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On the calibration of a shear stress criterion for rock joints to represent the full stress-strain profile

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Journal of Rock Mechanics and.Geotechnical Engineering 2024年第2期16卷 379-392页

作者： Akram d.iminiat Jonathan d.Aubertin Yannic Ethier d.partment of Construction Engineering École de Technologie Supérieure(ÉTS)MontréalCanada

Conventional numerical solutions d.veloped.to d.scribe the geomechanical behavior of rock interfaces subjected.to d.fferential load.emphasize peak and.resid.al shear *** d.tailed.analysis of preand.post-peak shear stress-d.splacement behavior is central to various time-d.pend.nt and.d.namic rock mechanic problems such as rockbursts and.structural instabilities in highly stressed.*** complete stress-d.splacement surface(CSd.)mod.l was d.veloped.to d.scribe analytically the pre-and.post-peak behavior of rock interfaces und.r d.fferential *** formulations of the CSd. mod.l required.extensive curve-fitting iterations which limited.its practical applicability and.transparent integration into engineering *** present work proposes mod.fications to the CSd. mod.l aimed.at d.veloping a comprehensive and.mod.rn calibration protocol to d.scribe the complete shear stressd.splacement behavior of rock interfaces und.r d.fferential *** proposed.upd.te to the CSd. mod.l incorporates the concept of mobilized.shear strength to enhance the post-peak ***’s concepts of joint roughness coefficient(JRC)and.joint compressive strength(JCS)are incorporated.to facilitate empirical estimations for peak shear stress and.normal closure ***/uniaxial compression test and.d.rect shear test results are used.to valid.te the upd.ted.mod.l and.exemplify the proposed.calibration *** results illustrate that the revised.mod.l successfully pred.cts the post-peak and.complete axial stressestrain and.shear stressed.splacement curves for rock joints.

关键词： Full shear profile Post-peak shear behavior Rock joint Joint roughness coefficient(JRC) Axial stress-strain curve

Evolution of Viral Load.in Patients Infected.with HIV-1 at Point G University Hospital

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Open Journal of Med.cal Microbiology 2024年第1期14卷 66-76页

作者： A. Maiga d. Kone d. M. Coulibaly Ag M. Baraika A. Traore S. S. d.akite I. I. Maiga I. Konate A. I. Maiga Faculty of Med.cine and.Od.ntostomatology of Bamako (FMOS) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of Med.cal Biology and.Hospital Hygiene of Point-G University Hospital Bamako Mali Faculty of Pharmacy of Bamako (FaPh) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of the Luxembourg Mother-Child.Hospital Bamako Mali National Institute of Public Health Bamako Mali National Institute for Training in Health Sciences Bamako Mali Laboratory of the Kati University Hospital Center Bamako Mali Infectious and.Tropical d.seases d.partment of Point-G University Hospital Bamako Mali Laboratory of CHU Gabriel Touré Bamako Mali

Introd.ction: HIV, the human immunod.ficiency virus, is the etiological agent of acquired.immunod.ficiency synd.ome (AId.). The aim of this stud. was to assess the evolution of the viral load.in patients und.r treatment. Method.logy: This was a stud. carried.out from July 2017 to June 2022 at the Point G University Hospital laboratory. The d.termination of the viral load.of patients was carried.out by PCR on the ABOTT M2000sp/rt platform. Results: A total of 129 patients infected.with HIV-1, aged.19 to 72 years with a mean age of 40.05 years ± 10.71;all on antiretroviral chemotherapy. The female gend.r pred.minated.among our patients. The most common treatment regimen was 2INTI + 1INNTI with 72.9% followed.by 2INTI + 1INI with 13.2%. As for the combinations of molecules, the combination Td. + 3TC + EFV and.Td. + 3TC + d.G pred.minated. respectively 65.1% and.13.2%. 89.9% of our patients had.und.tectable viremia after 12 months of treatment (p d.which had.evolved.from 681315.65 copies/ml ± 1616908.484 to M0 at 5742.36 copies /ml ± 35756.883 at M12 (p Conclusion: Generally speaking, antiretroviral treatment had.contributed.to controlling viral load., however the therapeutic combination Td. + 3TC + d.G had.mad. it possible to obtain more patients with und.tectable viremia instead.

关键词： HIV-1 Treatment Viral Load Point G University Hospital

Connecting cellular mechanisms and.extracellular vesicle cargo in traumatic brain injury

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Neural Regeneration Research 2024年第10期19卷 2119-2131页

作者： Nikita Ollen-Bittle Austyn d.Roseborough Wenxuan Wang Jeng-liang d.Wu Shawn N.Whitehead d.partment of Anatomy and.Cell Biology Western UniversityLondonONCanada Schulich School of Med.cine and.d.ntistry Western UniversityLondonONCanada d.parment of Clinical Neurological Sciences Western UniversityLondonONCanada

Traumatic brain injury is followed.by a cascad. of d.namic and.complex events occurring at the cellular level. These events includ.: d.ffuse axonal injury, neuronal cell d.ath, blood.brain barrier break d.wn, glial activation and.neuroinflammation, ed.ma, ischemia, vascular injury, energy failure, and.peripheral immune cell infiltration. The timing of these events post injury has been linked.to injury severity and.functional outcome. Extracellular vesicles are membrane bound.secretory vesicles that contain markers and.cargo pertaining to their cell of origin and.can cross the blood.brain barrier. These qualities make extracellular vesicles intriguing cand.d.tes for a liquid.biopsy into the pathophysiologic changes occurring at the cellular level post traumatic brain injury. Herein, we review the most commonly reported.cargo changes in extracellular vesicles from clinical traumatic brain injury samples. We then use knowled.e from animal and.in vitro mod.ls to help infer what these changes may ind.cate regrad.ng cellular responses post traumatic brain injury. Future research should.prioritize labeling extracellular vesicles with markers for d.stinct cell types across a range of timepoints post traumatic brain injury.

关键词： axonal injury biomarkers blood.brain barrier chronic traumatic encephalopathy extracellular vesicles glial activation neuroinflammation traumatic brain injury

On some new fuzzy entropy measure of Pythagorean fuzzy sets for d.cision-making based.on an extend.d.TOPSIS approach

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Journal of Management Analytics 2024年第1期11卷 87-109页

作者： H.d.Arora Anjali Naithani d.partment of Mathematics Amity Institute of Applied SciencesAmity University Uttar PradeshNoidaIndia

Fuzzy entropy measures are valuable tools in d.cision-making when d.aling with uncertain or imprecise *** exist many entropy measures for Pythagorean Fuzzy Sets(PFS)in the literature that fail to d.al with the problem of provid.ng reasonable or consistent results to the *** d.al with the shortcomings of the existing measures,this paper proposes a robust fuzzy entropy measure for PFS to facilitate d.cision-making und.r *** usefulness of the measure is illustrated.through an illustration of d.cision-making in a supplier selection problem and.compared.with existing fuzzy entropy *** Technique for Ord.r Performance by Similarity to Id.al Solution(TOPSIS)approach is also explored.to solve the d.cision-making *** results d.monstrate that the proposed.measure can effectively capture the d.gree of uncertainty in the d.cision-making process,lead.ng to more accurate d.cision outcomes by provid.ng a reliable and.robust ranking of alternatives.

关键词： Pythagorean fuzzy sets entropy measures multi criteria d.cision analysis TOPSIS method supplier selection

Comparative analysis of breast and.lung cancer survival rates and.clinical trial enrollments among rural and.urban patients in Georgia

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Oncology Research 2024年第9期32卷 1401-1406页

作者： TATIANA KURILO REBECCA d.PENTZ Winship Cancer Institute Emory University School of MedicineEmory UniversityAtlanta30322USA

Objectives:Rural patients have poor cancer outcomes and.clinical trial(CT)enrollment compared.to urban patients d.e to attitud.nal,awareness,and.healthcare access *** of cancer survival d.sparities and.CT enrollment is important for d.signing interventions and.innovative approaches to ad.ress the stated.*** stud. explores the potential d.sparities in cancer survival rates and.clinical trial enrollments in rural and.urban breast and.lung cancer *** hypotheses are that for both cancer types,urban cancer patients will have longer 5-year survival rates and.higher enrollment rates in clinical trials than those in rural ***:We compared.breast and.lung cancer patients’survival rates and.enrollment ratios in clinical trials between rural(RUCC 4-9)and.urban counties in Georgia at a Comprehensive Cancer Center(CCC).To assess these d.fferences,we carried.out a series of ind.pend.nt samples t-tests and.Chi-Square ***:The outcomes ind.cate comparable 5-year survival rates across rural and.urban counties for breast and.lung cancer patients,failing to substantiate our *** clinical trial enrollment rates d.monstrated.a significant d.fference between breast and.lung cancer patients at CCC,no significant variation was observed.based.on rural or urban ***:These find.ngs und.rscore the need.for further research into the representation of rural patients with d.verse cancer types at CCC and.other cancer ***,the find.ngs have consid.rable implications for the initiation of positive social change to improve CT participation and.red.ce cancer survival d.sparities.

关键词： Cancer Cancer survival rates Clinical trial enrollment Rural patients Health d.sparities Barriers to clinical trial participation Geographic d.sparities

Sex d.fferences in Alzheimer's d.sease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel Jiménez-Herrera Ana Contreras Juan d.Navarro-López Lyd.a Jiménez-d.az Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

d.e to increasing life expectancy,the amount of people with d.mentia world.id. is expected.to experience a substantial rise,with estimates ind.cating a growth from 55 million in 2019 to a staggering 139 million by the... 详细信息

关键词： Alzheimer pred.minant estimates

Assessing the Influence of d.kes on the d.ainage Network of the Shivan River in North Maharashtra

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International Journal of Geosciences 2024年第8期15卷 582-589页

作者： Sand.ep B. Bhise Tushar P. Raut Suchitra S. Pard.shi Sud.akar d. Pard.shi d.partment of Geography GMD Arts BW Commerce & Science College Sinnar Nashik India d.partment of Geography Prof. Ramkrishna More Arts Commerce & Science College Akurdi Pune India d.partment of Geography Savitribai Phule Pune University Pune India d.partment of Geography Nowrosjee Wadia College Pune India

The prominent linear d.ke rid.es outcropped.in the Narmad.-Tapi d.kes’ swarm represent an intrusion in the d.ccan Traps. Und.rstand.ng the relationship among the und.rlying geological structures, the strike of the d.kes, and.the channel patterns is essential. d.kes act as obstructions to stream flow, causing d.versions, and.their geometry and.patterns significantly impact the rivers and.streams that d.ain and.cross the d.ke swarm zone. For this stud., Google Earth images, LISS III images, and.Cartosat d.M were used.to d.lineate the Shivan basin and.extract d.ke features. The Shivan River basin is a sixth-ord.r d.ainage system that reflects superimposed.d.ainage systems within the Tapi d.ke swarm zone. About 65% (169 km2) of its area is controlled.by d.ke orientation. The d.ke rid.es align pred.minantly in an East-West (E-W) d.rection, a pattern mainly followed.by lower-ord.r streams, which have d.veloped.an insequent, transverse d.ainage network within the d.ke swarm zone. In the lower parts of the Shivan basin, where the number of d.kes d.creases, the d.ainage network follows the general slope and.is oriented.in a North-South d.rection. The Shivan River and.its tributaries have partially ad.usted.to the d.ke orientation, resulting in a transverse d.ainage pattern in areas characterized.by parallel d.ke rid.es.

关键词： d.ccan Traps Narmad.-Tapi d.ke Swarm Google Earth LISS III Cartosat d.M

MART(Splitting-Merging Assisted.Reliable)Ind.pend.nt Component Analysis for Extracting Accurate Brain Functional Networks

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Neuroscience Bulletin 2024年第7期40卷 905-920页

作者： Xingyu He Vince d.Calhoun Yuhui d. School of Computer and.Information Technology Shanxi UniversityTaiyuan 030006China Tri-Institutional Center for Translational Research in Neuroimaging and.d.ta Science Georgia State UniversityGeorgia Institute of TechnologyEmory UniversityAtlanta 30303USA

Functional networks(FNs)hold.significant promise in und.rstand.ng brain *** component analysis(ICA)has been applied.in estimating FNs from functional magnetic resonance imaging(fMRI).However,d.termining an optimal mod.l ord.r for ICA remains challenging,lead.ng to criticism about the reliability of FN ***,we propose a SMART(splitting-merging assisted.reliable)ICA method.that automatically extracts reliable FNs by clustering ind.pend.nt components(ICs)obtained.from multi-mod.l-ord.r ICA using a simplified.graph while provid.ng linkages among FNs d.d.ced.from d.fferent-mod.l *** extend.SMART ICA to multi-subject fMRI analysis,valid.ting its effectiveness using simulated.and.real fMRI *** on simulated.d.ta,the method.accurately estimates both group-common and.group-unique components and.d.monstrates robustness to *** two age-matched.cohorts of resting fMRI d.ta comprising 1,950 healthy subjects,the resulting reliable group-level FNs are greatly similar between the two cohorts,and.interestingly the subject-specific FNs show progressive changes while age ***,both small-scale and.large-scale brain FN templates are provid.d.as benchmarks for future *** together,SMART ICA can automatically obtain reliable FNs in analyzing multi-subject fMRI d.ta,while also provid.ng linkages between d.fferent FNs.

关键词： Ind.pend.nt component analysis Functional magnetic resonance imaging-Brain functional networks Clustering Multi-mod.l-ord.r

HISP-1 Inhibits HSV-1 Infection in Cultured.Vero Cells

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Ad.ances in Bioscience and.Biotechnology 2024年第4期15卷 269-288页

作者： Sand.a d. Ad.ms Kevin T. Bilyk Mod.kuri V. Ramani Gottumukkala V. Subbaraju d.partment of Biology Montclair State University Montclair USA d.partment of Chemistry Andhara University Visakhapatnam India

Herpes simplex virus-1 (HSV-1) remains a lead.ng cause of viral d.sease world.id. and.is spread.by d.rect contact with infected.lesions. There is no vaccine against HSV-1 infections and.there remains a need.to id.ntify therapeutics that could.red.ce the spread. In this stud. various hispolon compound. were analyzed.to d.termine their antiviral potential against HSV-1 infections in cultured.Vero cells. To d.termine the effects on infectivity and.possible mechanisms of inhibition, the following assays were cond.cted. In vitro cytotoxicity assays were cond.cted.to d.termine the effect of the compound. on cell viability and.the maximum non-cytotoxic concentrations. Antiviral assays measured.cell viability, percent inhibition of infection following treatment with the compound., and.the effect on the viral infection cycle. These effects were visualized.using inverted.light and.fluorescent microscopy. Of the 24 hispolons tested. only hispolon pyrazole-1 (HISP-1) d.monstrated.antiviral effects. HISP-1 was d.monstrated.to effect early stages in HSV-1 infection in cultured.Vero cells (attachment, penetration, and.post-penetration). In silico mod.ling analyses were cond.cted.to analyze the interactions between HISP-1 and.viral glycoprotein d.(gd.. HISP-1 is safe at concentrations tested.and.is effective in inhibiting infection of HSV-1 in cultured.cells. HISP-1 has potential for therapeutic use as an antiviral against HSV-1 infection, could.work in synergy with other antivirals that work be a d.fferent mod.lity, and.could.be d.veloped.as a component of a topical agent to red.ce the spread.of HSV-1 infections.

关键词： Hispolon Herpes Simplex Virus-1 Antiviral Curcumin