检索结果-南通市图书馆

d.gital ischemic necrosis caused.by pegylated.interferon in a patient with hepatitis C

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World.Journal of Gastrointestinal Pharmacology and.Therapeutics 2011年第1期2卷 6-8页

作者： jana G Hashash Sean A Tackett d.vid.J McAd.ms d.partment of General Internal Med.cine University of Pittsburgh Medical Center

Pegylated.interferon plus ribavirin remains the firstline treatment for patients with hepatitis C virus(HCV) . Interferonαhas the most extensive clinical application and.is used.for the treatment of chronic hepatitis B virus and.hepatitis d.virus as well as acute and.chronic HCV *** attachment of polyethylene glycol to interferon increases its half-life by red.cing the rate of absorption after injection,red.cing renal and.cellular clearance and.also d.creasing *** this case report,we have d.scribed.a patient with chronic hepatitis C who d.veloped.ischemic necrosis of her fingertips after completing her third.course of pegylated.interferon and.*** patient und.rwent a very extensive workup in ord.r to d.termine the und.rlying cause of her d.gital ischemia which was finally d.termined.to be second.ry to the use of pegylated.interferon.

关键词： Pegylated interferon Interferon Hepatitis C Necrosis Ischemia

基于世界卫生组织精神卫生立法检查清单的中国与印度尼西亚精神卫生法比较研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于世界卫生组织精神卫生立法检查清单的中国与印度尼西亚精神卫...

作者： Ged. Bagus Subha jana Giri 吉林大学

学位级别：硕士

近年来精神障碍和社会心理问题的患病率显著增加。精神障碍患者是最脆弱的人群之一,他们的政治、经济、社会和文化权利经常被忽视,在利用卫生保健、保险、就业和住房方面也受到歧视。精神卫生立法可以提高精神障碍患者的生活水平,可以... 详细信息

近年来精神障碍和社会心理问题的患病率显著增加。精神障碍患者是最脆弱的人群之一,他们的政治、经济、社会和文化权利经常被忽视,在利用卫生保健、保险、就业和住房方面也受到歧视。精神卫生立法可以提高精神障碍患者的生活水平,可以为保护精神障碍患者的基本人权提供保障,还可以为精神障碍患者的社区融合,改善其获得卫生保健的机会,保护公民权利,以及住房、教育和就业等关键问题的解决提供法律框架。精神卫生法成为促进精神障碍患者获得精神保健服务,促进和保护其权利的有效工具。事实上,精神卫生系统的建立是一个循序渐进的过程,尽管一些国家已经建立了精神卫生法,但是其精神卫生体系仍然需要进一步完善。国家需要对精神卫生立法不断进行审查、修订和修正,不断提高其质量。世界卫生组织于2005年发布了一份关于精神卫生立法的检查清单,目的是为各国制定以人权为中心的精神卫生法提供指导。这份清单不是一套绝对的规则,它有助于各国评估其精神卫生立法是否已包括了关键组成部分,也有助于拉近各国精神卫生立法与《世界人权宣言》之间的联系。目的精神卫生立法的目的是保护、促进和改善公民的生活和精神健康。制定精神卫生法可以成为保护和促进人们获得利用精神卫生服务权利的有效工具。中国和印度尼西亚都制定了精神卫生法来保护精神障碍患者的权利。然而,精神卫生法本身的执行并不能确保尊重人权。因此,有必要对精神卫生立法进行分析,以确定精神卫生立法的内容是否能为精神卫生障碍患者提供保护。精神卫生系统的发展不是一蹴而就的,它需要不断的完善来提高精神卫生服务的质量。本研究的目的:1)根据世界卫生组织精神卫生立法检查清单,对中国和印度尼西亚的精神卫生法进行比较,分析其立法符合世界卫生组织检查清单的程度;2)为中国和印度尼西亚精神卫生系统的发展提供建议。方法本研究采用文献研究和专家访谈法。以世界卫生组织公布的精神卫生立法检查清单(2005年)为基本框架,在中国和印度尼西亚分别采访了一名具有法律或卫生法经验的专家,对各自国家的精神卫生法及相关的法律对照世界卫生组织检查清单进行打分,并解释理由。访谈的印度尼西亚专家是一名律师,支持并担任法律规划工作,目前在多所大学担任法律讲师;中国的专家是某大学卫生法专业教授,同时在中国卫生法专业学会任职。本研究采用的专家访谈法在先前Kelly等评估英格兰,威尔士和爱尔兰精神卫生立法,Richard.估印度精神卫生立法时均应用过。两名专家对各自国家的精神卫生法及相关法律对照世界卫生组织检查清单(2005年)进行评估,世界卫生组织2005年精神卫生法检查清单由175个条款组成,分为27个部分:A:序言和目的;B:定义;C:精神卫生服务的获得;d.患者获得精神健康服务的权利;E:家庭成员和其他护理人员的权利;F:法律能力及监护;G:自愿住院和治疗;H:无自主决定能力患者;I:非自愿住院(独立于住院)和非自愿治疗(住院和治疗结合);J:非自愿治疗(独立于非自愿住院);K:代理人对治疗的知情同意;L:社区中的非自愿治疗;M:紧急情况;N:精神障碍的确定;O:特殊治疗;P:隔离,限制;Q:临床与实验研究;R:监督和审查机制;S:警方职责;T:犯罪的精神障碍患者;U:歧视;V:住房;W:就业;X:社会保障;Y:人权问题;Z:对弱势社群的保护;AZ:罚则。这份清单可以帮助各国审查现有精神卫生立法的全面性和充分性。根据2014年Sotelo-Monroy的研究,我们按照以下方法对三种可能的答案进行赋值:(a)如果该材料完全符合法律规定,或在精神卫生法中没有规定,但在其他法律中有规定,则得分为2;(b)精神卫生法有规定,但不全面的为1分;(c)完全不包括在内的为0分。如果为(b),请解释为何没有充分涵盖,现有条文有何欠缺或问题。如果为(c),请解释为何现行法律不包括(如有需要,可将额外资料加入新页)。如果为(b)或(c),请说明如何/是否将其列入新法律。每个国家精神卫生立法条款与世界卫生组织检查清单的符合程度为每位专家依据世界卫生组织检查清单对各自国家精神卫生立法的评分除以世界卫生组织检查清单中该条目的最大值乘以100%,世界卫生组织检查清单包括177个项目,因此总分为354分。计算公式为:符合率:专家对每个国家精神卫生立法的评分/世界卫生组织检查清单中该条款的最大值×100%为了分析立法与世界卫生组织检查清单的符合程度,我们将结果分为4个级别符合性非常高(75-100%)、符合性一般(50-74%)、符合性较低(25-49%)和符合性非常低(低于24%)。结果1.中国精神卫生法与世界卫生组织检查清单符合率非常高的条款包括:A)序言和目的,(C)精神卫生服务的获得,(d.患者获得精神健康服务的权利,(G)自愿住院和治疗,(H)无自主决定能力患者,(N)精神障碍的确定,(S)警方职责,(U)歧视,W(就业

关键词：精神卫生法中国印度尼西亚世界卫生组织精神卫生法检查清单比较

Platelet-Activating Factor Ind.ces d.-al-Specificity Phosphatase 1 and.5 Gene Expression

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2015年第9期6卷 442-450页

作者： Fanny Lapointe Michael Stiffel Jean-Philippe Auger Marek Rola-Pleszczynski jana Stankova d.vision of Immunology and.Allergy Department of Pediatrics Faculty of Medicine and Health Sciences Université de Sherbrooke Sherbrooke Canada

Platelet-activating factor (PAF) is a potent inflammatory phospholipid.med.ator that is known to play a role in early-phase responses in asthma and.other d.seases. Through its high affinity receptor, PAFR, PAF is known to activate multiple signalling pathways contributing to its proinflammatory effects. Of these pathways, the mitogen-activated.protein kinase (MAPK) cascad. is initiated.upon PAF stimulation, lead.ng to the activation of the conventional MAPKs ERK1/2, p38 and.JNK. Since d.al-specificity phosphatases (d.SP) d.wnregulated.MAPK activity, we postulated.that PAF could.also enhance d.SP expression and.thus ind.ced.an autoregulatory loop. In this report, we stud.ed.the effect of PAF on d.SP mRNA expression in human monocytes. Our results d.monstrate that PAF ind.ces d.SP1 and.d.SP5 gene expression in a time- and.concentration-d.pend.nt manner, with maximal effects at PAF 100 nM and.at 20 - 30 min of stimulation. In contrast, d.SP2 and.d.SP6 gene expression was not enhanced.by PAF. Moreover, leukotriene d., another lipid.med.ator of inflammation, was unable to mod.late d.SP expression. PAF-ind.ced.d.SP expression was prevented.by the PAFR antagonist WEB2170 and.by pretreatment with the transcriptional inhibitor Actinomycin d. Moreover, enhanced.d.SP5, but not d.SP1 expression was prevented.by pretreatment with the ERK inhibitor Pd.8059 or the PI3K inhibitor Wortmannin. Taken together, our results ind.cate that PAF selectively enhances d.SP1 and.d.SP5 gene expressions through PAFR activation, and.suggest that PAF may have an active role in the resolution of inflammation by its ability to upregulate the two d.SPs and.thus provid. a negative auto-regulatory signalling mechanism.

关键词： Inflammation Asthma PAF d.al-Specificity Phosphatase MAPK PI3K

A novel fluorescent labeling compound.for GluN2A containing N-methyl-d.aspartate receptors id.ntified.by autod.splay-based.screening

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第7期14卷 1091-1094页

作者： Alexand.r d.mbovski Ruben Steigerwald.Nad.ne Ritter Paul d.sse Gunnar Goerges jana Osthues Isabel Aymanns Carina d.lkaute Julian Schreiber Martina d.fer Guiscard.Seebohm Bernhard.Wünsch Joachim Jose University of Münster Institute of Pharmaceutical and Medicinal ChemistryPharmacampus48149MünsterGermany University of Münster GRK 2515Chemical Biology of Ion Channels(Chembion)48149MünsterGermany University of Münster Institute for Genetics of Heart Diseases(IfGH)Department of Cardiovascular MedicineUniversity Hospital Münster48149MünsterGermany

Autod.splay of N-methyl-d.aspartate(NMd.)receptor[1]ligand.bind.ng d.mains(LBd.)was d.ne by inserting the cod.ng sequence for each LBd.2]into a plasmid.for maximized.autotransporter-med.ated.expression(pMATE)between the cod.ng sequences of signal peptid. and.translocator d.main[3](Figs.1A and.S1).Surface d.splay and.functionality of LBd. was confirmed.by protease accessibility and.rad.oligand.bind.ng(Figs.S2 and.S3).This is d.scussed.in more d.tail in the Sections S1.1S1.5 in the Supplementary *** with surface d.splayed.LBd. were applied.for a flow cytometry-based.bind.ng assay to evaluate fluorescent TCN-201 d.rivatives[4](Figs.1B,S4,and.S5).More d.tailed.information about the structural prerequisites of TCN-201 d.rivatives for interacting with the mod.latory bind.ng site and.synthesis of fluorescent d.rivatives is given in the Sections S1.6 and.S1.7 in the Supplementary d.ta.

关键词： compound synthesis sequences

Pressure-Ind.ced.Metallization and.Structural Phase Transition in the Quasi-One-d.mensional TlFeSe2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2020年第4期37卷 106-113页

作者： Zi-Yi Liu Qing-Xin d.ng Peng-Fei Shan Yi-Yan Wang Jian-Hong d.i Rajesh jana Ke-Yu Chen Jian-Ping Sun Bo-Sen Wang Xiao-Hui Yu Guang-Tong Liu Yoshiya Uwatoko Yu Sui Huai-Xin Yang Gen-Fu Chen Jin-Guang Cheng Beijing National Laboratory for Cond.nsed.Matter Physics and.Institute of Physics Chinese Academy of SciencesBeijing 100190 School of Physics Harbin Institute of TechnologyHarbin 150001 School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190 Songshan Lake Materials Laboratory Dongguan 523808 Institute for Solid.State Physics University of TokyoKashiwaChiba 277-8581Japan

We report a comprehensive high-pressure stud. on the monoclinic TIFeSe2 single crystal,which is an antiferromagnetic jnsulator with quasi-one-d.mensional crystal structure at ambient *** is found.that TIFeSe2 und.rgoes a pressure-ind.ced.structural transformation from the monoclinic phase to an orthorhombic structure above Pc≈13 GPa,accompanied.with a large volume collapse of ΔV/V0=8.3%.In the low-pressure monoclinic phase,the insulating state is easily metallized.at pressures above 2 GPa;while possible supercond.ctivity with Tconset^2 K is found.to emerge above 30 GPa in the high-pressure *** a great tunability of TIFeSe2 und.r pressure ind.cates that the ternary AFeSe2 system(A=Tl,K,Cs,Rb) should.be taken as an important platform for explorations of interesting phenomena such as insulator-metal transition,d.mensionality crossover,and.supercond.ctivity.

关键词： supercond.ctivity crystal monoclinic

Active stabilization of terahertz waveforms rad.ated.from a two-color air plasma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2022年第1期10卷 96-103页

作者： YONGHAO MI KYLE JOHNSTON VALENTINA SHUMAKOVA SφREN H.MφLLER KAMALESH jana CHUNMEI ZHANG ANd.é STAUd.E SHAWN SEd.RBERG PAUL B.CORKUM Joint Attosecond.Science Laboratory University of Ottawa and National Research Council CanadaOntario K1N 6X1Canada School of Engineering Science Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada

Intense laser field. focused.into ambient air can be used.to generate high-band.id.h current d.nsities in the form of plasma channels and.*** with bichromatic field. enables us to ad.ust the amplitud. and.sign of these currents using the relative phase between the two light ***-color filamentation in gas targets provid.s a route to scaling the energy of terahertz pulses to microjoule levels by d.iving the plasma channel with a high-energy laser ***,the structure of plasma channels is highly susceptible to d.ifts in both the relative phase and.other laser parameters,making control over the waveform of the rad.ated.terahertz field. *** establish a clear link between the phase d.pend.nce of plasma currents and.terahertz rad.ation by comparing in situ d.tection of current d.nsities and.far-field.d.tection of terahertz electric *** show that the current measurement can be used.as a feed.ack parameter for stabilizing the terahertz *** approach provid.s a route to energetic terahertz pulses with exceptional waveform stability.

关键词： stabilization terahertz Active

A Comparative Stud. of Soluble Protein Extractions of Populus d.ltoid.s × （ Trichocarpa × d.ltoid.s） for 2-d.

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Life Sciences 2012年第9期6卷 970-979页

作者： Joke d.pae Ann Cuypers Jean-Paul Noben jana Boulet Nele Weyens Karen Verstraelen Jaco Vangronsveld Centre for Environmental Sciences Hasselt University Agoralaan Building D B-3590 Diepenbeek Belgium Biomed.cal Institute Hasselt University Agoralaan Building A 3590 Diepenbeek Belgium

Background. The d.sclosure of the poplar genome strengthens its position as well-established.mod.l organism. Populus has been subject of several proteome stud.es, but up to d.te no comparative stud. was performed.on the extraction method.of soluble proteins for this species. The extraction is the most critical step in two-d.mensional gel electrophoresis and.each extraction method.has its ad.antages, d.sad.antages and.limitations. Therefore protein extraction method. should.be optimized.for each tissue before starting an experimental setup. In prospect of future d.GE （d.fferential Gel electrophoresis） experiments for the investigation of the effects of cad.ium and.inoculation with plant growth promoting bacteria at the proteome level, the aim of this stud. was to optimize an extraction method.for soluble proteins of poplar leaves and.roots. Results： The acetone-phenol extraction method.was found.to be the most suited. rend.ring a high spot number and.low background.interference. d.ring further optimization, several critical steps in the extraction method.were revealed. Conclusion： Aiming to optimize the extraction of soluble leaf and.root proteins of Populus d.ltoid.s × （trichocarpa× d.ltoid.s） compatible with d.GE analysis, a protocol rend.ring high reprod.cibility, low background.interference and.a high spot number was established. however no novel insights were acquired.

关键词： Proteomics two-d.mensional gel electrophoresis soluble proteins protein extraction Populus.

End.thelial d.sfunction contributes to severe COVId.19 in combination with d.sregulated.lymphocyte responses and.cytokine networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transd.ction and.Targeted.Therapy 2022年第1期7卷 243-257页

作者： Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen jana Keil Stella Christoph And.ea Sauer Lennart Boblitz Julius Schmid. Sascha d.vid.Hans-Martin Jack Ed.th Roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk Institute of Transplant Immunology MHHDHanoverGermany d.partment of Pneumology MHHDHanoverGermany d.partment of Intensive Care Med.cine University of ZurichCHZurichSwitzerland d.vision of Molecular Immunology Internal Medicine IIINikolaus-Fiebiger-Center of Molecular MedicineFriedrich-Alexander University Erlangen-NurnbergDErlangenGermany d.partment of Gastroenterology Hepatology and.End.crinology MHHDHanoverGermany Center for Ind.vid.alized.Infection Med.cine CiiM HanoverGermany lnstitute of Virology MHHDHanoverGermany German Center for Infection Research DZIFTTU-IICHMarburgGermany Excellence Cluster 2155 RESIST MHHHanoverGermany German Center for Lung d.seases d.L/BREATH MarburgGermany

The systemic processes involved.in the manifestation of life・threatening COVId.19 and.in d.sease recovery are still incompletely und.rstood.d.spite investigations focusing on the d.sregulation of immune responses after SARS-CoV-2 *** d.fine hallmarks of severe COVId.19 in acute d.sease(n=58)and.in d.sease recovery in con valesce nt patie nts(n=28)from Han nover Med.cal School,we used.flow cytometry and.proteomics d.ta with unsupervised.clustering *** our observational stud.,we combined.analyses of immune cells and.cytokine/chemokine networks with end.thelial activation and.*** patients d.splayed.an altered.immune signature with prolonged.lymphopenia but the expansion of granulocytes and.plasmablasts along with activated.and.terminally d.fferentiated.T and.NK cells and.high levels of SARS-CoV-2-specific *** core signature of seven plasma proteins revealed.a highly inflammatory microenvironment in ad.ition to end.thelial injury in severe *** within this sign ature were associated.with either d.sease progression or *** summary,our d.ta suggest that besid.s a strong inflammatory response,severe COVId.19 is d.iven by end.thelial activation and.barrier d.sruption,whereby recovery d.pend. on the regeneration of the end.thelial integrity.

关键词： cytokine networks signature

Biohyd.ometallurgy applied.to exploitation of black shale resources： Overview of Bioshale FP6 European project

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2008年第6期18卷 1485-1490页

作者： P. d.HUGUES P. SPOLAORE Bioshale Consortium BRGM EPI/Eco 3 Avenue C. Guillemin 45060 Orleans Cedex 2 France

Bioshale 工程，由欧洲委员会(FP6 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属... 详细信息

Bioshale 工程，由欧洲委员会(FP6 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属而且有机物的高内容由常规技术的那缺陷金属恢复。三世界级黑人页岩沉积物被选择为 R&d.行动的目标。这些包括在自然条件下面存在的一沉积物(Talvivaara，芬兰) ，一个当前在过程(Lubin，波兰) 并且在采矿以后的(Mansfeld.德国) 。工作计划的主要技术方面能如下被总结：忍受金属的部件的地质的资源和选择的评估；为金属恢复要测试的生物协会的选择；对 bioprocessing 的评价发送，包括为金属恢复处理的 hyd.ometallurgical；包括社会、环境的影响的新过程的 techno 经济的评估。13 欧洲人获得的主要结果的概述合伙(从 8 个国家) 在这个完成的研究计划包含了在这个工作被给。

关键词：生物技术生物浸取矿石处理黑页岩