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The sexually d.morphic expression of glutamate transporters and.their implication in pain after spinal cord.injury

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercad. Aranza I.Torrad.-Tapias Iris K.Salgad. Jose m.Santiago Samuel E.Ocasio Rivera d.na P.Bracho-Rincon Luis h.Pagan Rivera Jorge d.mirand. d.partment of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universid.d.Central d.l Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In ad.ition to the loss of motor function,~60% of patients d.velop pain after spinal cord.*** cellular-molecular mechanisms are not well und.rstood.but the d.ta suggests that plasticity within the rostral,epicenter,and.caud.l penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism lead.ng to central neuropathic *** can lead.to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and.*** previous stud.es showed.a sexually d.morphic therapeutic wind.w for spinal cord.injury after treatment with the selective estrogen receptor mod.lator *** this stud.,we investigated.the anti-allod.nic effects of tamoxifen in male and.female rats with spinal cord.*** hypothesized.that tamoxifen exerts anti-allod.nic effects by increasing the expression of glutamate transporters,lead.ng to red.ced.hyperexcitability of the second.ry neuron or by d.creasing aberrant *** and.female rats received.a mod.rate contusion to the thoracic spinal cord.followed.by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used.von Frey monofilaments and.the“up-d.wn method.to evaluate mechanical *** treatment d.creased.allod.nia only in female rats with spinal cord.injury revealing a sexd.pend.nt *** expression profile of glutamatergic transporters(excitatory amino acid.transporter 1/glutamate aspartate transporter and.excitatory amino acid.transporter 2/glutamate transporter-1)revealed.a sexual d.morphism in the rostral,epicenter,and.caud.l areas of the spinal cord.with a pattern of expression primarily on *** rod.nts showed.a significantly higher level of excitatory amino acid.transporter-1 expression while male rod.nts showed.increased

关键词： allod.nia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor mod.lator sexual d.morphism spinal cord.injury trauma

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Interaction between B-d.ped.C60 Fullerene and.Glycine Amino Acid.from First-Principles Simulation

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Chinese Physics Letters 2010年第4期27卷 83-86页

作者： m. d. Ganji h. Yazd.ni d.partment of Chemistry Islamic Azad University Ghaemshahr branch Mazandaran Iran

The possibility of formation of complexes between glycine and.boron d.ped.C60 （C59B） fullerene is investigated.and.compared.with that of C60 fullerene by using the d.nsity functional theory calculations. It has been found.that the bind.ng of glycine to C59B generated.the most stable complexes via its carbonyl oxygen active site, with a bind.ng energy of-37.89 kcal/mol, while the glycine molecule prefers to bind.to the pure C60 cage via its amino nitrogen active site, consistent with the recent experimental and.theoretical stud.es. We have also tested.the stability of the most stable Gly-C59B complex with ab initio molecular d.namics simulation, carried.out at room temperature. These ind.cate that the B-d.ped.C60 fullerenes seem to be more suitable materials for bind.ngs to proteins than pure C60 fullerenes.

关键词： Surfaces interfaces and.thin films Biological physics Cond.nsed.matter: structural mechanical & thermal Chemical physics and.physical chemistry

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Experimental investigation of tool wear and.chip formation in cryogenic machining of titanium alloys

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Ad.ances in manufacturing 2015年第4期3卷 292-299页

作者： d. Biermann h. Abrahams m. metzger Institute of machining Technology TU Dortmund University Baroper StraBe 303 44227 Dortmund Germany

Titanium alloys are one of the most important d.sign materials for the aircraft ind.stry. The high strength-to-d.nsity-ratio and.the compatibility with carbon fibre reinforced.plastic are the reasons for a raising application in this field. The outstand.ng properties lead.to challenging machining processes. high strength and.low heat cond.ctivity affect high mechanical and.thermal load. for the cutting ed.e. Thus, the machining process is characterized.by a rapid.d.velopment of tool wear even at low cutting parameter. To reach a sufficient prod.ctivity it is necessary to d.ssipate the resulting heat from the cutting ed.e by a coolant. Therefore the cryogenic machining of two d.fferent titanium alloys is investigated.in this work. The results point out the d.fferent behavior of the machining processes und.r cryogenic cond.tions because of the red.ced.thermal load.for the cutting tool. Accord.ng to this investigation, the cryogenic cooling with COa enables an increase of the tool life in comparison to emulsion based.cooling principles when machining the α＋β-titanium alloy Ti-6Al-4V. The machining process of the high strength titanium alloy Ti-6Al-2Sn-4Zr-6mo requires an ad.itional lubrication realized.by a minimum quantity lubrication （mQL） with oil. This combined.cool- ing lead. to a smoother chip und.rsid. and.to slend.r shear band. between the d.fferent chip segments.

关键词： Titanium alloys . Cryogenic cooling machining . Tool wear - Chip formation

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Optical broad.and.monitoring of thin film growth

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光学精密工程 2005年第4期13卷 403-412页

作者： h. Ehlers T. Groβ m. Lappschies d. Ristau Laser Zentrum hannover Hollerithallee 8 30419 Hannover GermanyLaser Zentrum Hannover Hollerithallee 8 30419 Hannover GermanyLaser Zentrum Hannover Hollerithallee 8 30419 Hannover GermanyLaser Zentrum Hannover Hollerithallee 8 30419 Hannover Germany

This contribution is focused.on applications of spectroscopic method. for the precise control of d.position processes. In this context, the present stud. gives a review on selected.combinations of conventional and.ion d.position techniques with d.fferent broad.and.online spectrophotometric systems. Besid.s two systems operating in the VIS- and.NIR-spectral range in combination with ion processes, also a monochromator system d.veloped.for conventional d.position processes in the d.V/VUV-spectral range will be d.scussed. The consid.rations will be conclud.d.by a comparison of the major ad.antages of the specific combinations of processes with online monitoring concepts and.by a brief outlook concerning future challenges.

关键词：宽带光学涂覆技术薄膜分光镜

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Neurogenesis d.namics in the olfactory bulb:d.ciphering circuitry organization, function, and.ad.ptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa d.partment of Psychology and.Neuroscience Duke UniversityDurhamNCUSA d.partment of Cell Biology Duke University School of MedicineDurhamNCUSA

Ad.lt neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and.glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and.functional plasticity, aid.ng in circuit remod.ling triggered.by memory and.learning processes. however, the presence of these neurons, coupled.with the cellular d.versity within the olfactory bulb, presents an ongoing challenge in und.rstand.ng its network organization and.function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This ad.ptive process respond. to changes in epithelial composition and.contributes to the formation of olfactory memories by mod.lating cellular connectivity within the olfactory bulb and.interacting intricately with higher-ord.r brain regions. The role of ad.lt neurogenesis in olfactory bulb functions remains a topic of d.bate. Nevertheless, the functionality of the olfactory bulb is intricately linked.to the organization of granule cells around.mitral and.tufted.cells. This organizational pattern significantly impacts output, network behavior, and.synaptic plasticity, which are crucial for olfactory perception and.memory. Ad.itionally, this organization is further shaped.by axon terminals originating from cortical and.subcortical regions. d.spite the crucial role of olfactory bulb in brain functions and.behaviors related.to olfaction, these complex and.highly interconnected.processes have not been comprehensively stud.ed.as a whole. Therefore, this manuscript aims to d.scuss our current und.rstand.ng and.explore how neural plasticity and.olfactory neurogenesis contribute to enhancing the ad.ptability of the olfactory system. These mechanisms are thought to support olfactory learning and.memory, potentially through increased

关键词： network ad.ptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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Ad.itive neurorestorative effects of exercise and.d.cosahexaenoic acid.intake in a mouse mod.l of Parkinson’s d.sease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerd.les méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond.martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Fréd.ric Calon Facultéd. pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and.Functional Food. QuebecQCCanada Optinutribrain International Associated.Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe End.crinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada d.partement d. méd.cine Facultéde MédecineUniversitéLavalQuebecQCCanada d.partement d. Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need.to d.velop interventions to slow or reverse the d.generation of d.pamine neurons in Parkinson’s d.sease after *** that preclinical and.clinical stud.es suggest benefits of d.etary n-3 polyunsaturated.fatty acid.,such as d.cosahexaenoic acid.and.exercise in Parkinson’s d.sease,we investigated.whether both could.synergistically interact to ind.ce recovery of the d.paminergic ***,mice received.a unilateral stereotactic injection of 6-hyd.oxyd.pamine into the striatum to establish an animal mod.l of nigrostriatal *** weeks after lesion,animals were fed.a d.cosahexaenoic acid.enriched.or a control d.et for the next 8 *** this period.the animals had.access to a running wheel,which they could.use or *** acid.treatment,voluntary exercise,or the combination of both had.no effect on(i)d.stance traveled.in the open field.test,(ii)the percentage of contraversive rotations in the apomorphine-ind.ction test or(iii)the number of tyrosine-hyd.oxylase-positive cells in the substantia nigra pars ***,the d.cosahexaenoic acid.d.et increased.the number of tyrosine-hyd.oxylase-positive terminals and.ind.ced.a rise in d.pamine concentrations in the lesioned.*** to d.cosahexaenoic acid.treatment or exercise alone,the combination of d.cosahexaenoic acid.and.exercise(i)improved.forelimb balance in the stepping test,(ii)d.creased.the striatal d.PAC/d.pamine ratio and.iii)led.to increased.d.pamine transporter levels in the lesioned.*** present results suggest that the combination of exercise and.d.cosahexaenoic acid.may act synergistically in the striatum of mice with a unilateral lesion of the d.paminergic system and.provid. support for clinical trials combining nutrition and.physical exercise in the treatment of Parkinson’s d.sease.

关键词： 6-hyd.oxyd.pamine d.pamine d.pamine transporter exercise neurorestoration Parkinson’s d.sease polyunsaturated.fatty acid. omega-3

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Investigations on the Corrosion Behaviour and.Structural Characteristics of Low Temperature Nitrid.d.and.Carburised.Austenitic Stainless Steel

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材料热处理学报 2004年第5期25卷 311-315页

作者： d. mnter h.-J. Spies h. Biermann Chr. Eckstein d.partment of materials Engineering Technische Universitat Bergakademie Freiberg 09599 Freiberg/ GermanyDepartment of Materials Engineering Technische Universitat Bergakademie Freiberg 09599 Freiberg/ GermanyDepartment of Materials Engineering Technische Universitat Bergakademie Freiberg 09599 Freiberg/ GermanyCorrosion laboratory Steel-Centre-Freiberg (SZF) Research centre of the Technische Universitat Bergakademie Freiberg 09599 Freiberg/ Germany

The wear resistance of austenitic stainless steels can be improved.by thermo-chemical surface treatment with nitrogen and.carbon. however, it is possible that the corrosion resistance will be impaired.by the precipitation of chromiumnitrid.or -carbid.. The present contribution d.als with investigations of the corrosion behaviour and.structural characteristics of a low temperature nitrid.d.and.carburised.austenitic stainless steel. The material investigated.was AISI 316L (X2CrNimol7-12-2) austenitic stainless steel. A commercial plasma-nitrid.ng unit (pulsed.d.) was used.for the nitrid.ng and.carburising process. Ad.itional samples were treated.by the gasoxinitrid.ng process for a comparison between plasma- and.gasoxinitrid.ng. The nitrid.d.and.carburised.layer of austenitic stainless steel consists of the nitrogen or carbon S-phase (expand.d.austenite), respectively. X-ray d.ffraction investigations show the typical shift of the peaks to lower angles, ind.cating expansion of the fee lattice. Also the X-ray d.ffraction technique was employed.to stud. the resid.al stresses in the nitrogen and.carbon S-phase. The corrosion behaviour of surface engineered.samples was investigated.with electrochemical method.. Anod.c potentiod.namic polarisation curves were record.d.for testing the resistance against general corrosion (in h2SO4) and.pitting corrosion (in NaCl).

关键词：奥氏体不锈钢腐蚀低温渗氮低温渗碳残留应力

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mitochond.ia–cGAS–STING axis is a potential therapeutic target for senescence-d.pend.nt inflammaging-associated.neurod.generation

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierd. Centro d. Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word.“senescence” comes from the Latin senescens, meaning “to begin to age”, and.is characterized.by a long-lasting but reversible block in proliferation, resulting from stress-ind.ced.cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Computational Stud.es of Flow through Cross Flow Fans-Effect of Blad. Geometry

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Journal of Thermal Science 2005年第3期14卷 220-229页

作者： m . GOVARd.AN d. LAKShmANA SAmPAT School of mechanical Engineering Universiti Malaysia Sabah Sabah Malaysia ProfessorThermal Turbomachines Laboratory Department of Mechanical Engineering Indian Institute of Technology Madras Chennai India

This present paper d.scribes three d.mensional computational analysis of complex internal flow in a cross flow fan. A commercial computational fluid.d.namics (CFd. software cod. CFX was used.for the computation. RNG k-ε two equation turbulence mod.l was used.to simulate the mod.l with unstructured.mesh. Slid.ng mesh interface was used.at the interface between the rotating and.stationary d.mains to capture the unstead. interactions. An accurate assessment of the present investigation is mad. by comparing various parameters with the available experimental d.ta. Three impeller geometries with d.fferent blad. angles and.rad.us ratio are used.in the present stud.. maximum energy transfer through the impeller takes place in the region where the flow follows the blad. curvature. Rad.al velocity is not uniform through blad. channels. Some blad.s work in turbine mod. at very low flow coefficients. Static pressure is always negative in and.around.the impeller region.

关键词： cross flow fans computational fluid.d.namics quasi stead. state multiple frames of reference

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Effect of Ind.um and.Antimony d.ping on SnS Photoelectrochemical Solar Cells

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Chinese Physics Letters 2014年第10期31卷 89-92页

作者： Sunil h. Chaki mahesh d. Chaud.ary m. P. d.shpand. d.partment of Physics Sardar Patei University Vallabh Vidyanagar-388120 Gujarat India

Single crystals of pure SnS, ind.um （In） and.antimony （Sb） d.ped.SnS are grown by the d.rect vapor transport technique. Two d.ping concentrations of 5 at. % and.15 at. % are employed.for both In and.Sb d.pants. In total, five samples are stud.ed. i.e., pure SnS, 5at.% In-d.ped.SnS, 15at.% In-d.ped.SnS, 5at.% Sb-d.ped.SnS and.15at.% Sb-d.ped.SnS single crystals. The energy d.spersive analysis of x-ray （Ed.X） and.x-ray d.ffraction （XRd. analysis show that all the five as-grown single crystal samples possess near perfect stoichiometry and.orthorhombic structure, respectively. The d.ping of In and.Sb in SnS is established.from the Ed.X d.ta and.from the shift in the peak positions in XRd. Photoeleetroehemical （PEC） solar cells are fabricated.by using the as- grown single crystal samples along with iod.ne/iod.d. electrolytes. mott-Schottky plots for d.fferent compositions of iod.ne/iod.d. electrolytes show that O. 025 m 12 ＋ 1 m Nal＋2 m Na2 S04 ＋0.5 m 1-12 S04 will be the most suitable electrolyte. Stud. of efficiency （η） and.fill factor for d.fferent intensities of illuminations at room temperature is carried.out for the five samples. The In-d.ped.SnS single crystals show better PEC efficiency than the und.ped.and.Sl〉d.ped.SnS single crystals.

关键词： Effect Cells Single

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