to medium-pressure UV.

关键词： UV disinfection dNA damage qPCR ATP

Cu and Zn Isotopic Evidence for the Magnitude of Organic Burial in the Mesoproterozoic Ocean

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Journal of Earth Science 2022年第1期33卷 92-99页

作者： Yiwen Lü Sheng-ao Liu State Key Laboratory of Geological Processes and Mineral Resources and Institute of Earth SciencesChina University of GeosciencesBeijing 100083China

The rate of net primary production in the Proterozoic ocean was suggested to be no more than 10% of its modern value(Laakso and Schrag,2019),however,in the Mesoproterozoic Xiamaling Formation,the export production values could reach 20%-150% of the present-day Equatorial Atlantic average values(Zhang et al.,2016).Here,we report Zn and Cu isotope data for black shales from the Xiamaling Formation to illustrate the biogeochemical cycling of Zn and Cu in the Mesoproterozoic *** ^(65)Cu-enriched signature in the authigenic fraction is similar to that in bioauthigenic Cu of the modern marine *** Zn isotope ratios of sediments deposited in euxinic conditions are commonly higher than those of clastic sediments,indicating light Zn sinks in the coeval *** with previously reported Mo isotope data,the proportion of organic carbon to total carbon burial in the Mesoproterozoic was about as half as that at present,which is larger than the previous estimation―a quarter of today’s value(e.g.,Ozaki et al.,2019) and is evidenced by a wide distribution of black *** organic burial may be ascribed to the increasing phosphorus inputs from large igneous provinces and consequently high primary productivity,which has spurred the hypothesized atmosphere-ocean oxygenation at ~1.4 Ga.

关键词： zinc isotopes organic carbon Xiamaling Formation

Using mRNA to investigate the effect of low-pressure ultraviolet disinfection on the viability of ***

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Frontiers of Environmental Science & Engineering 2019年第2期13卷 125-132页

作者： Chao Yang Wenjun Sun Xiuwei ao School of Environment Tsinghua UniversityBeijing 100084China

The efficacy of ultraviolet(UV)disinfection has been analyzed and validated by numerous studies using culture-based methods,yet the discovery of the viable but nonculturable state necessitates the investigation of UV disinfection based on viability *** regulators of the SOS response system,recA-lexA,and the programmed cell death system,mazEF,in Escherichia coli were chosen as the target genes,and the effect of UV irradiation on the mRNAs of the four genes was *** research showed that,after UV irradiation,the responses of the mRNAs were highly consistent,with reduction percentages of approximately 60% at 20 mJ/cm2,70% at 40 mJ/cm2,and 90% at 80 mJ/cm2,and these reductions were believed to be the result of direct UV damage to nucleic *** 24 h of dark incubation,recA and lexA were both upregulated but to a lesser extent for repressor lexA;and mazE and mazF were both *** result implies that UV irradiation induces the dark repair system more actively,and the cells will proceed to death at a rate similar to that associated with natural decay.

关键词： UV disinfection Viability mRNA SOS response Programmed cell death

Thermal transport mechanism of electrons and phonons in pristine and defective HfB_(2)

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Rare Metals 2023年第11期42卷 3651-3661页

作者： ao Wang Shou-Hang Li Hua Bao Global Institute of Future Technology Shanghai Jiao Tong UniversityShanghai200240China University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai200240China College of Mechanical Engineering Donghua UniversityShanghai201620China

Hafnium diboride(HfB_(2))is an important metallic ceramic that works in harsh environments,due to its high strength and thermal *** the thermal conductivity of HfB_(2) has been measured,the experimental results are ***,the thermal transport mechanism of HfB_(2) is not well *** this work,we study the thermal transport in both pristine and defective HfB_(2) from first-principles *** the pristine HfB_(2),the room-temperature thermal conductivities are 175.0 and 157.7 W·m^(-1)·K^(-1)on a-and c-axes,respectively,where the contributions from electron and phonon are *** Lorenz number is significantly smaller than the Sommerfeld value and shows a temperature dependence,which demonstrates that the Wiedemann-Franz law cannot be used to estimate electronic thermal *** phonon-isotope and the phonon-electron scattering are non-negligible compared to the phonon-phonon *** the defective HfB_(2),the grain size effects are negligible with length scales larger than 1μ*** pore can limit thermal conductivity when its occupancy is larger than 10%.The vacancy is found to induce scattered results in *** phonon thermal conductivity significantly reduces even with only 1%vacancy,while the electronic thermal conductivity is not sensitive to the *** study provides an in-depth understanding of the thermal transport in HfB_(2),and the revealed mechanisms provide important guidance on the design of HfB_(2)-based materials.

关键词： Thermal conductivity Electrical transport properties Boltzmann transport equation Vacancy scattering First-principles calculation

Copper isotope constraints on the origins of basaltic and andesitic magmas in the Tengchong volcanic field,SE Tibet

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Geoscience Frontiers 2024年第4期15卷 290-303页

作者： Yuan-Ru Qu Sheng-ao Liu State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China

The Tengchong volcano field(TVF),situated at the southeastern margin of the Tibetan Plateau,holds crucial information regarding Cenozoic volcanic activities and geotectonic evolution of the SE *** provide new constraints on petrogenesis and evolution of the Tengchong volcanism,here we conducted copper(Cu)elemental and isotopic analyses on a suite of samples that document the evolution from basalts to andesites in the *** basalts are Cu-depleted(29.7-36.9 ppm)and have higherδ65Cu val-ues(0.19‰-0.40‰,mean=0.31‰±0.05‰;n=11)than those of mid-ocean ridge basalts(MORBs,~0.09‰)and the mantle(~0.06‰)as well as the majority of island arc *** with the low Cu/Zr ratios,these characteristics are interpreted to reflect the fractionation of isotopically light sulfides in the S-saturated systems during magma ascent,rather than source heterogeneity induced by recycled materials and redox *** with the basalts,the andesites have slightly lower Cu contents(14.4-29.4 ppm)and lighter Cu isotopic compositions(mean=-0.14‰±0.06‰;n=13).These differences cannot be attributed to progressive sulfide fractionation of basaltic magmas but require the assimilation of lower crustal materials with lowδ65Cu values during evolution of the andesitic *** results collectively suggest that Cu isotopes can provide valuable insights into magma origin and evolution.

关键词： Copper isotopes Sulfide segregation Magmatic differentiation Tengchong volcanic field

Microscopic dynamic observation of adhesion hysteresis friction and exploration of the influence of different pressures on friction transmission

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Friction 2021年第4期9卷 758-773页

作者： Cun-ao FENG de-kun ZHANG Kai CHEN School of Mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China department of Mechanical Engineering University of British Columbia Vancouver V6T1Z4Canada School of Materials Science and Engineering China University of Mining and Technology Xuzhou 221116China

The mechanism of adhesive friction between viscoelastic materials is a key *** this study,the friction process of the adhesive interface between a friction lining and a wire rope is dynamically observed in real time to analyze the adhesion hysteresis friction intuitively and *** adhesion is determined by the state of motion,while the relative displacement of the wire rope and lining is used to find the magnitude of the adhesive *** hysteresis friction is reflected by the internal deformation of the *** magnitude of the hysteresis friction is determined by the displacement difference(Ax)in the sliding direction of two marked points at different distances from the contact *** results show that the adhesion friction is proportional to the loss modulus and the hysteresis friction is proportional to the ratio of the loss modulus to the square of the storage modulus(E"/(E'^(2))).The frictional vibration first decreases and then increases with the increase in *** K25 lining has the highest adhesion hysteresis friction and minimal frictional *** result provides a simple and intuitive method for research into the friction transmission and vibration of viscoelastic materials.

关键词： adhesion hysteresis friction viscoelasticity frictional vibration dynamic monitoring