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Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice

World Journal of Gastroenterology 2022年第48期28卷 6935-6949页

作者： Karim Atmani Fabien Wuestenberghs Maximilien baron Illona Bouleté Charlène Guérin Wafa Bahlouli david Vaudry Jean Claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi moïse Coëffier Mathieu Meleine Guillaume Gourcerol Nutrition Gut and Brain Unit(Inserm U1073)Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France department of Gastroenterology and Hepatology UniversitéCatholique de LouvainCHU UCL NamurYvoir 5530Belgium department of Physiology CHU RouenUniversitéde Rouen NormandieRouen 76031France department of Urology CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm UMR 1245Team Epigenetics and Pathophysiology of Neurodevelopmental DisordersUniversitéde Rouen NormandieRouen 76000France Behavioural Analysis Platform(SCAC) HeRacLeS Inserm US51-CNRS UAR2026Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France department of Nutrition CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm U1107 NeuroDolClermont Auvergne UniversityClermont-Ferrand 63000France

BACKGROUNd Irritable bowel syndrome and bladder pain syndrome often overlap and.a.e both characterized by visceral *** pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the *** precise pathophysiology remains poorly *** To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms *** Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane *** sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal ***,used.a. a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used.a. a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using *** fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal *** expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western *** Visceral hypersensitivity to colorectal distension was observed.a.ter the intravesical injection of acetic acid vs saline(Pd 1 h post-injection and lasted up to 7 d *** increased permeability or inflammation was shown in the bladder or colon 7 d *** hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(Pd injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(Pd MAPK-p38 levels were increased in the spinal cord up to 7 d.a.ter

关键词： Cross-organ sensitization MAPK-p38 Microglia NK1 receptor Pain Visceral hypersensitivity

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Flexible ion-conducting membranes with 3d continuous nanohybrid networks for high-performance solid-state metallic lithium batteries

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Journal of Energy Chemistry 2022年第12期75卷 360-368,I0009页

作者： Lehao Liu dongmei Zhang Tianrong Yang Weihao Hu Xianglong Meng Jinshan mo Wenyan Hou Qianxiao Fan Kai Liu Bing Jiang Lihua Chu Meicheng Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources School of New EnergyNorth China Electric Power UniversityBeijing 102206China

Polyethylene oxide(PEO)-based electrolytes are considered.a. one of the most promising solid-state electrolytes for next-generation lithium batteries with high safety and energy density;however,the d.a.backs such as insufficient ion conductance,mechanical strength and electrochemical stability hinder their applications in metallic lithium *** enhance their overall properties,flexible and thin composite polymer electrolyte(CPE)membranes with 3d continuous aramid nanofiber(ANF)–Li_(1.4)Al_(0.4)Ti_(1.6)(PO_(4))_(3)(LATP)nanoparticle hybrid frameworks are facilely prepared by filling PEO–Li TFSI in the 3d nanohybrid scaffolds via a solution infusion *** construction of the 3d continuous nanohybrid networks can effectively inhibit the PEO crystallization,facilitate the lithium salt dissociation and meanwhile increase the fast-ion transport in the continuous LATP electrolyte phase,and thus greatly improving the ionic conductivity(~3 times that of the pristine one).With the integration of the 3d continuity and flexibility of the 3d.a.F networks and the thermostability of the LATP phase,the CPE membranes also show a wider electrochemical window(~5.0 V vs.4.3 V),higher tensile strength(~4–10times that of the pristine one)and thermostability,and better lithium dendrite resistance ***,the CPE-based Li FePO_(4)/Li cells exhibit superior cycling stability(133 m Ah/g after 100 cycles at 0.3 C)and rate performance(100 m Ah/g at 1 C)than the pristine electrolyte-based cell(79 and 29m Ah/g,respectively).This work offers an important CPE design criteria to achieve comprehensivelyupgraded solid-state electrolytes for safe and high-energy metal battery applications.

关键词： Composite polymer electrolyte Aramid nanofiber Ceramic electrolyte nanoparticle Ion conductivity Mechanical strength Solid-state battery

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molecular toxicity of earthworms induced by cadmium contaminated soil and biomarkers screening

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Journal of Environmental Sciences 2012年第8期24卷 1504-1510页

作者： Xiaohui mo Yuhui Qiao Zhenjun Sun Xiaofei Sun Yang Li department of Ecology Science and Engineering China Agricultural UniversityBeijing 100193China State Key Laboratory for Agrobiotechnology China Agricultural UniversityBeijing 100193China

Earthworms （Eiseniafetida） were used to study the impact of low-dose cadmium in treated.a.tificial soil （0, 0.6, 3, 6, 15, 30 mg/kg） and contaminated natural soil （1.46 mg/kg）. The changes of earthworms＇ physiological related gene expressions of metallothionein （MT）, armetocin, calreticulin and.a.timicrobial peptides were detected using real-time PCR after a 70-day incubation period. The results showed that low doses of cadmium could up regulate earthworms＇ MT and down regulate annetocin gene expression and show a significant positive and negative correlation respectively. The expression of two other genes, calreticulin and.a.ti-microbial peptides, was induced.a. low doses of cadmium （highest gene expression at 0.6 mg/kg for calreticulin and 6 mg/kg for anti-microbial peptides） and inhibited.a. high doses. No significant correlation was found for these two genes. This study shows that MT and.a.netocin genes expression found in earthworms in contaminated soil have the potential to be developed.a. biomarkers of soil cadmium pollution.

关键词： earthworm cadmium low-dose genes expression molecular toxicity

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New method of improving parts accuracy by adding heat balance support in selective laser sintering

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第3期10卷 361-369页

作者： Bing LIU Li-chao ZHANG Jian-hua mo Bo QIAN State Key Laboratory of Plastic Forming Simulation and die and mould Technology School of Material Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

In order to improve parts accuracy, a method of adding heat balance support （HBS） was proposed, and the detailed.a.gorithm for generating HBS was developed. A number of experiments and.a.comparison between similar softwares, showed that the algorithm is efficient and feasible. moreover, different features of riBS were studied for different kinds of materials, such as PS and nylon. The research findings indicate that automatically adding HBS can significantly improve the accuracy of the parts, and that the algorithm for generating HBS is efficient and precise.

关键词： Selective laser sintering (SLS) Accuracy Heat balance support (HBS) Triangular facet 3d rings

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Size and dynamics of Ring Polymers under different Topological Constraints

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Chinese Journal of Polymer Science 2023年第4期41卷 516-524,I0006页

作者： Jiang-Yang mo Zhen-Hua Wang Yu-Yuan Lu Li-Jia An State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China

The impact of ring polymer length N and the influence of interchain and intrachain interactions on the size and dynamic behaviors of ring polymers,including the structural relaxation time τ_(R) and self-diffusion coefficient d,remain poorly understood.a. present due to a lack of systematic studies with relatively large N *** work addressed this issue by applying dynamic monte Carlo simulations with independently tuned interchain and intrachain interactions to investigate the size and dynamics of the ring melts with chain lengths over a wide range of 0.2N_(e)≤N≤80N_(e)(N_(e) is the entanglement length of corresponding linear chains)under different topological constraints,including all-crossing and intercrossing *** found that it was inappropriate to treat the unknotting constraint free energy of the ring chains in the melts as the free energy contributed by the excluded volume interactions of polymers in a good *** exponents of 2.5 and 1.5 reflecting the Ndependence of τ_(R) were obtained for long ring chains in non-crossing and intra-crossing systems,respectively,suggesting that the ring chains behaved.a. individ.a. clusters and exhibited Zimm-like dynamics in intra-crossing systems.A single scaling exponent of-2 reflecting the Ndependence of d was obtained for ring chains in non-crossing and intra-crossing systems,indicating that the intrachain constraints affected only the value of d.a.d had little influence on the scaling relationship between d.a.d ***,the extended Stokes-Einstein relation broke down for the ring chains in the non-crossing and intra-crossing systems because the structural relaxation and translational diffusion were decoupled for the short ring systems,while both the translational diffusion and rotational relaxations,as well as diffusion at short and long time scales,were decoupled for long ring systems.

关键词： Ring polymer Topological constraint Extended Stokes-Einstein relation monte Carlo simulation

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Erratum to:Self-enhancing photothermal conversion of 2d Weyl semimetal WTe_(2)with topological surface states for efficient solar vapor generation

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Nano Research 2024年第6期17卷 5758-5759页

作者： Chun du Ziyi Yang Anzhen mo Xuanming d.a. Guowei Yang Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan UniversityGuangzhou 511443China State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275China

The funding numbers of Guangzhou Basic and.a.plied Basic Research Foundation and Fundamental Research Funds for the Central Universities in the original version of the paper were *** are corrected.a.“Guangzhou Basic and.a.plied Basic Research Foundation(No.202201010243)”and“Fundamental Research Funds for the Central Universities(No.21621019)”.And the two funding numbers in the online version of this paper has been *** is a misspelling in Fig.5(e)and the figure of Graphical abstract,“Photon”on the top right corner of the figures should be corrected to“Phonon”.And the two misspellings in the online version of this paper have been corrected.

关键词： corrected topological Basic

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Structural Feature and Internal motion of Hyperbranching Cluster System with Low Polydispersity and Featured Pattern in dilute Solutions

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Chinese Journal of Polymer Science 2022年第12期40卷 1515-1521,I0006页

作者： Si-Qi Huang mo Zhu Jin-Xian Yang Lian-Wei Li College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China department of Chemical Physics University of Science and Technology of ChinaHefei 230026China

This work reports the structural feature and internal motion of one novel hyperbranching cluster system in dilution *** cluster system is composed of HB-PS_(300)-g-Pt BA_(45) hypergraft copolymer chains with uniform subchain,high molar mass and low polydispersity(M_(w)=1.73×106 g/mol and≈1.07),where HB-PS and Pt BA represent hyperbranched polystyrene core and poly(tert-butyl polyacrylate)graft,*** the selective solvent of PS blocks(cyclohexane,T_(θ)=34.5℃),the aggregation kinetics and structural feature are found to be precisely tunable for assembled clusters by the aggregation temperature(11℃d time(0 hd,namely,the fractal dimension(d_(f))of clusters is found to first increases and then decreases with t,eventually,it reaches a plateau value of d_(f)≈3.0,corresponds to a uniform spherical *** using dynamic light scattering(dLS)to monitor the number and strength of relaxation modes inΓ(q)withΓbeing the decay rate and q being the scattering vector,it is quantitatively revealed that the relaxation,intensity contribution and mode origin of internal motions of clusters are neither similar with previously reported cluster systems with high polydispersity,nor with the classical linear chain *** particular,in the broad range of 2.0d that the reduced first cumulant[Γ^(*)=Γ(q)/(q^(3)k_(B)T/η_(0))]does not display an asymptotic ***,a better asymptotic behavior is observed by plottingΓ(q)/q^(4) versus *** the first time,our observation provides direct evidence supporting that,for hyperbranching cluster system with low polydispersity and high local chain segment density,the hydrodynamic interaction is greatly weakened due to the enhanced hydrodynamic shielding effect.

关键词： Hyperbranching cluster Structural feature Internal motion

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Formaldehyde concentration and its influencing factors in residential homes after decoration at Hangzhou,China

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Journal of Environmental Sciences 2013年第5期25卷 908-915页

作者： Min Guo Xiaoqiang Pei Feifei mo Jianlei Liu Xueyou Shen department of Environmental Sciences Zhejiang University Zhejiang Taohuayuan Environmental Engineering Company Limited Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control

Air pollution surveys of formaldehyde（HCHO） were conducted in 2324 rooms decorated within one year in 2007-2009 in Hangzhou,*** mean HCHO concentration（C HCHO） was 0.107 ± 0.095 mg/m 3,and 38.9% of samples exceeded the Chinese National Standard GB *** the past 3 years,the C HCHO decreased with time（p 〈 0.05）.Relationships of potential factors to indoor C HCHO were also evaluated.C HCHO was related to temperature（T）,relative humidity（RH）,time duration of the windows and doors being closed before sampling（dC）,time duration from the end of decoration to sampling（dR） and source characteristics（d）.A model to relate indoor C HCHO to these five factors（T,RH,dC,dR,d） was established based on 298 samples（R 2 = 0.87）.Various factors contributed to C HCHO in the following order：T,43.7%;d,31.0%;dC,10.2%;dR,8.0%;RH,7.0%;specifically,meteorological conditions（i.e.,RH plus T） accounted for 50.7%.The coefficient of T and RH,R TH,was proposed to describe their combined influence on HCHO emission,which also had.a.linear relationship（R 2 = 0.9387） with HCHO release in a simulation chamber *** addition,experiments confirm that it is a synergistic action as T and RH accelerate the release of HCHO,and that is a significant factor influencing indoor HCHO *** achievements could lead to reference values of measures for the efficient reduction of indoor HCHO pollution.

关键词： formaldehyde indoor air quality emission factor analysis temperature relative humidity

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VA族元素修饰对二维AlN电磁性质调控的理论研究

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原子与分子物理学报 2025年第6期42卷 159-166页

作者：莫秋燕陈广萍张颂荆涛吴家隐凯里学院大数据工程学院凯里556011 凯里学院理学院凯里556011 广东开放大学(广东理工职业学院)工程技术学院广州510091

采用基于密度泛函理论的第一性原理计算方法,研究了VA族元素(N、P、As、Sb、Bi)对二维AlN电磁性质的影响.研究发现,VA族元素修饰后,二维AlN的能带结构发生显著劈裂,表明体系转变为磁性材料.同时,导带底部向低能量区域移动,使得二维AlN... 详细信息

采用基于密度泛函理论的第一性原理计算方法,研究了VA族元素(N、P、As、Sb、Bi)对二维AlN电磁性质的影响.研究发现,VA族元素修饰后,二维AlN的能带结构发生显著劈裂,表明体系转变为磁性材料.同时,导带底部向低能量区域移动,使得二维AlN的吸收阈值从紫外线区域扩展至可见光区域.因此,VA族元素的修饰显著调控了二维AlN的电子结构和磁性,为实现可见光响应的光电子和自旋电子器件提供了新思路和可能性.

关键词：二维AlN 第一性原理修饰电子结构

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2d hierarchical lattices' imperfection sensitivity to missing bars defect

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Theoretical & Applied Mechanics Letters 2015年第4期5卷 141-145页

作者： Bo Wang Yunfeng Shi Rui Li Youwei Chen Yihua mo State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology Beijing Institute of Astronautical Systems Engineering

Commercially available lattices contain various kinds of morphological imperfections which result in great degradation in lattices＇ mechanical properties, therefore, to obtain imperfection insensitive lattice structure is obviously a practical research subject. Hierarchical structure materials were found to be a class of promising anti-defect materials, This paper builds hierarchical lattice by adding soft adhesion to lattice＇s cell edges and numerical results show that its imperfection sensitivity to missing bars is minor compared with the classic lattice. Soft adhesion with appropriate properties reinforce cell edge＇s bending stiffness and thus reduce the bending deformation in lattice caused by missing bars defect, which is confirmed by statistical analysis of normalized node displacements of imperfect lattices under hydrostatic compression and shear loads.

关键词： Hierarchical structures Lattices Imperfection sensitivity Elastic properties Missing bars

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