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Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease

2011年

作者： Musée national d''art moderne (France)

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World Journal of Gastroenterology 2016年第26期22卷 6027-6035页

作者： dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres department of Pediatrics and Pediatric Health Care Center University of Szeged H-6725 Szeged Hungary 1st department of Pediatrics Semmelweis University H-1083 Budapest Hungary 2nd department of Pathology Semmelweis University H-1091 Budapest Hungary 1st department of Pediatrics Semmelweis University and MTA-SE Pediatrics and Nephrology Research Group H-1083 Budapest Hungary

AIM: To evaluate the role of microRNA (miR)-146a, -155 and -122 in the duodenal mucosa of pediatric patients with Crohn’s disease (Cd) and the effect of transforming growth factor-β (TGF-β) on these miRs in duodenal epithelial and fibroblast ***: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed (Cd inflamed: n = 10) and intact (Cd intact: n = 10) duodenal mucosa of pediatric Cd patients and control children (C: n = 10) were examined. Expression of miR-146a, -155 and -122 was determined by real-time polymerase-chain reaction (PCR). The expression of the above miRs was investigated in recombinant human TGF-β (1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells (CCL-241) and primary duodenal fibroblast cells derived from healthy children as ***: Expression of miR-146a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with Cd (Cd inflamed: 3.21 ± 0.50 vs Cd intact: 0.62 ± 0.26, P ≤ 0.01) and to the control group (Cd inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, P ≤ 0.05). The expression of miR-155 was significantly increased in the inflamed region of the duodenum compared to the control group (Cd inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, P ≤ 0.001). The expression of miR-122 was unchanged in the inflamed or intact mucosa of Cd patients compared to controls. TGF-β treatment significantly decreased the expression of miR-155 in small intestinal epithelial cells (TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, P ≤ 0.05) and also the expression of miR-146a (TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, P ≤ 0.01) and miR-155 (TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, P ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated control

关键词： Inflammatory bowel disease Crohn’ s disease Pediatric MicroRNAs Transforming growth factor-β

direct Atomic Images of dislocation Motion Caused by Image Force near Surfaces of Pd Crystal

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Chinese Physics Letters 1992年第6期9卷 301-304页

作者： YE Hengqiang NING Xiaoguang d.J.Smith Laboratory of Atomic Imaging of Solids Institute of Metal ResearchAcademia SinicaShenyang 110015 Center for Solid State Science Arizona State UniversityTempeArizona 85287U.S.A.

The motion of a Lomer dislocation near clean(110)surface of the Pd metal was observed in situ at the atomic level by surface profile imaging *** observed distances between the location of the Lomer dislocation and the surface was just covered by the calculated critical range I,within which the image force alone may become the cause of dislocation.

关键词： technique dislocation Image

Multi-detector CT angiography for the assessment of anterior spinal artery and artery of Adamkiewicz patency in patients suspected of having thoracic aortic pathology

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Journal of Geriatric Cardiology 2006年第1期3卷 52-56页

作者： Laura Logan Pamela Schraedley Geoffrey d.Rubin department of Radiology Stanford University Medical Center Room S-072B Stanford CA 94305-5105 USA.

Objective To evaluate the visualization of the anterior spinal artery (ASA) and the artery of Adamkiewicz (AKA) as well as the affecting factors for the detection rate using multidetector row CT (MdCT). Methods Ninety-nine consecutive patients (31 women and 68 men; age range, 25-90 years; average age 61.3 years) with suspicion for thoracic aortic lesions necessitating surgical intervention (31 aortic aneurysm, 45 dissection, 5 intramural hematoma, and 18 normal), underwent 16-slice MdCT angiography from the aortic arch to the aortic bifurcation. Transverse sections, multiplanar reformations (MPR) and thin maximum intensity projections (MIP) were used to assess the ASA and AKA. The level of the ASA and AKA origins and CT acquisition parameters were recorded. The contrast-to-noise ratio (CNR) of the image, an index of the mass of the T11 body (vertebral mass index), the subcutaneous fat thickness,and the CT value within the aortic arch and at the T11 level were measured. The detection of the ASA and AKA was evaluated relative to the acquisition parameters, scan characteristics, and aortic lesion type. differences were assessed with Wilcoxon rank-sum and t tests. Results The ASA was visualized in 51 patients (52%) and the AKA in 18 patients (18 %). The ASA was identified in 36/67 (54%)patients with 1.25 mm thickness and in15/32 (47%) patients with 2.5-3.0 mm thickness. This difference did not achieve significance (P=0.13). The detection rate of the ASA and the AKA was influenced by vertebral mass index and the CNR (P＜0.05). The amount of subcutaneous fat affected the detection rate of the ASA (P＜0.05) but not the AKA. In CT scans with ASA detection, the mean CT values in the aorta at the arch and at T11 were 360 and 358 HU, respectively; whereas in CT scans without ASA detection, the CT values in the aorta at the arch and at T11 were lower (297 and 317 HU, respectively; both P＜0.05). Conclusion The ASA and AKA were less frequently detected in our cohorts than previous

关键词： Aneurysm, aortic arteries, Adamkiewicz arteries, spinal computed tomography (CT) angiography

Total Phenols,Flavonoids and Antioxidant Activity in Annona muricata and Annona purpurea Callus Culture

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Phyton-International Journal of Experimental Botany 2019年第2期88卷 139-147页

作者： M.Y.Ovando-domínguez M.C.Luján-Hidalgo d.González-Mendoza A.A.Vargas-díaz N.Ruiz-Lau F.A.Gutiérrez-Miceli C.A.Lecona-Guzmán Laboratorio de Cultivo de Tejidos Vegetales.Tecnológico Nacional de México/Instituto Tecnológico de Tuxtla Gutiérrez Carretera Panamericana Km.1080.Tuxtla GutiérrezChiapasC.P.29050México Instituto de Ciencias Agrícolas de la Universidad Autónoma de Baja California(ICA-UABC).Carretera a delta s/n C.P.21705 Ejido Nuevo LeónBaja CaliforniaMéxico CONACYT-Colegio de Postgraduados Campus CampecheCarretera Federal Haltunchén-Edzna km 17.5.SihochacChampotónCampecheCP 24450México CONACYT-Tecnológico Nacional de México/Instituto Tecnológico de Tuxtla Gutiérrez.Carretera Panamericana Km.1080.Tuxtla Gutiérrez ChiapasC.P.03940México

Callus cultures of Annona muricata and Annona purpurea were induced in Murashige and Skoog(MS)medium supplemented with different concentrations of 1-naphthylacetic acid(NAA),6-benzyladenine(BA)and 2,4-dichlorophenoxyacetic acid(2,4-d)utilized hypocotyls with *** highest percentage of callus formation was the treatment supplemented with 3 mg L-1 NAA for ***(100%)while for *** in lower percentage(75%).BA stimulated the formation of shoots in all the evaluated concentrations,being the concentration of 2 mg L-1 the one that induced the greater formation of shoots for ***(23 shoots/explant)and ***(28 shoots/explant).The content of total phenols,flavonoids and antioxidant activity was measured in the callus obtained from both *** results showed that a higher content of total phenols was quantified in callus of ***(27.8 mg g-1 dw)compared to ***(23.2 mg g-1 dw).The highest content of total flavonoids was observed in the callus of ***(8.0μg g-1 dw).Antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydracil radical *** concentration required for 50%inhibition(IC50)of the 2,2-diphenyl-1-picrylhydracil radicals were 4.22μg mL-1 in methanolic extracts of callus of ***,while in extracts of callus of *** was 2.86μg mL-1,in both cases was greater than that found for *** culture of the species studied in this work represents an alternative for the production of natural antioxidants.

关键词： Annonaceae antioxidant activity 6-benzyladenine secondary metabolites tissue culture

Phonetic drill reader /

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Phonetic drill reader /

REVIEW OF MULTIBOdY CHARM ANALYSES

丛书名： Cambridge English language learning

1973年

作者： J.d. O'Connor.

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Chinese Physics C 2016年第10期40卷 718-721页

作者： d. M. Asner J. Rademacker Pacific Northwest National Laboratory University of Bristol

Kinematics ＆ Models The differential decay rate to a point s - （s1,..., sn） in n dimensional phase space can be expressed as

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Incompatibility of published ac magnetic susceptibility of a room temperature superconductor with measured raw data

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Matter and Radiation at Extremes 2022年第4期7卷 65-80页

作者： J.E.Hirsch d.van der Mare department of Physics University of CaliforniaSan DiegoLa JollaCalifornia 92093-0319USA department of Quantum Matter Physics University of Geneva24 Quai Ernest-Ansermet1211 GenevaSwitzerland

A material termed“carbonaceous sulfur hydride”has recently been reported to be a high-pressure room temperature superconductor[Snider et al.,Nature 586,373(2020)].We have previously pointed out that certain anomalies observed in the published data for the ac magnetic susceptibility of this material would be cleared up once the measured raw data were made available[***,arXiv:2110.12854v1(2021)and ***,Physica C 590,1353964(2021)(temporarily removed)].The measured raw data,as well as numerical values of the data presented in figures in the aforementioned paper by Snider et al.,have recently been posted on the arXiv[*** and ***,arXiv:2111.15017v1(2021)and *** and ***,arXiv:2111.15017v2(2021)].Here,we report the results of our analysis of these raw data and published data and our conclusion that the raw data are incompatible with the published *** of these results for the claim that the material is a room temperature superconductor are discussed.

关键词： compatibility superconductor removed

Endothelial progenitor cells and burn injury–exploring the relationship

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Burns & Trauma 2016年第1期4卷 27-33页

作者： derek A.Banyard Blake O.Adnani Satenik Melkumyan Cheryl Ann Araniego Alan d.Widgerow department of Plastic Surgery Center for Tissue EngineeringUniversity of CaliforniaIrvine200S Manchester AveSte 650OrangeCA 92868USA

Burn wounds result in varying degrees of soft tissue damage that are typically graded *** a key participant in neovascularization,the endothelial progenitor cel,has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular *** this review,we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn *** there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity,it is clear that they play an important role in wound *** and controlled studies are needed to clarify this relationship,and whether this population can serve as a biomarker for burn severity.

关键词： Endothelial progenitor cells Burn depth Circulating angiogenic cells Burn biomarker

Profile of Bionectriaceae,Calcarisporiaceae,Hypocreaceae,Nectriaceae,Tilachlidiaceae,Ijuhyaceae ***.,Stromatonectriaceae *** Xanthonectriaceae ***

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Fungal diversity 2023年第1期118卷 95-271页

作者： R.H.Perera K.d.Hyde E.B.G.Jones S.S.N.Maharachchikumbura d.Bundhun E.Camporesi A.Akulov J.K.Liu Z.Y.Liu Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Key Laboratory for Plant diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Innovative Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand department of Botany and Microbiology College of ScienceKingdom of Saudi ArabiaKing Saud UniversityP.O Box 2455Riyadh 11451Saudi Arabia A.M.B Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18ForliItaly Societaper Gli Studi Naturalistici della Romagna C.P.143BagnacavalloRAItaly department of Mycology and Plant Resistance V.N.Karazin Kharkiv National UniversityMaidan Svobody 4Kharkiv 61022Ukraine

This paper provides outlines for Bionectriaceae,Calcarisporiaceae,Hypocreaceae,Nectriaceae,Tilachlidiaceae,Ijuhy-aceae,Stromatonectriaceae and Xanthonectriaceae with taxonomic *** provide up-to-date dNA sequence-based phylogenies including combined gene analysis of ITS,LSU,rpb2,tef1 and tub2 for Hypocreales and accept 17 *** new families and 12 new species are introduced with descriptions and illustrations,while 13 new records and one new species combination are *** we mainly detail the taxonomy of Bionectriaceae,Hypocreaceae,Nectriaceae and Tilachlidiaceae,Ijuhyaceae ***.,Stromatonectriaceae *** Xanthonectriaceae *** introduced in this study based on phenotypic and molecular *** each family we provide a list of accepted genera,the taxo-nomic history,morphological descriptions,taxonomic placement based on dNA sequence data and illustrate the type *** of each family are illustrated based on the type herbarium material or fresh specimens where available,or provide relevant *** on ecological and economic importance of the families are also given.

关键词： 15 New taxa Genera incertae sedis Hypocreales New records Outline Phylogeny Sordariomycetes Taxonomy