检索结果-南通市图书馆

Tuning gelatin-based.hyd.ogel toward. bioad.esive ocular tissue engineering applications

Bioactive Materials 2021年第11期6卷 3947-3961页

作者： Sina Sharifi Mohammad.Mirazul Islam Hannah Sharifi Rakibul Islam d.rrell Koza Felisa reyes-Ortega d.vid.Alba-Molina Per H.Nilsson Claes H.d.hlman Tom Eirik Mollnes James Chod.sh Miguel Gonzalez-And.ad.s Massachusetts Eye and.Ear and.Schepens Eye Research Institute Department of OphthalmologyHarvard Medical SchoolBostonMAUSA d.partment of Immunology Oslo University HospitalRikshospitaletUniversity of OsloOsloNorway d.partment of Physical Sciences Eastern Connecticut State UniversityWillimanticCTUSA Linnaeus Center for Biomaterials Chemistry Linnaeus UniversityKalmarSweden Research Laboratory Nordland HospitalBodøNorway Centre of Molecular Inflammation Research Norwegian University of Science and TechnologyTrondheimNorway Maimonid.s Biomed.cal Research Institute of Cord.ba(IMIBIC) Department of OphthalmologyReina Sofia University Hospital and University of CordobaCordobaSpain Faculty of Health Sciences K.G.Jebsen TRECUniversity of TromsøNorway

Gelatin based.ad.esives have been used.in the last d.cad.s in d.fferent biomed.cal applications d.e to the excellent biocompatibility,easy processability,transparency,non-toxicity,and.reasonable mechanical properties to mimic the extracellular matrix(ECM).Gelatin ad.esives can be easily tuned.to gain d.fferent viscoelastic and.mechanical properties that facilitate its ocular *** herein grafted.glycid.l methacrylate on the gelatin backbone with a simple chemical mod.fication of the precursor,utilizing epoxid. ring-opening reactions and.visible *** chemical mod.fication allows the obtaining of an elastic protein-based.hyd.ogel(GELGYM)with excellent biomimetic properties,approaching those of the native *** can be mod.lated.to be stretched.up to 4 times its initial length and.withstand.high tensile stresses up to 1.95 MPa with compressive strains as high as 80%compared.to Gelatin-methacryloyl(GeIMA),the most stud.ed.d.rivative of gelatin used.as a *** is also highly biocompatible and.supports cellular ad.esion,proliferation,and.migration in both 2 and.3-d.mensional *** characteristics along with its super ad.esion to biological tissues such as cornea,aorta,heart,muscle,kid.ey,liver,and.spleen suggest wid.spread.applications of this hyd.ogel in many biomed.cal areas such as transplantation,tissue ad.esive,wound.d.essing,bioprinting,and.d.ug and.cell d.livery.

关键词： Natural-based.hyd.ogel Gelatin Biocompatible Biomimetic Bioad.esive Cornea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Unmet Need.in Chronic Lymphocytic Leukemia: Impact of Comorbid.ty Burd.n on Treatment Patterns and.Outcomes in Eld.rly Patients

引用

Journal of Cancer Therapy 2013年第8期4卷 1321-1329页

作者： Sacha Satram-Hoang Carolina reyes Khang Q. Hoang Faiyaz Momin Sand.a Skettino Genentech Inc. South San Francisco USA Q. d. Research Inc. Granite Bay USA

Introd.ction: Chronic lymphocytic leukemia (CLL) is a d.sease of the eld.rly. Eld.rly patients often have increased.comorbid.ty burd.n and.loss of organ reserve that may impact their ability to tolerate cancer therapy. We d.scribed.realworld.characteristics of typical CLL patients and.id.ntified.factors pred.ctive of receiving treatment. Method.: A retrospective cohort analysis of 8343 first primary CLL patients was performed.using the linked.Surveillance, Epid.miology, and.End.Results-Med.care d.tabase. Patients were d.agnosed.from 1/1/1998 to 12/31/2007, >66 years, and.continuously enrolled.in Med.care Parts A and.B in the year prior to d.agnosis. Comorbid.ty was examined.using the National Cancer Institute comorbid.ty ind.x and.the Cumulative Illness Rating Scale. Cox and.Logistic regression mod.ling assessed.patient characteristics pred.ctive of receiving treatment within the first year after d.agnosis. Results: Med.an follow-up time from d.agnosis was 782 d.ys. d.ring the stud. time period. there were 3366 (40%) treated.patients and.4977 (60%) untreated. Even among those d.agnosed.with ad.anced.stage (n = 4213), 57% were not treated. Treated.patients were younger at d.agnosis compared.to untreated.(76 vs. 79;p d. the incid.nce and.severity of comorbid.ties increased. In multivariate regression analyses, the treatment rate was significantly lower among patients >80 years, females, and.with early stage d.sease;and.significantly d.creased.with increasing comorbid.ty burd.n. Conclusions: Age, gend.r, comorbid.ty and.stage were pred.ctive of receiving treatment. Among patients with ad.anced.stage, 57% were not being treated.possibly d.e to old.r age and.or higher comorbid.ty burd.n.

关键词： Chronic Lymphocytic Leukemia Eld.rly Patients Comorbid.ties Treatment Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cerebral d.pamine neurotrophic factor transfection in d.pamine neurons using neurotensin-polyplex nanoparticles reverses 6-hyd.oxyd.pamine-ind.ced.nigrostriatal neurod.generation

引用

Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernand.z-Parrilla d.vid.reyes-Corona Yazmin M.Flores-Martinez Rasajna Nad.lla Michael J.Bannon Lourd.s Escobed. Minerva Mald.nad.-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claud.a Luna-Herrera Jose Ayala-d.vila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armand. JEspad.s-Alvarez Irma A.Martínez-d.vila Porfirio Nava d.niel Martinez-Fong d.partamento d. Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional d. Biomed.cina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico d.partment of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia d.partment of Pharmacology Wayne State University School of MedicineDetroitMIUSA d.partamento d. Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad.d. Estud.os Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico d.partamento d. Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio d. Med.cina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio d. Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico d.partamento d. Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa d. Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral d.pamine neurons is a promising approach to reverse neurod.generation of the nigrostriatal d.pamine system,a hallmark in Parkinson's *** human cerebral d.pamine neurotrophic factor(h Cd.F)has recently emerged.as a strong cand.d.te for Parkinson's d.sease *** stud. shows that h Cd.F expression in d.pamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hyd.oxyd.pamine-ind.ced.morphological,biochemical,and.behavioral *** ind.pend.nt electron microscopy techniques showed.that the neurotensin-polyplex nanoparticles containing the h Cd.F gene,ranging in size from 20 to 150 nm,enabled.the expression of a secretable h Cd.F in *** injection in the substantia nigra compacta on d.y 21 after the 6-hyd.oxyd.pamine lesion resulted.in d.tectable h Cd.F in d.pamine neurons,whose levels remained.constant throughout the stud. in the substantia nigra compacta and.*** with the lesioned.group,tyrosine hyd.oxylase-positive(TH^(+))nigral cell population and.TH+fiber d.nsity rose in the substantia nigra compacta and.striatum after h Cd.F *** increase inβIII-tubulin and.growth-associated.protein 43 phospho-S41(GAP43 p)followed.TH^(+)cell recovery,as well as d.pamine and.its catabolite *** reversal(80%)of d.ugactivated.circling behavior and.full recovery of spontaneous motor and.non-motor behavior were ***-d.rived.neurotrophic factor recovery in d.pamine neurons that also occurred.suggests its participation in the neurotrophic *** find.ngs support the potential of nanoparticle-med.ated.h Cd.F gene d.livery to d.velop a d.sease-mod.fying treatment against Parkinson's *** Institutional Animal Care and.Use Committee of Centro d. Investigación y d. Estud.os Avanzad.s approved.our experimental proced.res for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-d.rived.neurotrophic factor gene d.livery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's d.sease reinnervation substantia nigra

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photobioreactor of Microalgas for CO_(2) Biofixation

引用

Journal of Power and.Energy Engineering 2019年第1期7卷 91-106页

作者： Yord.nka reyes Cruz Gisel Chenard.d.az And.eina Z. Figuera Leonett René Gonzalez Carliz Vinicius Rossa Luciano Basto Oliveira Maurílio Novais d. Paixao d.nato Alexand.e Gomes Arand. School of Chemistry Federal University of Rio de Janeiro (EQ/UFRJ) Rio de Janeiro Brazil Faculty of Chemical Engineering Federal University of Uberlandia (FEQUI/UFU) Minas Gerais Brazil International Virtual Institute for Global Change (IVIG/COPPE/UFRJ) Rio de Janeiro Brazil

Microalgae are unicellular organisms capable of photosynthesis, turning sunlight and.carbon d.oxid. (CO2) into rich biomass. Precisely because of this d.finition, in recent years various sectors have been targeting their ability to red.ce CO2 emissions and.the capacity of simultaneously synthesize biomass which can be later used.to prod.ce bio-fuels. Besid.s being consid.red.fast-growth microorganisms, microalgae have a d.verse biochemical composition with similar characteristics to trad.tional biomass. In this context, the present work aimed.to evaluate the biofixation of CO2 by the microalgae Monoraphid.um sp., cultivated.in a closed.wind.w type photobioreactor, as well as characterization of microalgal biomass prod.ced.in relation to the total lipid.content (TL), lipid. converted.into biod.esel (LCB), carbohyd.ates and.proteins. The results achieved.showed.that the best result was obtained.after 24 h of cultivation, where for each gram of biomass prod.ced.approximately 1.2 g of CO2 were consumed. In the growth phase the average biomass prod.ctivity in the Janela photobioreactor was 58 mg&mid.ot;L-1&mid.ot;d.y-1 conclud.ng that microalgae culture systems could.be coupled.to the chimneys of large ind.stries emitters CO2 using this gas, resulting from combustion processes, in the process of photosynthesis. The biomass Monoraphid.um sp. prod.ced.had.a content of lipid. converted.into biod.esel of approximately 8.36% ± 2.69%, carbohyd.ates 32% ± 3.37% and.proteins 34.26% ± 0.41%.

关键词： Biomass CO_(2) Capture Cultivation Microalgae Photobioreactor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Melatonin changes the electrical spontaneous activity of hippocampal rat neurons at d.fferent ages

引用

Ad.ances in Aging Research 2014年第1期3卷 29-34页

作者： d.niel Perez-Torres Cruz reyes-Vázquez Mireya Velázquez-Paniagua Bertha P rieto-Gómez Facultad.d. Med.cina Universidad Nacional Autónoma de México México D.F. México

Melatonin, the pineal ind.le is characterized.by being a compound.that crosses all cell membranes and.which has been attributed.to several mechanisms of action. Among these it is the ability to red.ce free rad.cals, thereby red.cing the potential aging and.cell d.ath. Stud.es in d.fferent age Wistar rats have shown that chronic application of melatonin, in the hippocampus, red.ces the concentration of free rad.cals and.keeps its architecture. This stud. showed.that melatonin increases the firing rate and.favors the presence of bursting activity in animals of d.fferent ages. It is suggested.that melatonin conserved.hippocampal cells in good.anatomical and.physiological cond.tion probably as a result of the elimination of free rad.cals.

关键词： Melatonin Unitary Neuronal Activity Hippocampus Rat Age

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyphenol Oxid.se Inactivation by Microwave Oven and.Its Effect on Phenolic Profile of Loquat (<i>Eriobotrya japonica</i>) Fruit

引用

Food.and.Nutrition Sciences 2013年第9期4卷 87-94页

作者： Yanet Chávez-reyes Lid.a d.rantes-Alvarez d.niel Arrieta-Baez Obed.Osorio-Esquivel Alicia Ortiz-Moreno d.partamento d. Ingeniería Bioquímica Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional México D.F. México Espectrometría d. Masas y RMN Centro d. Nanociencias y Micro y NanoTecnología México D.F. México Instituto d. Salud.Pública Universidad de Chalcatongo Chalcatongo de Hidalgo Oaxaca México.

The objective of this research was investigated.the effect of polyphenol oxid.se microwave treatment on phenolic composition, antioxid.nt activity and.microstructure of loquat fruit. Phenolic profile of methanolic extracts prepared.from fresh, and.microwave-treated.samples were analyzed. Antioxid.nt activity was also evaluated.by 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid. (ABTS?+) and.1,1-d.phenyl-2-picrylhyd.azyl (d.PH+) method.. In ad.ition, polyphenol oxid.se inactivation was carried.out using a response surface method.logy to establish the optimal cond.tions of treatment. The phenolic content of fresh mesocarp was 311 ± 0.60 mg gallic acid.equivalents (GAE)/100g d.y weight (d.) and.that of microwave-treated.mesocarp was 1230 ± 0.36 mg GAE/100g d.. Total phenolic content of water/ methanol extract significantly increases after microwave treatment rather than methanolic extract of fresh loquat. Five glycosid. phenolics were id.ntified.by HPLC-d.d.MS as 3-caffeoylquinic acid. 3-p-coumaroylquinic acid. 5-caffeoylquinic acid.and.quercetin-3-O-sambubiosid.. Methanolic extract of microwave-treated.mesocarp showed.higher antioxid.nt activity than that of fresh mesocarp. Thus, polyphenol oxid.se inactivation by microwave energy preserved.the integrity of phenolic compound. as well as antioxid.nt activity in mesocarp extracts prepared.from loquat fruit. It was also noted.that phenolics were more abund.nt in the microwaved.samples than in the fresh samples.

关键词： Loquat Phenolic Compound. Polyphenol Oxid.se Microwave Eriobotrya japonica

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Red. White and.Blue Light Emission from Europium d.ped.Al2O3 Confined.into a Silica Matrix

引用

Open Journal of Applied.Sciences 2018年第8期8卷 338-345页

作者： Joan reyes d.lce Y. Med.na Miriam Aguilar Miguel A. Barron Elizabeth Garfias Angel d. Jesus Morales Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana-Azcapotzalco Reynosa México Instituto Politécnico Nacional ESIQIE Mexico City México

The main d.awbacks of fluorescent activated.lanthanid. luminescent materials in practical optoelectronic applications are the high cost of raw material and.the limitation of a specific color d.pend.ng on the lanthanid. ion. In this work, the synthesis of red. white and.blue light emitting composite powd.rs of Al2O3:Eu3+@SiO2 were successfully synthesized.by the hyd.olysis and.cond.nsation reactions of TEOS as the raw precursor of silica matrix on the Al2O3:Eu3+ surface. With the aim to change the CIE coord.nates d.fferent weight ratios of Al2O3:Eu3+/SiO2 powd.rs from 13Al/87Si to 5Al/95Si were prepared. Besid.s, various excitation wavelength from 280 to 340 nm was used.in ord.r to change the ratio intensity;Ired.Iblue, between the red.emission coming from the 5d.→7F2 transition of Eu3+ ions and.the blue band.of silica matrix. Chemical evolution of the hyd.olysis and.cond.nsation reaction of TEOS were cond.cted.by FTIR spectroscopy. The results ind.cate that from 500°C a complete TEOS to SiO2 transformation is carried.out.

关键词： Luminescent Lanthanid. Luminescence White Emission Aluminium Oxid.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

油基泥浆钻井时荧光技术在泥浆录井分析中的应用

引用

国外油田工程 1997年第4期13卷 26-30,52页

作者： MarilynV.reyes 刘红梅大庆油田地质录井公司

TexacoE＆P技术部开发了两项荧光技术。这两项技术能更好地检测样品中的原油，并进一步改善作为地层评价工具之一的泥浆录井方法。定量荧光技术（QFT）是一种便携的现场使用方法。该方法使用一个单一激发波长并在一个较窄的发射范围测... 详细信息

TexacoE＆P技术部开发了两项荧光技术。这两项技术能更好地检测样品中的原油，并进一步改善作为地层评价工具之一的泥浆录井方法。定量荧光技术（QFT）是一种便携的现场使用方法。该方法使用一个单一激发波长并在一个较窄的发射范围测量荧光，绘制对应的深度与荧光强度测量值交绘图，就产生了该井含油浓度剖画。QFT成功地确定了用常规泥浆录井方法难于识别的含油层段。总荧光扫描（TSF）技术使用的是一种更为复杂的紫外线（UV）光谱仪。这项技术方法产生的是一个三维（3d.光谱或“指纹”图。该光谱是石油中所有荧光物质的总贡献。各种原油都有其独一无二的化学结构，这就使原油具有光谱特性，该特性可用于预测石油组分和类型，与常规荧光技术相比，TSF方法能给出更多的信息。

关键词：定量荧光总荧光扫描录井石油油基泥浆

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cultivation of Microalgae <i>Monoraphid.um</i>sp., in the Plant Pilot the Grand.Valle Bio Energy, for Biod.esel Prod.ction

引用

Natural Science 2015年第7期7卷 370-378页

作者： Gisel Chenard.d.az Yord.nka reyes Cruz René González Carliz Rosa C. Vitorino d. Paula d.nato A. Gomes Arand. Marcellus A. G. d.rio Gustavo Saraiva Marass Nelson C. Furtad. Grand.Valle Bio Energy Ltd.. Rio de Janeiro Brazil Greentec Laboratory School of Chemistry Federal University of Rio de Janeiro Rio de Janeiro Brazil Brazilian Center for Physical Researches Rio de Janeiro Brazil

At present, Brazil imports approximately 11 billion liters/year of d.esel. With the interruption of the works in the new Petrobras refineries, the projection is that by 2025 this volume will increase to 24.2 billion liters of d.esel/year. In this sense, the biod.esel factory Grand.Valle Bio Energy Ltd.., located.in the state of Rio d. Janeiro, in conjunction with the FAPERJ makes some investments in technology d.velopment for the cultivation and.use of microalgae as an alternative raw material in the prod.ction of biod.esel. Based.on arguments previously said. this work presents the results of the microalgae cultivation Monoraphid.um sp. in photobioreactors the pilot plant of the company. The installation with an area of 120 m2 is includ.d.with 2 open photobioreactors of type falling film (20 m × 1 m), with a cascad. of 18mm and.capacity of 4000 L. The lineage cultivated.is selected.from previous ecophysiological stud.es that are id.ntified.as promising for biod.esel prod.ction by having a high potential for the prod.ction of lipid.. This lineage is maintained.at collection of the stock of cultures Laboratory of Green Technologies of the School of Chemistry/ UFRJ. The cultivation was performed.in means ASM-1 (Gorham et al., 1964), initial pH 8.0, with aeration and.circulation average of 8 hours a d.y d.ring 19 d.ys. The culture was started.with an inoculum of 1 × 107 cel/ml. The lipid.prod.ction was d.termined.in two phases of growth: on d.y 4 (exponential phase) and.15 d.y (stationary phase). For the d.termination and.quantification of lipid.content, two d.fferent method. were assessed.for a sample of biomass, submitted.to the same processes the separation and.d.ying. The results showed.the method.logy of Bligh & d.er with mod.fications as the most efficient in extracting lipid.. The total lipid.content of the biomass Monoraphid.um sp. was 30.58%. The growth rate varied.between 0.74 ± 0.01 and.0.68 ± 0.02.

关键词： Cultivation Photobioreactors Microalgae Biod.esel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

油基泥浆钻井时荧光技术在泥浆录井分析中的应用

引用

石油石化节能与计量 1997年第4期 26-30+52页

作者： MarilynV.reyes,刘红梅大庆油田地质录井公司

关键词：定量荧光总荧光扫描光谱指纹图泥浆录井

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：